메뉴 건너뛰기




Volumn 12, Issue 12, 2017, Pages

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; NIAGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE RIBOSIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; URIC ACID; NICOTINAMIDE; NICOTINAMIDE-BETA-RIBOSIDE;

EID: 85037345104     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0186459     Document Type: Article
Times cited : (186)

References (23)
  • 1
    • 84883425232 scopus 로고    scopus 로고
    • Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes
    • PMID: 23948585
    • Kolwicz SC Jr., Purohit S, Tian R. Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res. 2013; 113(5):603–16. https://doi.org/10.1161/CIRCRESAHA.113.302095 PMID: 23948585
    • (2013) Circ Res , vol.113 , Issue.5 , pp. 603-616
    • Kolwicz, S.C.1    Purohit, S.2    Tian, R.3
  • 2
    • 41249086364 scopus 로고    scopus 로고
    • Mitochondrial centrality in heart failure
    • PMID: 18185992
    • Marin-Garcia J, Goldenthal MJ. Mitochondrial centrality in heart failure. Heart Fail Rev. 2008; 13 (2):137–50. https://doi.org/10.1007/s10741-007-9079-1 PMID: 18185992
    • (2008) Heart Fail Rev , vol.13 , Issue.2 , pp. 137-150
    • Marin-Garcia, J.1    Goldenthal, M.J.2
  • 3
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart—an engine out of fuel
    • PMID: 17360992
    • Neubauer S. The failing heart—an engine out of fuel. N Engl J Med. 2007; 356(11):1140–51. https://doi.org/10.1056/NEJMra063052 PMID: 17360992
    • (2007) N Engl J Med , vol.356 , Issue.11 , pp. 1140-1151
    • Neubauer, S.1
  • 4
    • 84873413349 scopus 로고    scopus 로고
    • Mitochondria as a therapeutic target in heart failure
    • PMID: 23219298
    • Bayeva M, Gheorghiade M, Ardehali H. Mitochondria as a therapeutic target in heart failure. Journal of the American College of Cardiology. 2013; 61(6):599–610. https://doi.org/10.1016/j.jacc.2012.08.1021 PMID: 23219298
    • (2013) Journal of The American College of Cardiology , vol.61 , Issue.6 , pp. 599-610
    • Bayeva, M.1    Gheorghiade, M.2    Ardehali, H.3
  • 5
    • 84883562084 scopus 로고    scopus 로고
    • Cardiac metabolism in heart failure: Implications beyond ATP production
    • PMID: 23989714
    • Doenst T, Nguyen TD, Abel ED. Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013; 113(6):709–24. https://doi.org/10.1161/CIRCRESAHA.113.300376 PMID: 23989714
    • (2013) Circ Res , vol.113 , Issue.6 , pp. 709-724
    • Doenst, T.1    Nguyen, T.D.2    Abel, E.D.3
  • 6
    • 84878396502 scopus 로고    scopus 로고
    • Myocardial energetics in heart failure
    • PMID: 23740216
    • Nickel A, Loffler J, Maack C. Myocardial energetics in heart failure. Basic research in cardiology. 2013; 108(4):358. https://doi.org/10.1007/s00395-013-0358-9 PMID: 23740216
    • (2013) Basic Research in Cardiology , vol.108 , Issue.4 , pp. 358
    • Nickel, A.1    Loffler, J.2    Maack, C.3
  • 7
    • 84975748778 scopus 로고    scopus 로고
    • Novel targets for mitochondrial medicine
    • PMID: 26888432
