메뉴 건너뛰기




Volumn 44, Issue 3, 2018, Pages 217-225

Low-dose aspirin for primary prevention of cardiovascular events in patients with diabetes: Benefit or risk?

Author keywords

Cardiovascular disease; Diabetes mellitus; Low dose aspirin; Primary prevention

Indexed keywords

ACETYLSALICYLIC ACID; IBUPROFEN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; FIBRINOLYTIC AGENT;

EID: 85035112214     PISSN: 12623636     EISSN: 18781780     Source Type: Journal    
DOI: 10.1016/j.diabet.2017.11.002     Document Type: Review
Times cited : (13)

References (96)
  • 1
    • 84982113684 scopus 로고    scopus 로고
    • 2016 European Guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on cardiovascular disease prevention in clinical practice (constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)
    • Piepoli, M.F., Hoes, A.W., Agewall, S., Albus, C., Brotons, C., Catapano, A.L., et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on cardiovascular disease prevention in clinical practice (constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J 37 (2016), 2315–2381.
    • (2016) Eur Heart J , vol.37 , pp. 2315-2381
    • Piepoli, M.F.1    Hoes, A.W.2    Agewall, S.3    Albus, C.4    Brotons, C.5    Catapano, A.L.6
  • 2
    • 79952168736 scopus 로고    scopus 로고
    • Diabetes and antiplatelet therapy in acute coronary syndrome
    • Ferreiro, J.L., Angiolillo, D.J., Diabetes and antiplatelet therapy in acute coronary syndrome. Circulation 123 (2011), 798–813.
    • (2011) Circulation , vol.123 , pp. 798-813
    • Ferreiro, J.L.1    Angiolillo, D.J.2
  • 3
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    • Wild, S., Roglic, G., Green, A., Sicree, R., King, H., Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27 (2004), 1047–1053.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 4
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • Haffner, S.M., Lehto, S., Rönnemaa, T., Pyörälä K., Laakso, M., Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339 (1998), 229–234.
    • (1998) N Engl J Med , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Rönnemaa, T.3    Pyörälä, K.4    Laakso, M.5
  • 5
    • 84958584867 scopus 로고    scopus 로고
    • 8: cardiovascular disease and risk management
    • American Diabetes Association, 8: cardiovascular disease and risk management. Diabetes Care 39:Suppl. 1 (2016), S60–S71.
    • (2016) Diabetes Care , vol.39 , pp. S60-S71
    • American Diabetes Association1
  • 7
    • 0037092995 scopus 로고    scopus 로고
    • Diabetes and atherosclerosis: epidemiology, pathophysiology, and management
    • Beckman, J.A., Creager, M.A., Libby, P., Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 287 (2002), 2570–2581.
    • (2002) JAMA , vol.287 , pp. 2570-2581
    • Beckman, J.A.1    Creager, M.A.2    Libby, P.3
  • 8
    • 0042354827 scopus 로고    scopus 로고
    • Aspirin therapy in diabetes
    • American Diabetes Association, Aspirin therapy in diabetes. Diabetes Care 26:Suppl. 1 (2003), S87–S88.
    • (2003) Diabetes Care , vol.26 , pp. S87-S88
    • American Diabetes Association1
  • 9
    • 33744828023 scopus 로고    scopus 로고
    • Global guideline for type 2 diabetes: recommendations for standard, comprehensive, and minimal care
    • IDF Clinical Guidelines Task Force, Global guideline for type 2 diabetes: recommendations for standard, comprehensive, and minimal care. Diabet Med 23 (2006), 579–593.
    • (2006) Diabet Med , vol.23 , pp. 579-593
    • IDF Clinical Guidelines Task Force1
  • 10
    • 33846083971 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association
    • Buse, J.B., Ginsberg, H.N., Bakris, G.L., Clark, N.G., Costa, F., Eckel, R., et al. Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation 115 (2007), 114–126.
    • (2007) Circulation , vol.115 , pp. 114-126
    • Buse, J.B.1    Ginsberg, H.N.2    Bakris, G.L.3    Clark, N.G.4    Costa, F.5    Eckel, R.6
  • 12
    • 0035852471 scopus 로고    scopus 로고
    • Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice: Collaborative Group of the Primary Prevention Project
    • de Gaetano, G., Collaborative Group of the Primary Prevention Project, Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice: Collaborative Group of the Primary Prevention Project. Lancet 357 (2001), 89–95.
    • (2001) Lancet , vol.357 , pp. 89-95
    • de Gaetano, G.1    Collaborative Group of the Primary Prevention Project2
  • 13
    • 15744378579 scopus 로고    scopus 로고
    • A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    • Ridker, P.M., Cook, N.R., Lee, I.M., Gordon, D., Gaziano, J.M., Manson, J.E., et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 352 (2005), 1293–1304.
    • (2005) N Engl J Med , vol.352 , pp. 1293-1304
    • Ridker, P.M.1    Cook, N.R.2    Lee, I.M.3    Gordon, D.4    Gaziano, J.M.5    Manson, J.E.6
  • 14
    • 0032513878 scopus 로고    scopus 로고
    • Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial: HOT Study Group
    • Hansson, L., Zanchetti, A., Carruthers, S.G., Dahlöf, B., Elmfeldt, D., Julius, S., et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial: HOT Study Group. Lancet 351 (1998), 1755–1762.
