Staphylococcus aureus Virulent PSMα Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation

Cell Host and Microbe

Volumn 22, Issue 5, 2017, Pages 667-677.e5

  Nakagawa, Seitaro ^a   Matsumoto, Masanori ^b   Katayama, Yuki ^a   Oguma, Rena ^a   Wakabayashi, Seiichiro ^a   Nygaard, Tyler ^b   Saijo, Shinobu ^c   Inohara, Naohiro ^b   Otto, Michael ^d   Matsue, Hiroyuki ^a,c   Núñez, Gabriel ^b   Nakamura, Yuumi ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c CHIBA UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Agr virulence; alarmins; IL 1; IL 36; Myd88; pathogen virulence; PSMs; S. aureus; skin infection

Indexed keywords

ALARMIN; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 36ALPHA; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDE DERIVATIVE; PHENOL SOLUBLE MODULIN ALPHA PEPTIDE; UNCLASSIFIED DRUG; AGR PROTEIN, STAPHYLOCOCCUS AUREUS; BACTERIAL PROTEIN; BACTERIAL TOXIN; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1F6, MOUSE; INTERLEUKIN-36 RECEPTOR, MOUSE; MYD88 PROTEIN, MOUSE; PEPTIDE; STAPHYLOCOCCAL DELTA TOXIN; TRANSACTIVATOR PROTEIN;

ANIMAL TISSUE; ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATITIS; GAMMA DELTA T LYMPHOCYTE; KERATINOCYTE; LYMPHOID CELL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; FEMALE; HUMAN; IMMUNOLOGY; INFLAMMATION; METABOLISM; MICROBIOLOGY; NEUTROPHIL; PATHOGENICITY; PATHOLOGY; STAPHYLOCOCCAL SKIN INFECTION; T LYMPHOCYTE; VIRULENCE;

ALARMINS; ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CYTOKINES; DERMATITIS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-17; INTERLEUKIN-1ALPHA; KERATINOCYTES; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; NEUTROPHILS; PEPTIDES; RECEPTORS, INTERLEUKIN-1; STAPHYLOCOCCAL SKIN INFECTIONS; STAPHYLOCOCCUS AUREUS; T-LYMPHOCYTES; TRANS-ACTIVATORS; VIRULENCE;

EID: 85032742379     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2017.10.008     Document Type: Article

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