메뉴 건너뛰기




Volumn 5, Issue 11, 2016, Pages

Lipid-free Apolipoprotein A-I Reduces Progression of Atherosclerosis by Mobilizing Microdomain Cholesterol and Attenuating the Number of CD131 Expressing Cells: Monitoring Cholesterol Homeostasis Using the Cellular Ester to Total Cholesterol Ratio

Author keywords

Apolipoprotein; Apolipoprotein A I; Cholesterol; Chronic inflammation; High density lipoprotein; Inflammation; Lipid rafts; Microdomains; Signaling pathways

Indexed keywords

APOLIPOPROTEIN A1; CD131 ANTIGEN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 3 RECEPTOR; CHOLESTEROL ESTER; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

EID: 85032586305     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.116.004401     Document Type: Article
Times cited : (20)

References (102)
  • 2
    • 79955476272 scopus 로고    scopus 로고
    • Novel HDL-directed pharmacotherapeutic strategies
    • Degoma EM, Rader DJ. Novel HDL-directed pharmacotherapeutic strategies. Nat Rev Cardiol. 2011;8:266-277.
    • (2011) Nat Rev Cardiol. , vol.8 , pp. 266-277
    • Degoma, E.M.1    Rader, D.J.2
  • 4
    • 84959569935 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein inhibition is not yet deadpro
    • Barter PJ, Rye KA. Cholesteryl ester transfer protein inhibition is not yet deadpro. Arterioscler Thromb Vasc Biol. 2016;36:439-441.
    • (2016) Arterioscler Thromb Vasc Biol. , vol.36 , pp. 439-441
    • Barter, P.J.1    Rye, K.A.2
  • 5
    • 84942879192 scopus 로고    scopus 로고
    • Small HDL promotes cholesterol efflux by the ABCA1 pathway in macrophages: implications for therapies targeted to HDL
    • Heinecke JW. Small HDL promotes cholesterol efflux by the ABCA1 pathway in macrophages: implications for therapies targeted to HDL. Circ Res. 2015;116:1101-1103.
    • (2015) Circ Res. , vol.116 , pp. 1101-1103
    • Heinecke, J.W.1
  • 7
    • 84952639394 scopus 로고    scopus 로고
    • Novel pathways of apolipoprotein A-I metabolism in high-density lipoprotein of different sizes in humans
    • Mendivil CO, Furtado J, Morton AM, Wang L, Sacks FM. Novel pathways of apolipoprotein A-I metabolism in high-density lipoprotein of different sizes in humans. Arterioscler Thromb Vasc Biol. 2016;36:156-165.
    • (2016) Arterioscler Thromb Vasc Biol. , vol.36 , pp. 156-165
    • Mendivil, C.O.1    Furtado, J.2    Morton, A.M.3    Wang, L.4    Sacks, F.M.5
  • 8
    • 84956839034 scopus 로고    scopus 로고
    • ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis
    • Yamauchi Y, Yokoyama S, Chang TY. ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis. J Lipid Res. 2016;57:77-88.
    • (2016) J Lipid Res. , vol.57 , pp. 77-88
    • Yamauchi, Y.1    Yokoyama, S.2    Chang, T.Y.3
  • 9
    • 84906242912 scopus 로고    scopus 로고
    • HDL and cardiovascular disease
    • Rader DJ, Hovingh GK. HDL and cardiovascular disease. Lancet. 2014;384:618-625.
    • (2014) Lancet. , vol.384 , pp. 618-625
    • Rader, D.J.1    Hovingh, G.K.2
  • 11
    • 84924116950 scopus 로고    scopus 로고
    • High density lipoproteins: measurement techniques and potential biomarkers of cardiovascular risk
    • Hafiane A, Genest J. High density lipoproteins: measurement techniques and potential biomarkers of cardiovascular risk. BBA Clin. 2015;3:175-188.
    • (2015) BBA Clin. , vol.3 , pp. 175-188
    • Hafiane, A.1    Genest, J.2
  • 13
    • 84988715284 scopus 로고    scopus 로고
    • Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL
    • Hutchins PM, Heinecke JW. Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL. Curr Opin Lipidol. 2015;26:388-393.
    • (2015) Curr Opin Lipidol. , vol.26 , pp. 388-393
    • Hutchins, P.M.1    Heinecke, J.W.2
  • 16
    • 84892938632 scopus 로고    scopus 로고
    • High-density lipoprotein and atherosclerosis regression: evidence from preclinical and clinical studies
    • Feig JE, Hewing B, Smith JD, Hazen SL, Fisher EA. High-density lipoprotein and atherosclerosis regression: evidence from preclinical and clinical studies. Circ Res. 2014;114:205-213.
    • (2014) Circ Res. , vol.114 , pp. 205-213
    • Feig, J.E.1    Hewing, B.2    Smith, J.D.3    Hazen, S.L.4    Fisher, E.A.5
  • 18
    • 77950894330 scopus 로고    scopus 로고
    • The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages
    • de la Llera-Moya M, Drazul-Schrader D, Asztalos BF, Cuchel M, Rader DJ, Rothblat GH. The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages. Arterioscler Thromb Vasc Biol. 2010;30:796-801.
    • (2010) Arterioscler Thromb Vasc Biol. , vol.30 , pp. 796-801
    • de la Llera-Moya, M.1    Drazul-Schrader, D.2    Asztalos, B.F.3    Cuchel, M.4    Rader, D.J.5    Rothblat, G.H.6
  • 21
    • 70350362707 scopus 로고    scopus 로고
    • Lipoproteomics: using mass spectrometrybased proteomics to explore the assembly, structure, and function of lipoproteins
    • Hoofnagle AN, Heinecke JW. Lipoproteomics: using mass spectrometrybased proteomics to explore the assembly, structure, and function of lipoproteins. J Lipid Res. 2009;50:1967-1975.
    • (2009) J Lipid Res. , vol.50 , pp. 1967-1975
    • Hoofnagle, A.N.1    Heinecke, J.W.2
  • 22
    • 84964370968 scopus 로고    scopus 로고
    • Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway
    • Pamir N, Hutchins P, Ronsein G, Vaisar T, Reardon CA, Getz GS, Lusis AJ, Heinecke JW. Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway. J Lipid Res. 2016;57:246-257.
    • (2016) J Lipid Res. , vol.57 , pp. 246-257
    • Pamir, N.1    Hutchins, P.2    Ronsein, G.3    Vaisar, T.4    Reardon, C.A.5    Getz, G.S.6    Lusis, A.J.7    Heinecke, J.W.8
  • 24
    • 0036234218 scopus 로고    scopus 로고
    • The effects of altered apolipoprotein A-I structure on plasma HDL concentration
    • Sorci-Thomas MG, Thomas MJ. The effects of altered apolipoprotein A-I structure on plasma HDL concentration. Trends Cardiovasc Med. 2002;12:121-128.
    • (2002) Trends Cardiovasc Med. , vol.12 , pp. 121-128
    • Sorci-Thomas, M.G.1    Thomas, M.J.2
  • 25
    • 84884671413 scopus 로고    scopus 로고
    • Why targeting HDL should work as a therapeutic tool, but has not
    • Sorci-Thomas MG, Thomas MJ. Why targeting HDL should work as a therapeutic tool, but has not. J Cardiovasc Pharmacol. 2013;62:239-246.
    • (2013) J Cardiovasc Pharmacol. , vol.62 , pp. 239-246
    • Sorci-Thomas, M.G.1    Thomas, M.J.2
  • 26
    • 84959058398 scopus 로고    scopus 로고
    • Microdomains, inflammation, and atherosclerosis
    • Sorci-Thomas MG, Thomas MJ. Microdomains, inflammation, and atherosclerosis. Circ Res. 2016;118:679-691.
    • (2016) Circ Res. , vol.118 , pp. 679-691
    • Sorci-Thomas, M.G.1    Thomas, M.J.2
  • 28
    • 0025322265 scopus 로고
    • Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit
    • Badimon JJ, Badimon L, Fuster V. Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit. J Clin Invest. 1990;85:1234-1241.
    • (1990) J Clin Invest. , vol.85 , pp. 1234-1241
    • Badimon, J.J.1    Badimon, L.2    Fuster, V.3
  • 35
    • 84937690175 scopus 로고    scopus 로고
