Dehydrosqualene desaturase as a novel target for anti-virulence therapy against Staphylococcus aureus

mBio

Volumn 8, Issue 5, 2017, Pages

  Gao, Peng ^a   Davies, Julian ^c   Kao, Richard Yi Tsun ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b THE UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Anti virulence; Bacterial infection; MRSA; Staphyloxanthin

Indexed keywords

BACTERIAL ENZYME; COMPOUND NP16; DEHYDROSQUALENE DESATURASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CRTN PROTEIN, STAPHYLOCOCCUS AUREUS; ENZYME INHIBITOR; OXIDOREDUCTASE; STAPHYLOXANTHIN; XANTHOPHYLL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL VIRULENCE; CELL KILLING; CONTROLLED STUDY; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOTHERAPY; INNATE IMMUNITY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGY; MUTATION; OXIDATIVE STRESS; PATHOGENICITY; VIRULENCE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; ENZYME INHIBITORS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MUTATION; NEUTROPHILS; OXIDATIVE STRESS; OXIDOREDUCTASES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE; VIRULENCE FACTORS; XANTHOPHYLLS;

EID: 85033717025     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.01224-17     Document Type: Article

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