Genetically determined schizophrenia is not associated with impaired glucose homeostasis

Schizophrenia Research

Volumn 195, Issue , 2018, Pages 286-289

  Polimanti, Renato ^a   Gelernter, Joel ^a,b   Stein, Dan J ^c  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Genetic correlation; Genetics; Mendelian randomization; Metabolic disorders; Psychiatry

Indexed keywords

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION STUDY; GENETIC CORRELATION; GENETIC TRAIT; GENETIC VARIABILITY; GLUCOSE HOMEOSTASIS; HOMEOSTASIS MODEL ASSESSMENT; HUMAN; MENDELIAN RANDOMIZATION ANALYSIS; MOLECULAR DYNAMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; OVERLAPPING GENE; PRIORITY JOURNAL; SCHIZOPHRENIA; DISORDERS OF CARBOHYDRATE METABOLISM; FEMALE; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MALE;

DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE METABOLISM DISORDERS; HUMANS; MALE; MENDELIAN RANDOMIZATION ANALYSIS; SCHIZOPHRENIA;

EID: 85032727265     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2017.10.033     Document Type: Article

References (23)

1. Bowden, J., Davey Smith, G., Burgess, S., Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int. J. Epidemiol. 44:2 (2015), 512–525.
2. Brion, M.J., Shakhbazov, K., Visscher, P.M., Calculating statistical power in Mendelian randomization studies. Int. J. Epidemiol. 42:5 (2013), 1497–1501.
3. Bulik-Sullivan, B., Finucane, H.K., Anttila, V., Gusev, A., Day, F.R., Loh, P.R., ReproGen, C, Psychiatric Genomics, C, Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control, C, Duncan, L., Perry, J.R., Patterson, N., Robinson, E.B., Daly, M.J., Price, A.L., Neale, B.M., An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47:11 (2015), 1236–1241.
4. Burgess, S., Butterworth, A., Thompson, S.G., Mendelian randomization analysis with multiple genetic variants using summarized data. Genet. Epidemiol. 37:7 (2013), 658–665.
5. Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A.U., Wheeler, E., Glazer, N.L., Bouatia-Naji, N., Gloyn, A.L., Lindgren, C.M., Magi, R., Morris, A.P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V., Henneman, P., Grallert, H., Dehghan, A., Hottenga, J.J., Franklin, C.S., Navarro, P., Song, K., Goel, A., Perry, J.R., Egan, J.M., Lajunen, T., Grarup, N., Sparso, T., Doney, A., Voight, B.F., Stringham, H.M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proenca, C., Kumari, M., Qi, L., Timpson, N.J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, J., Elliott, A., McCarroll, S.A., Payne, F., Roccasecca, R.M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J.P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A.J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L.L., Borch-Johnsen, K., Bottcher, Y., Brunner, E., Bumpstead, S.J., Charpentier, G., Chen, Y.D., Chines, P., Clarke, R., Coin, L.J., Cooper, M.N., Cornelis, M., Crawford, G., Crisponi, L., Day, I.N., de Geus, E.J., Delplanque, J., Dina, C., Erdos, M.R., Fedson, A.C., Fischer-Rosinsky, A., Forouhi, N.G., Fox, C.S., Frants, R., Franzosi, M.G., Galan, P., Goodarzi, M.O., Graessler, J., Groves, C.J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., Hartikainen, A.L., Hassanali, N., Hayward, C., Heath, S.C., Hercberg, S., Herder, C., Hicks, A.A., Hillman, D.R., Hingorani, A.D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P.R., Jorgensen, T., Jula, A., Kaakinen, M., Kaprio, J., Kesaniemi, Y.A., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K.O., Lathrop, G.M., Lawlor, D.A., Le