    • (1998) Lancet , vol.351 , pp. 1755-1762
    • Hansson, L.1    Zanchetti, A.2    Carruthers, S.G.3    Dahlöf, B.4    Elmfeldt, D.5    Julius, S.6
  • 15
    • 0037065502 scopus 로고    scopus 로고
    • Cllaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
    • Antithrombotic Trialists’ Collaboration, Cllaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324 (2002), 71–86.
    • (2002) BMJ , vol.324 , pp. 71-86
    • Antithrombotic Trialists’ Collaboration1
  • 16
  • 17
    • 0036363108 scopus 로고    scopus 로고
    • Cause-specific mortality in a population with diabetes: South Tees Diabetes Mortality Study
    • Roper, N.A., Bilous, R.W., Kelly, W.F., Unwin, N.C., Connolly, V.M., Cause-specific mortality in a population with diabetes: South Tees Diabetes Mortality Study. Diabetes Care 25 (2002), 43–48.
    • (2002) Diabetes Care , vol.25 , pp. 43-48
    • Roper, N.A.1    Bilous, R.W.2    Kelly, W.F.3    Unwin, N.C.4    Connolly, V.M.5
  • 18
    • 65849268320 scopus 로고    scopus 로고
    • Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
    • Antithrombotic Trialists’ (ATT) Collaboration, Baigent, C., Blackwell, L., Collins, R., Emberson, J., Godwin, J., et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 373 (2009), 1849–1860.
    • (2009) Lancet , vol.373 , pp. 1849-1860
    • Antithrombotic Trialists’ (ATT) Collaboration1    Baigent, C.2    Blackwell, L.3    Collins, R.4    Emberson, J.5    Godwin, J.6
  • 19
    • 84878883894 scopus 로고    scopus 로고
    • Guidelines for Secondary Prevention of Myocardial Infarction (JCS 2011)
    • JCS Joint Working Group, Guidelines for Secondary Prevention of Myocardial Infarction (JCS 2011). Circ J 77 (2013), 231–248.
    • (2013) Circ J , vol.77 , pp. 231-248
    • JCS Joint Working Group1
  • 20
    • 71749105108 scopus 로고    scopus 로고
    • Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials
    • De Berardis, G., Sacco, M., Strippoli, G.F., Pellegrini, F., Graziano, G., Tognoni, G., et al. Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials. BMJ, 339, 2009, b4531.
    • (2009) BMJ , vol.339 , pp. b4531
    • De Berardis, G.1    Sacco, M.2    Strippoli, G.F.3    Pellegrini, F.4    Graziano, G.5    Tognoni, G.6
  • 21
    • 72249095825 scopus 로고    scopus 로고
    • Aspirin for the primary prevention of cardiovascular events: a systematic review and meta-analysis comparing patients with and without diabetes
    • Calvin, A.D., Aggarwal, N.R., Murad, M.H., Shi, Q., Elamin, M.B., Geske, J.B., et al. Aspirin for the primary prevention of cardiovascular events: a systematic review and meta-analysis comparing patients with and without diabetes. Diabetes Care 32 (2009), 2300–2306.
    • (2009) Diabetes Care , vol.32 , pp. 2300-2306
    • Calvin, A.D.1    Aggarwal, N.R.2    Murad, M.H.3    Shi, Q.4    Elamin, M.B.5    Geske, J.B.6
  • 22
    • 78049310315 scopus 로고    scopus 로고
    • Aspirin for primary prevention of cardiovascular disease in diabetes mellitus
    • Pignone, M., Williams, C.D., Aspirin for primary prevention of cardiovascular disease in diabetes mellitus. Nat Rev Endocrinol 6 (2010), 619–628.
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 619-628
    • Pignone, M.1    Williams, C.D.2
  • 23
    • 77954087762 scopus 로고    scopus 로고
    • Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation
    • Pignone, M., Alberts, M.J., Colwell, J.A., Cushman, M., Inzucchi, S.E., Mukherjee, D., et al. Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation. Circulation 121 (2010), 2694–2701.
    • (2010) Circulation , vol.121 , pp. 2694-2701
    • Pignone, M.1    Alberts, M.J.2    Colwell, J.A.3    Cushman, M.4    Inzucchi, S.E.5    Mukherjee, D.6
  • 24
    • 77956076027 scopus 로고    scopus 로고
    • Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation
    • Pignone, M., Alberts, M.J., Colwell, J.A., Cushman, M., Inzucchi, S.E., Mukherjee, D., et al. Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation. Diabetes Care 33 (2010), 1395–1402.
    • (2010) Diabetes Care , vol.33 , pp. 1395-1402
    • Pignone, M.1    Alberts, M.J.2    Colwell, J.A.3    Cushman, M.4    Inzucchi, S.E.5    Mukherjee, D.6
  • 26
    • 84862119222 scopus 로고    scopus 로고
    • European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts)
    • Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Z., Verschuren, M., et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 33 (2012), 1635–1701.
    • (2012) Eur Heart J , vol.33 , pp. 1635-1701
    • Perk, J.1    De Backer, G.2    Gohlke, H.3    Graham, I.4    Reiner, Z.5    Verschuren, M.6
  • 28
    • 9644272529 scopus 로고    scopus 로고
    • Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice
    • Kobayashi, T., Tahara, Y., Matsumoto, M., Iguchi, M., Sano, H., Murayama, T., et al. Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J Clin Invest 114 (2004), 784–794.
    • (2004) J Clin Invest , vol.114 , pp. 784-794
    • Kobayashi, T.1    Tahara, Y.2    Matsumoto, M.3    Iguchi, M.4    Sano, H.5    Murayama, T.6
  • 29
    • 0034699601 scopus 로고    scopus 로고
    • Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding
    • Lanas, A., Bajador, E., Serrano, P., Fuentes, J., Carreño, S., Guardia, J., et al. Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding. N Engl J Med 343 (2000), 834–839.
