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Volumn 22, Issue 6, 2019, Pages 425-434

Neurobehavioural effects of Lactobacillus rhamnosus GG alone and in combination with prebiotics polydextrose and galactooligosaccharide in male rats exposed to early-life stress

Author keywords

early life stress; microbiota gut brain axis; prebiotics; probiotics

Indexed keywords

4 AMINOBUTYRIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; GALACTOSE OLIGOSACCHARIDE; GLUCOCORTICOID RECEPTOR; GLUCOSE; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; POLYDEXTROSE; PREBIOTIC AGENT; PROBIOTIC AGENT; UNCLASSIFIED DRUG; GLUCAN; OLIGOSACCHARIDE;

EID: 85035138000     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1080/1028415X.2017.1397875     Document Type: Article
Times cited : (64)

References (53)
  • 1
    • 0038407848 scopus 로고    scopus 로고
    • Trajectories of brain development: point of vulnerability or window of opportunity?
    • Andersen SL., Trajectories of brain development: point of vulnerability or window of opportunity? Neurosci Biobehav Rev 2003;27:3–18. doi: 10.1016/S0149-7634(03)00005-8
    • (2003) Neurosci Biobehav Rev , vol.27 , pp. 3-18
    • Andersen, S.L.1
  • 2
    • 85027945471 scopus 로고    scopus 로고
    • Microbiota and neurodevelopmental windows: implications for brain disorders
    • Borre YE, O’Keeffe GW, Clarke G, Stanton C, Dinan TG, Cryan JC., Microbiota and neurodevelopmental windows: implications for brain disorders. Trends Mol Med 2014;20(9):509–18. doi: 10.1016/j.molmed.2014.05.002
    • (2014) Trends Mol Med , vol.20 , Issue.9 , pp. 509-518
    • Borre, Y.E.1    O’Keeffe, G.W.2    Clarke, G.3    Stanton, C.4    Dinan, T.G.5    Cryan, J.C.6
  • 3
    • 0018376668 scopus 로고
    • Synaptic density in human frontal cortex–developmental changes and effects of aging
    • Huttenlocher PR., Synaptic density in human frontal cortex–developmental changes and effects of aging. Brain Res 1979;163:195–205. doi: 10.1016/0006-8993(79)90349-4
    • (1979) Brain Res , vol.163 , pp. 195-205
    • Huttenlocher, P.R.1
  • 6
    • 84964068267 scopus 로고    scopus 로고
    • Reframing the teenage wasteland: adolescent microbiota-gut-brain axis
    • McVey Neufeld KA, Luczynski P, Dinan TG, Cryan JF., Reframing the teenage wasteland: adolescent microbiota-gut-brain axis. Cdn J Psych 2016. 61(4):214–21
    • (2016) Cdn J Psych , vol.61 , Issue.4 , pp. 214-221
    • McVey Neufeld, K.A.1    Luczynski, P.2    Dinan, T.G.3    Cryan, J.F.4
  • 7
    • 0029928064 scopus 로고    scopus 로고
    • Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders
    • Coplan JD, Andrews MW, Rosenblum LA, Owens MJ, Friedman S, Gorman JM, et al. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc Natl Acad Sci USA 1996;93:1619–23. doi: 10.1073/pnas.93.4.1619
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1619-1623
    • Coplan, J.D.1    Andrews, M.W.2    Rosenblum, L.A.3    Owens, M.J.4    Friedman, S.5    Gorman, J.M.6
  • 8
    • 33847289264 scopus 로고    scopus 로고
    • Age of onset of child maltreatment predicts long-term mental health outcomes
    • Kaplow JB, Widom CS., Age of onset of child maltreatment predicts long-term mental health outcomes. J Abnorm Psychol 2007;116:176–87. doi: 10.1037/0021-843X.116.1.176
