Remission and recovery from first-episode psychosis in adults: Systematic review and meta-analysis of long-term outcome studies

British Journal of Psychiatry

Volumn 211, Issue 6, 2017, Pages 350-358

  Lally, John ^a,b,c   Ajnakina, Olesya ^a   Stubbs, Brendon ^a   Cullinane, Michael ^d   Murphy, Kieran C ^b   Gaughran, Fiona ^a   Murray, Robin M ^e  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^d St Fintan's Hospital   (Ireland)

^e SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLOW UP; HUMAN; LONG TERM CARE; META ANALYSIS; PREVALENCE; PSYCHOSIS; REMISSION; REVIEW; SYSTEMATIC REVIEW; ADULT; OUTCOME ASSESSMENT; STATISTICS AND NUMERICAL DATA;

ADULT; HUMANS; OUTCOME ASSESSMENT (HEALTH CARE); PSYCHOTIC DISORDERS;

EID: 85037832899     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.117.201475     Document Type: Review

References (103)

1. Tandon R, Nasrallah HA, Keshavan MS. Schizophrenia, 'just the facts' 4. Clinical features and conceptualization. Schizophr Res 2009;110:1-23.
2. Zipursky RB, Reilly TJ, Murray RM. The myth of schizophrenia as a progressive brain disease. Schizophr Bull 2013;39:1363-72.
3. McGorry P, Johanessen JO, Lewis S, Birchwood M, Malla A, Nordentoft M, et al. Early intervention in psychosis: keeping faith with evidence-based health care. Psychol Med 2010;40:399-404.
4. Craig TKJ, Garety P, Power P, Rahaman N, Colbert S, Fornells-Ambrojo M, et al. The Lambeth Early Onset (LEO) Team: randomised controlled trial of the effectiveness of specialised care for early psychosis. BMJ 2004;329:1067.
5. Warner R. Recovery from Schizophrenia: Psychiatry and Political Economy. Brunner-Routledge, 2004.
6. AlAqeel B, Margolese HC. Remission in schizophrenia: critical and systematic review. Harv Rev Psychiatry 2012;20:281-97.
7. Menezes NM, Arenovich T, Zipursky RB. A systematic review of longitudinal outcome studies of first-episode psychosis. Psychol Med 2006;36:1349-62.
8. Hegarty JD, Baldessarini RJ, Tonen M, Waternaux C, Oepen G. One hundred years of schizophrenia: a meta-analysis of the outcome literature. Am J Psychiatry 1994;151:1409-16.
9. Jääskeläinen E, Juola P, Hirvonen N, McGrath JJ, saha S, isohanni M, et al. A systematic review and meta-analysis of recovery in schizophrenia. Schizophr Bull 2013;39:1296-306.
10. Henry LP, Amminger GP, Harris MG, Yuen HP, Harrigan SM, Prosser AL, et al. The eppic follow-up study of first-episode psychosis: longer-term clinical and functional outcome 7 years after index admission. J Clin Psychiatry 2010;71:716-28.
11. Morgan C, Lappin J, Heslin M, Donoghue K, Lomas B, Reininghaus U, et al. Reappraising the long-term course and outcome of psychotic disorders: the AESOP-10 Study. Psychol Med 2014;44:2713-26.
12. Tang JYM, Chang WC, Hui CLM, Wong GHY, Chan SKW, Lee EHM, et al. Prospective relationship between duration of untreated psychosis and 13-year clinical outcome: a first-episode psychosis study. Schizophr Res 2014;153:1-8.
13. Evensen J, Rossberg JI, Barder H, Haahr U, Hegelstad WW, Joa I, et al. Flat affect and social functioning: a 10 year follow-up study of first episode psychosis patients. Schizophr Res 2012;139:99-104.
14. Andreasen NC, Carpenter WT, Kane JM, Lasser RA, Marder SR, Weinberger DR. Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry 2005;162:441-9.
15. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008-12.
16. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151:264-9.
17. Warner R. Recovery from schizophrenia and the recovery model. Curr Opin Psychiatry 2009;22:374-80.
18. Leucht S, Lasser R. The concepts of remission and recovery in schizophrenia. Pharmacopsychiatry 2006;39:161-70.
19. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34.
20. Duvall S, Tweedie R. A non-parametric 'trim and fill' method for assessing publication bias in meta-analysis. J Am Stat Assoc 2000;95:89-98.
21. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60.