    • (2000) N Engl J Med , vol.343 , pp. 834-839
    • Lanas, A.1    Bajador, E.2    Serrano, P.3    Fuentes, J.4    Carreño, S.5    Guardia, J.6
  • 31
    • 84907430377 scopus 로고    scopus 로고
    • Updates on NSAIDs in patients with and without coronary artery disease: pitfalls, interactions and cardiovascular outcomes
    • Gargiulo, G., Capodanno, D., Longo, G., Capranzano, P., Tamburino, C., Updates on NSAIDs in patients with and without coronary artery disease: pitfalls, interactions and cardiovascular outcomes. Expert Rev Cardiovasc Ther 12 (2014), 1185–1203.
    • (2014) Expert Rev Cardiovasc Ther , vol.12 , pp. 1185-1203
    • Gargiulo, G.1    Capodanno, D.2    Longo, G.3    Capranzano, P.4    Tamburino, C.5
  • 33
    • 84923307510 scopus 로고    scopus 로고
    • Association of NSAID use with risk of bleeding and cardiovascular events in patients receiving antithrombotic therapy after myocardial infarction
    • Schjerning Olsen, A.M., Gislason, G.H., McGettigan, P., Fosbøl, E., Sørensen, R., Hansen, M.L., et al. Association of NSAID use with risk of bleeding and cardiovascular events in patients receiving antithrombotic therapy after myocardial infarction. JAMA 313 (2015), 805–814.
    • (2015) JAMA , vol.313 , pp. 805-814
    • Schjerning Olsen, A.M.1    Gislason, G.H.2    McGettigan, P.3    Fosbøl, E.4    Sørensen, R.5    Hansen, M.L.6
  • 34
    • 84872728410 scopus 로고    scopus 로고
    • Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin
    • Grosser, T., Fries, S., Lawson, J.A., Kapoor, S.C., Grant, G.R., FitzGerald, G.A., Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin. Circulation 127 (2013), 377–385.
    • (2013) Circulation , vol.127 , pp. 377-385
    • Grosser, T.1    Fries, S.2    Lawson, J.A.3    Kapoor, S.C.4    Grant, G.R.5    FitzGerald, G.A.6
  • 35
    • 60049093774 scopus 로고    scopus 로고
    • Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin “resistance”
    • Santilli, F., Rocca, B., De Cristofaro, R., Lattanzio, S., Pietrangelo, L., Habib, A., et al. Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin “resistance”. J Am Coll Cardiol 53 (2009), 667–677.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 667-677
    • Santilli, F.1    Rocca, B.2    De Cristofaro, R.3    Lattanzio, S.4    Pietrangelo, L.5    Habib, A.6
  • 36
    • 58249142825 scopus 로고    scopus 로고
    • Variability in responsiveness to oral antiplatelet therapy
    • Angiolillo, D.J., Variability in responsiveness to oral antiplatelet therapy. Am J Cardiol 103 (2009), 27A–34A.
    • (2009) Am J Cardiol , vol.103 , pp. 27A-34A
    • Angiolillo, D.J.1
  • 38
    • 27444434164 scopus 로고    scopus 로고
    • Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation
    • Tantry, U.S., Bliden, K.P., Gurbel, P.A., Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation. J Am Coll Cardiol 46 (2005), 1705–1709.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1705-1709
    • Tantry, U.S.1    Bliden, K.P.2    Gurbel, P.A.3
  • 39
    • 0242488090 scopus 로고    scopus 로고
    • Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus
    • Keating, F.K., Sobel, B.E., Schneider, D.J., Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus. Am J Cardiol 92 (2003), 1362–1365.
    • (2003) Am J Cardiol , vol.92 , pp. 1362-1365
    • Keating, F.K.1    Sobel, B.E.2    Schneider, D.J.3
  • 40
    • 0035131476 scopus 로고    scopus 로고
    • Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro
    • Assert, R., Scherk, G., Bumbure, A., Pirags, V., Schatz, H., Pfeiffer, A.F., Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro. Diabetologia 44 (2001), 188–195.
    • (2001) Diabetologia , vol.44 , pp. 188-195
    • Assert, R.1    Scherk, G.2    Bumbure, A.3    Pirags, V.4    Schatz, H.5    Pfeiffer, A.F.6
  • 41
    • 33751524662 scopus 로고    scopus 로고
    • Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects
    • Vaidyula, V.R., Boden, G., Rao, A.K., Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects. Platelets 17 (2006), 577–585.
    • (2006) Platelets , vol.17 , pp. 577-585
    • Vaidyula, V.R.1    Boden, G.2    Rao, A.K.3
  • 43
    • 0942276398 scopus 로고    scopus 로고
    • IRS-1 mediates inhibition of Ca2+ mobilization by insulin via the inhibitory G-protein Gi
    • Ferreira, I.A., Eybrechts, K.L., Mocking, A.I., Kroner, C., Akkerman, J.W., IRS-1 mediates inhibition of Ca2+ mobilization by insulin via the inhibitory G-protein Gi. J Biol Chem 279 (2004), 3254–3264.
