-
2
-
-
84897026062
-
Established and novel diseasemodifying treatments in multiple sclerosis
-
Cross AH, Naismith RT. Established and novel diseasemodifying treatments in multiple sclerosis. J Intern Med 2014;275:350-363.
-
(2014)
J Intern Med
, vol.275
, pp. 350-363
-
-
Cross, A.H.1
Naismith, R.T.2
-
3
-
-
84866423965
-
Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis
-
Gold R, Kappos L, Arnold DL, et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 2012;367:1098-1107.
-
(2012)
N Engl J Med
, vol.367
, pp. 1098-1107
-
-
Gold, R.1
Kappos, L.2
Arnold, D.L.3
-
4
-
-
84866355653
-
Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis
-
Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med 2012;367:1087-1097.
-
(2012)
N Engl J Med
, vol.367
, pp. 1087-1097
-
-
Fox, R.J.1
Miller, D.H.2
Phillips, J.T.3
-
6
-
-
84925846204
-
Dimethyl fumarate in relapsing-remitting multiple sclerosis: Rationale, mechanisms of action, pharmacokinetics, efficacy and safety
-
Dubey D, Kieseier BC, Hartung HP, et al. Dimethyl fumarate in relapsing-remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety. Expert Rev Neurother 2015;15:339-346.
-
(2015)
Expert Rev Neurother
, vol.15
, pp. 339-346
-
-
Dubey, D.1
Kieseier, B.C.2
Hartung, H.P.3
-
7
-
-
84934941371
-
Dimethyl fumarate protects neural stem/progenitor cells and neurons from oxidative damage through Nrf2-ERK1/2 MAPK pathway
-
Wang Q, Chuikov S, Taitano S, et al. Dimethyl fumarate protects neural stem/progenitor cells and neurons from oxidative damage through Nrf2-ERK1/2 MAPK pathway. Int J Mol Sci 2015;16:13885-13907.
-
(2015)
Int J Mol Sci
, vol.16
, pp. 13885-13907
-
-
Wang, Q.1
Chuikov, S.2
Taitano, S.3
-
8
-
-
84927155177
-
PML in a patient with lymphocytopenia treated with dimethyl fumarate
-
Rosenkranz T, Novas M, Terborg C. PML in a patient with lymphocytopenia treated with dimethyl fumarate. N Engl J Med 2015;372:1476-1478.
-
(2015)
N Engl J Med
, vol.372
, pp. 1476-1478
-
-
Rosenkranz, T.1
Novas, M.2
Terborg, C.3
-
9
-
-
84927144781
-
PML in a patient without severe lymphocytopenia receiving dimethyl fumarate
-
Nieuwkamp DJ, Murk JL, van Oosten BW, et al. PML in a patient without severe lymphocytopenia receiving dimethyl fumarate. N Engl J Med 2015;372:1474-1476.
-
(2015)
N Engl J Med
, vol.372
, pp. 1474-1476
-
-
Nieuwkamp, D.J.1
Murk, J.L.2
Van Oosten, B.W.3
-
10
-
-
84942373937
-
Progressive neurologic dysfunction in a psoriasis patient treated with dimethyl fumarate
-
Bartsch T, Rempe T, Wrede A, et al. Progressive neurologic dysfunction in a psoriasis patient treated with dimethyl fumarate. Ann Neurol 2015;78:501-514.
-
(2015)
Ann Neurol
, vol.78
, pp. 501-514
-
-
Bartsch, T.1
Rempe, T.2
Wrede, A.3
-
11
-
-
84937389250
-
Reduction of CD8(1) T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate
-
Spencer CM, Crabtree-Hartman EC, Lehmann-Horn K, Cree BA, Zamvil SS. Reduction of CD8(1) T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate. Neurol Neuroimmunol Neuroinflamm 2015; 2:e76. doi: 10.1212/NXI.0000000000000076.
-
(2015)
Neurol Neuroimmunol Neuroinflamm
, vol.2
, pp. e76
-
-
Spencer, C.M.1
Crabtree-Hartman, E.C.2
Lehmann-Horn, K.3
Cree, B.A.4
Zamvil, S.S.5
-
12
-
-
84937436086
-
Effects of dimethyl fumarate on lymphocyte subsets
-
Berkovich R, Weiner LP. Effects of dimethyl fumarate on lymphocyte subsets. Mult Scler Relat Disord 2015;4: 339-341.
