Serum levels of interleukins IL-6 and IL-10 in individuals with posttraumatic stress disorder in a population-based sample

Psychiatry Research

Volumn 260, Issue , 2018, Pages 111-115

  de Oliveira, Jacqueline Flores ^a   Wiener, Carolina David ^a,b   Jansen, Karen ^a   Portela, Luis Valmor ^c   Lara, Diogo R ^d   Souza, Luciano Dias de Mattos ^a   da Silva, Ricardo Azevedo ^a   Moreira, Fernanda Pedrotti ^a   Oses, Jean Pierre ^a  

^a CATHOLIC UNIVERSITY OF PELOTAS   (Brazil)

^b FEDERAL UNIVERSITY OF PELOTAS   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

IL 10; IL 6; Interleukins; PTSD

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6; BIOLOGICAL MARKER; IL10 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN;

ADULT; AGE; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENDER; HUMAN; IMMUNE SYSTEM; MALE; MINI INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; NERVOUS SYSTEM INFLAMMATION; POPULATION RESEARCH; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; YOUNG ADULT; ADOLESCENT; BLOOD; HEALTH SURVEY; PROCEDURES; PSYCHOLOGY;

ADOLESCENT; ADULT; BIOMARKERS; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; MALE; POPULATION SURVEILLANCE; STRESS DISORDERS, POST-TRAUMATIC; YOUNG ADULT;

EID: 85035318092     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2017.11.061     Document Type: Article

References (30)

