What is fetal programming?: A lifetime health is under the control of in utero health

Obstetrics and Gynecology Science

Volumn 60, Issue 6, 2017, Pages 506-519

  Kwon, Eun Jin ^a   Kim, Young Ju ^a  

^a Ewha Womans University School of Medicine   (South Korea)

Author keywords

Chronic disease; Fetal development; Fetal nutrition disorders

Indexed keywords

EID: 85034107150     PISSN: 22878572     EISSN: 22878580     Source Type: Journal    
DOI: 10.5468/ogs.2017.60.6.506     Document Type: Review

References (61)

1. Barker DJ. In utero programming of chronic disease. Clin Sci (Lond) 1998;95:115-28.
2. Widdowson EM, McCance RA. A review: new thoughts on growth. Pediatr Res 1975;9:154-6.
3. Lucas A. Programming by early nutrition in man. In: Bock GR, Whelan J, editors. The childhood environment and adult disease. Chichester: John Wiley & Sons; 1991. p.38-55.
4. Lucas A. Role of nutritional programming in determining adult morbidity. Arch Dis Child 1994;71:288-90.
5. Barker DJ. Fetal origins of coronary heart disease. BMJ 1995;311:171-4.
6. Barker DJ. Mothers, babies, and health in later life. 2nd ed. Edinburgh: Churchill Livingstone; 1998.
7. Fowden AL. Endocrine regulation of fetal growth. Reprod Fertil Dev 1995;7:351-63.
8. Harding JE, Johnston BM. Nutrition and fetal growth. Reprod Fertil Dev 1995;7:539-47.
9. Campbell AG, Dawes GS, Fishman AP, Hyman AI. Regional redistribution of blood flow in the mature fetal lamb. Circ Res 1967;21:229-35.
10. Rudolph AM. The fetal circulation and its response to stress. J Dev Physiol 1984;6:11-9.
11. Fowden AL. The role of insulin in prenatal growth. J Dev Physiol 1989;12:173-82.
12. Oliver MH, Harding JE, Breier BH, Evans PC, Gluckman PD. Glucose but not a mixed amino acid infusion regulates plasma insulin-like growth factor-I concentrations in fetal sheep. Pediatr Res 1993;34:62-5.
13. Fowden AL, Forhead AJ. Endocrine mechanisms of intrauterine programming. Reproduction 2004;127:515-26.
14. Osmond C, Barker DJ, Winter PD, Fall CH, Simmonds SJ. Early growth and death from cardiovascular disease in women. BMJ 1993;307:1519-24.
15. Barker DJ. Maternal nutrition, fetal nutrition, and disease in later life. Nutrition 1997;13:807-13.
16. Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 1993;36:62-7.
17. Leon DA, Lithell HO, Vâgerö D, Koupilová I, Mohsen R, Berglund L, et al. Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15 000 Swedish men and women born 1915-29. BMJ 1998;317:241-5.
18. Lithell HO, McKeigue PM, Berglund L, Mohsen R, Lithell UB, Leon DA. Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years. BMJ 1996;312:406-10.
19. Barker DJ, Eriksson JG, Forsén T, Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol 2002;31:1235-9.
20. Law CM, Shiell AW. Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature. J Hypertens 1996;14:935-41.
21. Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Mol Cell Endocrinol 2001;185:93-8.
22. Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 1991;303:1019-22.
23. Phillips DI, Hirst S, Clark PM, Hales CN, Osmond C. Fetal growth and insulin secretion in adult life. Diabetologia 1994;37:592-6.
24. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992;35:595-601.
25. Hales CN, Barker DJ. The thrifty phenotype hypothesis. Br Med Bull 2001;60:5-20.
26. Hales CN, Ozanne SE. The dangerous road of catch-up growth. J Physiol 2003;547:5-10.
27. Godfrey KM. The role of the placenta in fetal programming-a review. Placenta 2002;23 Suppl A:S20-7.
28. Cunningham S, Cameron IT. Consequences of fetal growth restriction during childhood and adult life. Curr Obstet Gynaecol 2003;13:212-7.
29. Reik W, Constância M, Fowden A, Anderson N, Dean W, Ferguson-Smith A, et al. Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. J Physiol 2003;547:35-44.
30. Benediktsson R, Calder AA, Edwards CR, Seckl JR. Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure. Clin Endocrinol (Oxf) 1997;46:161-6.
31. Seckl JR, Cleasby M, Nyirenda MJ. Glucocorticoids, 11beta-hydroxysteroid dehydrogenase, and fetal programming. Kidney Int 2000;57:1412-7.
32. Vaughan OR, Forhead AJ, Fowden AL. Glucocorticoids and placental programming. In: Burton GJ, Barker DJ, Moffett A, Thornburg KL, editors. The placenta and human developmental programming. Cambridge: Cambridge University Press; 2011. p.175-87.
33. Lesage J, Blondeau B, Grino M, Bréant B, Dupouy JP. Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamopituitary adrenal axis in the newborn rat. Endocrinology 2001;142:1692-702.
