Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

Molecular Psychiatry

Volumn 23, Issue 5, 2018, Pages 1145-1156

  Rutten, B P F ^a   Vermetten, E ^b,c,d   Vinkers, C H ^b   Ursini, G ^e   Daskalakis, N P ^f   Pishva, E ^a   De Nijs, L ^a   Houtepen, L C ^b   Eijssen, L ^a   Jaffe, A E ^e   Kenis, G ^a   Viechtbauer, W ^a   Van Den Hove, D ^a,g   Schraut, K G ^g   Lesch, K P ^a,g   Kleinman, J E ^e   Hyde, T M ^e   Weinberger, D R ^e,h   Schalkwyk, L ⁱ   Lunnon, K ^j   Mill, J ^j   Cohen, H ^k   Yehuda, R ^f   Baker, D G ^l,m,n   Maihofer, A X ^l,m,n   Nievergelt, C M ^l,m,n   Geuze, E ^b,c   Boks, M P M ^b   more..

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Ministerie van Defensie   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF WÜRZBURG   (Germany)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF ESSEX   (United Kingdom)

^j UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^k BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^l UNIVERSITY OF CALIFORNIA   (United States)

^m VA CENTER OF EXCELLENCE FOR STRESS AND MENTAL HEALTH   (United States)

ⁿ VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AFGHANISTAN; ARTICLE; BIOINFORMATICS; CHROMOSOME 6; COHORT ANALYSIS; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DUTCHMAN; GENE; GENE EXPRESSION REGULATION; GENE LOCUS; GENE REPLICATION; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; GPR12 GENE; HIST1H2APS2 GENE; HOOK2 GENE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MILITARY DEPLOYMENT; MILITARY SERVICE; PAX8 GENE; PM20D1 GENE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROSPECTIVE STUDY; RNF39 GENE; SMAD5 GENE; SOLDIER; SPATC1L GENE; SYMPTOM; TRANSCRIPTION INITIATION SITE; VALIDATION PROCESS; ZFP57 GENE; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; METABOLISM; PROCEDURES; PSYCHOLOGY;

DNA BINDING PROTEIN; IMMEDIATE EARLY PROTEIN; RNF39 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; ZFP-57 PROTEIN, HUMAN;

ADULT; COHORT STUDIES; DNA METHYLATION; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HUMANS; IMMEDIATE-EARLY PROTEINS; LONGITUDINAL STUDIES; MALE; MILITARY PERSONNEL; PROSPECTIVE STUDIES; STRESS DISORDERS, POST-TRAUMATIC; TRANSCRIPTION FACTORS;

EID: 85035074660     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2017.120     Document Type: Article

References (36)