Bacquer, O., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A.K., Martinez-Larrad, M.T., McAteer, J.B., McCulloch, L.J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B.D., Morken, M.A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M.J., Oostra, B.A., Orru, M., Pakyz, R., Palmer, C.N., Paolisso, G., Pattaro, C., Pearson, D., Peden, J.F., Pedersen, N.L., Perola, M., Pfeiffer, A.F., Pichler, I., Polasek, O., Posthuma, D., Potter, S.C., Pouta, A., Province, M.A., Psaty, B.M., Rathmann, W., Rayner, N.W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A.A., Scheet, P., Scott, L.J., Seedorf, U., Sharp, S.J., Shields, B., Sigurethsson, G., Sijbrands, E.J., Silveira, A., Simpson, L., Singleton, A., Smith, N.L., Sovio, U., Swift, A., Syddall, H., Syvanen, A.C., Tanaka, T., Thorand, B., Tichet, J., Tonjes, A., Tuomi, T., Uitterlinden, A.G., van Dijk, K.W., van Hoek, M., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P.J., Walley, A., Walters, G.B., Ward, K.L., Watkins, H., Weedon, M.N., Wild, S.H., Willemsen, G., Witteman, J.C., Yarnell, J.W., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J.H., Zillikens, M.C., Consortium, D., Consortium, G., Global, B.C., Borecki, I.B., Loos, R.J., Meneton, P., Magnusson, P.K., Nathan, D.M., Williams, G.H., Hattersley, A.T., Silander, K., Salomaa, V., Smith, G.D., Bornstein, S.R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A.R., Cooper, C., Dedoussis, G.V., Serrano-Rios, M., Morris, A.D., Lind, L., Palmer, L.J., Hu, F.B., Franks, P.W., Ebrahim, S., Marmot, M., Kao, W.H., Pankow, J.S., Sampson, M.J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P.P., Wichmann, H.E., Illig, T., Rudan, I., Wright, A.F., Stumvoll, M., Campbell, H., Wilson, J.F., Anders Hamsten on behalf of Procardis, C., investigators, M., Bergman, R.N., Buchanan, T.A., Collins, F.S., Mohlke, K.L., Tuomilehto, J., Valle, T.T., Altshuler, D., Rotter, J.I., Siscovick, D.S., Penninx, B.W., Boomsma, D.I., Deloukas, P., Spector, T.D., Frayling, T.M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., van Duijn, C.M., Aulchenko, Y.S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., Jarvelin, M.R., Waterworth, D.M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G.R., Wareham, N.J., Sladek, R., Froguel, P., Watanabe, R.M., Meigs, J.B., Groop, L., Boehnke, M., McCarthy, M.I., Florez, J.C., Barroso, I., 2010. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat. Genet. 42(2), 105–116.
6. Emdin, C.A., Khera, A.V., Natarajan, P., Klarin, D., Zekavat, S.M., Hsiao, A.J., Kathiresan, S., Genetic association of waist-to-hip ratio with cardiometabolic traits, type 2 diabetes, and coronary heart disease. JAMA 317:6 (2017), 626–634.
7. Hartwig, F.P., Bowden, J., Loret de Mola, C., Tovo-Rodrigues, L., Davey Smith, G., Horta, B.L., Body mass index and psychiatric disorders: a Mendelian randomization study. Sci Rep, 6, 2016, 32730.
8. van't Hof, F.N., Vaucher, J., Holmes, M.V., de Wilde, A., Baas, A.F., Blankensteijn, J.D., Hofman, A., Kiemeney, L.A., Rivadeneira, F., Uitterlinden, A.G., Vermeulen, S.H., Rinkel, G.J., de Bakker, P.I., Ruigrok, Y.M., Genetic variants associated with type 2 diabetes and adiposity and risk of intracranial and abdominal aortic aneurysms. Eur. J. Hum. Genet., 2017.
9. Liu, Y., Li, Z., Zhang, M., Deng, Y., Yi, Z., Shi, T., Exploring the pathogenetic association between schizophrenia and type 2 diabetes mellitus diseases based on pathway analysis. BMC Med. Genomics, 2013 (6 Suppl 1, S17).