22. Harrow M, Grossman LS, Jobe TH, Herbener ES. Do patients with schizophrenia ever show periods of recovery? A 15-year multi-follow-up study. Schizophr Bull 2005;31:723-34.
23. Mojtabai R, Süsser ES, Bromet EJ. Clinical characteristics, 4-year course, and DSM-Iv classification of patients with nonaffective acute remitting psychosis. Am J Psychiatry 2003;160:2108-15.
24. Naz B, Craig TJ, Bromet EJ, Finch SJ, Fochtmann U, Carlson GA. Remission and relapse after the first hospital admission in psychotic depression: a 4-year naturalistic follow-up. Psychol Med 2007;37:1173-81.
25. Carlson GA, Bromet EJ, Sievers S. Phenomenology and outcome of subjects with early- and adult-onset psychotic mania. Am J Psychiatry 2000;157:213-9.
26. Craig TJ, Bromet EJ, Fennig S, Tanenberg-Karant M, Lavelle J, Galambos N. Is there an association between duration of untreated psychosis and 24-month clinical outcome in a first-admission series? Am J Psychiatry 2000;157:60-6.
27. Zarate CA, Tonen M, Land ML. First-episode schizophreniform disorder: comparisons with first-episode schizophrenia. Schizophr Res 2000;46:31-4.
28. Tohen M, Hennen J, Zarate CM, Baldessarini RJ, strakowski SM, stoll AL, et al. Two-year syndromal and functional recovery in 219 cases of first-episode major affective disorder with psychotic features. Am J Psychiatry 2000;157:220-8.
29. Tohen M, Khalsa HMK, Salvatore P, Vieta E, Ravichandran C, Baldessarini RJ. Two-year outcomes in first-episode psychotic depression: the McLean-Harvard first-episode project. J Affect Disord 2012;136:1-8.
30. simonsen E, Friis S, Opjordsmoen S, Mortensen EL, Haahr U, Melle I, et al. Early identification of non-remission in first-episode psychosis in a two-year outcome study. Acta Psychiatr Scand 2010;122:375-83.
31. Kua J, Wong KE, Kua EH, Tsoi WF. A 20-year follow-up study on schizophrenia in Singapore. Acta Psychiatr Scand 2003;108:118-25.
32. DeLisi LE, sakuma M, Ge S, Kushner M. Association of brain structural change with the heterogeneous course of schizophrenia from early childhood through five years subsequent to a first hospitalization. Psychiatry Res Neuroimaging 1998;84:75-88.
33. Thara R. Twenty-year course of schizophrenia: the Madras Longitudinal Study. Can J Psychiatry 2004;49:564-9.
34. Kurihara T, Kato M, Reverger R, Tirta IG. Seventeen-year clinical outcome of schizophrenia in Bali. Eur Psychiatry 2011;26:333-8.
35. Alaghband-Rad J, Boroumand M, Amini H, Sharifi V, Omid A, Davari-Ashtiani R, et al. Non-affective acute remitting psychosis: a preliminary report from Iran. Acta Psychiatr Scand 2006;113:96-101.
36. Srivastava AK, stitt L, Thakar M, Shah N, Chinnasamy G. The abilities of improved schizophrenia patients to work and live independently in the community: a 10-year long-term outcome study from Mumbai, India. Ann Gen Hosp Psychiatry 2009;8:24.
37. Verma S, Subramaniam M, Abdin E, Poon LY, Chong SA. Symptomatic and functional remission in patients with first-episode psychosis. Acta Psychiatr Scand 2012;126:282-9.
38. Helgason L. Twenty years' follow-up of first psychiatric presentation for schizophrenia: what could have been prevented? Acta Psychiatr scand 1990;81:231-5.
39. Wiersma D, Wanderling J, Dragomirecka E, Ganev K, Harrison G, An Der Heiden W, et al. Social disability in schizophrenia: its development and prediction over 15 years in incidence cohorts in six European centres. Psychol Med 2000;30:1155-67.
40. Mason P, Harrison G, Glazebrook C, Medley I, Croudace T. The course of schizophrenia over 13 years. A report from the International Study on Schizophrenia (ISoS) coordinated by the World Health Organization. Br J Psychiatry 1996;169:580-6.
41. Vázquez-Barquero JL, Cuesta MJ, Herrera Castañedo S, Lastra I, Herran A, Dunn G. Cantabria first-episode schizophrenia study: three-year follow-up. Br J Psychiatry 1999;174:141-9.
