The apelin-APJ axis is an endogenous counterinjury mechanism in experimental acute lung injury

Chest

Volumn 147, Issue 4, 2015, Pages 969-978

  Fan, Xiao Fang ^a   Xue, Feng ^a   Zhang, Yue Qi ^a   Xing, Xue Ping ^a   Liu, Hui ^a   Mao, Sun Zhong ^a   Kong, Xiao Xia ^a   Gao, Yu Qi ^b   Liu, Shu F ^c   Gong, Yong Sheng ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; APELIN 12; APELIN 13; APELIN 36; APELIN PREPROPROTEIN; APELIN RECEPTOR; LIPOPOLYSACCHARIDE; MALONALDEHYDE; MONOCYTE CHEMOTACTIC PROTEIN 1; OLEIC ACID; PROTEIN PRECURSOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; APLN PROTEIN, MOUSE; APLNR PROTEIN, MOUSE; G PROTEIN COUPLED RECEPTOR; SIGNAL PEPTIDE;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CAPILLARY LEAK SYNDROME; CONTROLLED STUDY; DISEASE EXACERBATION; HISTOPATHOLOGY; HYPOXEMIA; LUNG FLUID; LUNG LAVAGE; LUNG PARENCHYMA; MALE; NONHUMAN; OXIDATIVE STRESS; OXYGENATION; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; PROTECTION; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; RAT MODEL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TISSUE LEVEL; UPREGULATION; ANIMAL; BIOSYNTHESIS; CHEMISTRY; DISEASE MODEL; METABOLISM;

ACUTE LUNG INJURY; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; RATS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84927127458     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.14-1426     Document Type: Article

References (29)

1. Matthay MA , Ware LB , Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest. 2012; 122 (8): 2731-2740.
2. Tsushima K , King LS , Aggarwal NR , De Gorordo A , D'Alessio FR , Kubo K. Acute lung injury review. Intern Med. 2009; 48 (9): 621-630.
3. Herold S , GabriellinM , Vadász I. Novel concepts of acute lung injury and alveolarcapillary barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2013; 305 (10): L665-L681.
4. Bhattacharya J , Matthay MA. Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol. 2013; 75: 593-615.
5. Sarma JV , Ward PA. Oxidants and redox signaling in acute lung injury. Compr Physiol. 2011; 1 (3): 1365-1381.
6. Mulligan MS , Warner RL , Foreback JL , Shanley TP , Ward PA. Protective effects of IL-4, IL-10, IL-12, and IL-13 in IgG immune complex-induced lung injury: role ofendogenous IL-12. J Immunol. 1997; 159 (7): 3483-3489.
7. Yan C , Ward PA , Wang X , Gao H. Myeloid depletion of SOCS3 enhances LPS-induced acute lung injury through CCAAT/enhancer binding protein d pathway. FASEB J. 2013; 27 (8): 2967-2976.
8. Kleinz MJ , Davenport AP. Emerging roles of apelin in biology and medicine. Pharmacol Ther. 2005; 107 (2): 198-211.
9. Galanth C , Hus-Citharel A , Li B , Llorens-Cortès C. Apelin in the control of body fl uid homeostasis and cardiovascular functions. Curr Pharm Des. 2012; 18 (6): 789-798.
10. Zhong JC , Yu XY , Huang Y , Yung LM , Lau CW, Lin SG. Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice. Cardiovasc Res. 2007; 74 (3): 388-395.
11. Lee DK, Saldivia VR, Nguyen T, Cheng R , George SR , O'Dowd BF. Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology. 2005; 146 (1): 231-236.
12. Chun HJ , Ali ZA , Kojima Y , et al. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest. 2008; 118 (10): 3343-3354.
13. Ashley EA , Powers J , Chen M , et al. The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc Res. 2005; 65 (1): 73-82.
14. Kang Y , Kim J , Anderson JP , et al. Apelin-APJ signaling is a critical regulator ofendothelial MEF2 activation in cardiovascular development. Circ Res. 2013; 113 (1): 22-31.
15. Eyries M , Siegfried G , Ciumas M , et al. Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis. Circ Res. 2008; 103 (4): 432-440.
16. Kasai A, Ishimaru Y, Kinjo T, et al. Apelin is a crucial factor for hypoxia-induced retinal angiogenesis. Arterioscler Thromb Vasc Biol. 2010; 30(11): 2182-2187.
17. Rastaldo R , Cappello S , Folino A , Losano G. Effect of apelin-apelin receptor system in postischaemic myocardial protection: a pharmacological postconditioning tool? Antioxid Redox Signal. 2011; 14 (5): 909-922.
18. Zeng XJ , Zhang LK , Wang HX , Lu LQ , Ma LQ , Tang CS. Apelin protects heart against ischemia/reperfusion injury in rat. Peptides. 2009; 30 (6): 1144-1152.
19. Han S , Englander EW , Gomez GA , et al. Pancreatitis activates pancreatic apelin-APJ axis in mice. Am J Physiol Gastrointest Liver Physiol. 2013; 305 (2): G139-G150.
20. Yasuzaki H , Yoshida S , Hashimoto T , et al. Involvement of the apelin receptor APJ in Fas-induced liver injury. Liver Int. 2013; 33 (1): 118-126.
21. Lang L , Ingorokva S , Hausott B , et al. Selective up-regulation of the vasodilator peptide apelin after dorsal root but not after spinal nerve injury. Neuroscience. 2010; 170 (3): 954-960.
22. Hosoya M , Kawamata Y , Fukusumi S ,et al. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem. 2000; 275 (28): 21061-21067.
23. Andersen CU , Hilberg O , Mellemkjær S , Nielsen-Kudsk JE , Simonsen U. Apelin and pulmonary hypertension. Pulm Circ. 2011; 1 (3): 334-346.
24. Falcão-Pires I , Gonçalves N , Henriques-Coelho T , Moreira-Gonçalves D , Roncon-Albuquerque R Jr , Leite-Moreira AF. Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2009; 296 (6): H2007-H2014.
25. Chandra SM , Razavi H , Kim J , et al. Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vasc Biol. 2011; 31 (4): 814-820.
26. Visser YP , Walther FJ , Laghmani H , Laarse Av , Wagenaar GT. Apelin attenuates hyperoxic lung and heart injury in neonatal rats. Am J Respir Crit Care Med. 2010; 182 (10): 1239-1250.
27. Matute-Bello G , Frevert CW , Martin TR. Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008; 295 (3): L379-L399.
28. Liu SF, Malik ABNF. NF-k B activation as a pathological mechanism of septic shock and infl ammation. A m J Physiol Lung Cell Mol Physiol. 2006; 290(4): L622-L645.
29. Foussal C , Lairez O , Calise D , et al. Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy. FEBS Lett. 2010; 584 (11): 2363-2370.