10. Manning, A.K., Hivert, M.F., Scott, R.A., Grimsby, J.L., Bouatia-Naji, N., Chen, H., Rybin, D., Liu, C.T., Bielak, L.F., Prokopenko, I., Amin, N., Barnes, D., Cadby, G., Hottenga, J.J., Ingelsson, E., Jackson, A.U., Johnson, T., Kanoni, S., Ladenvall, C., Lagou, V., Lahti, J., Lecoeur, C., Liu, Y., Martinez-Larrad, M.T., Montasser, M.E., Navarro, P., Perry, J.R., Rasmussen-Torvik, L.J., Salo, P., Sattar, N., Shungin, D., Strawbridge, R.J., Tanaka, T., van Duijn, C.M., An, P., de Andrade, M., Andrews, J.S., Aspelund, T., Atalay, M., Aulchenko, Y., Balkau, B., Bandinelli, S., Beckmann, J.S., Beilby, J.P., Bellis, C., Bergman, R.N., Blangero, J., Boban, M., Boehnke, M., Boerwinkle, E., Bonnycastle, L.L., Boomsma, D.I., Borecki, I.B., Bottcher, Y., Bouchard, C., Brunner, E., Budimir, D., Campbell, H., Carlson, O., Chines, P.S., Clarke, R., Collins, F.S., Corbaton-Anchuelo, A., Couper, D., de Faire, U., Dedoussis, G.V., Deloukas, P., Dimitriou, M., Egan, J.M., Eiriksdottir, G., Erdos, M.R., Eriksson, J.G., Eury, E., Ferrucci, L., Ford, I., Forouhi, N.G., Fox, C.S., Franzosi, M.G., Franks, P.W., Frayling, T.M., Froguel, P., Galan, P., de Geus, E., Gigante, B., Glazer, N.L., Goel, A., Groop, L., Gudnason, V., Hallmans, G., Hamsten, A., Hansson, O., Harris, T.B., Hayward, C., Heath, S., Hercberg, S., Hicks, A.A., Hingorani, A., Hofman, A., Hui, J., Hung, J., Jarvelin, M.R., Jhun, M.A., Johnson, P.C., Jukema, J.W., Jula, A., Kao, W.H., Kaprio, J., Kardia, S.L., Keinanen-Kiukaanniemi, S., Kivimaki, M., Kolcic, I., Kovacs, P., Kumari, M., Kuusisto, J., Kyvik, K.O., Laakso, M., Lakka, T., Lannfelt, L., Lathrop, G.M., Launer, L.J., Leander, K., Li, G., Lind, L., Lindstrom, J., Lobbens, S., Loos, R.J., Luan, J., Lyssenko, V., Magi, R., Magnusson, P.K., Marmot, M., Meneton, P., Mohlke, K.L., Mooser, V., Morken, M.A., Miljkovic, I., Narisu, N., O'Connell, J., Ong, K.K., Oostra, B.A., Palmer, L.J., Palotie, A., Pankow, J.S., Peden, J.F., Pedersen, N.L., Pehlic, M., Peltonen, L., Penninx, B., Pericic, M., Perola, M., Perusse, L., Peyser, P.A., Polasek, O., Pramstaller, P.P., Province, M.A., Raikkonen, K., Rauramaa, R., Rehnberg, E., Rice, K., Rotter, J.I., Rudan, I., Ruokonen, A., Saaristo, T., Sabater-Lleal, M., Salomaa, V., Savage, D.B., Saxena, R., Schwarz, P., Seedorf, U., Sennblad, B., Serrano-Rios, M., Shuldiner, A.R., Sijbrands, E.J., Siscovick, D.S., Smit, J.H., Small, K.S., Smith, N.L., Smith, A.V., Stancakova, A., Stirrups, K., Stumvoll, M., Sun, Y.V., Swift, A.J., Tonjes, A., Tuomilehto, J., Trompet, S., Uitterlinden, A.G., Uusitupa, M., Vikstrom, M., Vitart, V., Vohl, M.C., Voight, B.F., Vollenweider, P., Waeber, G., Waterworth, D.M., Watkins, H., Wheeler, E., Widen, E., Wild, S.H., Willems, S.M., Willemsen, G., Wilson, J.F., Witteman, J.C., Wright, A.F., Yaghootkar, H., Zelenika, D., Zemunik, T., Zgaga, L., Replication, D.I.G., Meta-analysis, C., Multiple Tissue Human Expression Resource, C., Wareham, N.J., McCarthy, M.I., Barroso, I., Watanabe, R.M., Florez, J.C., Dupuis, J., Meigs, J.B., Langenberg, C., 2012. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat. Genet. 44(6), 659–669.