42. Madsen AL, Vorstrup S, Rubin P, Larsen JK, Hemmingsen R. Neurological abnormalities in schizophrenic patients: a prospective follow-up study 5 years after first admission. Acta Psychiatr Scand 1999;100:119-25.
43. Clarke M, Whitty P, Browne S, McTigue O, Kamali M, Gervin M, et al. Untreated illness and outcome of psychosis. Br J Psychiatry 2006;189:235-40.
44. Nyman AK, Jonsson H. Differential evaluation of outcome in schizophrenia. Acta Psychiatr Scand 1983;68:458-75.
45. Mattsson M, Topor A, Cullberg J, ForseIl Y. Association between financial strain, social network and five-year recovery from first episode psychosis. Soc Psychiatry Psychiatr Epidemiol 2008;43:947-52.
46. Whitty P, Clarke M, McTigue O, Browne S, Kamali M, Kinsella A, et al. Predictors of outcome in first-episode schizophrenia over the first 4 years of illness. Psychol Med 2008;38:1141-6.
47. Hill M, Crumlish N, Clarke M, Whitty P, Owens E, Renwick L, et al. Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12 years. Schizophr Res 2012;141:215-21.
48. Rund BR, Barder HE, Evensen J, Haahr U, Hegelstad WT, Joa I, et al. Neurocognition and duration of psychosis: a 10-year follow-up of firstepisode patients. Schizophr Bull 2016;42:87-95.
49. Langeveld J, Joa I, Friis S, Ten Velden Hegelstad W, Melle I, Johannessen JO, et al. A comparison of adolescent- and adult-onset first-episode, nonaffective psychosis: 2-year follow-up. Eur Arch Psychiatry Clin Neurosci 2012;262:599-605.
50. Boden R, Sundstrom J, Lindstrom E, Lindstrom L. Association between symptomatic remission and functional outcome in first-episode schizophrenia. Schizophr Res 2009;107:232-7.
51. Austin SF, Mors O, Secher RG, Hjorthoj CR, Albert N, Bertelsen M, et al. Predictors of recovery In first episode psychosis: the OPUS cohort at 10 year follow-up. Schizophr Res 2013;150:163-8.
52. Albert N, Bertelsen M, Thorup A, Petersen L, Jeppesen P, Le Quach P, et al. Predictors of recovery from psychosis. Analyses of clinical and social factors associated with recovery among patients with first-episode psychosis after 5 years. Schizophr Res 2011;125:257-66.
53. Bertelsen M, Jeppesen P, Petersen L, Thorup A, Ohlenschlaeger J, Quach PL, et al. Course of illness in a sample of 265 patients with first-episode psychosis - five-year follow-up of the Danish OPUS trial. Schizophr Res 2009;107:173-8.
54. Ceskova E, Prikryl R, Kasparek T. Outcome in males with first-episode schizophrenia: 7-year follow-up. World J Biol Psychiatry 2011;12:66-72.
55. Thorup A, Albert N, Bertelsen M, Petersen L, Jeppesen P, Le Quach P, et al. Gender differences in first-episode psychosis at 5-year follow-up - two different courses of disease? Results from the OPUS study at 5-year followup. Eur Psychiatry 2014;29:44-51.
56. Lambert M, Schimmelmann BG, Naber D, Schacht A, Karow A, Wagner T, et al. Prediction of remission as a combination of symptomatic and functional remission and adequate subjective well-being in 2960 patients with schizophrenia. J Clin Psychiatry 2006;67:1690-7.
57. Wunderink L, Sytema S, Nienhuis FJ, Wiersma D. Clinical recovery in firstepisode psychosis. Schizophr Bull 2009;35:362-9.
58. Lambert M, Schimmelmann BG, Schacht A, Karow A, Wagner T, Wehmeier PM, et al. Long-term patterns of subjective wellbeing in schizophrenia: cluster, predictors of cluster affiliation, and their relation to recovery criteria in 2842 patients followed over 3 years. Schizophr Res 2009;107:165-72.
59. Gasquet I, Haro JM, Tcherny-Lessenot S, Charter F, Lepine JP. Remission in the outpatient care of schizophrenia: 3-year results from the Schizophrenia Outpatients Health Outcomes (SOHO) study in France. Eur Psychiatry 2008;23:491-6.
60. Fraguas D, del Rey-Mejias T, Moreno C, Castro-Fornieles J, Graell M, Otero S, et al. Duration of untreated psychosis predicts functional and clinical outcome in children and adolescents with first-episode psychosis: a 2-year longitudinal study. Schizophr Res 2014;152:130-8.