    • (2007) J Abnorm Psychol , vol.116 , pp. 176-187
    • Kaplow, J.B.1    Widom, C.S.2
  • 9
    • 84887241841 scopus 로고    scopus 로고
    • Unraveling the longstanding scars of early neurodevelopmental stress
    • Cryan JF, Dinan TG., Unraveling the longstanding scars of early neurodevelopmental stress. Biol Psychiatry 2013;74:788–9. doi: 10.1016/j.biopsych.2013.10.004
    • (2013) Biol Psychiatry , vol.74 , pp. 788-789
    • Cryan, J.F.1    Dinan, T.G.2
  • 10
    • 78149495829 scopus 로고    scopus 로고
    • Maternal separation decreases adult hippocampal cell proliferation and impairs cognitive performance but has little effects on stress sensitivity and anxiety in adult wistar rats
    • Hulshof HJ, Novati A, Sgoifo A, Luiten PG, den Boer JA, Meerlo P., Maternal separation decreases adult hippocampal cell proliferation and impairs cognitive performance but has little effects on stress sensitivity and anxiety in adult wistar rats. Behav Brain Res 2011;216:552–60. doi: 10.1016/j.bbr.2010.08.038
    • (2011) Behav Brain Res , vol.216 , pp. 552-560
    • Hulshof, H.J.1    Novati, A.2    Sgoifo, A.3    Luiten, P.G.4    den Boer, J.A.5    Meerlo, P.6
  • 11
    • 79952280881 scopus 로고    scopus 로고
    • Maternal separation as a model of brain-gut axis dysfunction
    • O’Mahony SM, Hyland NP, Dinan TG, Cryan JF., Maternal separation as a model of brain-gut axis dysfunction. Psychopharmacology (Berl) 2011;214(1):71–88. doi: 10.1007/s00213-010-2010-9
    • (2011) Psychopharmacology (Berl) , vol.214 , Issue.1 , pp. 71-88
    • O’Mahony, S.M.1    Hyland, N.P.2    Dinan, T.G.3    Cryan, J.F.4
  • 12
    • 84951325446 scopus 로고    scopus 로고
    • Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
    • O’Mahony SM, Clarke G, Dinan TG, Cryan JF., Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle? Neuroscience. 2017a;342:37–54. doi: 10.1016/j.neuroscience.2015.09.068
    • (2017) Neuroscience , vol.342 , pp. 37-54
    • O’Mahony, S.M.1    Clarke, G.2    Dinan, T.G.3    Cryan, J.F.4
  • 13
    • 84924170953 scopus 로고    scopus 로고
    • The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations
    • Maccari S, Krugers HJ, Morley-Fletcher S, Szyf M, Brunton PJ., The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations. J Neuroendocrinol 2014;26:707–23 doi: 10.1111/jne.12175
    • (2014) J Neuroendocrinol , vol.26 , pp. 707-723
    • Maccari, S.1    Krugers, H.J.2    Morley-Fletcher, S.3    Szyf, M.4    Brunton, P.J.5
  • 14
    • 58149291318 scopus 로고    scopus 로고
    • Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illness
    • O’Mahony SM, Marchesi JR, Scully P, Codling C, Ceolho A-M, Quigley EMM, et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illness. Biol Psychiatry 2009;65:263-67. doi: 10.1016/j.biopsych.2008.06.026
    • (2009) Biol Psychiatry , vol.65 , pp. 263-267
    • O’Mahony, S.M.1    Marchesi, J.R.2    Scully, P.3    Codling, C.4    Ceolho, A.-M.5    Quigley, E.M.M.6
  • 16
    • 84920087729 scopus 로고    scopus 로고
    • Early-life stress selectively affects gastrointestinal but not behavioural responses in a genetic model of brain-gut axis dysfunction
    • Hyland NP, O’Mahony SM, O’Malley D, O’Mahony CM, Dinan TG, Cryan JF., Early-life stress selectively affects gastrointestinal but not behavioural responses in a genetic model of brain-gut axis dysfunction. Neurogastroenterol Motil 2015;27:105–13. doi: 10.1111/nmo.12486