11. Morris, A.P., Voight, B.F., Teslovich, T.M., Ferreira, T., Segre, A.V., Steinthorsdottir, V., Strawbridge, R.J., Khan, H., Grallert, H., Mahajan, A., Prokopenko, I., Kang, H.M., Dina, C., Esko, T., Fraser, R.M., Kanoni, S., Kumar, A., Lagou, V., Langenberg, C., Luan, J., Lindgren, C.M., Muller-Nurasyid, M., Pechlivanis, S., Rayner, N.W., Scott, L.J., Wiltshire, S., Yengo, L., Kinnunen, L., Rossin, E.J., Raychaudhuri, S., Johnson, A.D., Dimas, A.S., Loos, R.J., Vedantam, S., Chen, H., Florez, J.C., Fox, C., Liu, C.T., Rybin, D., Couper, D.J., Kao, W.H., Li, M., Cornelis, M.C., Kraft, P., Sun, Q., van Dam, R.M., Stringham, H.M., Chines, P.S., Fischer, K., Fontanillas, P., Holmen, O.L., Hunt, S.E., Jackson, A.U., Kong, A., Lawrence, R., Meyer, J., Perry, J.R., Platou, C.G., Potter, S., Rehnberg, E., Robertson, N., Sivapalaratnam, S., Stancakova, A., Stirrups, K., Thorleifsson, G., Tikkanen, E., Wood, A.R., Almgren, P., Atalay, M., Benediktsson, R., Bonnycastle, L.L., Burtt, N., Carey, J., Charpentier, G., Crenshaw, A.T., Doney, A.S., Dorkhan, M., Edkins, S., Emilsson, V., Eury, E., Forsen, T., Gertow, K., Gigante, B., Grant, G.B., Groves, C.J., Guiducci, C., Herder, C., Hreidarsson, A.B., Hui, J., James, A., Jonsson, A., Rathmann, W., Klopp, N., Kravic, J., Krjutskov, K., Langford, C., Leander, K., Lindholm, E., Lobbens, S., Mannisto, S., Mirza, G., Muhleisen, T.W., Musk, B., Parkin, M., Rallidis, L., Saramies, J., Sennblad, B., Shah, S., Sigurethsson, G., Silveira, A., Steinbach, G., Thorand, B., Trakalo, J., Veglia, F., Wennauer, R., Winckler, W., Zabaneh, D., Campbell, H., van Duijn, C., Uitterlinden, A.G., Hofman, A., Sijbrands, E., Abecasis, G.R., Owen, K.R., Zeggini, E., Trip, M.D., Forouhi, N.G., Syvanen, A.C., Eriksson, J.G., Peltonen, L., Nothen, M.M., Balkau, B., Palmer, C.N., Lyssenko, V., Tuomi, T., Isomaa, B., Hunter, D.J., Qi, L., Welcome Trust Case Control, C, Meta-Analyses of, G, Insulin-related traits Consortium, I, Genetic Investigation of, A.T.C, Asian Genetic Epidemiology Network-Type 2 Diabetes, C, South Asian Type 2 Diabetes, C, Shuldiner, A.R., Roden, M., Barroso, I., Wilsgaard, T., Beilby, J., Hovingh, K., Price, J.F., Wilson, J.F., Rauramaa, R., Lakka, T.A., Lind, L., Dedoussis, G., Njolstad, I., Pedersen, N.L., Khaw, K.T., Wareham, N.J., Keinanen-Kiukaanniemi, S.M., Saaristo, T.E., Korpi-Hyovalti, E., Saltevo, J., Laakso, M., Kuusisto, J., Metspalu, A., Collins, F.S., Mohlke, K.L., Bergman, R.N., Tuomilehto, J., Boehm, B.O., Gieger, C., Hveem, K., Cauchi, S., Froguel, P., Baldassarre, D., Tremoli, E., Humphries, S.E., Saleheen, D., Danesh, J., Ingelsson, E., Ripatti, S., Salomaa, V., Erbel, R., Jockel, K.H., Moebus, S., Peters, A., Illig, T., de Faire, U., Hamsten, A., Morris, A.D., Donnelly, P.J., Frayling, T.M., Hattersley, A.T., Boerwinkle, E., Melander, O., Kathiresan, S., Nilsson, P.M., Deloukas, P., Thorsteinsdottir, U., Groop, L.C., Stefansson, K., Hu, F., Pankow, J.S., Dupuis, J., Meigs, J.B., Altshuler, D., Boehnke, M., McCarthy, M.I., Replication, D.I.G., Meta-analysis, C, Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44:9 (2012), 981–990.