-
(2015)
Mult Scler Relat Disord
, vol.4
, pp. 339-341
-
-
Berkovich, R.1
Weiner, L.P.2
-
13
-
-
0031661686
-
The antipsoriatic agent dimethylfumarate immunomodulates T-cell cytokine secretion and inhibits cytokines of the psoriatic cytokine network
-
Ockenfels HM, Schultewolter T, Ockenfels G, Funk R, Goos M. The antipsoriatic agent dimethylfumarate immunomodulates T-cell cytokine secretion and inhibits cytokines of the psoriatic cytokine network. Br J Dermatol 1998;139:390-395.
-
(1998)
Br J Dermatol
, vol.139
, pp. 390-395
-
-
Ockenfels, H.M.1
Schultewolter, T.2
Ockenfels, G.3
Funk, R.4
Goos, M.5
-
14
-
-
33745162188
-
Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration
-
Schilling S, Goelz S, Linker R, Luehder F, Gold R. Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration. Clin Exp Immunol 2006;145:101-107.
-
(2006)
Clin Exp Immunol
, vol.145
, pp. 101-107
-
-
Schilling, S.1
Goelz, S.2
Linker, R.3
Luehder, F.4
Gold, R.5
-
15
-
-
0345732760
-
Dimethylfumarate is a potent inducer of apoptosis in human T cells
-
Treumer F, Zhu K, Glaser R, Mrowietz U. Dimethylfumarate is a potent inducer of apoptosis in human T cells. J Invest Dermatol 2003;121:1383-1388.
-
(2003)
J Invest Dermatol
, vol.121
, pp. 1383-1388
-
-
Treumer, F.1
Zhu, K.2
Glaser, R.3
Mrowietz, U.4
-
16
-
-
33947283177
-
B cell regulation of CD41CD251 T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis
-
Mann MK, Maresz K, Shriver LP, Tan Y, Dittel BN. B cell regulation of CD41CD251 T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis. J Immunol 2007;178: 3447-3456.
-
(2007)
J Immunol
, vol.178
, pp. 3447-3456
-
-
Mann, M.K.1
Maresz, K.2
Shriver, L.P.3
Tan, Y.4
Dittel, B.N.5
-
17
-
-
77956895769
-
Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis
-
Matsushita T, Horikawa M, Iwata Y, Tedder TF. Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. J Immunol 2010;185:2240-2252.
-
(2010)
J Immunol
, vol.185
, pp. 2240-2252
-
-
Matsushita, T.1
Horikawa, M.2
Iwata, Y.3
Tedder, T.F.4
-
18
-
-
33745051595
-
Oral fumaric acid esters for the treatment of active multiple sclerosis: An open-label, baseline-controlled pilot study
-
Schimrigk S, Brune N, Hellwig K, et al. Oral fumaric acid esters for the treatment of active multiple sclerosis: an open-label, baseline-controlled pilot study. Eur J Neurol 2006;13:604-610.
-
(2006)
Eur J Neurol
, vol.13
, pp. 604-610
-
-
Schimrigk, S.1
Brune, N.2
Hellwig, K.3
-
19
-
-
39649095149
-
Phenotypic and functional heterogeneity of human memory B cells
-
Sanz I, Wei C, Lee FE, Anolik J. Phenotypic and functional heterogeneity of human memory B cells. Semin Immunol 2008;20:67-82.
-
(2008)
Semin Immunol
, vol.20
, pp. 67-82
-
-
Sanz, I.1
Wei, C.2
Lee, F.E.3
Anolik, J.4
-
20
-
-
65449188259
-
Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice
-
Blair PA, Chavez-Rueda KA, Evans JG, et al. Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. J Immunol 2009;182:3492-3502.
-
(2009)
J Immunol
, vol.182
, pp. 3492-3502
-
-
Blair, P.A.1
Chavez-Rueda, K.A.2
Evans, J.G.3
-
21
-
-
74649083783
-
CD19(+) CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients
-
Blair PA, Norena LY, Flores-Borja F, et al. CD19(+) CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 2010;32: 129-140.