    • (2015) Neurogastroenterol Motil , vol.27 , pp. 105-113
    • Hyland, N.P.1    O’Mahony, S.M.2    O’Malley, D.3    O’Mahony, C.M.4    Dinan, T.G.5    Cryan, J.F.6
  • 17
    • 67650333217 scopus 로고    scopus 로고
    • Principles and clinical implications of the brain-gut-enteric microbiota axis
    • Rhee SH, Pothoulakis C, Mayer EA., Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol. 2009;6(5):306–14. doi: 10.1038/nrgastro.2009.35
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , Issue.5 , pp. 306-314
    • Rhee, S.H.1    Pothoulakis, C.2    Mayer, E.A.3
  • 18
    • 84866546211 scopus 로고    scopus 로고
    • Mind-altering microorganisms: the impact of the gut microbiota on brain and behavior
    • Cryan JF, Dinan TG., Mind-altering microorganisms: the impact of the gut microbiota on brain and behavior. Nat Rev Neurosci 2012;13(10):701–12. doi: 10.1038/nrn3346
    • (2012) Nat Rev Neurosci , vol.13 , Issue.10 , pp. 701-712
    • Cryan, J.F.1    Dinan, T.G.2
  • 19
    • 84868555218 scopus 로고    scopus 로고
    • The microbiota link to irritable bowel syndrome: an emerging story
    • Jeffery IB, Quigley EM, Ohman L, Simren M, O’Toole PW., The microbiota link to irritable bowel syndrome: an emerging story. Gut Microbes 2012;3(6):572–6. doi: 10.4161/gmic.21772
    • (2012) Gut Microbes , vol.3 , Issue.6 , pp. 572-576
    • Jeffery, I.B.1    Quigley, E.M.2    Ohman, L.3    Simren, M.4    O’Toole, P.W.5
  • 20
    • 84877145046 scopus 로고    scopus 로고
    • Gut-brain axis: how the microbiome influences anxiety and depression
    • McVey Neufeld KA, Foster JA., Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci 2013;36(5):305–12 doi: 10.1016/j.tins.2013.01.005
    • (2013) Trends Neurosci , vol.36 , Issue.5 , pp. 305-312
    • McVey Neufeld, K.A.1    Foster, J.A.2
  • 21
    • 84905716488 scopus 로고    scopus 로고
    • A role for the gut microbiota in IBS
    • Collins SM., A role for the gut microbiota in IBS. Nat Rev Gastroenterol Hepatol 2014;11(8):497–505. doi: 10.1038/nrgastro.2014.40
    • (2014) Nat Rev Gastroenterol Hepatol , vol.11 , Issue.8 , pp. 497-505
    • Collins, S.M.1
  • 22
    • 84904337496 scopus 로고    scopus 로고
    • The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?
    • De Palma G, Collins SM, Bercik P, Verdu EF., The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both? J Physiol 2014;592(Pt 14):2989–97. doi: 10.1113/jphysiol.2014.273995
    • (2014) J Physiol , vol.592 , pp. 2989-2997
    • De Palma, G.1    Collins, S.M.2    Bercik, P.3    Verdu, E.F.4
  • 23
    • 84908152766 scopus 로고    scopus 로고
    • Altered brain-gut axis in autism: comorbidity or causative mechanisms?
    • Mayer EA, Padua D, Tillisch K., Altered brain-gut axis in autism: comorbidity or causative mechanisms? Bioessays 2014;36(10):933–9. doi: 10.1002/bies.201400075
    • (2014) Bioessays , vol.36 , Issue.10 , pp. 933-939
    • Mayer, E.A.1    Padua, D.2    Tillisch, K.3
  • 24
    • 85021450018 scopus 로고    scopus 로고
    • The gut microbiota as a key regulator of visceral pain
    • O’Mahony SM, Dinan TG., Cryan JF., The gut microbiota as a key regulator of visceral pain. Pain. 2017;158(Suppl 1):S19–S28. doi:10.1097/j.pain.0000000000000779.