34. Edwards CR, Benediktsson R, Lindsay RS, Seckl JR. Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension? Lancet 1993;341:355-7.
35. Sloboda DM, Newnham JP, Moss TJ, Challis JR. The fetal hypothalamic-pituitary-adrenal axis: relevance to developmental origins of health and disease. In: Gluckman PD, Hanson MA, editors. Developmental origins of health and disease. New York (NY): Cambridge University Press; 2006. p.191-205.
36. Jellyman JK, Valenzuela OA, Fowden AL. Horse species symposium: glucocorticoid programming of hypothalamicpituitary-adrenal axis and metabolic function: animal studies from mouse to horse. J Anim Sci 2015;93:3245-60.
37. Brown RW, Diaz R, Robson AC, Kotelevtsev YV, Mullins JJ, Kaufman MH, et al. The ontogeny of 11 betahydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development. Endocrinology 1996;137:794-7.
38. Mackenzie HS, Lawler EV, Brenner BM. Congenital oligonephropathy: the fetal flaw in essential hypertension? Kidney Int Suppl 1996;55:S30-4.
39. Mañalich R, Reyes L, Herrera M, Melendi C, Fundora I. Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int 2000;58:770-3.
40. Barker DJ, Martyn CN, Osmond C, Hales CN, Fall CH. Growth in utero and serum cholesterol concentrations in adult life. BMJ 1993;307:1524-7.
41. Barker DJ, Meade TW, Fall CH, Lee A, Osmond C, Phipps K, et al. Relation of fetal and infant growth to plasma fibrinogen and factor VII concentrations in adult life. BMJ 1992;304:148-52.
42. Leeson CP, Whincup PH, Cook DG, Donald AE, Papacosta O, Lucas A, et al. Flow-mediated dilation in 9-to 11-year-old children: the influence of intrauterine and childhood factors. Circulation 1997;96:2233-8.
43. Veille JC, Hanson R, Sivakoff M, Hoen H, Ben-Ami M. Fetal cardiac size in normal, intrauterine growth retarded, and diabetic pregnancies. Am J Perinatol 1993;10:275-9.
44. Murotsuki J, Challis JR, Han VK, Fraher LJ, Gagnon R. Chronic fetal placental embolization and hypoxemia cause hypertension and myocardial hypertrophy in fetal sheep. Am J Physiol 1997;272:R201-7.
45. van Assche FA, Aerts L. The fetal endocrine pancreas. Contrib Gynecol Obstet 1979;5:44-57.
46. Fall CH, Stein CE, Kumaran K, Cox V, Osmond C, Barker DJ, et al. Size at birth, maternal weight, and type 2 diabetes in South India. Diabet Med 1998;15:220-7.
47. Fowden AL, Coan PM, Angiolini E, Burton GJ, Constancia M. Imprinted genes and the epigenetic regulation of placental phenotype. Prog Biophys Mol Biol 2011;106:281-8.
48. Byrne CD. Programming other hormones that affect insulin. Br Med Bull 2001;60:153-71.
49. Breier BH, Vickers MH, Ikenasio BA, Chan KY, Wong WP. Fetal programming of appetite and obesity. Mol Cell Endocrinol 2001;185:73-9.
50. Lee S, Lee KA, Choi GY, Desai M, Lee SH, Pang MG, et al. Feed restriction during pregnancy/lactation induces programmed changes in lipid, adiponectin and leptin levels with gender differences in rat offspring. J Matern Fetal Neonatal Med 2013;26:908-14.
51. Forhead AJ, Fowden AL. The hungry fetus? Role of leptin as a nutritional signal before birth. J Physiol 2009;587:1145-52.
52. Cooper C, Javaid MK, Taylor P, Walker-Bone K, Dennison E, Arden N. The fetal origins of osteoporotic fracture. Calcif Tissue Int 2002;70:391-4.
53. Krebs C, Macara LM, Leiser R, Bowman AW, Greer IA, Kingdom JC. Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree. Am J Obstet Gynecol 1996;175:1534-42.
54. Jansson T, Ekstrand Y, Björn C, Wennergren M, Powell TL. Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetes. Diabetes 2002;51:2214-9.
55. Myatt L. Placental adaptive responses and fetal programming. J Physiol 2006;572:25-30.
56. Genbacev O, Zhou Y, Ludlow JW, Fisher SJ. Regulation of human placental development by oxygen tension. Science 1997;277:1669-72.
57. Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 1996;19:157-67.
58. Lee JH, Yoo JY, You YA, Kwon WS, Lee SM, Pang MG, et al. Proteomic analysis of fetal programming-related obesity markers. Proteomics 2015;15:2669-77.
59. You YA, Lee JH, Kwon EJ, Yoo JY, Kwon WS, Pang MG, et al. Proteomic analysis of one-carbon metabolism-related marker in liver of rat offspring. Mol Cell Proteomics 2015;14:2901-9.
60. Lee S, You YA, Kwon EJ, Jung SC, Jo I, Kim YJ. Maternal food restriction during pregnancy and lactation adversely affect hepatic growth and lipid metabolism in threeweek-old rat offspring. Int J Mol Sci 2016;17:E2115.
61. Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005;135:1382-6.