Liver-resident NK cells and their potential functions

Cellular and Molecular Immunology

Volumn 14, Issue 11, 2017, Pages 890-894

  Peng, Hui ^a   Sun, Rui ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN; LIVER; NATURAL KILLER CELL; RESIDENT;

EID: 85032986941     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2017.72     Document Type: Review

References (61)

1. Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL et al. Innate or adaptive immunity? The example of natural killer cells. Science 2011; 331: 44-49.
2. Sun C, Sun H, Zhang C, Tian Z. NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma. Cell Mol Immunol 2015; 12: 292-302.
3. Narni-Mancinelli E, Ugolini S, Vivier E. Tuning the threshold of natural killer cell responses. Curr Opin Immunol 2013; 25: 53-58.
4. Martin-Fontecha A, Thomsen LL, Brett S, Gerard C, Lipp M, Lanzavecchia A et al. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat Immunol 2004; 5: 1260-1265.
5. Crome SQ, Lang PA, Lang KS, Ohashi PS. Natural killer cells regulate diverse T cell responses. Trends Immunol 2013; 34: 342-349.
6. Schuster IS, Wikstrom ME, Brizard G, Coudert JD, Estcourt MJ, Manzur M et al. TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity. Immunity 2014; 41: 646-656.
7. Yokoyama WM, Sojka DK, Peng H, Tian Z. Tissue-resident natural killer cells. Cold Spring Harb Symp Quant Biol 2013; 78: 149-156.
8. Sojka DK, Tian Z, Yokoyama WM. Tissue-resident natural killer cells and their potential diversity. Semin Immunol 2014; 26: 127-131.
9. Spits H, Di Santo JP. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol 2011; 12: 21-27.
10. Spits H, Bernink JH, Lanier L. NK cells and type 1 innate lymphoid cells: partners in host defense. Nat Immunol 2016; 17: 758-764.
11. Erick TK, Brossay L. Phenotype and functions of conventional and nonconventional NK cells. Curr Opin Immunol 2016; 38: 67-74.
12. Peng H, Jiang X, Chen Y, Sojka DK, Wei H, Gao X et al. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest 2013; 123: 1444-1456.
13. Sojka DK, Plougastel-Douglas B, Yang L, Pak-Wittel MA, Artyomov MN, Ivanova Y et al. Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells. Elife 2014; 3: e01659.
14. Cortez VS, Cervantes-Barragan L, Robinette ML, Bando JK, Wang Y, Geiger TL et al. Transforming Growth Factor-beta Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands. Immunity 2016; 44: 1127-1139.
15. O'Sullivan TE, Rapp M, Fan X, Weizman OE, Bhardwaj P, Adams NM et al. Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance. Immunity 2016; 45: 428-441.
16. Peng H, Wisse E, Tian Z. Liver natural killer cells: subsets and roles in liver immunity. Cell Mol Immunol 2016; 13: 328-336.
17. Kim S, Iizuka K, Kang HS, Dokun A, French AR, Greco S et al. In vivo developmental stages in murine natural killer cell maturation. Nat Immunol 2002; 3: 523-528.
18. Takeda K, Cretney E, Hayakawa Y, Ota T, Akiba H, Ogasawara K et al. TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood 2005; 105: 2082-2089.
19. Gordon SM, Chaix J, Rupp LJ, Wu J, Madera S, Sun JC et al. The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity 2012; 36: 55-67.
20. Burt BM, Plitas G, Zhao Z, Bamboat ZM, Nguyen HM, Dupont B et al. The lytic potential of human liver NK cells is restricted by their limited expression of inhibitory killer Ig-like receptors. J Immunol 2009; 183: 1789-1796.
21. Rosmaraki EE, Douagi I, Roth C, Colucci F, Cumano A, Di Santo JP. Identification of committed NK cell progenitors in adult murine bone marrow. Eur J Immunol 2001; 31: 1900-1909.
22. Hudspeth K, Donadon M, Cimino M, Pontarini E, Tentorio P, Preti M et al. Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways. J Autoimmun 2016; 66: 40-50.
23. Marquardt N, Beziat V, Nystrom S, Hengst J, Ivarsson MA, Kekalainen E et al. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol 2015; 194: 2467-2471.
24. Stegmann KA, Robertson F, Hansi N, Gill U, Pallant C, Christophides T et al. CXCR6 marks a novel subset of T-bet(lo)Eomes(hi) natural killer cells residing in human liver. Sci Rep 2016; 6: 26157.
25. Harmon C, Robinson MW, Fahey R, Whelan S, Houlihan DD, Geoghegan J et al. Tissue-resident Eomes(hi) T-bet(lo) CD56(bright) NK cells with reduced proinflammatory potential are enriched in the adult human liver. Eur J Immunol 2016; 46: 2111-2120.
26. Aw Yeang HX, Piersma SJ, Lin Y, Yang L, Malkova ON, Miner C et al. Cutting edge: human CD49e-NK cells are tissue resident in the liver. J Immunol 2017; 198: 1417-1422.
27. Tang L, Peng H, Zhou J, Chen Y, Wei H, Sun R et al. Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s. J Autoimmun 2016; 67: 29-35.