1. Yehuda R, Hoge CW, McFarlane AC, Vermetten E, Lanius RA, Nievergelt CM et al. Post-traumatic stress disorder. Nat Rev Dis Primers 2015; 1: 15057.
2. Zannas AS, Provencal N, Binder EB. Epigenetics of posttraumatic stress disorder: current evidence, challenges, and future directions. Biol Psychiatry 2015; 78: 327-335.
3. Vinkers CH, Kalafateli AL, Rutten BP, Kas MJ, Kaminsky Z, Turner JD et al. Traumatic stress and human DNA methylation: a critical review. Epigenomics 2015; 7: 593-608.
4. Mehta D, Klengel T, Conneely KN, Smith AK, Altmann A, Pace TW et al. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proc Natl Acad Sci USA 2013; 110: 8302-8307.
5. Uddin M, Galea S, Chang SC, Aiello AE, Wildman DE, de los Santos R et al. Gene expression and methylation signatures of MAN2C1 are associated with PTSD. Dis Markers 2011; 30: 111-121.
6. Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 2007; 8: 355-367.
7. Reijnen A, Rademaker AR, Vermetten E, Geuze E. Prevalence of mental health symptoms in Dutch military personnel returning from deployment to Afghanistan: a 2-year longitudinal analysis. Eur Psychiatry 2015; 30: 341-346.
8. Eekhout I, Reijnen A, Vermetten E, Geuze E. Post-traumatic stress symptoms 5 years after military deployment to Afghanistan: an observational cohort study. Lancet Psychiatry 2015; 3: 58-64.
9. Boks MP, Mierlo HC, Rutten BP, Radstake TR, De Witte L, Geuze E et al. Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder. Psychoneuroendocrinology 2014; 51: 506-512.
10. van Zuiden M, Geuze E, Willemen HL, Vermetten E, Maas M, Heijnen CJ et al. Pre-existing high glucocorticoid receptor number predicting development of posttraumatic stress symptoms after military deployment. Am J Psychiatry 2011; 168: 89-96.
11. Vermetten E, Bremner JD, Skelton L, Spiegel D. PTSD and Vietnam Veterans. Science 2007; 315: 184-187; author reply 184-187.
12. Chen YA, Lemire M, Choufani S, Butcher DT, Grafodatskaya D, Zanke BW et al. Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics 2013; 8: 203-209.
13. Pedersen BS, Schwartz DA, Yang IV, Kechris KJ. Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values. Bioinformatics 2012; 28: 2986-2988.
14. Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J et al. Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol 2016; 17: 27.
15. Baker DG, Nash WP, Litz BT, Geyer MA, Risbrough VB, Nievergelt CM et al. Predictors of risk and resilience for posttraumatic stress disorder among ground combat Marines: methods of the Marine Resiliency Study. Prev Chronic Dis 2012; 9: E97.
16. Minassian A, Maihofer AX, Baker DG, Nievergelt CM, Geyer MA, Risbrough VB et al. Association of predeployment heart rate variability with risk of postdeployment posttraumatic stress disorder in active-duty marines. JAMA Psychiatry 2015; 72: 979-986.
17. Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD et al. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics 2014; 30: 1363-1369.
18. Nievergelt CM, Maihofer AX, Mustapic M, Yurgil KA, Schork NJ, Miller MW et al. Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: a genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. Psychoneuroendocrinology 2015; 51: 459-471.
19. Mikeska T, Craig JM. DNA methylation biomarkers: cancer and beyond. Genes (Basel) 2014; 5: 821-864.
20. Boks MP, Derks EM, Weisenberger DJ, Strengman E, Janson E, Sommer IE et al. The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS ONE 2009; 4: e6767.
21. Jaffe AE, Gao Y, Deep-Soboslay A, Tao R, Hyde TM, Weinberger DR et al. Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex. Nat Neurosci 2016; 19: 40-47.
22. Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM et al. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci 2016; 19: 48-54.
23. Plant K, Fairfax BP, Makino S, Vandiedonck C, Radhakrishnan J, Knight JC. Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57. Eur J Hum Genet 2014; 22: 568-571.
24. Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P et al. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell 2008; 15: 547-557.
25. Jakobsson J, Cordero MI, Bisaz R, Groner AC, Busskamp V, Bensadoun JC et al. KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress. Neuron 2008; 60: 818-831.
26. Sullivan PF, Lin D, Tzeng JY, van den Oord E, Perkins D, Stroup TS et al. Genomewide association for schizophrenia in the CATIE study: results of stage 1. Mol Psychiatry 2008; 13: 570-584.
27. Mick E, McGough J, Deutsch CK, Frazier JA, Kennedy D, Goldberg RJ. Genome-wide association study of proneness to anger. PLoS ONE 2014; 9: e87257.
28. Lotan A, Fenckova M, Bralten J, Alttoa A, Dixson L, Williams RW et al. Neuroinformatic analyses of common and distinct genetic components associated with major neuropsychiatric disorders. Front Neurosci 2014; 8: 331.
29. Matsuo R, Asada A, Fujitani K, Inokuchi K. LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein. Biochem Biophys Res Commun 2001; 289: 479-484.
30. Datson NA, van den Oever JM, Korobko OB, Magarinos AM, de Kloet ER, McEwen BS. Previous history of chronic stress changes the transcriptional response to glucocorticoid challenge in the dentate gyrus region of the male rat hippocampus. Endocrinology 2013; 154: 3261-3272.
31. Ploski JE, Park KW, Ping J, Monsey MS, Schafe GE. Identification of plasticityassociated genes regulated by Pavlovian fear conditioning in the lateral amygdala. J Neurochem 2010; 112: 636-650.
32. Feder A, Nestler EJ, Charney DS. Psychobiology and molecular genetics of resilience. Nat Rev Neurosci 2009; 10: 446-457.
33. LaPlant Q, Vialou V, Covington HE 3rd, Dumitriu D, Feng J, Warren BL et al. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci 2010; 13: 1137-1143.
34. Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D et al. beta-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature 2014; 516: 51-55.
35. Daskalakis NP, Cohen H, Cai G, Buxbaum JD, Yehuda R. Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes. Proc Natl Acad Sci USA 2014; 111: 13529-13534.
36. Logue MW, Amstadter AB, Baker DG, Duncan L, Koenen KC, Liberzon I et al. The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: posttraumatic stress disorder enters the age of large-scale genomic collaboration. Neuropsychopharmacology 2015; 40: 2287-2297.