    • (2017) Pain , vol.158 , pp. S19-S28
    • O’Mahony, S.M.1    Dinan, T.G.2    Cryan, J.F.3
  • 26
    • 84875863443 scopus 로고    scopus 로고
    • An update on the use and investigation of probiotics in health and disease
    • Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EMM, Sartor RB, et al. An update on the use and investigation of probiotics in health and disease. Gut 2013;62(5):787–96. doi: 10.1136/gutjnl-2012-302504
    • (2013) Gut , vol.62 , Issue.5 , pp. 787-796
    • Sanders, M.E.1    Guarner, F.2    Guerrant, R.3    Holt, P.R.4    Quigley, E.M.M.5    Sartor, R.B.6
  • 27
    • 77957142793 scopus 로고    scopus 로고
    • Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
    • Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan JF, Dinan TG., Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 2010;170:1179–88. doi: 10.1016/j.neuroscience.2010.08.005
    • (2010) Neuroscience , vol.170 , pp. 1179-1188
    • Desbonnet, L.1    Garrett, L.2    Clarke, G.3    Kiely, B.4    Cryan, J.F.5    Dinan, T.G.6
  • 28
    • 84875213222 scopus 로고    scopus 로고
    • Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, BDNF expression, and cognition
    • Suri D, Veenit V, Sarkar A, Thiagarajan D, Kumar A, Nestler EJ, et al. Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, BDNF expression, and cognition. Biol Psychiatry 2013;73:658–66. doi: 10.1016/j.biopsych.2012.10.023
    • (2013) Biol Psychiatry , vol.73 , pp. 658-666
    • Suri, D.1    Veenit, V.2    Sarkar, A.3    Thiagarajan, D.4    Kumar, A.5    Nestler, E.J.6
  • 29
    • 84891813044 scopus 로고    scopus 로고
    • Early stress evokes temporally distinct consequences on the hippocampal transcriptome, anxiety and cognitive behavior
    • Suri D, Bhattacharya A, Vaidya VA., Early stress evokes temporally distinct consequences on the hippocampal transcriptome, anxiety and cognitive behavior. Int J Neuropsychopharmacol 2014;17:289–301. doi: 10.1017/S1461145713001004
    • (2014) Int J Neuropsychopharmacol , vol.17 , pp. 289-301
    • Suri, D.1    Bhattacharya, A.2    Vaidya, V.A.3
  • 30
    • 0029013322 scopus 로고
    • Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics
    • Gibson GR, Roberfroid MB., Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 1995;125(6):1401–12. doi: 10.1093/jn/125.6.1401
    • (1995) J Nutr , vol.125 , Issue.6 , pp. 1401-1412
    • Gibson, G.R.1    Roberfroid, M.B.2
  • 31
    • 33947136322 scopus 로고    scopus 로고
    • Prebiotics: the concept revisited
    • Roberfroid M., Prebiotics: the concept revisited. J Nutr 2007;137(3 Suppl 2):830S–7S. doi: 10.1093/jn/137.3.830S
    • (2007) J Nutr , vol.137 , Issue.3 , pp. 830S-7S
    • Roberfroid, M.1
  • 32
    • 85013756511 scopus 로고    scopus 로고
    • Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice
    • Burokas A, Arboleya S, Moloney RD, Peterson VL, Murphy K, Clarke G, et al. Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice. Biol Psychiatry 2017;82(7):472–487. doi: 10.1016/j.biopsych.2016.12.031
    • (2017) Biol Psychiatry , vol.82 , Issue.7 , pp. 472-487
    • Burokas, A.1    Arboleya, S.2    Moloney, R.D.3    Peterson, V.L.4    Murphy, K.5    Clarke, G.6
  • 33
    • 84936803964 scopus 로고    scopus 로고
    • The prebiotics 3’sialyllactose and 6’sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: evidence for effects on the gut-brain axis
    • Tarr AJ, Galley JD, Fisher SE, Chichlowski M, Berg BM, Bailey MT., The prebiotics 3’sialyllactose and 6’sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: evidence for effects on the gut-brain axis. Brain Behav Immun 2015;50:166–77 doi: 10.1016/j.bbi.2015.06.025
    • (2015) Brain Behav Immun , vol.50 , pp. 166-177
    • Tarr, A.J.1    Galley, J.D.2    Fisher, S.E.3    Chichlowski, M.4    Berg, B.M.5    Bailey, M.T.6
  • 34
    • 85001875280 scopus 로고    scopus 로고
    • Early life diets with prebiotics and bioactive milk fractions attenuate the impact of stress on learned helplessness behaviours and later gene expression within neural circuits important for stress resistance
    • Mika A, Day HED, Martinez A, Rumian NL, Greenwood BN, Chichlowski M, et al. Early life diets with prebiotics and bioactive milk fractions attenuate the impact of stress on learned helplessness behaviours and later gene expression within neural circuits important for stress resistance. Eur J Neurosci. 2016. doi:10.1111/ejn.13444.
