Differences in blood volume components between hyporesponders and responders to erythropoietin alfa: The heart failure with preserved ejection fraction (HFPEF) anemia trial

Journal of Cardiac Failure

Volumn 19, Issue 10, 2013, Pages 685-691

  Borovka, Margarita ^a   Teruya, Sergio ^a   Alvarez, Julissa ^a   Helmke, Stephen ^a   Maurer, Mathew S ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

Anemia; blood volume; erythropoietin alfa; heart failure

Indexed keywords

ALBUMIN I 131; HEMOGLOBIN; RECOMBINANT ERYTHROPOIETIN; UNCLASSIFIED DRUG; VOLUMEX;

AGED; ANEMIA; ARTICLE; BLOOD VOLUME; BODY SURFACE; COMPARATIVE STUDY; DRUG RESPONSE; ERYTHROCYTE VOLUME; FEMALE; FOLLOW UP; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEMODILUTION; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PHASE 2 CLINICAL TRIAL (TOPIC); PLASMA VOLUME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY;

ANEMIA; BLOOD VOLUME; ERYTHROPOIETIN ALFA; HEART FAILURE;

AGED; AGED, 80 AND OVER; ANEMIA; BLOOD VOLUME; ERYTHROCYTE VOLUME; ERYTHROPOIETIN; FEMALE; HEART FAILURE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; PLASMA VOLUME; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; SINGLE-BLIND METHOD; STROKE VOLUME; TREATMENT OUTCOME;

EID: 84885933575     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2013.08.508     Document Type: Article

References (27)

1. J.A. Ezekowitz, F.A. McAlister, and P.W. Armstrong Anemia is common in heart failure and is associated with poor outcomes Circulation 107 2003 223 225
2. J.G. Cleland, J.T. Sullivan, S. Ball, J.D. Horowitz, B. Agoram, and D. Rosser Once-monthly administration of darbepoetin alfa for the treatment of patients with chronic heart failure and anemia: a pharmacokinetic and pharmacodynamic investigation J Cardiovasc Pharmacol 46 2005 155 161
3. B. Cosyns, S. Velez-Roa, S. Droogmans, L.A. Pierard, and P. Lancellotti Effects of eythropoietin administration on mitral regurgitation and left ventricular remodeling in heart failure patients In J Cardiol 138 2010 306 307
4. J.K. Ghali, I.S. Anand, W.T. Abraham, G.C. Fonarow, B. Greenberg, and H. Krum Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia Circulation 117 2008 526 535
5. K. Kourea, J.T. Parissis, D. Farmakis, I. Paraskevaidis, F. Panou, and G. Filippatos Effects of darbepoetin-alpha on quality of life and emotional stress in anemic patients with chronic heart failure Eur J Cardiovasc Prev Rehabil 15 2008 365 369
6. D.M. Mancini, S.D. Katz, C.C. Lang, J. LaManca, A. Hudaihed, and A.S. Androne Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure Circulation 107 2003 294 299
7. A. Palazzuoli, D. Silverberg, F. Iovine, S. Capobianco, G. Giannotti, and A. Calabro Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia Am Heart J 152 2006 1096.e9 1096.e15
8. A. Palazzuoli, D.S. Silverberg, F. Iovine, A. Calabro, M.S. Campagna, and M. Gallotta Effects of beta-erythropoietin treatment on left ventricular remodeling, systolic function, and B-type natriuretic peptide levels in patients with the cardiorenal anemia syndrome Am Heart J 154 2007 645.e9 645.e15
9. J.T. Parissis, K. Kourea, F. Panou, D. Farmakis, I. Paraskevaidis, and I. Ikonomidis Effects of darbepoetin alpha on right and left ventricular systolic and diastolic function in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy Am Heart J 155 2008 751.e1 751.e7
10. P. Ponikowski, S.D. Anker, J. Szachniewicz, D. Okonko, M. Ledwidge, and R. Zymlinski Effect of darbepoetin alfa on exercise tolerance in anemic patients with symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled trial J Am Coll Cardiol 49 2007 753 762
11. D.S. Silverberg, D. Wexler, D. Sheps, M. Blum, G. Keren, and R. Baruch The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study J Am Coll Cardiol 37 2001 1775 1780
12. M.S. Maurer, S. Teruya, B. Chakraborty, S. Helmke, and D. Mancini Treating anemia in older adults with heart failure with a preserved ejection fraction (HFPEF) with epoetin alfa: single blind randomized clinical trial of safety and efficacy Circ Heart Fail 6 2013 254 263
13. M.A. Pfeffer, E.A. Burdmann, C.Y. Chen, M.E. Cooper, D. de Zeeuw, and K.U. Eckardt A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease N Engl J Med 361 2009 2019 2032
14. S.D. Solomon, H. Uno, E.F. Lewis, K.U. Eckardt, J. Lin, and E.A. Burdmann Erythropoietic response and outcomes in kidney disease and type 2 diabetes N Engl J Med 363 2010 1146 1155
15. K. Swedberg, J.B. Young, I.S. Anand, S. Cheng, A.S. Desai, and R. Diaz Treatment of Anemia with darbepoetin alfa in systolic heart failure N Engl J Med 368 2013 1210 1219
16. A.S. Androne, S.D. Katz, L. Lund, J. LaManca, A. Hudaihed, and K. Hryniewicz Hemodilution is common in patients with advanced heart failure Circulation 107 2003 226 229
17. D. Abramov, R.S. Cohen, S.D. Katz, D. Mancini, and M.S. Maurer Comparison of blood volume characteristics in anemic patients with low versus preserved left ventricular ejection fractions Am J Cardiol 102 2008 1069 1072
18. A. Altincatal, R.B. Macarthur, S. Teruya, S. Helmke, and M.S. Maurer A dosing algorithm for erythropoietin alpha in older adults with heart failure and a preserved ejection fraction Cardiovasc Ther 31 2013 92 99
19. J. Feldschuh, and Y. Enson Prediction of the normal blood volume. Relation of blood volume to body habitus Circulation 56 1977 605 612
20. US Food and Drug Administration Epogen medication guide 2012 US Food and Drug Administration
21. J.E. Hall, M.W. Brands, W.N. Dixon, and M.J. Smith Jr. Obesity-induced hypertension. Renal function and systemic hemodynamics Hypertension 22 1993 292 299
22. A.P. Rocchini, C. Moorehead, E. Wentz, and S. Deremer Obesity-induced hypertension in the dog Hypertension 9 1987 III64 III68
23. A.P. Rocchini, C.P. Moorehead, S. DeRemer, and D. Bondie Pathogenesis of weight-related changes in blood pressure in dogs Hypertension 13 1989 922 928
24. G. Licata, R. Scaglione, M. Barbagallo, G. Parrinello, G. Capuana, and R. Lipari Effect of obesity on left ventricular function studied by radionuclide angiocardiography Int J Obes 15 1991 295 302
25. S.D. Anker, J. Comin Colet, G. Filippatos, R. Willenheimer, K. Dickstein, and H. Drexler Ferric carboxymaltose in patients with heart failure and iron deficiency N Engl J Med 361 2009 2436 2448
26. R.S. Cohen, P. Karlin, M. Yushak, D. Mancini, and M.S. Maurer The effect of erythropoietin on exercise capacity, left ventricular remodeling, pressure-volume relationships, and quality of life in older patients with anemia and heart failure with preserved ejection fraction Congest Heart Fail 16 2010 96 103
27. C. Lundby, J.J. Thomsen, R. Boushel, M. Koskolou, J. Warberg, and J.A. Calbet Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume J Physiol 578 2007 309 314