-
(2010)
Immunity
, vol.32
, pp. 129-140
-
-
Blair, P.A.1
Norena, L.Y.2
Flores-Borja, F.3
-
22
-
-
78651509914
-
Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70
-
Griffin DO, Holodick NE, Rothstein TL. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70. J Exp Med 2011;208:67-80.
-
(2011)
J Exp Med
, vol.208
, pp. 67-80
-
-
Griffin, D.O.1
Holodick, N.E.2
Rothstein, T.L.3
-
23
-
-
78751469622
-
Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
-
Iwata Y, Matsushita T, Horikawa M, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011;117: 530-541.
-
(2011)
Blood
, vol.117
, pp. 530-541
-
-
Iwata, Y.1
Matsushita, T.2
Horikawa, M.3
-
24
-
-
84916607910
-
Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-kappaB nuclear translocation and downregulation of Bcl-xL and XIAP
-
Tsubaki M, Ogawa N, Takeda T, et al. Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-kappaB nuclear translocation and downregulation of Bcl-xL and XIAP. Biomed Pharmacother 2014;68:999-1005.
-
(2014)
Biomed Pharmacother
, vol.68
, pp. 999-1005
-
-
Tsubaki, M.1
Ogawa, N.2
Takeda, T.3
-
25
-
-
11144325701
-
Identification of anti-inflammatory drugs according to their capacity to suppress type-1 and type-2 T cell profiles
-
Moed H, Stoof TJ, Boorsma DM, et al. Identification of anti-inflammatory drugs according to their capacity to suppress type-1 and type-2 T cell profiles. Clin Exp Allergy 2004;34:1868-1875.
-
(2004)
Clin Exp Allergy
, vol.34
, pp. 1868-1875
-
-
Moed, H.1
Stoof, T.J.2
Boorsma, D.M.3
-
26
-
-
0029846154
-
Selective stimulation of T helper 2 cytokine responses by the antipsoriasis agent monomethylfumarate
-
de Jong R, Bezemer AC, Zomerdijk TP, van de Pouw-Kraan T, Ottenhoff TH, Nibbering PH. Selective stimulation of T helper 2 cytokine responses by the antipsoriasis agent monomethylfumarate. Eur J Immunol 1996;26:2067-2074.
-
(1996)
Eur J Immunol
, vol.26
, pp. 2067-2074
-
-
De Jong, R.1
Bezemer, A.C.2
Zomerdijk, T.P.3
Van De Pouw-Kraan, T.4
Ottenhoff, T.H.5
Nibbering, P.H.6
-
27
-
-
84881094269
-
Interleukin-5 supports the expansion of fas ligand-expressing killer B cells that induce antigen-specific apoptosis of CD4(+) T cells and secrete interleukin-10
-
Klinker MW, Reed TJ, Fox DA, Lundy SK. Interleukin-5 supports the expansion of fas ligand-expressing killer B cells that induce antigen-specific apoptosis of CD4(+) T cells and secrete interleukin-10. PLoS One 2013;8: e70131.
-
(2013)
PLoS One
, vol.8
, pp. e70131
-
-
Klinker, M.W.1
Reed, T.J.2
Fox, D.A.3
Lundy, S.K.4
-
28
-
-
84858648216
-
Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroidderived 2)-like 2 pathway
-
Scannevin RH, Chollate S, Jung MY, et al. Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroidderived 2)-like 2 pathway. J Pharmacol Exp Ther 2012; 341:274-284.
-
(2012)
J Pharmacol Exp Ther
, vol.341
, pp. 274-284
-
-
Scannevin, R.H.1
Chollate, S.2
Jung, M.Y.3
-
29
-
-
79952490499
-
Hepatic overexpression of heme oxygenase-1 improves liver allograft survival by expanding T regulatory cells
-
Sun L, Shi T, Qiao H, et al. Hepatic overexpression of heme oxygenase-1 improves liver allograft survival by expanding T regulatory cells. J Surg Res 2011;166:e187-194.
-
(2011)
J Surg Res
, vol.166
, pp. e187-194
-
-
Sun, L.1
Shi, T.2
Qiao, H.3
-
30
-
-
46749110831
-
Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells
-
George JF, Braun A, Brusko TM, et al. Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells. Am J Pathol 2008;173:154-160.