    • (2016) Eur J Neurosci
    • Mika, A.1    Day, H.E.D.2    Martinez, A.3    Rumian, N.L.4    Greenwood, B.N.5    Chichlowski, M.6
  • 35
    • 84911483659 scopus 로고    scopus 로고
    • Probiotic Lactobacillus rhamnosus GG (LGG) and prebiotic prevent neonatal inflammation-induced visceral hypersensitivity in adult rats
    • Kannampalli P, Pochiraju S, Chichlowski M, Berg BM, Rudolph C, Brukert M, et al. Probiotic Lactobacillus rhamnosus GG (LGG) and prebiotic prevent neonatal inflammation-induced visceral hypersensitivity in adult rats. Neurogastroenterol Motil 2014;12:1694–704. doi: 10.1111/nmo.12450
    • (2014) Neurogastroenterol Motil , vol.12 , pp. 1694-1704
    • Kannampalli, P.1    Pochiraju, S.2    Chichlowski, M.3    Berg, B.M.4    Rudolph, C.5    Brukert, M.6
  • 36
    • 17044411282 scopus 로고    scopus 로고
    • Differential effects of periodic maternal separation on adult stress coping in rat models of extremes in trait anxiety
    • Neumann ID, Wigger A, Kromer S, Frank E, Landgraf R, Bosch OJ., Differential effects of periodic maternal separation on adult stress coping in rat models of extremes in trait anxiety. Neuroscience 2005;132:867–77. doi: 10.1016/j.neuroscience.2005.01.034
    • (2005) Neuroscience , vol.132 , pp. 867-877
    • Neumann, I.D.1    Wigger, A.2    Kromer, S.3    Frank, E.4    Landgraf, R.5    Bosch, O.J.6
  • 37
    • 84907059504 scopus 로고    scopus 로고
    • Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive of anxiety-related behaviors in male rats
    • O’Mahony SM, Felice VD, Nally K, Savignac HM, Claesson MJ, Scully P, et al. Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive of anxiety-related behaviors in male rats. Neuroscience. 2014;277:885–901. doi: 10.1016/j.neuroscience.2014.07.054
    • (2014) Neuroscience , vol.277 , pp. 885-901
    • O’Mahony, S.M.1    Felice, V.D.2    Nally, K.3    Savignac, H.M.4    Claesson, M.J.5    Scully, P.6
  • 38
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method
    • Livak KJ, Schmittgen TD., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001;25(4):402–8 doi: 10.1006/meth.2001.1262
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 39
    • 33847128460 scopus 로고    scopus 로고
    • The open field test: reinventing the wheel
    • Stanford SC., The open field test: reinventing the wheel. J Psychopharmacol 2007;21:134–5. doi: 10.1177/0269881107073199
    • (2007) J Psychopharmacol , vol.21 , pp. 134-135
    • Stanford, S.C.1
  • 40
    • 85008675464 scopus 로고    scopus 로고
    • Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress
    • Bharwani A, Mian MF, Surette MG, Bienenstock J, Forsythe P., Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress. BMC Med 2017;15:7. doi: 10.1186/s12916-016-0771-7
    • (2017) BMC Med , vol.15 , pp. 7
    • Bharwani, A.1    Mian, M.F.2    Surette, M.G.3    Bienenstock, J.4    Forsythe, P.5
  • 41
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: procedures for assessing spatial and related forms of learning and memory
    • Vorhees CV, Williams MT., Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006;1(2):848–58 doi: 10.1038/nprot.2006.116
    • (2006) Nat Protoc , vol.1 , Issue.2 , pp. 848-858
    • Vorhees, C.V.1    Williams, M.T.2
  • 42
    • 84911461416 scopus 로고    scopus 로고
    • Assessing spatial learning and memory in rodents
    • Vorhees CV, Williams MT., Assessing spatial learning and memory in rodents. ILAR J 2014;55:310–32. doi: 10.1093/ilar/ilu013
    • (2014) ILAR J , vol.55 , pp. 310-332
    • Vorhees, C.V.1    Williams, M.T.2
  • 43
    • 84926144982 scopus 로고    scopus 로고
    • Bifidobactera modulate cognitive processes in an anxious mouse strain
    • Savignac HM, Tramullas M, Kiely B, Dinan TG, Cryan JF., Bifidobactera modulate cognitive processes in an anxious mouse strain. Behav Brain Res 2015;287:59–72. doi: 10.1016/j.bbr.2015.02.044
