Obesity: "Priming" the lung for injury

Pulmonary Pharmacology and Therapeutics

Volumn 26, Issue 4, 2013, Pages 427-429

  Konter, Jason ^a   Baez, Elizabeth ^a   Summer, Ross S ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute Lung Injury; Adipokines; Adiponectin; Leptin; Obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; CADHERIN; COMPLEMENT COMPONENT C1Q; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ADIPOSE TISSUE; ARTICLE; BODY FAT; CARDIOVASCULAR DISEASE; CRITICAL ILLNESS; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; EXPERIMENTAL STUDY; HUMAN; LUNG ENDOTHELIUM; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; RISK FACTOR; UPREGULATION;

ACUTE LUNG INJURY; ADIPOSE TISSUE; ANIMALS; DISEASE SUSCEPTIBILITY; HUMANS; OBESITY; RISK FACTORS;

EID: 84880512889     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2012.03.003     Document Type: Article

References (44)

1. Ware L.B., Matthay M.A. The acute respiratory distress syndrome. N Engl J Med 2000, 342:1334-1349.
2. Rubenfeld G.D., Caldwell E., Peabody E., Weaver J., Martin D.P., Neff M., et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005, 353:1685-1693.
3. Gong M.N., Bajwa E.K., Thompson B.T., Christiani D.C. Body mass index is associated with the development of acute respiratory distress syndrome. Thorax 2010, 65:44-50.
4. Lederer D.J., Kawut S.M., Wickersham N., Winterbottom C., Bhorade S., Palmer S.M., et al. Obesity and primary graft dysfunction after lung transplantation: The ltog obesity study. Am J Respir Crit Care Med 2011, 10.1164/rccm.201104-07280c.
5. Gajic O., Dabbagh O., Park P.K., Adesanya A., Chang S.Y., Hou P., et al. Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med 2010, 183:462-470.
6. Morris A.E., Stapleton R.D., Rubenfeld G.D., Hudson L.D., Caldwell E., Steinberg K.P. The association between body mass index and clinical outcomes in acute lung injury. Chest 2007, 131:342-348.
7. Akinnusi M.E., Pineda L.A., El Solh A.A. Effect of obesity on intensive care morbidity and mortality: A meta-analysis. Crit Care Med 2008, 36:151-158.
8. Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
9. Wellen K.E., Hotamisligil G.S. Inflammation, stress, and diabetes. J Clin Invest 2005, 115:1111-1119.
10. Shoelson S.E., Lee J., Goldfine A.B. Inflammation and insulin resistance. J Clin Invest 2006, 116:1793-1801.
11. Xu H., Barnes G.T., Yang Q., Tan G., Yang D., Chou C.J., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003, 112:1821-1830.
12. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003, 112:1796-1808.
13. Ohashi K., Parker J.L., Ouchi N., Higuchi A., Vita J.A., Gokce N., et al. Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem 2009, 285:6153-6160.
14. Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
15. Fried S.K., Bunkin D.A., Greenberg A.S. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 1998, 83:847-850.
16. Hack C.E., Aarden L.A., Thijs L.G. Role of cytokines in sepsis. Adv Immunol 1997, 66:101-195.
17. Thijs L.G., Hack C.E. Time course of cytokine levels in sepsis. Intensive Care Med 1995, 21(Suppl. 2):S258-S263.
18. Bhatia M., Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004, 202:145-156.
19. Simpson S.Q., Casey L.C. Role of tumor necrosis factor in sepsis and acute lung injury. Crit Care Clin 1989, 5:27-47.
20. Klein C.L., Hoke T.S., Fang W.F., Altmann C.J., Douglas I.S., Faubel S. Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy. Kidney Int 2008, 74:901-909.
21. Berg A.H., Scherer P.E. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005, 96:939-949.
22. Ouchi N., Kihara S., Funahashi T., Matsuzawa Y., Walsh K. Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol 2003, 14:561-566.