61. Torgalsboen AK, Mohn C, Czajkowski N, Rund BR. Relationship between neurocognition and functional recovery in first-episode schizophrenia: results from the second year of the Oslo multi-follow-up study. Psychiatry Res 2015;227:185-91.
62. Van Os J, Fahy TA, Jones P, Harvey I, Sham P, Lewis S, et al. Psychopathological syndromes in the functional psychoses: associations with course and outcome. Psychol Med 1996;26:161-76.
63. De Haan L, Nimwegen L, Amelsvoort T, Dingemans P, Linszen D. Improvement of subjective well-being and enduring symptomatic remission, a 5-year follow-up of first episode schizophrenia. Pharmacopsychiatry 2008;41:125-8.
64. Shepherd M, Watt D, Falloon I, Smeeton N. The natural history of schizophrenia: a five-year follow-up study of outcome and prediction in a representative sample of schizophrenics. Psychol Med Monogr Suppl 1989;15:1-46.
65. Jablensky A, Sartorius N, Ernberg G, Anker M, Korten A, Cooper JE, et al. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monogr Suppl 1992;20:1-97.
66. Kinoshita H, Nakane Y, Nakane H, Ishizaki Y, Honda S, Ohta Y, et al. Nagasaki schizophrenia study: influence of the duration of untreated psychosis on long-term outcome. Acta Medica Nagasakiensia 2005;50:17-22.
67. Harrison G, Hopper K, Craig T, Laska E, Siegel C, Wanderling J, et al. Recovery from psychotic illness: a 15- and 25-year international follow-up study. Br J Psychiatry 2001;178:506-17.
68. Kaleda VG. The course and outcomes of episodic endogenous psychoses with juvenile onset (a follow-up study). Neurosci Behav Physiol 2009;39:873-84.
69. Bromet EJ, Finch SJ, Carlson GA, Fochtmann L, Mojtabai R, Craig TJ, et al. Time to remission and relapse after the first hospital admission in severe bipolar disorder. Soc Psychiatry Psychiatr Epidemiol 2005;40:106-13.
70. Alvarez-Jimenez M, Gleeson JF, Henry LP, Harrigan SM, Harris MG, Killackey E, et al. Road to full recovery: longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 years. Psychol Med 2012;42:595-606.
71. ucok A, Serbest S, Kandemir PE. Remission after first-episode schizophrenia: results of a long-term follow-up. Psychiatry Res 2011;189:33-7.
72. Emsley R, Rabinowitz J, Medori R. Remission in early psychosis: rates, predictors, and clinical and functional outcome correlates. Schizophr Res 2007;89:129-39.
73. Addington J, Addington D. Symptom remission In first episode patients. Schizophr Res 2008;106:281-5.
74. Perkins DO, Lieberman JA, Gu H, Tohen M, McEvoy J, Green AL, et al. Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders. Br J Psychiatry 2004;185:18-24.
75. Emsley R, Oosthuizen PP, Kidd M, Koen L, Niehaus DJH, Turner HJ. Remission in first-episode psychosis: predictor variables and symptom improvement patterns. J Clin Psychiatry 2006;67:1707-12.
76. Salem MO, Moselhy HF, Attia H, Yousef S. Psychogenic psychosis revisited: a follow up study. Int J Health Sci (Qassim) 2009;3:45-9.
77. Jordan G, Lütgens D, Joober R, Lepage M, Iyer SN, Malla A. The relative contribution of cognition and symptomatic remission to functional outcome following treatment of a first episode of psychosis. J Clin Psychiatry 2014;75:e566-72.
78. Manchanda R, Norman RMG, Malla AK, Harricharan R, Northcott S. Persistent psychoses in first episode patients. Schizophr Res 2005;80:113-6.
79. Hassan GAM, Taha GRA. Long term functioning in early onset psychosis: two years prospective follow-up study. Behav Brain Fund 2011;7:28.
80. Norman RMG, Manchanda R, Winden D. The prognostic significance of early remission of positive symptoms in first treated psychosis. Psychiatry Res 2014;218:44-7.
81. Benoit A, Bodnar M, Malla AK, Joober R, Bherer L, Lepage M. Changes in memory performance over a 12-month period in relation to achieving symptomatic remission after a first-episode psychosis. Schizophr Res 2014;153:103-8.
82. Lieberman JA, Alvir JMJ, woerner M, Degreef G, Bilder RM, Ashtari M, et al. Prospective study of psychobiology in first-episode schizophrenia at Hillside Hospital. Schizophr Bull 1992;18:351-71.
