A vital sugar code for ricin toxicity

Cell Research

Volumn 27, Issue 11, 2017, Pages 1351-1364

  Taubenschmid, Jasmin ^a   Stadlmann, Johannes ^a   Jost, Markus ^b   Klokk, Tove Irene ^c   Rillahan, Cory D ^d   Leibbrandt, Andreas ^a   Mechtler, Karl ^a   Paulson, James C ^d   Jude, Julian ^e   Zuber, Johannes ^e   Sandvig, Kirsten ^c,f   Elling, Ulrich ^a   Marquardt, Thorsten ^g   Thiel, Christian ^b   Koerner, Christian ^b   Penninger, Josef M ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^f UNIVERSITY OF OSLO   (Norway)

^g UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Fucosylation; Intracellular trafficking; Lewis X; Ricin; Sialylation; Toxin

Indexed keywords

CARRIER PROTEIN; FUCOSYLTRANSFERASE; FUCOSYLTRANSFERASE 9, MOUSE; GLUCOSE TRANSPORTER; HAEMATOSIDE SYNTHETASE; RICIN; SIALYLTRANSFERASE; SLC35C1 PROTEIN, HUMAN; SLC35C1 PROTEIN, MOUSE;

ANIMAL; GENE DELETION; GENETICS; GOLGI COMPLEX; HUMAN; METABOLISM; MOUSE; MUTATION; PHYSIOLOGY;

ANIMALS; FUCOSYLTRANSFERASES; GENE DELETION; GOLGI APPARATUS; HUMANS; MEMBRANE TRANSPORT PROTEINS; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; MUTATION; RICIN; SIALYLTRANSFERASES;

EID: 85032984793     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2017.116     Document Type: Article

References (35)

1. Audi J, Belson M, Patel M, Schier J, Osterloh J. Ricin poisoning: A comprehensive review. JAMA 2005; 294:2342-2351.
2. Sandvig K, Skotland T, van Deurs B, Klokk TI. Retrograde transport of protein toxins through the Golgi apparatus. Histochem Cell Biol 2013; 140:317-326.
3. Crompton R, Gall D. Georgi Markov-death in a pellet. Med Leg J 1980; 48: 51-62.
4. Barbier J, Bouclier C, Johannes L, Gillet D. Inhibitors of the cellular trafficking of ricin. Toxins 2012; 4:15-27.
5. Pawar V, De A, Briggs L, et al. RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance. J Biomol Screen 2011; 16:436-442.
6. Moreau D, Kumar P, Wang SC, et al. Genome-wide RNAi screens identify genes required for Ricin and PE intoxications. Dev Cell 2011; 21:231-244.
7. Bassik MC, Kampmann M, Lebbink RJ, et al. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell 2013; 152:909-922.
8. Cummings L, Warren CE, Granovsky M, Dennis JW. Antisense and sense cDNA expression cloning using autonomously replicating vectors and toxic lectin selection. Biochem Biophys Res Commun 1993; 195:814-822.
9. Baenziger JU, Fiete D. Structural determinants of Ricinus communis agglutinin and toxin specificity for oligosaccharides. J Biol Chem 1979; 254:9795-9799.
10. Patnaik SK, Stanley P. Lectin-resistant CHO glycosylation mutants. Methods Enzymol 2006; 416:159-182.
11. Chen W, Tang J, Stanley P. Suppressors of (1, 3)fucosylation identified by expression cloning in the LEC11B gain-of-function CHO mutant. Glycobiology 2005; 15:259-269.
12. Elling U, Taubenschmid J, Wirnsberger G, et al. Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell 2011; 9:563-574.
13. Potvin B, Stanley P. Activation of two new (1, 3)fucosyltransferase activities in Chinese hamster ovary cells by 5-azacytidine. Cell Regul 1991; 2:989-1000.
14. Potvin B, Raju TS, Stanley P. Lec32 is a new mutation in Chinese hamster ovary cells that essentially abrogates CMP-N-acetylneuraminic acid synthetase activity. J Biol Chem 1995; 270:30415-30421.
15. Lübke T, Marquardt T, Etzioni A, Hartmann E, von Figura K, Körner C. Complementation cloning identifies CDGIIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Nat Genet 2001; 28:73-76.
16. Kaneko M, Kudo T, Iwasaki H, et al. 1, 3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX. FEBS Lett 1999; 452:237-242.
17. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292:154-156.
18. Hellbusch CC, Sperandio M, Frommhold D, et al. Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II. J Biol Chem 2007; 282:10762-10772.
19. Challoner KR, McCarron MM. Castor bean intoxication. Ann Emerg Med 1990; 19:1177-1183.
20. Gagneux P, Varki A. Evolutionary considerations in relating oligosaccharide diversity to biological function. Glycobiology 1999; 9:747-755.
21. Marquardt T, Lühn K, Srikrishna G, Freeze HH, Harms E, Vestweber D. Correction of leukocyte adhesion deficiency type II with oral fucose. Blood 1999; 94:3976-3985.
22. Rillahan CD, Antonopoulos A, Lefort CT, et al. Global metabolic inhibitors of sialyl-A nd fucosyltransferases remodel the glycome. Nat Chem Biol 2012; 8:661-668.
23. Okeley NM, Alley SC, Anderson ME, et al. Development of orally active inhibitors of protein and cellular fucosylation. Proc Natl Acad Sci USA 2013; 110:5404-5409.
24. Rapak A, Falnes PO, Olsnes S. Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol. Proc Natl Acad Sci USA 1997; 94:3783-3788.
25. Hanisch FG, Mitsakos A, Schroten H, Uhlenbruck G. Biosynthesis of cancer-associated sialyl-X antigen by a (1-3)-L-fucosyltransferase of human amniotic fluid. Carbohydr Res 1988; 178:23-28.
26. Noro E, Togayachi A, Sato T, et al. Large-scale identification of N-glycan glycoproteins carrying Lewis x and site-specific N-glycan alterations in Fut9 knockout mice. J Proteome Res 2015; 14:3823-3834.
27. Ellies LG, Sperandio M, Underhill GH, et al. Sialyltransferase specificity in selectin ligand formation. Blood 2002; 100:3618-3625.
28. Gilbert LA, Horlbeck MA, Adamson B, et al. Genome-scale CRISPR-mediated control of gene repression and activation. Cell 2014; 159:647-661.
29. Sasaki K, Watanabe E, Kawashima K, et al. Expression cloning of a novel Gal (1-3/1-4) GlcNAc 2, 3-sialyltransferase using lectin resistance selection. J Biol Chem 1993; 268:22782-22787.
30. Bürckstümmer T, Banning C, Hainzl P, et al. A reversible gene trap collection empowers haploid genetics in human cells. Nat Methods 2013; 10:965-971.
31. van Deurs B, Sandvig K, Petersen OW, Olsnes S, Simons K, Griffiths G. Estimation of the amount of internalized ricin that reaches the trans-Golgi network. J Cell Biol 1988; 106:253-267.
32. Zuber J, McJunkin K, Fellmann C, et al. Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol 2011; 29:79-83.
33. Simmons BM, Russell JH. A single affinity column step method for the purification of ricin toxin from castor beans (Ricinus communis). Anal Biochem 1985; 146:206-210.
34. Pust S, Dyve AB, Torgersen ML, van Deurs B, Sandvig K. Interplay between toxin transport and flotillin localization. PLoS One 2010; 5:e8844.
35. Sato T, Stange DE, Ferrante M, et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, Barrett's epithelium. Gastroenterology 2011; 141:1762-1772.