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Volumn 23, Issue 5, 2018, Pages 526-534

Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of β-lactam plus macrolide combination therapy

Author keywords

algorithms; antibiotics; community acquired pneumonia; drug resistance, bacterial; pneumonia

Indexed keywords

AZITHROMYCIN; BETA LACTAM; CEFOTAXIME; CEFTRIAXONE; CLARITHROMYCIN; ERYTHROMYCIN; MACROLIDE; SULTAMICILLIN; ANTIINFECTIVE AGENT; CARBON DIOXIDE; SERUM ALBUMIN;

EID: 85038003452     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/resp.13232     Document Type: Article
Times cited : (17)

References (41)
  • 1
    • 85045581182 scopus 로고    scopus 로고
    • The top 10 causes of death. [Accessed 28 Sept 2016.] Available from
    • World Health Organization. The top 10 causes of death. [Accessed 28 Sept 2016.] Available from URL: http://www.who.int/mediacentre/factsheets/fs310/en/
  • 5
    • 85014252045 scopus 로고    scopus 로고
    • Year in review 2016: respiratory infections, acute respiratory distress syndrome, pleural diseases, lung cancer and interventional pulmonology
    • Restrepo MI, Chalmers JD, Song Y, Mallow C, Hewlett J, Maldonado F, Yarmus L. Year in review 2016: respiratory infections, acute respiratory distress syndrome, pleural diseases, lung cancer and interventional pulmonology. Respirology 2017; 22: 602–11.
    • (2017) Respirology , vol.22 , pp. 602-611
    • Restrepo, M.I.1    Chalmers, J.D.2    Song, Y.3    Mallow, C.4    Hewlett, J.5    Maldonado, F.6    Yarmus, L.7
  • 6
    • 84952870722 scopus 로고    scopus 로고
    • Polymicrobial community-acquired pneumonia: an emerging entity
    • Cilloniz C, Civljak R, Nicolini A, Torres A. Polymicrobial community-acquired pneumonia: an emerging entity. Respirology 2016; 21: 65–75.
    • (2016) Respirology , vol.21 , pp. 65-75
    • Cilloniz, C.1    Civljak, R.2    Nicolini, A.3    Torres, A.4
  • 7
    • 84886434344 scopus 로고    scopus 로고
    • Risk factors for drug-resistant pathogens in community-acquired and healthcare-associated pneumonia., Am. J. Respir. Crit. Care Med., 188 985–95
    • Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Shiraki A, Goto Y, Fukui Y, Iwaki M, Okumura J et al.; on behalf of the Central Japan Lung Study Group. Risk factors for drug-resistant pathogens in community-acquired and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med. 2013; 188: 985–95.
    • (2013)
    • Shindo, Y.1    Ito, R.2    Kobayashi, D.3    Ando, M.4    Ichikawa, M.5    Shiraki, A.6    Goto, Y.7    Fukui, Y.8    Iwaki, M.9    Okumura, J.10
  • 9
    • 84960106693 scopus 로고    scopus 로고
    • Empiric antibiotic selection and risk prediction of drug-resistant pathogens in community-onset pneumonia
    • Webb BJ, Jones B, Dean NC. Empiric antibiotic selection and risk prediction of drug-resistant pathogens in community-onset pneumonia. Curr. Opin. Infect. Dis. 2016; 29: 167–77.
    • (2016) Curr. Opin. Infect. Dis. , vol.29 , pp. 167-177
    • Webb, B.J.1    Jones, B.2    Dean, N.C.3
  • 12
    • 22644444626 scopus 로고    scopus 로고
    • Addition of macrolide in treating adult hospitalized community-acquired pneumonia
    • Loh LC, Quah SY, Khoo SK, Vijayasingham P, Thayaparan T. Addition of macrolide in treating adult hospitalized community-acquired pneumonia. Respirology 2005; 10: 371–7.
    • (2005) Respirology , vol.10 , pp. 371-377