12. Padmanabhan, J.L., Nanda, P., Tandon, N., Mothi, S.S., Bolo, N., McCarroll, S., Clementz, B.A., Gershon, E.S., Pearlson, G.D., Sweeney, J.A., Tamminga, C.A., Keshavan, M.S., Polygenic risk for type 2 diabetes mellitus among individuals with psychosis and their relatives. J. Psychiatr. Res. 77 (2016), 52–58.
13. Pasaniuc, B., Price, A.L., Dissecting the genetics of complex traits using summary association statistics. Nat. Rev. Genet. 18:2 (2017), 117–127.
14. Perry, B.I., McIntosh, G., Weich, S., Singh, S., Rees, K., The association between first-episode psychosis and abnormal glycaemic control: systematic review and meta-analysis. Lancet Psychiatry 3:11 (2016), 1049–1058.
15. Pillinger, T., Beck, K., Gobjila, C., Donocik, J.G., Jauhar, S., Howes, O.D., Impaired glucose homeostasis in first-episode schizophrenia: a systematic review and meta-analysis. JAMA Psychiatry 74:3 (2017), 261–269.
16. Polimanti, R., Agrawal, A., Gelernter, J., Schizophrenia and substance use comorbidity: a genome-wide perspective. Genome Med., 9(1), 2017, 25.
17. Saxena, R., Hivert, M.F., Langenberg, C., Tanaka, T., Pankow, J.S., Vollenweider, P., Lyssenko, V., Bouatia-Naji, N., Dupuis, J., Jackson, A.U., Kao, W.H., Li, M., Glazer, N.L., Manning, A.K., Luan, J., Stringham, H.M., Prokopenko, I., Johnson, T., Grarup, N., Boesgaard, T.W., Lecoeur, C., Shrader, P., O'Connell, J., Ingelsson, E., Couper, D.J., Rice, K., Song, K., Andreasen, C.H., Dina, C., Kottgen, A., Le Bacquer, O., Pattou, F., Taneera, J., Steinthorsdottir, V., Rybin, D., Ardlie, K., Sampson, M., Qi, L., van Hoek, M., Weedon, M.N., Aulchenko, Y.S., Voight, B.F., Grallert, H., Balkau, B., Bergman, R.N., Bielinski, S.J., Bonnefond, A., Bonnycastle, L.L., Borch-Johnsen, K., Bottcher, Y., Brunner, E., Buchanan, T.A., Bumpstead, S.J., Cavalcanti-Proenca, C., Charpentier, G., Chen, Y.D., Chines, P.S., Collins, F.S., Cornelis, M., Delplanque, J., Doney, A., Egan, J.M., Erdos, M.R., Firmann, M., Forouhi, N.G., Fox, C.S., Goodarzi, M.O., Graessler, J., Hingorani, A., Isomaa, B., Jorgensen, T., Kivimaki, M., Kovacs, P., Krohn, K., Kumari, M., Lauritzen, T., Levy-Marchal, C., Mayor, V., McAteer, J.B., Meyre, D., Mitchell, B.D., Mohlke, K.L., Morken, M.A., Narisu, N., Palmer, C.N., Pakyz, R., Pascoe, L., Payne, F., Pearson, D., Rathmann, W., Sandbaek, A., Sayer, A.A., Scott, L.J., Sharp, S.J., Sijbrands, E., Singleton, A., Siscovick, D.S., Smith, N.L., Sparso, T., Swift, A.J., Syddall, H., Thorleifsson, G., Tonjes, A., Tuomi, T., Tuomilehto, J., Valle, T.T., Waeber, G., Walley, A., Waterworth, D.M., Zeggini, E., Zhao, J.H., Consortium, G., Investigators, M., Illig, T., Wichmann, H.E., Wilson, J.F., van Duijn, C., Hu, F.B., Morris, A.D., Frayling, T.M., Hattersley, A.T., Thorsteinsdottir, U., Stefansson, K., Nilsson, P., Syvanen, A.C., Shuldiner, A.R., Walker, M., Bornstein, S.R., Schwarz, P., Williams, G.H., Nathan, D.M., Kuusisto, J., Laakso, M., Cooper, C., Marmot, M., Ferrucci, L., Mooser, V., Stumvoll, M., Loos, R.J., Altshuler, D., Psaty, B.M., Rotter, J.I., Boerwinkle, E., Hansen, T., Pedersen, O., Florez, J.C., McCarthy, M.I., Boehnke, M., Barroso, I., Sladek, R., Froguel, P., Meigs, J.B., Groop, L., Wareham, N.J., Watanabe, R.M., 2010. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat. Genet. 42(2), 142–148.