    • (2004) J Biol Chem , vol.279 , pp. 3254-3264
    • Ferreira, I.A.1    Eybrechts, K.L.2    Mocking, A.I.3    Kroner, C.4    Akkerman, J.W.5
  • 44
    • 0029085504 scopus 로고
    • Activation of tissue factor-induced coagulation and endothelial cell dysfunction in non-insulin-dependent diabetic patients with microalbuminuria
    • Kario, K., Matsuo, T., Kobayashi, H., Matsuo, M., Sakata, T., Miyata, T., Activation of tissue factor-induced coagulation and endothelial cell dysfunction in non-insulin-dependent diabetic patients with microalbuminuria. Arterioscler Thromb Vasc Biol 15 (1995), 1114–1120.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1114-1120
    • Kario, K.1    Matsuo, T.2    Kobayashi, H.3    Matsuo, M.4    Sakata, T.5    Miyata, T.6
  • 45
    • 0028302590 scopus 로고
    • Platelet turnover in advanced diabetes
    • Winocour, P.D., Platelet turnover in advanced diabetes. Eur J Clin Invest 24:Suppl. 1 (1994), 34–37.
    • (1994) Eur J Clin Invest , vol.24 , pp. 34-37
    • Winocour, P.D.1
  • 46
    • 79959318812 scopus 로고    scopus 로고
    • Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery disease
    • Capodanno, D., Patel, A., Dharmashankar, K., Ferreiro, J.L., Ueno, M., Kodali, M., et al. Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery disease. Circ Cardiovasc Interv 4 (2011), 180–187.
    • (2011) Circ Cardiovasc Interv , vol.4 , pp. 180-187
    • Capodanno, D.1    Patel, A.2    Dharmashankar, K.3    Ferreiro, J.L.4    Ueno, M.5    Kodali, M.6
  • 47
    • 77956922337 scopus 로고    scopus 로고
    • Antiplatelet effect of once- or twice-daily aspirin dosage in stable coronary artery disease patients with diabetes
    • Addad, F., Chakroun, T., Elalamy, I., Abderazek, F., Chouchene, S., Dridi, Z., et al. Antiplatelet effect of once- or twice-daily aspirin dosage in stable coronary artery disease patients with diabetes. Int J Hematol 92 (2010), 296–301.
    • (2010) Int J Hematol , vol.92 , pp. 296-301
    • Addad, F.1    Chakroun, T.2    Elalamy, I.3    Abderazek, F.4    Chouchene, S.5    Dridi, Z.6
  • 48
    • 80052306473 scopus 로고    scopus 로고
    • Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications
    • Spectre, G., Arnetz, L., Östenson, C.G., Brismar, K., Li, N., Hjemdahl, P., Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. Thromb Haemost 106 (2011), 491–499.
    • (2011) Thromb Haemost , vol.106 , pp. 491-499
    • Spectre, G.1    Arnetz, L.2    Östenson, C.G.3    Brismar, K.4    Li, N.5    Hjemdahl, P.6
  • 49
    • 34347340649 scopus 로고    scopus 로고
    • Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study
    • Gurbel, P.A., Bliden, K.P., DiChiara, J., Newcomer, J., Weng, W., Neerchal, N.K., et al. Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study. Circulation 115 (2007), 3156–3164.
    • (2007) Circulation , vol.115 , pp. 3156-3164
    • Gurbel, P.A.1    Bliden, K.P.2    DiChiara, J.3    Newcomer, J.4    Weng, W.5    Neerchal, N.K.6
  • 50
    • 36849082996 scopus 로고    scopus 로고
    • The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) study
    • DiChiara, J., Bliden, K.P., Tantry, U.S., Hamed, M.S., Antonino, M.J., Suarez, T.A., et al. The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) study. Diabetes 56 (2007), 3014–3019.
    • (2007) Diabetes , vol.56 , pp. 3014-3019
    • DiChiara, J.1    Bliden, K.P.2    Tantry, U.S.3    Hamed, M.S.4    Antonino, M.J.5    Suarez, T.A.6
  • 51
    • 84955310958 scopus 로고    scopus 로고
    • Randomized controlled trial comparing impact on platelet reactivity of twice-daily with once-daily aspirin in people with Type 2 diabetes
    • Bethel, M.A., Harrison, P., Sourij, H., Sun, Y., Tucker, L., Kennedy, I., et al. Randomized controlled trial comparing impact on platelet reactivity of twice-daily with once-daily aspirin in people with Type 2 diabetes. Diabet Med 33 (2016), 224–230.
    • (2016) Diabet Med , vol.33 , pp. 224-230
    • Bethel, M.A.1    Harrison, P.2    Sourij, H.3    Sun, Y.4    Tucker, L.5    Kennedy, I.6
  • 52
    • 84867562008 scopus 로고    scopus 로고
    • Biological efficacy of twice daily aspirin in type 2 diabetic patients with coronary artery disease
    • Dillinger, J.G., Drissa, A., Sideris, G., Bal dit Sollier, C., Voicu, S., Manzo Silberman, S., et al. Biological efficacy of twice daily aspirin in type 2 diabetic patients with coronary artery disease. Am Heart J 164 (2012), 600–606.
    • (2012) Am Heart J , vol.164 , pp. 600-606
    • Dillinger, J.G.1    Drissa, A.2    Sideris, G.3    Bal dit Sollier, C.4    Voicu, S.5    Manzo Silberman, S.6
  • 53
    • 84859856401 scopus 로고    scopus 로고
    • Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target
    • Pascale, S., Petrucci, G., Dragani, A., Habib, A., Zaccardi, F., Pagliaccia, F., et al. Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target. Blood 119 (2012), 3595–3603.
    • (2012) Blood , vol.119 , pp. 3595-3603
    • Pascale, S.1    Petrucci, G.2    Dragani, A.3    Habib, A.4    Zaccardi, F.5    Pagliaccia, F.6
  • 54
    • 0026775578 scopus 로고
    • Aspirin effects on mortality and morbidity in patients with diabetes mellitus
    • ETDRS Investigators, Aspirin effects on mortality and morbidity in patients with diabetes mellitus. JAMA 268 (1992), 1292–1300.
