The bidirectional relationship between anxiety disorders and circulating levels of inflammatory markers: Results from a large longitudinal population-based study

Depression and Anxiety

Volumn 35, Issue 4, 2018, Pages 360-371

  Glaus, Jennifer ^a,b   von Känel, Roland ^c,d   Lasserre, Aurélie M ^a   Strippoli, Marie Pierre F ^a   Vandeleur, Caroline L ^a   Castelao, Enrique ^a   Gholam Rezaee, Mehdi ^a   Marangoni, Ciro ^b   Wagner, En Young N ^d   Marques Vidal, Pedro ^a   Waeber, Gérard ^a   Vollenweider, Peter ^a   Preisig, Martin ^a   Merikangas, Kathleen R ^b  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c Clinic Barmelweid   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

agoraphobia; anxiety disorders; body mass index; C reactive protein; cytokines; panic disorder; social phobia

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; IL6 PROTEIN, HUMAN; TNF PROTEIN, HUMAN;

ADULT; AGORAPHOBIA; ANXIETY DISORDER; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; INFLAMMATION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SEMI STRUCTURED INTERVIEW; BLOOD; FOLLOW UP;

ADULT; AGORAPHOBIA; ANXIETY DISORDERS; BIOMARKERS; C-REACTIVE PROTEIN; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFLAMMATION; INTERLEUKIN-6; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; STRESS DISORDERS, POST-TRAUMATIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85037996527     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.22710     Document Type: Article

References (41)