1. Amorim, P., Mini International Neuropsychiatric Interview (MINI): validation of a short structured diagnostic psychiatric interview. Rev. Bras. Psiquiatr. 22:3 (2000), 106–115.
2. Barros, A.J., Victora, C.G., Indicador econômico para o Brasil baseado no censo demográfico de 2000. Rev. Saúde Pública 39:4 (2005), 523–529.
3. Bersani, F.S., Wolkowitz, O.M., Lindqvist, D., Yehuda, R., Flory, J., Bierer, L.M., Makotine, I., Abu-Amara, D., Coy, M., Reus, V.I., Epel, E.S., Marmar, C., Mellon, S.H., Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation. Brain Behav. Immun. 52 (2016), 153–160.
4. Bomyea, J., Risbrough, V., Lang, A.J., A consideration of select pre-trauma factors as key vulnerabilities in PTSD. Clin. Psychol. Rev. 32:7 (2012), 630–641.
5. Buchsbaum, D.G., Buchanan, R.G., Welsh, J., Centor, R.M., Schnoll, S.H., Screening for drinking disorders in the elderly using the CAGE questionnaire. J. Am. Geriatr. Soc. 40:7 (1992), 662–665.
6. El Khoury-Malhame, M., Lanteaume, L., Beetz, E.M., Roques, J., Reynaud, E., Samuelian, J.C., Blin, O., Garcia, R., Khalfa, S., Attentional bias in post-traumatic stress disorder diminishes after symptom amelioration. Behav. Res. Ther. 49:11 (2011), 796–801.
7. Guo, M., Liu, T., Guo, J.C., Jiang, X.L., Chen, F., Gao, Y.S., Study on serum cytokine levels in posttraumatic stress disorder patients. Asian Pac. J. Trop. Med. 5:4 (2012), 323–325.
8. Haroon, E., Raison, C.L., Miller, A.H., Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol. 37:1 (2012), 137–162.
9. Heim, C.N., Fanslow, D.A., Dann, C.T., Development of quantitative microscopy-based assays for evaluating dynamics of living cultures of mouse spermatogonial stem/progenitor cells. Biol. Reprod., 87(4), 2012, 90.
10. Hoge, M.A., Morris, J.A., Stuart, G.W., Huey, L.Y., Bergeson, S., Flaherty, M.T., Morgan, O., Peterson, J., Daniels, A.S., Paris, M., Madenwald, K., A national action plan for workforce development in behavioral health. Psychiatr. Serv. 60:7 (2009), 883–887.
11. Javidi, H., Yadollahie, M., Post-traumatic stress disorder. Int. J. Occup. Environ. Med. 3:1 (2012), 2–9.
12. Lindqvist, D., Dhabhar, F.S., Mellon, S.H., Yehuda, R., Grenon, S.M., Flory, J.D., Bierer, L.M., Abu-Amara, D., Coy, M., Makotkine, I., Reus, V.I., Bersani, F.S., Marmar, C.R., Wolkowitz, O.M., Increased pro-inflammatory milieu in combat related PTSD – a new cohort replication study. Brain Behav. Immun. 59 (2017), 260–264.
13. Lindqvist, D., Wolkowitz, O.M., Mellon, S., Yehuda, R., Flory, J.D., Henn-Haase, C., Bierer, L.M., Abu-Amara, D., Coy, M., Neylan, T.C., Makotkine, I., Reus, V.I., Yan, X., Taylor, N.M., Marmar, C.R., Dhabhar, F.S., Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress. Brain Behav. Immun. 42 (2014), 81–88.
14. Lopez, W.D., Konrath, S.H., Seng, J.S., Abuse‐related post‐traumatic stress, coping, and tobacco use in pregnancy. J. Obstet. Gynecol. Neonatal Nurs. 40:4 (2011), 422–431.
15. Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., Maj, M., The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab. Brain Dis. 24:1 (2009), 27–53.
16. Michopoulos, V., Powers, A., Gillespie, C.F., Ressler, K.J., Jovanovic, T., Inflammation in fear- and anxiety-based disorders: PTSD, GAD, and beyond. Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol. 42:1 (2017), 254–270.
17. Newton, T.L., Fernandez-Botran, R., Miller, J.J., Burns, V.E., Interleukins-6 and soluble interleukin-6 receptor levels in posttraumatic stress disorder: associations with lifetime diagnostic status and psychological context. Biol. Psychol. 99 (2014), 150–159.
18. Norrholm, S.D., Jovanovic, T., Olin, I.W., Sands, L.A., Karapanou, I., Bradley, B., Ressler, K.J., Fear extinction in traumatized civilians with posttraumatic stress disorder: relation to symptom severity. Biol. Psychiatry 69:6 (2011), 556–563.
19. Oganesyan, L.P., Mkrtchyan, G.M., Sukiasyan, S.H., Boyajyan, A.S., Classic and alternative complement cascades in post-traumatic stress disorder. Bull. Exp. Biol. Med. 148:6 (2009), 859–861.
20. Passos, I.C., Vasconcelos-Moreno, M.P., Costa, L.G., Kunz, M., Brietzke, E., Quevedo, J., Salum, G., Magalhaes, P.V., Kapczinski, F., Kauer-Sant'Anna, M., Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression. Lancet Psychiatry 2:11 (2015), 1002–1012.
21. Perkonigg, A., Kessler, R.C., Storz, S., Wittchen, H.-U., Traumatic events and post-traumatic stress disorder in the community: prevalence, risk factors and comorbidity. Acta Psychiatr. Scand. 101 (2000), 46–59.
22. Smith, P., Trauma focused CBT for PTSD in young children is feasible, and may reduce PTSD symptoms. Evid. Based Ment. Health, 15(1), 2012, 18.
23. Song, Y., Zhou, D., Guan, Z., Wang, X., Disturbance of serum interleukin-2 and interleukin-8 levels in posttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China. Neuroimmunomodulation 14:5 (2007), 248–254.
24. Spitzer, A.R., Reclassification of clinical sleep disorders using traditional models of syndromic, neuroanatomic, pathophysiological and etiological diagnosis. Med. Hypotheses 83:3 (2014), 391–397.
25. Teche, S.P., Rovaris, D.L., Aguiar, B.W., Hauck, S., Vitola, E.S., Bau, C.H., Freitas, L.H., Grevet, E.H., Resilience to traumatic events related to urban violence and increased IL10 serum levels. Psychiatry Res. 250 (2017), 136–140.
26. Tucker, S., Brust, S., Pierce, P., Fristedt, C., Pankratz, V.S., Depression coping self-efficacy as a predictor of relapse 1 and 2 years following psychiatric hospital-based treatment. Res. Theory Nurs. Pract. 18:2–3 (2004), 261–275.
27. Tursich, M., Neufeld, R.W., Frewen, P.A., Harricharan, S., Kibler, J.L., Rhind, S.G., Lanius, R.A., Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis. Transl. Psychiatry, 4, 2014, e413.
28. von Kanel, R., Hepp, U., Kraemer, B., Traber, R., Keel, M., Mica, L., Schnyder, U., Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. J. Psychiatr. Res. 41:9 (2007), 744–752.
29. Yang, L., Wang, M., Guo, Y.Y., Sun, T., Li, Y.J., Yang, Q., Zhang, K., Liu, S.B., Zhao, M.G., Wu, Y.M., Systemic inflammation induces anxiety disorder through CXCL12/CXCR4 pathway. Brain Behav. Immun. 56 (2016), 352–362.
30. Zuardi, A.W., 2014. Fisiologia do estresse e sua influência na saúde. rnp.fmrp.usp.br/~psicmed/doc/Fisiologia%20do%20estresse.pdf. (Acesso em 3 October 2017).