Vaspin protects against LPS-induced ARDS by inhibiting inflammation, apoptosis and reactive oxygen species generation in pulmonary endothelial cells via the Akt/GSK-3β pathway

International Journal of Molecular Medicine

Volumn 40, Issue 6, 2017, Pages 1803-1817

  Qi, Di ^a   Wang, Daoxin ^a   Zhang, Chunrong ^a   Tang, Xumao ^a   He, Jing ^a   Zhao, Yan ^a   Deng, Wang ^a   Deng, Xinyu ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Acute respiratory distress syndrome; Akt GSK 3 ; Apoptosis; Endothelial cells; Inflammation; Reactive oxygen species; Vaspin

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1; VASPIN; RECOMBINANT PROTEIN; SERINE PROTEINASE INHIBITOR; SERPINA12 PROTEIN, HUMAN;

ACTIN FILAMENT; ADHERENS JUNCTION; ADULT RESPIRATORY DISTRESS SYNDROME; AKT GSK 3BETA SIGNALING PATHWAY; AKT SIGNALING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN PULMONARY MICROVASCULAR ENDOTHELIAL CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIPOPOLYSACCHARIDE INDUCED ADULT RESPIRATORY DISTRESS SYNDROME; MALE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; LUNG; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; ENDOTHELIAL CELLS; GLYCOGEN SYNTHASE KINASE 3 BETA; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; LUNG; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; RESPIRATORY DISTRESS SYNDROME, ADULT; SERPINS; SIGNAL TRANSDUCTION;

EID: 85032742399     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2017.3176     Document Type: Article

References (54)

1. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L and Slutsky AS; ARDS Definition Task Force: Acute respiratory distress syndrome: The Berlin Definition. JAMA 307: 2526-2533, 2012.
2. Phua J, Badia JR, Adhikari NK, Friedrich JO, Fowler RA, Singh JM, Scales DC, Stather DR, Li A, Jones A, et al: Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review. Am J Respir Crit Care Med 179: 220-227, 2009.
3. Müller-Redetzky HC, Suttorp N and Witzenrath M: Dynamics of pulmonary endothelial barrier function in acute inflammation: Mechanisms and therapeutic perspectives. Cell Tissue Res 355: 657-673, 2014.
4. Lucas R, Verin AD, Black SM and Catravas JD: Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochem Pharmacol 77: 1763-1772, 2009.
5. Gong MN, Bajwa EK, Thompson BT and Christiani DC: Body mass index is associated with the development of acute respiratory distress syndrome. Thorax 65: 44-50, 2010.
6. Anzueto A, Frutos-Vivar F, Esteban A, Bensalami N, Marks D, Raymondos K, Apezteguía C, Arabi Y, Hurtado J, González M, et al; Ventila group: Influence of body mass index on outcome of the mechanically ventilated patients. Thorax 66: 66-73, 2011.
7. Stapleton RD and Suratt BT: Obesity and nutrition in acute respiratory distress syndrome. Clin Chest Med 35: 655-671, 2014.
8. Konter J, Baez E and Summer RS: Obesity: ‘priming’ the lung for injury. Pulm Pharmacol Ther 26: 427-429, 2013.
9. Matsuzawa Y, Funahashi T and Nakamura T: The concept of metabolic syndrome: Contribution of visceral fat accumulation and its molecular mechanism. J Atheroscler Thromb 18: 629-639, 2011.
10. Van Gaal LF, Mertens IL and De Block CE: Mechanisms linking obesity with cardiovascular disease. Nature 444: 875-880, 2006.
11. Yamawaki H: Mechanisms of action of novel adipocytokines on the vascular system. Nihon Yakurigaku Zasshi 137: 131-135, 2011.
12. Mattu HS and Randeva HS: Role of adipokines in cardiovascular disease. J Endocrinol 216: T17-T36, 2013.
13. Ohashi K, Shibata R, Murohara T and Ouchi N: Role of anti-inflammatory adipokines in obesity-related diseases. Trends Endocrinol Metab 25: 348-355, 2014.
14. Wang C: Obesity, inflammation, and lung injury (OILI): The good. Mediators Inflamm 2014: 978463, 2014.
15. Shah D, Romero F, Duong M, Wang N, Paudyal B, Suratt BT, Kallen CB, Sun J, Zhu Y, Walsh K, et al: Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury. Sci Rep 5: 11362, 2015.
16. Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, et al: Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation. J Immunol 188: 854-863, 2012.
17. Fan XF, Xue F, Zhang YQ, Xing XP, Liu H, Mao SZ, Kong XX, Gao YQ, Liu SF and Gong YS: The Apelin-APJ axis is an endogenous counterinjury mechanism in experimental acute lung injury. Chest 147: 969-978, 2015.
18. Qi D, Tang X, He J, Wang D, Zhao Y, Deng W, Deng X, Zhou G, Xia J, Zhong X, et al: Omentin protects against LPS-induced ARDS through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/eNOS-dependent mechanism. Cell Death Dis 7: e2360, 2016.
19. Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, Hashimoto I, Okada T, Yasuhara A, Nakatsuka A, et al: Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 102: 10610-10615, 2005.
20. Dimova R and Tankova T: The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis. BioMed Res Int 2015: 823481, 2015.
21. Kobat MA, Celik A, Balin M, Altas Y, Baydas A, Bulut M, Aydin S, Dagli N, Yavuzkir MF and Ilhan S: The investigation of serum vaspin level in atherosclerotic coronary artery disease. J Clin Med Res 4: 110-113, 2012.
22. Aust G, Richter O, Rohm S, Kerner C, Hauss J, Klöting N, Ruschke K, Kovacs P, Youn BS and Blüher M: Vaspin serum concentrations in patients with carotid stenosis. Atherosclerosis 204: 262-266, 2009.
23. Wang HH and Wang QF: Low vaspin levels are related to endothelial dysfunction in patients with ankylosing spondylitis. Braz J Med Biol Res 49: e5231, 2016.
24. Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, et al: Visceral adipose tissue-derived serine proteinase inhibitor inhibits apoptosis of endothelial cells as a ligand for the cell-surface GRP78/voltage-dependent anion channel complex. Circ Res 112: 771-780, 2013.
25. Phalitakul S, Okada M, Hara Y and Yamawaki H: Vaspin prevents methylglyoxal-induced apoptosis in human vascular endothelial cells by inhibiting reactive oxygen species generation. Acta Physiol (Oxf) 209: 212-219, 2013.
26. Jung CH, Lee MJ, Kang YM, Lee YL, Yoon HK, Kang SW, Lee WJ and Park JY: Vaspin inhibits cytokine-induced nuclear factor-kappa B activation and adhesion molecule expression via AMP-activated protein kinase activation in vascular endothelial cells. Cardiovasc Diabetol 13: 41, 2014.