-
(2008)
Am J Pathol
, vol.173
, pp. 154-160
-
-
George, J.F.1
Braun, A.2
Brusko, T.M.3
-
31
-
-
79958153194
-
The antiinflammatory effects of dimethyl fumarate in astrocytes involve glutathione and heme oxygenase-1
-
Lin SX, Lisi L, Dello Russo C, et al. The antiinflammatory effects of dimethyl fumarate in astrocytes involve glutathione and heme oxygenase-1. ASN Neuro 2011;3:e00055.
-
(2011)
ASN Neuro
, vol.3
, pp. e00055
-
-
Lin, S.X.1
Lisi, L.2
Dello Russo, C.3
-
32
-
-
84873313098
-
Human "orchestrator" CD11b (+) B1 cells spontaneously secrete interleukin-10 and regulate T-cell activity
-
Griffin DO, Rothstein TL. Human "orchestrator" CD11b (+) B1 cells spontaneously secrete interleukin-10 and regulate T-cell activity. Mol Med 2012;18:1003-1008.
-
(2012)
Mol Med
, vol.18
, pp. 1003-1008
-
-
Griffin, D.O.1
Rothstein, T.L.2
-
33
-
-
84924362998
-
IFN-beta treatment requires B cells for efficacy in neuroautoimmunity
-
Schubert RD, Hu Y, Kumar G, et al. IFN-beta treatment requires B cells for efficacy in neuroautoimmunity. J Immunol 2015;194:2110-2116.
-
(2015)
J Immunol
, vol.194
, pp. 2110-2116
-
-
Schubert, R.D.1
Hu, Y.2
Kumar, G.3
-
34
-
-
84932615567
-
Fingolimod treatment promotes regulatory phenotype and function of B cells
-
Grutzke B, Hucke S, Gross CC, et al. Fingolimod treatment promotes regulatory phenotype and function of B cells. Ann Clin Transl Neurol 2015;2:119-130.
-
(2015)
Ann Clin Transl Neurol
, vol.2
, pp. 119-130
-
-
Grutzke, B.1
Hucke, S.2
Gross, C.C.3
-
35
-
-
84901979227
-
B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients
-
Rovituso D, Heller S, Schroeter M, Kleinschnitz C, Kuerten S. B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients. J Neuroimmunol 2014;272:86-90.
-
(2014)
J Neuroimmunol
, vol.272
, pp. 86-90
-
-
Rovituso, D.1
Heller, S.2
Schroeter, M.3
Kleinschnitz, C.4
Kuerten, S.5
-
36
-
-
79952280456
-
Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate
-
Begum-Haque S, Christy M, Ochoa-Reparaz J, et al. Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate. J Neuroimmunol 2011;232:136-144.
-
(2011)
J Neuroimmunol
, vol.232
, pp. 136-144
-
-
Begum-Haque, S.1
Christy, M.2
Ochoa-Reparaz, J.3
-
37
-
-
77249142775
-
Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis
-
Begum-Haque S, Sharma A, Christy M, et al. Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis. J Neuroimmunol 2010;219:47-53.
-
(2010)
J Neuroimmunol
, vol.219
, pp. 47-53
-
-
Begum-Haque, S.1
Sharma, A.2
Christy, M.3
-
38
-
-
79959459343
-
Increased peripheral blood CD5+ B cells predict earlier conversion to MS in high-risk clinically isolated syndromes
-
Villar LM, Espino M, Roldan E, et al. Increased peripheral blood CD5+ B cells predict earlier conversion to MS in high-risk clinically isolated syndromes. Mult Scler 2011; 17:690-694.
-
(2011)
Mult Scler
, vol.17
, pp. 690-694
-
-
Villar, L.M.1
Espino, M.2
Roldan, E.3
-
39
-
-
0036890032
-
Expression of CD5 on B lymphocytes correlates with disease activity in patients with multiple sclerosis
-
Seidi OA, Semra YK, Sharief MK. Expression of CD5 on B lymphocytes correlates with disease activity in patients with multiple sclerosis. J Neuroimmunol 2002;133:205-210.
-
(2002)
J Neuroimmunol
, vol.133
, pp. 205-210
-
-
Seidi, O.A.1
Semra, Y.K.2
Sharief, M.K.3
|