메뉴 건너뛰기




Volumn 130, Issue 21, 2017, Pages 2339-2343

Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; HEMOJUVELIN; HEPCIDIN; INTERLEUKIN 6; IRON; LIPOPOLYSACCHARIDE; MESSENGER RNA; SMAD5 PROTEIN; STAT3 PROTEIN; BMP6 PROTEIN, MOUSE; HFE2 PROTEIN, MOUSE; MEMBRANE PROTEIN;

EID: 85034838754     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2017-07-795658     Document Type: Article
Times cited : (38)

References (25)
  • 1
    • 85014966092 scopus 로고    scopus 로고
    • Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice
    • Canali S, Zumbrennen-Bullough KB, Core AB, et al. Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice. Blood. 2017;129(4): 405-414.
    • (2017) Blood , vol.129 , Issue.4 , pp. 405-414
    • Canali, S.1    Zumbrennen-Bullough, K.B.2    Core, A.B.3
  • 2
    • 85014960496 scopus 로고    scopus 로고
    • Liver sinusoidal endothelial cells as iron sensors
    • Parrow NL, Fleming RE. Liver sinusoidal endothelial cells as iron sensors. Blood. 2017; 129(4):397-398.
    • (2017) Blood , vol.129 , Issue.4 , pp. 397-398
    • Parrow, N.L.1    Fleming, R.E.2
  • 3
    • 9144252017 scopus 로고    scopus 로고
    • Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
    • Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004;36(1):77-82.
    • (2004) Nat Genet , vol.36 , Issue.1 , pp. 77-82
    • Papanikolaou, G.1    Samuels, M.E.2    Ludwig, E.H.3
  • 4
    • 84959440408 scopus 로고    scopus 로고
    • Heterozygous mutations in BMP6 pro-peptide lead to inappropriate hepcidin synthesis and moderate iron overload in humans
    • Daher R, Kannengiesser C, Houamel D, et al. Heterozygous mutations in BMP6 pro-peptide lead to inappropriate hepcidin synthesis and moderate iron overload in humans. Gastroenterology. 2016;150(3):672-683.e4.
    • (2016) Gastroenterology , vol.150 , Issue.3 , pp. 672-683.e4
    • Daher, R.1    Kannengiesser, C.2    Houamel, D.3
  • 5
    • 85018970824 scopus 로고    scopus 로고
    • Identification of new BMP6 pro-peptide mutations in patients with iron overload
    • Piubelli C, Castagna A, Marchi G, et al. Identification of new BMP6 pro-peptide mutations in patients with iron overload. Am J Hematol. 2017;92(6):562-568.
    • (2017) Am J Hematol , vol.92 , Issue.6 , pp. 562-568
    • Piubelli, C.1    Castagna, A.2    Marchi, G.3
  • 6
    • 63449103712 scopus 로고    scopus 로고
    • BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    • Andriopoulos B Jr, Corradini E, Xia Y, et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009; 41(4):482-487.
    • (2009) Nat Genet , vol.41 , Issue.4 , pp. 482-487
    • Jr, A.B.1    Corradini, E.2    Xia, Y.3
  • 8
    • 23644444316 scopus 로고    scopus 로고
    • Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
    • Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005; 115(8):2180-2186.
    • (2005) J Clin Invest , vol.115 , Issue.8 , pp. 2180-2186
    • Niederkofler, V.1    Salie, R.2    Arber, S.3
  • 10
    • 84893655780 scopus 로고    scopus 로고
    • Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin
    • Latour C, Kautz L, Besson-Fournier C, et al. Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology. 2014;59(2):683-694.
    • (2014) Hepatology , vol.59 , Issue.2 , pp. 683-694
    • Latour, C.1    Kautz, L.2    Besson-Fournier, C.3
  • 11
    • 84952639186 scopus 로고    scopus 로고
    • Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin
    • Latour C, Besson-Fournier C, Meynard D, et al. Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin. Hepatology. 2016;63(1):126-137.
    • (2016) Hepatology , vol.63 , Issue.1 , pp. 126-137
    • Latour, C.1    Besson-Fournier, C.2    Meynard, D.3
  • 13
    • 85014936657 scopus 로고    scopus 로고
    • Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B
    • Besson-Fournier C, Gineste A, Latour C, et al. Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B. Blood. 2017;129(4):533-536.
    • (2017) Blood , vol.129 , Issue.4 , pp. 533-536
    • Besson-Fournier, C.1    Gineste, A.2    Latour, C.3
  • 14
    • 0002413872 scopus 로고
    • Tissue iron stores
    • Cook JD, ed. New York, NY: Churchill Livingstone