    • (2015) Behav Brain Res , vol.287 , pp. 59-72
    • Savignac, H.M.1    Tramullas, M.2    Kiely, B.3    Dinan, T.G.4    Cryan, J.F.5
  • 44
    • 0142123106 scopus 로고    scopus 로고
    • Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioural stress response
    • Hsu F-C, Zhang G-J, Raol YSH, Valentino RF, Coulter DA, Brooks-Kayal AR., Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioural stress response. Proc Natl Acad Sci USA 2003;100(21):12213–8. doi: 10.1073/pnas.2131679100
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.21 , pp. 12213-12218
    • Hsu, F.-C.1    Zhang, G.-J.2    Raol, Y.S.H.3    Valentino, R.F.4    Coulter, D.A.5    Brooks-Kayal, A.R.6
  • 46
    • 80052965474 scopus 로고    scopus 로고
    • Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
    • Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 2011;108(38):16050–5. doi: 10.1073/pnas.1102999108
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.38 , pp. 16050-16055
    • Bravo, J.A.1    Forsythe, P.2    Chew, M.V.3    Escaravage, E.4    Savignac, H.M.5    Dinan, T.G.6
  • 47
    • 84947553551 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate
    • Janik R, Thomason LAM, Stanisz AM, Forsythe P, Bienenstock J, Stanisz GJ., Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate. NeuroImage 2016;125:988–95. doi: 10.1016/j.neuroimage.2015.11.018
    • (2016) NeuroImage , vol.125 , pp. 988-995
    • Janik, R.1    Thomason, L.A.M.2    Stanisz, A.M.3    Forsythe, P.4    Bienenstock, J.5    Stanisz, G.J.6
  • 49
    • 84908081526 scopus 로고    scopus 로고
    • Gabab(1) receptor subunit isoforms differentially regulate stress resilience
    • O’Leary OF, Felice D, Galimberti S, Savignac HM, Bravo JA, Crowley T, et al. Gabab(1) receptor subunit isoforms differentially regulate stress resilience. PNAS 2014;111(42):15232–7. doi: 10.1073/pnas.1404090111
    • (2014) PNAS , vol.111 , Issue.42 , pp. 15232-15237
    • O’Leary, O.F.1    Felice, D.2    Galimberti, S.3    Savignac, H.M.4    Bravo, J.A.5    Crowley, T.6
  • 50
    • 1042277738 scopus 로고    scopus 로고
    • Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation
    • Ladd CO, Huot RL, Thrivikraman KV, Nemeroff CB, Plotsky PM., Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation. Biol Psychiatry 2004;55(4):367–75. doi: 10.1016/j.biopsych.2003.10.007
    • (2004) Biol Psychiatry , vol.55 , Issue.4 , pp. 367-375
    • Ladd, C.O.1    Huot, R.L.2    Thrivikraman, K.V.3    Nemeroff, C.B.4    Plotsky, P.M.5
  • 51
    • 33947155494 scopus 로고    scopus 로고
    • Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats
    • Aisa B, Tordera R, Lasheras B, Del Rio J, Ramirez MJ., Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology 2007;32:256–66. doi: 10.1016/j.psyneuen.2006.12.013
    • (2007) Psychoneuroendocrinology , vol.32 , pp. 256-266
    • Aisa, B.1    Tordera, R.2    Lasheras, B.3    Del Rio, J.4    Ramirez, M.J.5
  • 52
    • 67349157695 scopus 로고    scopus 로고
    • Effects of stress throughout the lifespan on the brain, behavior and cognition
    • Lupien SJ, McEwen BS, Gunnar MR, Heim C., Effects of stress throughout the lifespan on the brain, behavior and cognition. Nat Rev Neurosci 2009;10:434–45. doi: 10.1038/nrn2639
    • (2009) Nat Rev Neurosci , vol.10 , pp. 434-445
    • Lupien, S.J.1    McEwen, B.S.2    Gunnar, M.R.3    Heim, C.4
  • 53
    • 84921414845 scopus 로고    scopus 로고
    • Impaired miR449a-induced downregulation of Crhr1 expression in low-birth-weight rats
    • Nemoto, T, Kakinuma Y, Shibasaki T., Impaired miR449a-induced downregulation of Crhr1 expression in low-birth-weight rats. J Endocrinol. 2015;224:195–203. doi: 10.1530/JOE-14-0537
    • (2015) J Endocrinol , vol.224 , pp. 195-203
    • Nemoto, T.1    Kakinuma, Y.2    Shibasaki, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.