18. Schizophrenia Working Group of the Psychiatric Genomics Consortium, Biological insights from 108 schizophrenia-associated genetic loci. Nature 511:7510 (2014), 421–427.
19. Soranzo, N., Sanna, S., Wheeler, E., Gieger, C., Radke, D., Dupuis, J., Bouatia-Naji, N., Langenberg, C., Prokopenko, I., Stolerman, E., Sandhu, M.S., Heeney, M.M., Devaney, J.M., Reilly, M.P., Ricketts, S.L., Stewart, A.F., Voight, B.F., Willenborg, C., Wright, B., Altshuler, D., Arking, D., Balkau, B., Barnes, D., Boerwinkle, E., Bohm, B., Bonnefond, A., Bonnycastle, L.L., Boomsma, D.I., Bornstein, S.R., Bottcher, Y., Bumpstead, S., Burnett-Miller, M.S., Campbell, H., Cao, A., Chambers, J., Clark, R., Collins, F.S., Coresh, J., de Geus, E.J., Dei, M., Deloukas, P., Doring, A., Egan, J.M., Elosua, R., Ferrucci, L., Forouhi, N., Fox, C.S., Franklin, C., Franzosi, M.G., Gallina, S., Goel, A., Graessler, J., Grallert, H., Greinacher, A., Hadley, D., Hall, A., Hamsten, A., Hayward, C., Heath, S., Herder, C., Homuth, G., Hottenga, J.J., Hunter-Merrill, R., Illig, T., Jackson, A.U., Jula, A., Kleber, M., Knouff, C.W., Kong, A., Kooner, J., Kottgen, A., Kovacs, P., Krohn, K., Kuhnel, B., Kuusisto, J., Laakso, M., Lathrop, M., Lecoeur, C., Li, M., Li, M., Loos, R.J., Luan, J., Lyssenko, V., Magi, R., Magnusson, P.K., Malarstig, A., Mangino, M., Martinez-Larrad, M.T., Marz, W., McArdle, W.L., McPherson, R., Meisinger, C., Meitinger, T., Melander, O., Mohlke, K.L., Mooser, V.E., Morken, M.A., Narisu, N., Nathan, D.M., Nauck, M., O'Donnell, C., Oexle, K., Olla, N., Pankow, J.S., Payne, F., Peden, J.F., Pedersen, N.L., Peltonen, L., Perola, M., Polasek, O., Porcu, E., Rader, D.J., Rathmann, W., Ripatti, S., Rocheleau, G., Roden, M., Rudan, I., Salomaa, V., Saxena, R., Schlessinger, D., Schunkert, H., Schwarz, P., Seedorf, U., Selvin, E., Serrano-Rios, M., Shrader, P., Silveira, A., Siscovick, D., Song, K., Spector, T.D., Stefansson, K., Steinthorsdottir, V., Strachan, D.P., Strawbridge, R., Stumvoll, M., Surakka, I., Swift, A.J., Tanaka, T., Teumer, A., Thorleifsson, G., Thorsteinsdottir, U., Tonjes, A., Usala, G., Vitart, V., Volzke, H., Wallaschofski, H., Waterworth, D.M., Watkins, H., Wichmann, H.E., Wild, S.H., Willemsen, G., Williams, G.H., Wilson, J.F., Winkelmann, J., Wright, A.F., Zabena, C., Zhao, J.H., Epstein, S.E., Erdmann, J., Hakonarson, H.H., Kathiresan, S., Khaw, K.T., Roberts, R., Samani, N.J., Fleming, M.D., Sladek, R., Abecasis, G., Boehnke, M., Froguel, P., Groop, L., McCarthy, M.I., Kao, W.H., Florez, J.C., Uda, M., Wareham, N.J., Barroso, I., Meigs, J.B., 2010. Common variants at 10 genomic loci influence hemoglobin A(1)(C) levels via glycemic and nonglycemic pathways. Diabetes 59(12), 3229–3239.
