Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3

Nature

Volumn 550, Issue 7676, 2017, Pages

  Hirschi, Marscha ^a   Herzik, Mark A ^b   Wie, Jinhong ^c   Suo, Yang ^a   Borschel, William F ^a   Ren, Dejian ^c   Lander, Gabriel C ^b   Lee, Seok Yong ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; LYSOSOMAL CALCIUM PERMEABLE CHANNEL TRPML3; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 3,5-DIPHOSPHATE; POLYPHOSPHOINOSITIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

CELLS AND CELL COMPONENTS; CHEMICAL BINDING; ELECTRON MICROSCOPY; GENE; INHIBITION; LIPID; MOLECULAR ANALYSIS; MUTATION; PHYSIOLOGY; PROTEIN; ULTRASTRUCTURE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CALCIUM CONDUCTANCE; CALLITHRIX JACCHUS; CHANNEL GATING; CONFORMATIONAL TRANSITION; CRYOELECTRON MICROSCOPY; ENDOSOME; GAIN OF FUNCTION MUTATION; HYDROPHOBICITY; ION CONDUCTANCE; LOSS OF FUNCTION MUTATION; LYSOSOME; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; ANIMAL; CALLITHRIX; CHEMISTRY; ION TRANSPORT; METABOLISM; MOLECULAR MODEL; ULTRASTRUCTURE;

CALLITHRIX JACCHUS;

ANIMALS; BINDING SITES; CALLITHRIX; CRYOELECTRON MICROSCOPY; ION TRANSPORT; MODELS, MOLECULAR; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN DOMAINS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 85032875994     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature24055     Document Type: Article

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