28. Paust S, Gill HS, Wang BZ, Flynn MP, Moseman EA, Senman B et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol 2010; 11: 1127-1135.
29. Cuff AO, Robertson FP, Stegmann KA, Pallett LJ, Maini MK, Davidson BR et al. Eomeshi NK cells in human liver are long-lived and do not recirculate but can be replenished from the circulation. J Immunol 2016; 197: 4283-4291.
30. Peng H, Tian Z. Re-examining the origin and function of liver-resident NK cells. Trends Immunol 2015; 36: 293-299.
31. Mackay LK, Minnich M, Kragten NA, Liao Y, Nota B, Seillet C et al. Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Science 2016; 352: 459-463.
32. Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E et al. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med 2014; 211: 563-577.
33. Male V, Nisoli I, Kostrzewski T, Allan DS, Carlyle JR, Lord GM et al. The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression. J Exp Med 2014; 211: 635-642.
34. Yu X, Wang Y, Deng M, Li Y, Ruhn KA, Zhang CC et al. The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. Elife 2014; 3.
35. Yang Q, Li F, Harly C, Xing S, Ye L, Xia X et al. TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol 2015; 16: 1044-1050.
36. Constantinides MG, Gudjonson H, McDonald BD, Ishizuka IE, Verhoef PA, Dinner AR et al. PLZF expression maps the early stages of ILC1 lineage development. Proc Natl Acad Sci USA 2015; 112: 5123-5128.
37. Klose CS, Flach M, Mohle L, Rogell L, Hoyler T, Ebert K et al. Differentiation of type 1 ILCs from a common progenitor to all helperlike innate lymphoid cell lineages. Cell 2014; 157: 340-356.
38. Fan X, Rudensky AY. Hallmarks of tissue-resident lymphocytes. Cell 2016; 164: 1198-1211.
39. Victorino F, Sojka DK, Brodsky KS, McNamee EN, Masterson JC, Homann D et al. Tissue-resident NK cells mediate ischemic kidney injury and are not depleted by anti-Asialo-GM1 antibody. J Immunol 2015; 195: 4973-4985.
40. Tayade C, Fang Y, Black GP, V Jr AP, Erlebacher A, Croy BA. Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells. J Leukoc Biol 2005; 78: 1347-1355.
41. Mueller SN, Mackay LK. Tissue-resident memory T cells: local specialists in immune defence. Nat Rev Immunol 2016; 16: 79-89.
42. Schenkel JM, Masopust D. Tissue-resident memory T cells. Immunity 2014; 41: 886-897.
43. Mackay LK, Kallies A. Transcriptional regulation of tissue-resident lymphocytes. Trends Immunol 2017; 38: 94-103.
44. Marcus A, Raulet DH. Evidence for natural killer cell memory. Curr Biol 2013; 23: R817-R820.
45. O'Leary JG, Goodarzi M, Drayton DL, von Andrian UH. T cell-and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol 2006; 7: 507-516.
46. Li T, Wang J, Wang Y, Chen Y, Wei H, Sun R et al. Respiratory influenza virus infection induces memory-like liver NK cells in mice. J Immunol 2017; 198: 1242-1252.
47. Paust S, von Andrian UH. Natural killer cell memory. Nat Immunol 2011; 12: 500-508.
48. Horst AK, Neumann K, Diehl L, Tiegs G. Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells. Cell Mol Immunol 2016; 13: 277-292.
49. Grakoui A, Crispe IN. Presentation of hepatocellular antigens. Cell Mol Immunol 2016; 13: 293-300.
50. Ju C, Tacke F. Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cell Mol Immunol 2016; 13: 316-327.
51. Shuai Z, Leung MW, He X, Zhang W, Yang G, Leung PS et al. Adaptive immunity in the liver. Cell Mol Immunol 2016; 13: 354-368.
52. Tian Z, Chen Y, Gao B. Natural killer cells in liver disease. Hepatology 2013; 57: 1654-1662.
53. Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis. Hepatology 2009; 49: 940-949.
54. Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 2006; 130: 435-452.
55. Gur C, Doron S, Kfir-Erenfeld S, Horwitz E, Abu-Tair L, Safadi R et al. NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis. Gut 2012; 61: 885-893.
56. Gao B, Radaeva S, Park O. Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J Leukoc Biol 2009; 86: 513-528.
57. Cai L, Zhang Z, Zhou L, Wang H, Fu J, Zhang S et al. Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients. Clin Immunol 2008; 129: 428-437.
58. Hoechst B, Voigtlaender T, Ormandy L, Gamrekelashvili J, Zhao F, Wedemeyer H et al. Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor. Hepatology 2009; 50: 799-807.
59. Yang Y, Han Q, Hou Z, Zhang C, Tian Z, Zhang J. Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction. Cell Mol Immunol 2017; 14: 465-475.
60. Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, Schurich A et al. Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion. J Exp Med 2013; 210: 99-114.
61. Krueger PD, Narayanan S, Surette FA, Brown MG, Sung SJ, Hahn YS. Murine liver-resident group 1 innate lymphoid cells regulate optimal priming of anti-viral CD8+ T cells. J Leukoc Biol 2017; 101: 329-338.