1. Baker, D. G., Ekhator, N. N., Kasckow, J. W., Hill, K. K., Zoumakis, E., Dashevsky, B. A., … Geracioti, T. D., Jr. (2001). Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder.Neuroimmunomodulation, 9(4), 209–217.
2. Berney, A., Preisig, M., Matthey, M. L., Ferrero, F., & Fenton, B. T. (2002). Diagnostic interview for genetic studies (DIGS): Inter-rater and test-retest reliability of alcohol and drug diagnoses. Drug and Alcohol Dependence, 65(2), 149–158.
3. Chalmers, J. A., Quintana, D. S., Abbott, M. J., & Kemp, A. H. (2014). Anxiety disorders are associated with reduced heart rate variability: A meta-analysis. Frontiers in Psychiatry, 5, 80.
4. Copeland, W. E., Shanahan, L., Worthman, C., Angold, A., & Costello, E. J. (2012). Generalized anxiety and C-reactive protein levels: A prospective, longitudinal analysis. Psychological Medicine, 42(12), 2641–2650.
5. Das, A. (2016). Psychosocial distress and inflammation: Which way does causality flow? Social Science and Medicine, 170, 1–8.
6. Elenkov, I. J. (2008). Neurohormonal-cytokine interactions: Implications for inflammation, common human diseases and well-being. Neurochemistry International, 52(1-2), 40–51.
7. Emdin, C. A., Odutayo, A., Wong, C. X., Tran, J., Hsiao, A. J., & Hunn, B. H. (2016). Meta-analysis of anxiety as a risk factor for cardiovascular disease. American Journal of Cardiology, 118(4), 511–519.
8. Endicott, J., & Spitzer, R. L. (1978). A diagnostic interview: The schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35(7), 837–844.
9. Firmann, M., Mayor, V., Vidal, P. M., Bochud, M., Pecoud, A., Hayoz, D., … Vollenweider, P. (2008). The CoLaus study: A population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovascular Disorders, 8, 6.
10. Furtado, M., & Katzman, M. A. (2015). Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders. Psychiatry Research, 229(1-2), 37–48.
11. Gill, J. M., Saligan, L., Woods, S., & Page, G. (2009). PTSD is associated with an excess of inflammatory immune activities. Perspectives in Psychiatric Care, 45(4), 262–277.
12. Glaus, J., Vandeleur, C., Gholam-Rezaee, M., Castelao, E., Perrin, M., Rothen, S., … Preisig, M. (2013). Atypical depression and alcohol misuse are related to the cardiovascular risk in the general population. ActaPsychiatricaScandinavica, 128(4), 282–293.
13. Glaus, J., Vandeleur, C. L., von Kanel, R., Lasserre, A. M., Strippoli, M. P., Gholam-Rezaee, M., … Preisig, M. (2014). Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study. Journala of Psychiatric Research, 58, 36–45.
14. Haensel, A., Mills, P. J., Nelesen, R. A., Ziegler, M. G., & Dimsdale, J. E. (2008). The relationship between heart rate variability and inflammatory markers in cardiovascular diseases. Psychoneuroendocrinology, 33(10), 1305–1312.
15. Hollingshead, A. B. (1975). Four factor Index of social status. London: Yale University Press.
16. Khandaker, G. M., Zammit, S., Lewis, G., & Jones, P. B. (2016). Association between serum C-reactive protein and DSM-IV generalized anxiety disorder in adolescence: Findings from the ALSPAC cohort. Neurobiology of Stress, 4, 55–61.
17. Leboyer, M., Barbe, B., Gorwood, P., Teherani, M., Allilaire, J. F., Preisig, M., … Ferrero, F. (1995). Interview Diagnostique pour les Etudes Génétiques. Paris: INSE, RM.
18. Leboyer, M., Maier, W., Teherani, M., Lichtermann, D., D'Amato, T., Franke, P., … McGuffin, P. (1991). The reliability of the SADS-LA in a family study setting. European Archives of Psychiatry and Clinical Neuroscience, 241(3), 165–169.
19. Liukkonen, T., Rasanen, P., Jokelainen, J., Leinonen, M., Jarvelin, M. R., Meyer-Rochow, V. B., & Timonen, M. (2011). The association between anxiety and C-reactive protein (CRP) levels: Results from the Northern Finland 1966 birth cohort study. European Psychiatry, 26(6), 363–369.
20. Liukkonen, T., Silvennoinen-Kassinen, S., Jokelainen, J., Rasanen, P., Leinonen, M., Meyer-Rochow, V. B., & Timonen, M. (2006). The association between C-reactive protein levels and depression: Results from the northern Finland 1966 birth cohort study. Biological Psychiatry, 60(8), 825–830.
21. Marques-Vidal, P., Bochud, M., Bastardot, F., Luscher, T., Ferrero, F., Gaspoz, J. M., … Vollenweider, P. (2011). Levels and determinants of inflammatory biomarkers in a Swiss population-based sample (CoLaus study). Plos One, 6(6), e21002.
22. Miller, R. J., Sutherland, A. G., Hutchison, J. D., & Alexander, D. A. (2001). C-reactive protein and interleukin 6 receptor in post-traumatic stress disorder: A pilot study. Cytokine, 13(4), 253–255.