83. Gignac A, McGirr A, Lam RW, Yatham LN. Course and outcome following a first episode of mania: four-year prospective data from the Systematic Treatment Optimization Program (STOP-EM). J Affect Disord 2015;175:411-7.
84. Rangaswamy T. Twenty-five years of schizophrenia: the Madras longitudinal study. Indian J Psychiatry 2012;54:134-7.
85. Harrow M, Sands JR, Silverstein ML, Goldberg JF. Course and outcome for schizophrenia versus other psychotic patients: a longitudinal study. Schizophr Bull 1997;23:287-303.
86. Wiersma D, Nienhuis FJ, Slooff CJ, Giel R. Natural course of schizophrenic disorders: a 15-year followup of a Dutch incidence cohort. Schizophr Bull 1998;24:75-85.
87. Chang WC, Chan TC, Chen ES, Hui CL, Wong GH, Chan SK, et al. The concurrent and predictive validity of symptomatic remission criteria in firstepisode schizophrenia. Schizophr Res 2013;143:107-15.
88. Aadamsoo K, Saluveer E, Kuunarpuu H, Vasar V, Marón E. Diagnostic stability over 2 years in patients with acute and transient psychotic disorders. Nord J Psychiatry 2011;65:381-8.
89. Wade D, Harrigan S, Edwards J, Burgess PM, Whelan G, McGorry PD. Substance misuse in first-episode psychosis: 15-month prospective followup study. Br J Psychiatry 2006;189:229-34.
90. Lieberman JA, Alvir JM, Koreen A, Geisler S, Chakos M, Sheitman B, et al. Psychobiologic correlates of treatment response in schizophrenia. Neuropsychopharmacology 1996;14:13S-21S.
91. Schimmelmann BG, Conus P, Cotton S, Kupferschmid S, McGorry PD, Lambert M. Prevalence and impact of cannabis use disorders in adolescents with early onset first episode psychosis. Eur Psychiatry 2012;27:463-9.
92. Chang WE, Tang JY, Hui CL, Lam MM, Chan SK, Wong GH, et al. Prediction of remission and recovery in young people presenting with first-episode psychosis in Hong Kong: a 3-year follow-up study. Aust NZ J Psychiatry 2012;46:100-8.
93. Shrivastava A, Shah N, Johnston M, stitt L, Thakar M. Predictors of long-term outcome of first-episode schizophrenia: a ten-year follow-up study. Indian J Psychiatry 2010;52:320-6.
94. Rangaswamy T, Mángala R, Mohan G, Joseph J, John S. Intervention for first episode psychosis in India - the SCARF experience. Asian J Psychiatry 2012;5:58-62.
95. Johnson S, Sathyaseelan M, Charles H, Jeyaseelan V, Jacob KS. Predictors of insight in first-episode schizophrenia: a 5-year cohort study from India. Int J Soc Psychiatry 2014;60:566-74.
96. Faber G, Smid HG, van Gool AR, Wunderink L, van den Bosch RJ, Wiersma D. Continued cannabis use and outcome in first-episode psychosis: data from a randomized, open-label, controlled trial. J Clin Psychiatry 2012;73:632-8.
97. Drake RE, Latimer E. Lessons learned in developing community mental health care in North America. World Psychiatry 2012;11:47-51.
98. Zipursky RB, Agid O. Recovery, not progressive deterioration, should be the expectation in schizophrenia. World Psychiatry 2015;14:94-6.
99. Lally J, Ajnakina O, Di Forti M, Trotta A, Demjaha A, Kolliakou A, et al. Two distinct patterns of treatment resistance: clinical predictors of treatment resistance in first-episode schizophrenia spectrum psychoses. Psychol Med 2016;46:3231-40.
100. Marshall M, Lewis S, Lockwood A, Drake R, Jones P, Croudace T. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry 2005;62:975-83.
101. Penttila M, Jaaskelainen E, Hirvonen N, Isohanni M, Miettunen J. Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis. Br J Psychiatry 2014;205:88-94.
102. Dixon LB, Holoshitz Y, Nossel I. Treatment engagement of individuals experiencing mental illness: review and update. World Psychiatry 2016;15:13-20.
103. Haro JM, Novick D, Bertsch J, Karagianis J, Dossenbach M, Jones PB. Cross-national clinical and functional remission rates: Worldwide Schizophrenia Outpatient Health Outcomes (W-SOHO) study. Br J Psychiatry 2011;199:194-201.