Design, synthesis, and evaluation of NDGA analogues as potential anti-ischemic stroke agents

European Journal of Medicinal Chemistry

Volumn 143, Issue , 2018, Pages 1165-1173

  Huang, Lili ^a   Wang, Jiabing ^a   Chen, Liping ^a   Zhu, Min ^a   Wu, Shoubiao ^a,b   Chu, Shenghui ^a   Zheng, Yuantie ^a   Fan, Ziliang ^a   Zhang, Jiafeng ^a   Li, Wulan ^a   Chen, Dahui ^a   Yang, Xiufei ^b   Wang, Sicen ^c   Qiu, Peihong ^a   Wu, Jianzhang ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b WENZHOU CENTRAL HOSPITAL   (China)

^c XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Anti ischemic stroke agent; Keap1 Nrf2 ARE pathway; ROS; Synthesis

Indexed keywords

1 BENZYL 3,5 BIS(3,4 DIHYDROXYBENZYLIDENE) PIPERIDIN 4 ONE; 1 CYCLOPROPYL 3,5 BIS(3,4 DIHYDROXYBENZYLIDENE)PIPERIDIN 4 ONE; 1,5 BIS(3,4 DIHYDROXYPHENYL)PENTA 1,4 DIEN 3 ONE; 2,5 BIS(3,4 DIHYDROXYBENZYLIDENE)CYCLOPENTANONE; 2,6 BIS(3,4 DIHYDROXYBENZYLIDENE)CYCLOHEXANONE; 3,5 BIS(3,4 DIHYDROXYBENZYLIDENE) 1 METHYLPIPERIDIN 4 ONE; 3,5 BIS(3,4 DIHYDROXYBENZYLIDENE) 1 PROPYLPIPERIDIN 4 ONE; 3,5 BIS(3,4 DIHYDROXYBENZYLIDENE)1 PHENETHYLPIPERIDIN 4 ONE; 3,5 BIS(3,4 DIHYDROXYBENZYLIDENE)DIHYDRO 2H PYRAN 4(3H) ONE; 3,5 BIS(3,4 DIHYDROXYBENZYLIDENE)DIHYDRO 2H THIOPYRAN 4(3H) ONE; 3,5 BIS(3,4 DIHYDROXYBENZYLIDENE)PIPERIDIN 4 ONE; ANTIOXIDANT; BENZYL 3,5 BIS(3,4 DIHYDROXYBENZYLIDENE) 4 OXOPIPERIDINE 1 CARBOXYLATE; ETHYL 3,5 BIS(3,4 DIHYDROXYBENZYLIDENE) 4 OXOPIPERIDINE 1 CARBOXYLATE; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; NORDIHYDROGUAIARETIC ACID; NORPHENAZONE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DPPH RADICAL SCAVENGING ASSAY; DRUG DESIGN; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; OXIDATIVE STRESS; PC12 CELL LINE; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; BRAIN ISCHEMIA; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HYDROGEN PEROXIDE; MALE; MASOPROCOL; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; PC12 CELLS; RATS; RATS, SPRAGUE-DAWLEY; STROKE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 85032944164     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2017.09.028     Document Type: Article

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