Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B

Blood

Volumn 129, Issue 4, 2017, Pages 533-536

  Besson Fournier, Céline ^a   Gineste, Aurélie ^a   Latour, Chloé ^a   Gourbeyre, Ophélie ^a   Meynard, Delphine ^a   Martin, Patricia ^a,b   Oswald, Eric ^a,b   Coppin, Hélène ^a   Roth, Marie Paule ^a  

^a UMR 1220 TCEM (INRA ENITAB)   (France)

^b TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HEPCIDIN; INHIBITOR OF DIFFERENTIATION 1; MYELOPID; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD7 PROTEIN; SMAD8 PROTEIN; STAT3 PROTEIN; 6 [4 (1 PIPERAZINYL)PHENYL] 3 (4 QUINOLINYL)PYRAZOLO[1,5 A]PYRIMIDINE; ACTIVIN; BMP6 PROTEIN, MOUSE; HAMP1 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE, E COLI O55-B5; MESSENGER RNA; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; SMAD PROTEIN; TURPENTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; ESCHERICHIA COLI INFECTION; GENE EXPRESSION; INFLAMMATION; LETTER; LIVER; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; ANIMAL; BACTERIAL INFECTION; BIOSYNTHESIS; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; ENDOTOXEMIA; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; UPREGULATION;

ACTIVINS; ANIMALS; BACTERIAL INFECTIONS; BONE MORPHOGENETIC PROTEIN 6; ENDOTOXEMIA; ESCHERICHIA COLI INFECTIONS; GENE EXPRESSION REGULATION; HEPCIDINS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRAZOLES; PYRIMIDINES; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD PROTEINS; TURPENTINE; UP-REGULATION;

EID: 85014936657     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-10-748541     Document Type: Letter

References (14)

1. Besson-Fournier C, Latour C, Kautz L, et al. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood. 2012;120(2):431-439.
2. Canali S, Core AB, Zumbrennen-Bullough KB, et al. Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice. Endocrinology. 2016;157(3):1146-1162.
3. Vassalli A, Matzuk MM, Gardner HA, Lee KF, Jaenisch R. Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev. 1994;8(4):414-427.
4. Pietrangelo A, Dierssen U, Valli L, et al. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology. 2007;132(1):294-300.
5. Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood. 2007;109(1):353-358.
6. Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108(9):3204-3209.
7. Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, Roth MP. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet. 2009;41(4):478-481.
8. Kautz L, Meynard D, Monnier A, et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood. 2008;112(4):1503-1509.
9. Corradini E, Meynard D, Wu Q, et al. Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice. Hepatology. 2011;54(1):273-284.
10. Steinbicker AU, Sachidanandan C, Vonner AJ, et al. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011;117(18):4915-4923.
11. Theurl I, Schroll A, Sonnweber T, et al. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood. 2011;118(18):4977-4984.
12. Mayeur C, Kolodziej SA, Wang A, et al. Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation. Haematologica. 2015;100(2):e68-e71.
13. Mayeur C, Lohmeyer LK, Leyton P, et al. The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6. Blood. 2014;123(14):2261-2268.
14. Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU. A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med (Berl). 2008;86(5):531-540.