    • Loh, L.C.1    Quah, S.Y.2    Khoo, S.K.3    Vijayasingham, P.4    Thayaparan, T.5
  • 13
    • 84940877479 scopus 로고    scopus 로고
    • Update on the combination effect of macrolide antibiotics in community-acquired pneumonia
    • Emmet O'Brien M, Restrepo MI, Martin-Loeches I. Update on the combination effect of macrolide antibiotics in community-acquired pneumonia. Respir. Investig. 2015; 53: 201–9.
    • (2015) Respir. Investig. , vol.53 , pp. 201-209
    • Emmet O'Brien, M.1    Restrepo, M.I.2    Martin-Loeches, I.3
  • 14
    • 84957922148 scopus 로고    scopus 로고
    • Antibiotic therapy for adults hospitalized with community-acquired pneumonia: a systematic review
    • Lee JS, Giesler DL, Gellad WF, Fine MJ. Antibiotic therapy for adults hospitalized with community-acquired pneumonia: a systematic review. JAMA 2016; 315: 593–602.
    • (2016) JAMA , vol.315 , pp. 593-602
    • Lee, J.S.1    Giesler, D.L.2    Gellad, W.F.3    Fine, M.J.4
  • 15
    • 58849116396 scopus 로고    scopus 로고
    • Can CAP guideline adherence improve patient outcome in internal medicine departments?
    • Blasi F, Iori I, Bulfoni A, Corrao S, Costantino S, Legnani D. Can CAP guideline adherence improve patient outcome in internal medicine departments? Eur. Respir. J. 2008; 32: 902–10.
    • (2008) Eur. Respir. J. , vol.32 , pp. 902-910
    • Blasi, F.1    Iori, I.2    Bulfoni, A.3    Corrao, S.4    Costantino, S.5    Legnani, D.6
  • 16
    • 35848941214 scopus 로고    scopus 로고
    • Comparison of beta-lactam and macrolide combination therapy versus fluoroquinolone monotherapy in hospitalized veterans affairs patients with community-acquired pneumonia
    • Lodise TP, Kwa A, Cosler L, Gupta R, Smith RP. Comparison of beta-lactam and macrolide combination therapy versus fluoroquinolone monotherapy in hospitalized veterans affairs patients with community-acquired pneumonia. Antimicrob. Agents Chemother. 2007; 51: 3977–82.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 3977-3982
    • Lodise, T.P.1    Kwa, A.2    Cosler, L.3    Gupta, R.4    Smith, R.P.5
  • 18
    • 84877600674 scopus 로고    scopus 로고
    • Contribution of host, bacterial factors and antibiotic treatment to mortality in adult patients with bacteraemic pneumococcal pneumonia
    • Naucler P, Darenberg J, Morfeldt E, Ortqvist A, Henriques Normark B. Contribution of host, bacterial factors and antibiotic treatment to mortality in adult patients with bacteraemic pneumococcal pneumonia. Thorax 2013; 68: 571–9.
    • (2013) Thorax , vol.68 , pp. 571-579
    • Naucler, P.1    Darenberg, J.2    Morfeldt, E.3    Ortqvist, A.4    Henriques Normark, B.5
  • 21
    • 84919486371 scopus 로고    scopus 로고
    • Beta-lactam monotherapy vs beta-lactam-macrolide combination treatment in moderately severe community-acquired pneumonia: a randomized noninferiority trial
    • Garin N, Genne D, Carballo S, Chuard C, Eich G, Hugli O, Lamy O, Nendaz M, Petignat PA, Perneger T et al. Beta-lactam monotherapy vs beta-lactam-macrolide combination treatment in moderately severe community-acquired pneumonia: a randomized noninferiority trial. JAMA Intern. Med. 2014; 174: 1894–901.
    • (2014) JAMA Intern. Med. , vol.174 , pp. 1894-1901
    • Garin, N.1    Genne, D.2    Carballo, S.3    Chuard, C.4    Eich, G.5    Hugli, O.6    Lamy, O.7    Nendaz, M.8    Petignat, P.A.9    Perneger, T.10
  • 23
    • 61349125517 scopus 로고    scopus 로고