    • Wang W, Karamanlidis G, Tian R. Novel targets for mitochondrial medicine. Sci Transl Med. 2016; 8 (326):326rv3. https://doi.org/10.1126/scitranslmed.aac7410 PMID: 26888432
    • (2016) Sci Transl Med , vol.8 , Issue.326 , pp. 326rv3
    • Wang, W.1    Karamanlidis, G.2    Tian, R.3
  • 8
    • 84881348520 scopus 로고    scopus 로고
    • Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure
    • PMID: 23931755
    • Karamanlidis G, Lee CF, Garcia-Menendez L, Kolwicz SC, Suthammarak W, Gong G, et al. Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metabolism. 2013; 18. https://doi.org/10.1016/j.cmet.2013.07.002 PMID: 23931755
    • (2013) Cell Metabolism , vol.18
    • Karamanlidis, G.1    Lee, C.F.2    Garcia-Menendez, L.3    Kolwicz, S.C.4    Suthammarak, W.5    Gong, G.6
  • 9
    • 85037364547 scopus 로고    scopus 로고
    • Restoration of NADH/NAD ration delays pressure overload-induced cardiac dysfunction via regulation of mitochondrial protein acetylation and permeability transition
    • abstr
    • Lee CF, Garcia-Menendez L, Karamanlidis G, Tian R. Restoration of NADH/NAD ration delays pressure overload-induced cardiac dysfunction via regulation of mitochondrial protein acetylation and permeability transition. Circulation. 2013; 128:A15979 (abstr)
    • (2013) Circulation , vol.128 , pp. A15979
    • Lee, C.F.1    Garcia-Menendez, L.2    Karamanlidis, G.3    Tian, R.4
  • 10
    • 70149095672 scopus 로고    scopus 로고
    • Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes
    • PMID: 19661458
    • Hsu CP, Oka S, Shao D, Hariharan N, Sadoshima J. Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res. 2009; 105(5):481–91. https://doi.org/10.1161/CIRCRESAHA.109.203703 PMID: 19661458
    • (2009) Circ Res , vol.105 , Issue.5 , pp. 481-491
    • Hsu, C.P.1    Oka, S.2    Shao, D.3    Hariharan, N.4    Sadoshima, J.5
  • 11
    • 84902579141 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion
    • PMID: 24905194
    • Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One. 2014; 9(6): e98972. https://doi.org/10.1371/journal.pone.0098972 PMID: 24905194
    • (2014) PLoS One , vol.9 , Issue.6
    • Yamamoto, T.1    Byun, J.2    Zhai, P.3    Ikeda, Y.4    Oka, S.5    Sadoshima, J.6
  • 12
    • 84862022077 scopus 로고    scopus 로고
    • The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
    • PMID: 22682224
    • Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metabolism. 2012; 15(6):838–47. https://doi.org/10.1016/j.cmet.2012.04.022 PMID: 22682224
    • (2012) Cell Metabolism , vol.15 , Issue.6 , pp. 838-847
    • Canto, C.1    Houtkooper, R.H.2    Pirinen, E.3    Youn, D.Y.4    Oosterveer, M.H.5    Cen, Y.6
  • 13
    • 84907095419 scopus 로고    scopus 로고
    • R: A language and environment for statistical computing
    • Internet: Vienna, Austria [https://www.r-project.org/
    • Team RC. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Internet: https://www.r-project.org/ Vienna, Austria 2015 [https://www.r-project.org/.