    • (1992) JAMA , vol.268 , pp. 1292-1300
    • ETDRS Investigators1
  • 55
    • 0028846030 scopus 로고
    • Lack of effect of aspirin in asymptomatic patients with carotid bruits and substantial carotid narrowing: The Asymptomatic Cervical Bruit Study Group
    • Côté R., Battista, R.N., Abrahamowicz, M., Langlois, Y., Bourque, F., Mackey, A., Lack of effect of aspirin in asymptomatic patients with carotid bruits and substantial carotid narrowing: The Asymptomatic Cervical Bruit Study Group. Ann Intern Med 123 (1995), 649–655.
    • (1995) Ann Intern Med , vol.123 , pp. 649-655
    • Côté, R.1    Battista, R.N.2    Abrahamowicz, M.3    Langlois, Y.4    Bourque, F.5    Mackey, A.6
  • 57
    • 33846966599 scopus 로고    scopus 로고
    • Prevention of serious vascular events by aspirin amongst patients with peripheral arterial disease: randomized, double-blind trial
    • Catalano, M., Born, G., Peto, R., Prevention of serious vascular events by aspirin amongst patients with peripheral arterial disease: randomized, double-blind trial. J Intern Med 261 (2007), 276–284.
    • (2007) J Intern Med , vol.261 , pp. 276-284
    • Catalano, M.1    Born, G.2    Peto, R.3
  • 58
    • 34547407889 scopus 로고    scopus 로고
    • Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals
    • Erkan, D., Harrison, M.J., Levy, R., Peterson, M., Petri, M., Sammaritano, L., et al. Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals. Arthritis Rheum 56 (2007), 2382–2391.
    • (2007) Arthritis Rheum , vol.56 , pp. 2382-2391
    • Erkan, D.1    Harrison, M.J.2    Levy, R.3    Peterson, M.4    Petri, M.5    Sammaritano, L.6
  • 60
    • 0032513878 scopus 로고    scopus 로고
    • Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
    • Hansson, L., Zanchetti, A., Carruthers, S.G., Dahlöf, B., Elmfeldt, D., Julius, S., et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 351 (1998), 1755–1762.
    • (1998) Lancet , vol.351 , pp. 1755-1762
    • Hansson, L.1    Zanchetti, A.2    Carruthers, S.G.3    Dahlöf, B.4    Elmfeldt, D.5    Julius, S.6
  • 61
    • 0032562005 scopus 로고    scopus 로고
    • Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk
    • The Medical Research Council's General Practice Research Framework, Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk. Lancet 351 (1998), 233–241.
    • (1998) Lancet , vol.351 , pp. 233-241
    • The Medical Research Council's General Practice Research Framework1
  • 62
    • 54949131747 scopus 로고    scopus 로고
    • The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease
    • Belch, J., MacCuish, A., Campbell, I., Cobbe, S., Taylor, R., Prescott, R., et al. The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease. BMJ, 337, 2008, a1840.
    • (2008) BMJ , vol.337 , pp. a1840
    • Belch, J.1    MacCuish, A.2    Campbell, I.3    Cobbe, S.4    Taylor, R.5    Prescott, R.6
  • 63
    • 56149113603 scopus 로고    scopus 로고
    • Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial
    • Ogawa, H., Nakayama, M., Morimoto, T., Uemura, S., Kanauchi, M., Doi, N., et al. Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial. JAMA 300 (2008), 2134–2141.
    • (2008) JAMA , vol.300 , pp. 2134-2141
    • Ogawa, H.1    Nakayama, M.2    Morimoto, T.3    Uemura, S.4    Kanauchi, M.5    Doi, N.6
  • 64
    • 77649198148 scopus 로고    scopus 로고
    • Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial
    • Fowkes, F.G., Price, J.F., Stewart, M.C., Butcher, I., Leng, G.C., Pell, A.C., et al. Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial. JAMA 303 (2010), 841–848.
    • (2010) JAMA , vol.303 , pp. 841-848
    • Fowkes, F.G.1    Price, J.F.2    Stewart, M.C.3    Butcher, I.4    Leng, G.C.5    Pell, A.C.6
  • 65
    • 84919346036 scopus 로고    scopus 로고
    • Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial
    • Ikeda, Y., Shimada, K., Teramoto, T., Uchiyama, S., Yamazaki, T., Oikawa, S., et al. Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial. JAMA 312 (2014), 2510–2520.
    • (2014) JAMA , vol.312 , pp. 2510-2520
    • Ikeda, Y.1    Shimada, K.2    Teramoto, T.3    Uchiyama, S.4    Yamazaki, T.5    Oikawa, S.6
  • 66
    • 79957954493 scopus 로고    scopus 로고
    • Meta-analysis of multiple primary prevention trials of cardiovascular events using aspirin
    • Bartolucci, A.A., Tendera, M., Howard, G., Meta-analysis of multiple primary prevention trials of cardiovascular events using aspirin. Am J Cardiol 107 (2011), 1796–1801.
    • (2011) Am J Cardiol , vol.107 , pp. 1796-1801
    • Bartolucci, A.A.1    Tendera, M.2    Howard, G.3
  • 67
    • 79959345305 scopus 로고    scopus 로고
    • Effect of aspirin on mortality in the primary prevention of cardiovascular disease
    • Raju, N., Sobieraj-Teague, M., Hirsh, J., O'Donnell, M., Eikelboom, J., Effect of aspirin on mortality in the primary prevention of cardiovascular disease. Am J Med 124 (2011), 621–629.