    • New insights into pneumococcal disease
    • Feldman C, Anderson R. New insights into pneumococcal disease. Respirology 2009; 14: 167–79.
    • (2009) Respirology , vol.14 , pp. 167-179
    • Feldman, C.1    Anderson, R.2
  • 24
    • 84940467171 scopus 로고    scopus 로고
    • Risk factors for 30-day mortality in patients with pneumonia who receive appropriate initial antibiotics an observational cohort study
    • Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Goto Y, Fukui Y, Iwaki M, Okumura J, Yamaguchi I et al.; Central Japan Lung Study Group. Risk factors for 30-day mortality in patients with pneumonia who receive appropriate initial antibiotics: an observational cohort study. Lancet Infect. Dis. 2015; 15: 1055–65.
    • (2015) Lancet Infect. Dis , vol.15 , pp. 1055-1065
    • Shindo, Y.1    Ito, R.2    Kobayashi, D.3    Ando, M.4    Ichikawa, M.5    Goto, Y.6    Fukui, Y.7    Iwaki, M.8    Okumura, J.9    Yamaguchi, I.10
  • 25
    • 0030015661 scopus 로고    scopus 로고
    • The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine
    • Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996; 22: 707–10.
    • (1996) Intensive Care Med. , vol.22 , pp. 707-710
    • Vincent, J.L.1    Moreno, R.2    Takala, J.3    Willatts, S.4    De Mendonca, A.5    Bruining, H.6    Reinhart, C.K.7    Suter, P.M.8    Thijs, L.G.9
  • 27
    • 0038554228 scopus 로고    scopus 로고
    • Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study
    • Lim WS, van der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI, Lewis SA, Macfarlane JT. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax 2003; 58: 377–82.
    • (2003) Thorax , vol.58 , pp. 377-382
    • Lim, W.S.1    van der Eerden, M.M.2    Laing, R.3    Boersma, W.G.4    Karalus, N.5    Town, G.I.6    Lewis, S.A.7    Macfarlane, J.T.8
  • 28
    • 47149086953 scopus 로고    scopus 로고
    • Comparison of severity scoring systems A-DROP and CURB-65 for community-acquired pneumonia
    • Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Imaizumi K, Hasegawa Y. Comparison of severity scoring systems A-DROP and CURB-65 for community-acquired pneumonia. Respirology 2008; 13: 731–5.
    • (2008) Respirology , vol.13 , pp. 731-735
    • Shindo, Y.1    Sato, S.2    Maruyama, E.3    Ohashi, T.4    Ogawa, M.5    Imaizumi, K.6    Hasegawa, Y.7
  • 31
    • 84923125114 scopus 로고    scopus 로고
    • Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial
    • Torres A, Sibila O, Ferrer M, Polverino E, Menendez R, Mensa J, Gabarrus A, Sellares J, Restrepo MI, Anzueto A et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. JAMA 2015; 313: 677–86.
    • (2015) JAMA , vol.313 , pp. 677-686
    • Torres, A.1    Sibila, O.2    Ferrer, M.3    Polverino, E.4    Menendez, R.5    Mensa, J.6    Gabarrus, A.7    Sellares, J.8    Restrepo, M.I.9    Anzueto, A.10
  • 32
    • 84995377035 scopus 로고    scopus 로고
    • Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society
    • Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, Napolitano LM, O'Grady NP, Bartlett JG, Carratala J et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin. Infect. Dis. 2016; 63: e61–e111.
    • (2016) Clin. Infect. Dis. , vol.63 , pp. e61-e111
    • Kalil, A.C.1    Metersky, M.L.2    Klompas, M.3    Muscedere, J.4    Sweeney, D.A.5    Palmer, L.B.6    Napolitano, L.M.7    O'Grady, N.P.8    Bartlett, J.G.9    Carratala, J.10
  • 33