    • Torrance JD, Bothwell TH. Tissue iron stores. In: Cook JD, ed. Iron Methods in Hematology, Vol. 1. New York, NY: Churchill Livingstone; 1980: 90-115.
    • (1980) Iron Methods in Hematology , vol.1 , pp. 90-115
    • Torrance, J.D.1    Bothwell, T.H.2
  • 16
    • 84864053080 scopus 로고    scopus 로고
    • Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling
    • Besson-Fournier C, Latour C, Kautz L, et al. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood. 2012;120(2):431-439.
    • (2012) Blood , vol.120 , Issue.2 , pp. 431-439
    • Besson-Fournier, C.1    Latour, C.2    Kautz, L.3
  • 17
    • 84960540727 scopus 로고    scopus 로고
    • Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: Evidence for a role in hepcidin induction by inflammation in Male mice
    • Canali S, Core AB, Zumbrennen-Bullough KB, et al. Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice. Endocrinology. 2016; 157(3):1146-1162.
    • (2016) Endocrinology , vol.157 , Issue.3 , pp. 1146-1162
    • Canali, S.1    Core, A.B.2    Zumbrennen-Bullough, K.B.3
  • 18
    • 85014911721 scopus 로고    scopus 로고
    • Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis
    • Koch PS, Olsavszky V, Ulbrich F, et al. Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood. 2017;129(4):415-419.
    • (2017) Blood , vol.129 , Issue.4 , pp. 415-419
    • Koch, P.S.1    Olsavszky, V.2    Ulbrich, F.3
  • 19
    • 85030172960 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6
    • published online ahead of print 17 August 2017
    • Canali S, Wang CY, Zumbrennen-Bullough KB, Bayer A, Babitt JL. Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6 [published online ahead of print 17 August 2017]. Am J Hematol. doi:10.1002/ajh.24888.
    • Am J Hematol
    • Canali, S.1    Wang, C.Y.2    Zumbrennen-Bullough, K.B.3    Bayer, A.4    Babitt, J.L.5
  • 20
    • 79958768845 scopus 로고    scopus 로고
    • Homomeric and heteromeric complexes among TGF-b and BMP receptors and their roles in signaling
    • Ehrlich M, Horbelt D, Marom B, Knaus P, Henis YI. Homomeric and heteromeric complexes among TGF-b and BMP receptors and their roles in signaling. Cell Signal. 2011;23(9):1424-1432.
    • (2011) Cell Signal , vol.23 , Issue.9 , pp. 1424-1432
    • Ehrlich, M.1    Horbelt, D.2    Marom, B.3    Knaus, P.4    Henis, Y.I.5
  • 21
    • 0037085287 scopus 로고    scopus 로고
    • The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways
    • Nohe A, Hassel S, Ehrlich M, et al. The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem. 2002;277(7): 5330-5338.
    • (2002) J Biol Chem , vol.277 , Issue.7 , pp. 5330-5338
    • Nohe, A.1    Hassel, S.2    Ehrlich, M.3
  • 22
    • 33749586993 scopus 로고    scopus 로고
    • Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling
    • Hartung A, Bitton-Worms K, Rechtman MM, et al. Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling. Mol Cell Biol. 2006;26(20):7791-7805.
    • (2006) Mol Cell Biol. , vol.26 , Issue.20 , pp. 7791-7805
    • Hartung, A.1    Bitton-Worms, K.2    Rechtman, M.M.3
  • 23
    • 84922191755 scopus 로고    scopus 로고
    • Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation
    • Mayeur C, Kolodziej SA, Wang A, et al. Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation. Haematologica. 2015; 100(2):e68-e71.
    • (2015) Haematologica , vol.100 , Issue.2 , pp. e68-e71
    • Mayeur, C.1    Kolodziej, S.A.2    Wang, A.3
  • 24
    • 79955980950 scopus 로고    scopus 로고
    • Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
    • Steinbicker AU, Sachidanandan C, Vonner AJ, et al. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011;117(18):4915-4923.
    • (2011) Blood , vol.117 , Issue.18 , pp. 4915-4923
    • Steinbicker, A.U.1    Sachidanandan, C.2    Vonner, A.J.3
  • 25
    • 80052647221 scopus 로고    scopus 로고
    • Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
    • Theurl I, Schroll A, Sonnweber T, et al. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood. 2011;118(18):4977-4984.
    • (2011) Blood , vol.118 , Issue.18 , pp. 4977-4984
    • Theurl, I.1    Schroll, A.2    Sonnweber, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.