    • (2011) Am J Med , vol.124 , pp. 621-629
    • Raju, N.1    Sobieraj-Teague, M.2    Hirsh, J.3    O'Donnell, M.4    Eikelboom, J.5
  • 68
    • 79960200973 scopus 로고    scopus 로고
    • Aspirin for the prevention of cardiovascular events in patients without clinical cardiovascular disease: a meta-analysis of randomized trials
    • Berger, J.S., Lala, A., Krantz, M.J., Baker, G.S., Hiatt, W.R., Aspirin for the prevention of cardiovascular events in patients without clinical cardiovascular disease: a meta-analysis of randomized trials. Am Heart J 162 (2011), 115–124.
    • (2011) Am Heart J , vol.162 , pp. 115-124
    • Berger, J.S.1    Lala, A.2    Krantz, M.J.3    Baker, G.S.4    Hiatt, W.R.5
  • 69
    • 84857376799 scopus 로고    scopus 로고
    • Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials
    • Seshasai, S.R., Wijesuriya, S., Sivakumaran, R., Nethercott, S., Erqou, S., Sattar, N., et al. Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials. Arch Intern Med 172 (2012), 209–216.
    • (2012) Arch Intern Med , vol.172 , pp. 209-216
    • Seshasai, S.R.1    Wijesuriya, S.2    Sivakumaran, R.3    Nethercott, S.4    Erqou, S.5    Sattar, N.6
  • 70
    • 84910018779 scopus 로고    scopus 로고
    • Aspirin for primary prevention of cardiovascular events: meta-analysis of randomized controlled trials and subgroup analysis by sex and diabetes status
    • Xie, M., Shan, Z., Zhang, Y., Chen, S., Yang, W., Bao, W., et al. Aspirin for primary prevention of cardiovascular events: meta-analysis of randomized controlled trials and subgroup analysis by sex and diabetes status. PLoS One, 9, 2014, e90286.
    • (2014) PLoS One , vol.9 , pp. e90286
    • Xie, M.1    Shan, Z.2    Zhang, Y.3    Chen, S.4    Yang, W.5    Bao, W.6
  • 71
    • 84965168651 scopus 로고    scopus 로고
    • Updated meta-analysis of aspirin in primary prevention of cardiovascular disease
    • Raju, N., Sobieraj-Teague, M., Bosch, J., Eikelboom, J.W., Updated meta-analysis of aspirin in primary prevention of cardiovascular disease. Am J Med 129 (2016), e35–e36.
    • (2016) Am J Med , vol.129 , pp. e35-e36
    • Raju, N.1    Sobieraj-Teague, M.2    Bosch, J.3    Eikelboom, J.W.4
  • 72
    • 84975230850 scopus 로고    scopus 로고
    • Aspirin for the primary prevention of cardiovascular events: a systematic evidence review for the U.S. Preventive Services Task Force
    • Guirguis-Blake, J.M., Evans, C.V., Senger, C.A., O'Connor, E.A., Whitlock, E.P., Aspirin for the primary prevention of cardiovascular events: a systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med 164 (2016), 804–813.
    • (2016) Ann Intern Med , vol.164 , pp. 804-813
    • Guirguis-Blake, J.M.1    Evans, C.V.2    Senger, C.A.3    O'Connor, E.A.4    Whitlock, E.P.5
  • 73
    • 84975223728 scopus 로고    scopus 로고
    • Bleeding risks with aspirin use for primary prevention in adults: a systematic review for the U.S. Preventive Services Task Force
    • Whitlock, E.P., Burda, B.U., Williams, S.B., Guirguis-Blake, J.M., Evans, C.V., Bleeding risks with aspirin use for primary prevention in adults: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med 164 (2016), 826–835.
    • (2016) Ann Intern Med , vol.164 , pp. 826-835
    • Whitlock, E.P.1    Burda, B.U.2    Williams, S.B.3    Guirguis-Blake, J.M.4    Evans, C.V.5
  • 74
    • 84856794168 scopus 로고    scopus 로고
    • Primary and secondary prevention of cardiovascular disease: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines
    • Vandvik, P.O., Lincoff, A.M., Gore, J.M., Gutterman, D.D., Sonnenberg, F.A., Alonso-Coello, P., et al. Primary and secondary prevention of cardiovascular disease: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 141 (2012), 637–668.
    • (2012) Chest , vol.141 , pp. 637-668
    • Vandvik, P.O.1    Lincoff, A.M.2    Gore, J.M.3    Gutterman, D.D.4    Sonnenberg, F.A.5    Alonso-Coello, P.6
  • 75
    • 84885136577 scopus 로고    scopus 로고
    • Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer: a systematic review and overview of reviews
    • Sutcliffe, P., Connock, M., Gurung, T., Freeman, K., Johnson, S., Kandala, N.B., et al. Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer: a systematic review and overview of reviews. Health Technol Assess 17 (2013), 1–253.
    • (2013) Health Technol Assess , vol.17 , pp. 1-253
    • Sutcliffe, P.1    Connock, M.2    Gurung, T.3    Freeman, K.4    Johnson, S.5    Kandala, N.B.6
  • 76
    • 84888269737 scopus 로고    scopus 로고
    • Effect of low-dose aspirin on primary prevention of cardiovascular events in Japanese diabetic patients at high risk
    • Okada, S., Morimoto, T., Ogawa, H., Sakuma, M., Soejima, H., Nakayama, M., et al. Effect of low-dose aspirin on primary prevention of cardiovascular events in Japanese diabetic patients at high risk. Circ J 77 (2013), 3023–3028.