    • (2015) R Foundation for Statistical Computing
  • 15
    • 34548416814 scopus 로고    scopus 로고
    • Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra
    • PMID: 17709435
    • Creeke PI, Dibari F, Cheung E, van den Briel T, Kyroussis E, Seal AJ. Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra. J Nutr. 2007; 137(9):2013–7. PMID: 17709435
    • (2007) J Nutr , vol.137 , Issue.9 , pp. 2013-2017
    • Creeke, P.I.1    Dibari, F.2    Cheung, E.3    Van Den Briel, T.4    Kyroussis, E.5    Seal, A.J.6
  • 16
    • 84991372712 scopus 로고    scopus 로고
    • Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
    • PMID: 27721479
    • Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016; 7:12948. https://doi.org/10.1038/ncomms12948 PMID: 27721479
    • (2016) Nat Commun , vol.7 , pp. 12948
    • Trammell, S.A.1    Schmidt, M.S.2    Weidemann, B.J.3    Redpath, P.4    Jaksch, F.5    Dellinger, R.W.6
  • 17
    • 33947118734 scopus 로고    scopus 로고
    • Safety considerations with niacin therapy
    • PMID: 17368274
    • Guyton JR, Bays HE. Safety considerations with niacin therapy. Am J Cardiol. 2007; 99(6A):22C–31C. https://doi.org/10.1016/j.amjcard.2006.11.018 PMID: 17368274
    • (2007) Am J Cardiol , vol.99 , Issue.6 , pp. 22C-31C
    • Guyton, J.R.1    Bays, H.E.2
  • 18
    • 84897970506 scopus 로고    scopus 로고
    • 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • PMID: 24222016
    • Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014; 129(25 Suppl 2):S1–45. https://doi.org/10.1161/01.cir.0000437738.63853.7a PMID: 24222016
    • (2014) Circulation , vol.129 , Issue.25 , pp. S1-S45
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3    Bairey Merz, C.N.4    Blum, C.B.5    Eckel, R.H.6
  • 19
    • 84991294515 scopus 로고    scopus 로고
    • NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
    • PMID: 27725675
    • Ratajczak J, Joffraud M, Trammell SA, Ras R, Canela N, Boutant M, et al. NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nat Commun. 2016; 7:13103. https://doi.org/10.1038/ncomms13103 PMID: 27725675
    • (2016) Nat Commun , vol.7 , pp. 13103
    • Ratajczak, J.1    Joffraud, M.2    Trammell, S.A.3    Ras, R.4    Canela, N.5    Boutant, M.6
  • 20
    • 80053920774 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- And age-induced diabetes in mice
    • PMID: 21982712
    • Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metabolism. 2011; 14(4):528–36. https://doi.org/10.1016/j.cmet.2011.08.014 PMID: 21982712
    • (2011) Cell Metabolism , vol.14 , Issue.4 , pp. 528-536
    • Yoshino, J.1    Mills, K.F.2    Yoon, M.J.3    Imai, S.4
  • 21
    • 0031020867 scopus 로고    scopus 로고
    • Nicotinamide riboside, an unusual, non-typical, substrate of purified purine-nucleoside phosphorylases
    • PMID: 9030766
    • Wielgus-Kutrowska B, Kulikowska E, Wierzchowski J, Bzowska A, Shugar D. Nicotinamide riboside, an unusual, non-typical, substrate of purified purine-nucleoside phosphorylases. Eur J Biochem. 1997; 243(1–2):408–14. PMID: 9030766
    • (1997) Eur J Biochem , vol.243 , Issue.1-2 , pp. 408-414
    • Wielgus-Kutrowska, B.1    Kulikowska, E.2    Wierzchowski, J.3    Bzowska, A.4    Shugar, D.5
  • 22
    • 84893442805 scopus 로고    scopus 로고
    • Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
    • PMID: 24360282
    • Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013; 155 (7):1624–38. https://doi.org/10.1016/j.cell.2013.11.037 PMID: 24360282
    • (2013) Cell , vol.155 , Issue.7 , pp. 1624-1638
    • Gomes, A.P.1    Price, N.L.2    Ling, A.J.3    Moslehi, J.J.4    Montgomery, M.K.5    Rajman, L.6
  • 23
    • 84874635096 scopus 로고    scopus 로고
    • Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression
    • PMID: 23426180
    • Santidrian AF, Matsuno-Yagi A, Ritland M, Seo BB, LeBoeuf SE, Gay LJ, et al. Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest. 2013; 123 (3):1068–81. https://doi.org/10.1172/JCI64264 PMID: 23426180
    • (2013) J Clin Invest , vol.123 , Issue.3 , pp. 1068-1081
    • Santidrian, A.F.1    Matsuno-Yagi, A.2    Ritland, M.3    Seo, B.B.4    LeBoeuf, S.E.5    Gay, L.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.