23. Ouchi N., Parker J.L., Lugus J.J., Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011, 11:85-97.
24. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.
25. Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
26. Matarese G., Moschos S., Mantzoros C.S. Leptin in immunology. J Immunol 2005, 174:3137-3142.
27. Matarese G., Mantzoros C., La Cava A. Leptin and adipocytokines: Bridging the gap between immunity and atherosclerosis. Curr Pharm Des 2007, 13:3676-3680.
28. Bellmeyer A., Martino J.M., Chandel N.S., Scott Budinger G.R., Dean D.A., Mutlu G.M. Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med 2007, 175:587-594.
29. Barazzone-Argiroffo C., Muzzin P., Donati Y.R., Kan C.D., Aubert M.L., Piguet P.F. Hyperoxia increases leptin production: A mechanism mediated through endogenous elevation of corticosterone. Am J Physiol Lung Cell Mol Physiol 2001, 281:L1150-L1156.
30. Jain M., Budinger G.R., Lo A., Urich D., Rivera S.E., Ghosh A.K., et al. Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-gamma. Am J Respir Crit Care Med 2011, 183:1490-1498.
31. Scherer P.E., Williams S., Fogliano M., Baldini G., Lodish H.F. A novel serum protein similar to c1q, produced exclusively in adipocytes. J Biol Chem 1995, 270:26746-26749.
32. Hu E., Liang P., Spiegelman B.M. Adipoq is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996, 271:10697-10703.
33. Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., Matsubara K. Cdna cloning and expression of a novel adipose specific collagen-like factor, apm1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 1996, 221:286-289.
34. Takemura Y., Ouchi N., Shibata R., Aprahamian T., Kirber M.T., Summer R.S., et al. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. The Journal of clinical investigation 2007, 117:375-386.
35. Yamauchi T., Nio Y., Maki T., Kobayashi M., Takazawa T., Iwabu M., et al. Targeted disruption of adipor1 and adipor2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 2007, 13:332-339.
36. Hug C., Wang J., Ahmad N.S., Bogan J.S., Tsao T.S., Lodish H.F. T-cadherin is a receptor for hexameric and high-molecular-weight forms of acrp30/adiponectin. Proc Natl Acad Sci U S A 2004, 101:10308-10313.
37. Denzel M.S., Scimia M.C., Zumstein P.M., Walsh K., Ruiz-Lozano P., Ranscht B. T-cadherin is critical for adiponectin-mediated cardioprotection in mice. J Clin Invest 2010, 120:4342-4352.
38. Zhu M., Hug C., Kasahara D.I., Johnston R.A., Williams A.S., Verbout N.G., et al. Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice. Am J Respir Cell Mol Biol 2010, 43:487-497.
39. Summer R., Little F.F., Ouchi N., Takemura Y., Aprahamian T., Dwyer D., et al. Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. American journal of physiology Lung cellular and molecular physiology 2008, 294:L1035-L1042.
40. Summer R., Fiack C.A., Ikeda Y., Sato K., Dwyer D., Ouchi N., et al. Adiponectin deficiency: A model of pulmonary hypertension associated with pulmonary vascular disease. American journal of physiology Lung cellular and molecular physiology 2009, 297:L432-L438.
41. Medoff B.D., Okamoto Y., Leyton P., Weng M., Sandall B.P., Raher M.J., et al. Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol 2009, 41:397-406.
42. Shore S.A., Terry R.D., Flynt L., Xu A., Hug C. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 2006, 118:389-395.
43. Konter J.M., Parker J.L., Baez E., Li S.Z., Ranscht B., Denzel M., et al. Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation. J Immunol 2012, 188:854-863.
44. Walkey A.J., Rice T.W., Konter J., Ouchi N., Shibata R., Walsh K., et al. Plasma adiponectin and mortality in critically ill subjects with acute respiratory failure. Crit Care Med 2010, 38:2329-2334.