    • (2013) Circ J , vol.77 , pp. 3023-3028
    • Okada, S.1    Morimoto, T.2    Ogawa, H.3    Sakuma, M.4    Soejima, H.5    Nakayama, M.6
  • 77
    • 29144453326 scopus 로고    scopus 로고
    • Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    • Nathan, D.M., Cleary, P.A., Backlund, J.Y., Genuth, S.M., Lachin, J.M., Orchard, T.J., et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 353 (2005), 2643–2653.
    • (2005) N Engl J Med , vol.353 , pp. 2643-2653
    • Nathan, D.M.1    Cleary, P.A.2    Backlund, J.Y.3    Genuth, S.M.4    Lachin, J.M.5    Orchard, T.J.6
  • 78
    • 53749096863 scopus 로고    scopus 로고
    • 10-Year follow-up of intensive glucose control in type 2 diabetes
    • Holman, R.R., Paul, S.K., Bethel, M.A., Matthews, D.R., Neil, H.A., 10-Year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359 (2008), 1577–1589.
    • (2008) N Engl J Med , vol.359 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Neil, H.A.5
  • 79
    • 38949210220 scopus 로고    scopus 로고
    • Effect of a multifactorial intervention on mortality in type 2 diabetes
    • Gaede, P., Lund-Andersen, H., Parving, H.H., Pedersen, O., Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 358 (2008), 580–591.
    • (2008) N Engl J Med , vol.358 , pp. 580-591
    • Gaede, P.1    Lund-Andersen, H.2    Parving, H.H.3    Pedersen, O.4
  • 80
    • 85007424354 scopus 로고    scopus 로고
    • Low-dose aspirin for primary prevention of cardiovascular events in patients with type 2 diabetes mellitus: 10-year follow-up of a randomized controlled trial
    • Saito, Y., Okada, S., Ogawa, H., Soejima, H., Sakuma, M., Nakayama, M., et al. Low-dose aspirin for primary prevention of cardiovascular events in patients with type 2 diabetes mellitus: 10-year follow-up of a randomized controlled trial. Circulation 135 (2017), 659–670.
    • (2017) Circulation , vol.135 , pp. 659-670
    • Saito, Y.1    Okada, S.2    Ogawa, H.3    Soejima, H.4    Sakuma, M.5    Nakayama, M.6
  • 81
    • 74449086639 scopus 로고    scopus 로고
    • Aspirin for primary prevention of cardiovascular events in patients with diabetes: a meta-analysis
    • Zhang, C., Sun, A., Zhang, P., Wu, C., Zhang, S., Fu, M., et al. Aspirin for primary prevention of cardiovascular events in patients with diabetes: a meta-analysis. Diabetes Res Clin Pract 87 (2010), 211–218.
    • (2010) Diabetes Res Clin Pract , vol.87 , pp. 211-218
    • Zhang, C.1    Sun, A.2    Zhang, P.3    Wu, C.4    Zhang, S.5    Fu, M.6
  • 82
    • 78651266855 scopus 로고    scopus 로고
    • Low-dose aspirin for primary prevention of cardiovascular events in patients with diabetes: a meta-analysis
    • Stavrakis, S., Stoner, J.A., Azar, M., Wayangankar, S., Thadani, U., Low-dose aspirin for primary prevention of cardiovascular events in patients with diabetes: a meta-analysis. Am J Med Sci 341 (2011), 1–9.
    • (2011) Am J Med Sci , vol.341 , pp. 1-9
    • Stavrakis, S.1    Stoner, J.A.2    Azar, M.3    Wayangankar, S.4    Thadani, U.5
  • 83
    • 79953246984 scopus 로고    scopus 로고
    • Aspirin effect on the incidence of major adverse cardiovascular events in patients with diabetes mellitus: a systematic review and meta-analysis
    • Butalia, S., Leung, A.A., Ghali, W.A., Rabi, D.M., Aspirin effect on the incidence of major adverse cardiovascular events in patients with diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Diabetol, 10, 2011, 25.
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 25
    • Butalia, S.1    Leung, A.A.2    Ghali, W.A.3    Rabi, D.M.4
  • 84
    • 84971328537 scopus 로고    scopus 로고
    • Aspirin for primary prevention of cardiovascular and all-cause mortality events in diabetes: updated meta-analysis of randomized controlled trials
    • Kunutsor, S.K., Seidu, S., Khunti, K., Aspirin for primary prevention of cardiovascular and all-cause mortality events in diabetes: updated meta-analysis of randomized controlled trials. Diabet Med 34 (2017), 316–327.
    • (2017) Diabet Med , vol.34 , pp. 316-327
    • Kunutsor, S.K.1    Seidu, S.2    Khunti, K.3
  • 85
    • 84885997413 scopus 로고    scopus 로고
    • ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the task force on diabetes, prediabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD)
    • Ryden, L., Grant, P.J., Anker, S.D., Berne, C., Cosentino, F., Danchin, N., et al. ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the task force on diabetes, prediabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J 34 (2013), 3035–3087.
    • (2013) Eur Heart J , vol.34 , pp. 3035-3087
    • Ryden, L.1    Grant, P.J.2    Anker, S.D.3    Berne, C.4    Cosentino, F.5    Danchin, N.6
  • 86
    • 84904548892 scopus 로고    scopus 로고
    • Aspirin therapy in primary cardiovascular disease prevention: a position paper of the European Society of Cardiology working group on thrombosis
    • Halvorsen, S., Andreotti, F., ten Berg, J.M., Cattaneo, M., Coccheri, S., Marchioli, R., et al. Aspirin therapy in primary cardiovascular disease prevention: a position paper of the European Society of Cardiology working group on thrombosis. J Am Coll Cardiol 64 (2014), 319–327.