20. Steiner, J., Berger, M., Guest, P.C., et al. Assessment of insulin resistance among drug-naive patients with first-episode schizophrenia in the context of hormonal stress axis activation. JAMA Psychiatry, 2017.
21. Strawbridge, R.J., Dupuis, J., Prokopenko, I., Barker, A., Ahlqvist, E., Rybin, D., Petrie, J.R., Travers, M.E., Bouatia-Naji, N., Dimas, A.S., Nica, A., Wheeler, E., Chen, H., Voight, B.F., Taneera, J., Kanoni, S., Peden, J.F., Turrini, F., Gustafsson, S., Zabena, C., Almgren, P., Barker, D.J., Barnes, D., Dennison, E.M., Eriksson, J.G., Eriksson, P., Eury, E., Folkersen, L., Fox, C.S., Frayling, T.M., Goel, A., Gu, H.F., Horikoshi, M., Isomaa, B., Jackson, A.U., Jameson, K.A., Kajantie, E., Kerr-Conte, J., Kuulasmaa, T., Kuusisto, J., Loos, R.J., Luan, J., Makrilakis, K., Manning, A.K., Martinez-Larrad, M.T., Narisu, N., Nastase Mannila, M., Ohrvik, J., Osmond, C., Pascoe, L., Payne, F., Sayer, A.A., Sennblad, B., Silveira, A., Stancakova, A., Stirrups, K., Swift, A.J., Syvanen, A.C., Tuomi, T., van't Hooft, F.M., Walker, M., Weedon, M.N., Xie, W., Zethelius, B., Consortium, D., Consortium, G., Mu, T.C., Consortium, C.A., Consortium, C.D., Ongen, H., Malarstig, A., Hopewell, J.C., Saleheen, D., Chambers, J., Parish, S., Danesh, J., Kooner, J., Ostenson, C.G., Lind, L., Cooper, C.C., Serrano-Rios, M., Ferrannini, E., Forsen, T.J., Clarke, R., Franzosi, M.G., Seedorf, U., Watkins, H., Froguel, P., Johnson, P., Deloukas, P., Collins, F.S., Laakso, M., Dermitzakis, E.T., Boehnke, M., McCarthy, M.I., Wareham, N.J., Groop, L., Pattou, F., Gloyn, A.L., Dedoussis, G.V., Lyssenko, V., Meigs, J.B., Barroso, I., Watanabe, R.M., Ingelsson, E., Langenberg, C., Hamsten, A., Florez, J.C., Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 60:10 (2011), 2624–2634.
22. Wang, Q., Polimanti, R., Kranzler, H.R., Farrer, L.A., Zhao, H., Gelernter, J., Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions. Hum. Genet. 136:1 (2017), 75–83.
23. Zheng, J., Erzurumluoglu, A.M., Elsworth, B.L., Kemp, J.P., Howe, L., Haycock, P.C., Hemani, G., Tansey, K., Laurin, C., Early, G., Lifecourse Epidemiology Eczema, C., Pourcain, B.S., Warrington, N.M., Finucane, H.K., Price, A.L., Bulik-Sullivan, B.K., Anttila, V., Paternoster, L., Gaunt, T.R., Evans, D.M., Neale, B.M., LD hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics 33:2 (2017), 272–279.