    • 58149260516 scopus 로고    scopus 로고
    • Initial antibiotic selection and patient outcomes: observations from the National Pneumonia Project
    • Bratzler DW, Ma A, Nsa W. Initial antibiotic selection and patient outcomes: observations from the National Pneumonia Project. Clin. Infect. Dis. 2008; 47(Suppl. 3): S193–201.
    • (2008) Clin. Infect. Dis. , vol.47 , pp. S193-201
    • Bratzler, D.W.1    Ma, A.2    Nsa, W.3
  • 34
    • 84886385257 scopus 로고    scopus 로고
    • Community-acquired pneumonia versus healthcare-associated pneumonia. The returning pendulum
    • Wunderink RG. Community-acquired pneumonia versus healthcare-associated pneumonia. The returning pendulum. Am. J. Respir. Crit. Care Med. 2013; 188: 896–8.
    • (2013) Am. J. Respir. Crit. Care Med. , vol.188 , pp. 896-898
    • Wunderink, R.G.1
  • 35
    • 0033596083 scopus 로고    scopus 로고
    • Associations between initial antimicrobial therapy and medical outcomes for hospitalized elderly patients with pneumonia
    • Gleason PP, Meehan TP, Fine JM, Galusha DH, Fine MJ. Associations between initial antimicrobial therapy and medical outcomes for hospitalized elderly patients with pneumonia. Arch. Intern. Med. 1999; 159: 2562–72.
    • (1999) Arch. Intern. Med. , vol.159 , pp. 2562-2572
    • Gleason, P.P.1    Meehan, T.P.2    Fine, J.M.3    Galusha, D.H.4    Fine, M.J.5
  • 37
    • 84903199584 scopus 로고    scopus 로고
    • Macrolides are associated with a better survival rate in patients hospitalized with community-acquired but not healthcare-associated pneumonia
    • McEvoy C, Micek ST, Reichley RM, Kan J, Hoban A, Hoffmann J, Shorr AF, Kollef MH. Macrolides are associated with a better survival rate in patients hospitalized with community-acquired but not healthcare-associated pneumonia. Surg. Infect. (Larchmt.) 2014; 15: 283–9.
    • (2014) Surg. Infect. (Larchmt.) , vol.15 , pp. 283-289
    • McEvoy, C.1    Micek, S.T.2    Reichley, R.M.3    Kan, J.4    Hoban, A.5    Hoffmann, J.6    Shorr, A.F.7    Kollef, M.H.8
  • 38
    • 77954595517 scopus 로고    scopus 로고
    • Mechanisms of action and clinical application of macrolides as immunomodulatory medications
    • Kanoh S, Rubin BK. Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin. Microbiol. Rev. 2010; 23: 590–615.
    • (2010) Clin. Microbiol. Rev. , vol.23 , pp. 590-615
    • Kanoh, S.1    Rubin, B.K.2
  • 40
    • 84903904746 scopus 로고    scopus 로고
    • Beta-lactam/macrolide dual therapy versus beta-lactam monotherapy for the treatment of community-acquired pneumonia in adults: a systematic review and meta-analysis
    • Nie W, Li B, Xiu Q. Beta-lactam/macrolide dual therapy versus beta-lactam monotherapy for the treatment of community-acquired pneumonia in adults: a systematic review and meta-analysis. J. Antimicrob. Chemother. 2014; 69: 1441–6.
    • (2014) J. Antimicrob. Chemother. , vol.69 , pp. 1441-1446
    • Nie, W.1    Li, B.2    Xiu, Q.3
  • 41
    • 85026738982 scopus 로고    scopus 로고
    • Regional differences in antibiotic-resistant pathogens in patients with pneumonia: implications for clinicians
    • Shindo Y, Hasegawa Y. Regional differences in antibiotic-resistant pathogens in patients with pneumonia: implications for clinicians. Respirology 2017; 22: 1536–46.
    • (2017) Respirology , vol.22 , pp. 1536-1546
    • Shindo, Y.1    Hasegawa, Y.2


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