    • (2014) J Am Coll Cardiol , vol.64 , pp. 319-327
    • Halvorsen, S.1    Andreotti, F.2    ten Berg, J.M.3    Cattaneo, M.4    Coccheri, S.5    Marchioli, R.6
  • 87
    • 84960878943 scopus 로고    scopus 로고
    • Standards of medical care in diabetes–2016
    • Association, A.D., Standards of medical care in diabetes–2016. Diabetes Care 39 (2016), 60–71.
    • (2016) Diabetes Care , vol.39 , pp. 60-71
    • Association, A.D.1
  • 88
    • 84958584867 scopus 로고    scopus 로고
    • Cardiovascular disease and risk management
    • Cardiovascular disease and risk management. Diabetes Care 39 (2016), 60–71.
    • (2016) Diabetes Care , vol.39 , pp. 60-71
  • 89
    • 84940706705 scopus 로고    scopus 로고
    • Update on prevention of cardiovascular disease in adults with type 2 diabetes mellitus in light of recent evidence: a scientific statement from the American Heart Association and the American Diabetes Association
    • Fox, C.S., Golden, S.H., Anderson, C., Bray, G.A., Burke, L.E., de Boer, I.H., et al. Update on prevention of cardiovascular disease in adults with type 2 diabetes mellitus in light of recent evidence: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation 132 (2015), 691–718.
    • (2015) Circulation , vol.132 , pp. 691-718
    • Fox, C.S.1    Golden, S.H.2    Anderson, C.3    Bray, G.A.4    Burke, L.E.5    de Boer, I.H.6
  • 90
    • 84975292439 scopus 로고    scopus 로고
    • Aspirin use for the primary prevention of cardiovascular disease and colorectal cancer: U.S. Preventive Services Task Force Recommendation Statement
    • Bibbins-Domingo, K., U.S. Preventive Services Task Force, Aspirin use for the primary prevention of cardiovascular disease and colorectal cancer: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med 164 (2016), 836–845.
    • (2016) Ann Intern Med , vol.164 , pp. 836-845
    • Bibbins-Domingo, K.1    U.S. Preventive Services Task Force2
  • 91
    • 84937395008 scopus 로고    scopus 로고
    • The multifaceted clinical readouts of platelet inhibition by low-dose aspirin
    • Patrono, C., The multifaceted clinical readouts of platelet inhibition by low-dose aspirin. J Am Coll Cardiol 66 (2015), 74–85.
    • (2015) J Am Coll Cardiol , vol.66 , pp. 74-85
    • Patrono, C.1
  • 92
    • 84975256623 scopus 로고    scopus 로고
    • Aspirin for the prevention of cancer incidence and mortality: sstematic evidence reviews for the U.S. Preventive Services Task Force
    • Chubak, J., Whitlock, E.P., Williams, S.B., Kamineni, A., Burda, B.U., Buist, D.S., et al. Aspirin for the prevention of cancer incidence and mortality: sstematic evidence reviews for the U.S. Preventive Services Task Force. Ann Intern Med 164 (2016), 814–825.
    • (2016) Ann Intern Med , vol.164 , pp. 814-825
    • Chubak, J.1    Whitlock, E.P.2    Williams, S.B.3    Kamineni, A.4    Burda, B.U.5    Buist, D.S.6
  • 93
    • 84903159932 scopus 로고    scopus 로고
    • 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Goff, D.C. Jr., Lloyd-Jones, D.M., Bennett, G., Coady, S., D'Agostino, R.B., Gibbons, R., et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 129:25 Suppl. 2 (2014), S49–S73.
    • (2014) Circulation , vol.129 , Issue.25 Suppl. 2 , pp. S49-S73
    • Goff, D.C.1    Lloyd-Jones, D.M.2    Bennett, G.3    Coady, S.4    D'Agostino, R.B.5    Gibbons, R.6
  • 94
    • 84995530822 scopus 로고    scopus 로고
    • Aspirin for primary cardiovascular risk prevention and beyond in diabetes mellitus
    • Capodanno, D., Angiolillo, D.J., Aspirin for primary cardiovascular risk prevention and beyond in diabetes mellitus. Circulation 134 (2016), 1579–1594.
    • (2016) Circulation , vol.134 , pp. 1579-1594
    • Capodanno, D.1    Angiolillo, D.J.2
  • 95
  • 96
    • 35348816110 scopus 로고    scopus 로고
    • Aspirin and simvastatin combination for cardiovascular events prevention trial in diabetes (ACCEPT-D): design of a randomized study of the efficacy of low-dose aspirin in the prevention of cardiovascular events in subjects with diabetes mellitus treated with statins
    • De Berardis, G., Sacco, M., Evangelista, V., Filippi, A., Giorda, C.B., Rognoni, G., et al. Aspirin and simvastatin combination for cardiovascular events prevention trial in diabetes (ACCEPT-D): design of a randomized study of the efficacy of low-dose aspirin in the prevention of cardiovascular events in subjects with diabetes mellitus treated with statins. Trials, 8, 2007, 21.
    • (2007) Trials , vol.8 , pp. 21
    • De Berardis, G.1    Sacco, M.2    Evangelista, V.3    Filippi, A.4    Giorda, C.B.5    Rognoni, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.