23. Nurnberger, J. I., Jr., Blehar, M. C., Kaufmann, C. A., York-Cooler, C., Simpson, S. G., Harkavy-Friedman, J., … Reich, T. (1994). Diagnostic interview for genetic studies.Rationale, unique features, and training.NIMH Genetics Initiative. Archives of General Psychiatry, 51(11), 849–859.
24. Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O. I., Criqui, M., … Vinicor, F. (2003). Markers of inflammation and cardiovascular disease: Application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation, 107(3), 499–511.
25. Pitsavos, C., Panagiotakos, D. B., Papageorgiou, C., Tsetsekou, E., Soldatos, C., & Stefanadis, C. (2006). Anxiety in relation to inflammation and coagulation markers, among healthy adults: The ATTICA Study. Atherosclerosis, 185(2), 320–326.
26. Plantinga, L., Bremner, J. D., Miller, A. H., Jones, D. P., Veledar, E., Goldberg, J., & Vaccarino, V. (2013). Association between posttraumatic stress disorder and inflammation: A twin study. Brain, Behavior and Immunity, 30, 125–132.
27. Preisig, M., Fenton, B. T., Matthey, M. L., Berney, A., & Ferrero, F. (1999). Diagnostic interview for genetic studies (DIGS): Inter-rater and test-retest reliability of the French version. European Archives of Psychiatry and Clinical Neuroscience, 249(4), 174–179.
28. Preisig, M., Waeber, G., Vollenweider, P., Bovet, P., Rothen, S., Vandeleur, C., … Muglia, P. (2009). The PsyCoLaus study: Methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors. Bmc Psychiatry [Electronic Resource], 9, 9.
29. Rougemont-Buecking, A., Rothen, S., Jeanpretre, N., Lustenberger, Y., Vandeleur, C. L., Ferrero, F., & Preisig, M. (2008). Inter-informant agreement on diagnoses and prevalence estimates of anxiety disorders: Direct interview versus family history method. Psychiatry Research, 157(1-3), 211–223.
30. Salim, S., Chugh, G., & Asghar, M. (2012). Inflammation in anxiety. Advances in Protein Chemistry and Structural Biology, 88, 1–25.
31. Skeppholm, M., Wallen, N. H., Blomback, M., & Kallner, A. (2008). Can both EDTA and citrate plasma samples be used in measurements of fibrinogen and C-reactive protein concentrations? Clinical Chemistryand Laboratory Medicine, 46(8), 1175–1179.
32. Spitzer, C., Barnow, S., Volzke, H., Wallaschofski, H., John, U., Freyberger, H. J., … Grabe, H. J. (2010). Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: Evidence from the general population. Journal of Psychiatry Research, 44(1), 15–21.
33. Tully, P. J., Cosh, S. M., & Baune, B. T. (2013). A review of the effects of worry and generalized anxiety disorder upon cardiovascular health and coronary heart disease. Psychology, Health &Medicine, 18(6), 627–644.
34. Turna, J., Grosman Kaplan, K., Anglin, R., & Van Ameringen, M. (2016). What's bugging the gut in OCD?”: A review of the gut microbiome in obsessive-compulsive disorder. Depression and Anxiety, 33(3), 171–178.
35. Van der Kooy, K., van Hout, H., Marwijk, H., Marten, H., Stehouwer, C., & Beekman, A. (2007). Depression and the risk for cardiovascular diseases: Systematic review and meta analysis. International Journal of Geriatric Psychiatry, 22(7), 613–626.
36. Vidovic, A., Gotovac, K., Vilibic, M., Sabioncello, A., Jovanovic, T., Rabatic, S., … Dekaris, D. (2011). Repeated assessments of endocrine- and immune-related changes in posttraumatic stress disorder. Neuroimmunomodulation, 18(4), 199–211.
37. Vlachopoulos, C., Xaplanteris, P., Aboyans, V., Brodmann, M., Cifkova, R., Cosentino, F., … Townsend, R. R. (2015). The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society. Atherosclerosis, 241(2), 507–532.
38. Vogelzangs, N., Beekman, A. T., de Jonge, P., & Penninx, B. W. (2013). Anxiety disorders and inflammation in a large adult cohort. Translational Psychiatry, 3, e249.
39. von Kanel, R., Begre, S., Abbas, C. C., Saner, H., Gander, M. L., & Schmid, J. P. (2010). Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms. Neuroimmunomodulation, 17(1), 39–46.
40. von Kanel, R., Hepp, U., Kraemer, B., Traber, R., Keel, M., Mica, L., & Schnyder, U. (2007). Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. Journal of Psychiatric Research, 41(9), 744–752.
41. Wagner, E. Y., Wagner, J. T., Glaus, J., Vandeleur, C. L., Castelao, E., Strippoli, M. P., … von Kanel, R. (2015). Evidence for chronic low-grade systemic inflammation in individuals with agoraphobia from a population-based prospective study. Plos One, 10(4), e0123757.