27. Jung CH, Lee WJ, Hwang JY, Seol SM, Kim YM, Lee YL and Park JY: Vaspin protects vascular endothelial cells against free fatty acid-induced apoptosis through a phosphatidylinositol 3-kinase/Akt pathway. Biochem Biophys Res Commun 413: 264-269, 2011.
28. Lin Y, Zhuang J, Li H, Zhu G, Zhou S, Li W, Peng W and Xu Y: Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress-induced macrophage apoptosis in apoE/mice. Mol Med Rep 13: 1509-1516, 2016.
29. National Research Council (US) Institute for Laboratory Animal Research: Guidance for the description of animal research in scientific publications. Washington (DC): National Academies Press (US); 2011.
30. Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM; Acute Lung Injury in Animals Study Group: An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol 44: 725-738, 2011.
31. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408, 2001.
32. Ryan D, Frohlich S and McLoughlin P: Pulmonary vascular dysfunction in ARDS. Ann Intensive Care 4: 28, 2014.
33. Shibata R, Ohashi K, Murohara T and Ouchi N: The potential of adipokines as therapeutic agents for cardiovascular disease. Cytokine Growth Factor Rev 25: 483-487, 2014.
34. Liu S, Dong Y, Wang T, Zhao S, Yang K, Chen X and Zheng C: Vaspin inhibited proinflammatory cytokine induced activation of nuclear factor-kappa B and its downstream molecules in human endothelial EA.hy926 cells. Diabetes Res Clin Pract 103: 482-488, 2014.
35. Taylor NJ and Shawcross DL: Alpha1-antitrypsin deficiency. N Engl J Med 361: 2102, author reply 2102, 2009.
36. Tumen J, Meyrick B, Berry L Jr and Brigham KL: Antiproteinases protect cultured lung endothelial cells from endotoxin injury. J Appl Physiol (1985) 65: 835-843, 1988.
37. Feng Y, Hu L, Xu Q, Yuan H, Ba L, He Y and Che H: Cytoprotective role of alpha-1 antitrypsin in vascular endothelial cell under hypoxia/reoxygenation condition. J Cardiovasc Pharmacol 66: 96-107, 2015.
38. Stockley RA: The multiple facets of alpha-1-antitrypsin. Ann Transl Med 3: 130, 2015.
39. Jie Z, Cai Y, Yang W, Jin M, Zhu W and Zhu C: Protective effects of alpha 1-antitrypsin on acute lung injury in rabbits induced by endotoxin. Chin Med J (Engl) 116: 1678-1682, 2003.
40. Petrache I, Fijalkowska I, Medler TR, Skirball J, Cruz P, Zhen L, Petrache HI, Flotte TR and Tuder RM: α-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. Am J Pathol 169: 1155-1166, 2006.
41. Wewers MD, Herzyk DJ and Gadek JE: Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin. J Clin Invest 82: 1260-1267, 1988.
42. Gadek JE and Pacht ER: The interdependence of lung antioxidants and antiprotease defense in ARDS. Chest 110 (Suppl 6): 273S-277S, 1996.
43. Gando S, Kameue T, Matsuda N, Sawamura A, Hayakawa M and Kato H: Systemic inflammation and disseminated intra-vascular coagulation in early stage of ALI and ARDS: Role of neutrophil and endothelial activation. Inflammation 28: 237-244, 2004.
44. Meduri GU, Annane D, Chrousos GP, Marik PE and Sinclair SE: Activation and regulation of systemic inflammation in ARDS: Rationale for prolonged glucocorticoid therapy. Chest 136: 1631-1643, 2009.
45. Phalitakul S, Okada M, Hara Y and Yamawaki H: A novel adipocytokine, vaspin inhibits platelet-derived growth factor-BB-induced migration of vascular smooth muscle cells. Biochem Biophys Res Commun 423: 844-849, 2012.
46. Phalitakul S, Okada M, Hara Y and Yamawaki H: Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat vascular smooth muscle cells. Pharmacol Res 64: 493-500, 2011.
47. Kása A, Csortos C and Verin AD: Cytoskeletal mechanisms regulating vascular endothelial barrier function in response to acute lung injury. Tissue Barriers 3: e974448, 2015.
48. Mehta D and Malik AB: Signaling mechanisms regulating endothelial permeability. Physiol Rev 86: 279-367, 2006.
49. Galani V, Tatsaki E, Bai M, Kitsoulis P, Lekka M, Nakos G and Kanavaros P: The role of apoptosis in the pathophysiology of Acute Respiratory Distress Syndrome (ARDS): An up-to-date cell-specific review. Pathol Res Pract 206: 145-150, 2010.
50. Lang JD, McArdle PJ, O'Reilly PJ and Matalon S: Oxidant-antioxidant balance in acute lung injury. Chest 122 (Suppl 6): 314S-320S, 2002.
51. Tasaka S, Amaya F, Hashimoto S and Ishizaka A: Roles of oxidants and redox signaling in the pathogenesis of acute respiratory distress syndrome. Antioxid Redox Signal 10: 739-753, 2008.
52. Shiizaki S, Naguro I and Ichijo H: Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling. Adv Biol Regul 53: 135-144, 2013.
53. Matsuzawa A, Nishitoh H, Tobiume K, Takeda K and Ichijo H: Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice. Antioxid Redox Signal 4: 415-425, 2002.
54. Manukyan MC, Weil BR, Wang Y, Abarbanell AM, Herrmann JL, Poynter JA and Meldrum DR: The phosphoinositide-3 kinase survival signaling mechanism in sepsis. Shock 34: 442-449, 2010.