    • Incubation of MDCO-216 (Apoa- Imilano/POPC) with human serum potentiates ABCA1-mediated cholesterol efflux capacity, generates new prebeta-1 HDL, and causes an increase in HDL size
    • Kempen HJ, Schranz DB, Asztalos BF, Otvos J, Jeyarajah E, Drazul-Schrader D, Collins HL, Adelman SJ, Wijngaard PL. Incubation of MDCO-216 (Apoa- Imilano/POPC) with human serum potentiates ABCA1-mediated cholesterol efflux capacity, generates new prebeta-1 HDL, and causes an increase in HDL size. J Lipids. 2014;2014:923903.
    • (2014) J Lipids. , vol.2014 , pp. 923903
    • Kempen, H.J.1    Schranz, D.B.2    Asztalos, B.F.3    Otvos, J.4    Jeyarajah, E.5    Drazul-Schrader, D.6    Collins, H.L.7    Adelman, S.J.8    Wijngaard, P.L.9
  • 36
    • 84959223562 scopus 로고    scopus 로고
    • High-density lipoprotein subfractions and cholesterol efflux capacities after infusion of MDCO-216 (apolipoprotein A-IMilano/ palmitoyl-oleoyl-phosphatidylcholine) in healthy volunteers and stable coronary artery disease patients
    • Kempen HJ, Asztalos BF, Moerland M, Jeyarajah E, Otvos J, Kallend DG, Bellibas SE, Wijngaard PL. High-density lipoprotein subfractions and cholesterol efflux capacities after infusion of MDCO-216 (apolipoprotein A-IMilano/ palmitoyl-oleoyl-phosphatidylcholine) in healthy volunteers and stable coronary artery disease patients. Arterioscler Thromb Vasc Biol. 2016;36:736- 742.
    • (2016) Arterioscler Thromb Vasc Biol. , vol.36 , pp. 736- 742
    • Kempen, H.J.1    Asztalos, B.F.2    Moerland, M.3    Jeyarajah, E.4    Otvos, J.5    Kallend, D.G.6    Bellibas, S.E.7    Wijngaard, P.L.8
  • 38
  • 48
    • 33646692002 scopus 로고    scopus 로고
    • Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
    • Galkina E, Kadl A, Sanders J, Varughese D, Sarembock IJ, Ley K. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med. 2006;203:1273-1282.
    • (2006) J Exp Med. , vol.203 , pp. 1273-1282
    • Galkina, E.1    Kadl, A.2    Sanders, J.3    Varughese, D.4    Sarembock, I.J.5    Ley, K.6
  • 49
    • 0028091785 scopus 로고
    • Regional adiposity and morbidity
    • Kissebah AH, Krakower GR. Regional adiposity and morbidity. Physiol Rev. 1994;74:761-811.
    • (1994) Physiol Rev. , vol.74 , pp. 761-811
    • Kissebah, A.H.1    Krakower, G.R.2
  • 51
    • 0022504130 scopus 로고
    • Measurement of total HDL, HDL2 and HDL3 by dextran sulfate-MgCl2 precipitation technique in human serum
    • Talameh Y, Wei R, Naito H. Measurement of total HDL, HDL2 and HDL3 by dextran sulfate-MgCl2 precipitation technique in human serum. Clin Chim Acta. 1986;158:33-41.
    • (1986) Clin Chim Acta. , vol.158 , pp. 33-41
    • Talameh, Y.1    Wei, R.2    Naito, H.3
  • 53
    • 51649179265 scopus 로고
    • Quantitative analysis of phospholipids by thin-layer chromatography and phosphorus analysis of spots
    • Rouser G, Siakotos AN, Fleischer S. Quantitative analysis of phospholipids by thin-layer chromatography and phosphorus analysis of spots. Lipids. 1966;1:85-86.
    • (1966) Lipids. , vol.1 , pp. 85-86
    • Rouser, G.1    Siakotos, A.N.2    Fleischer, S.3
  • 55
  • 58
    • 41649100060 scopus 로고    scopus 로고
    • Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice
    • Combadiere C, Potteaux S, Rodero M, Simon T, Pezard A, Esposito B, Merval R, Proudfoot A, Tedgui A, Mallat Z. Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice. Circulation. 2008;117:1649-1657.
    • (2008) Circulation. , vol.117 , pp. 1649-1657
    • Combadiere, C.1    Potteaux, S.2    Rodero, M.3    Simon, T.4    Pezard, A.5    Esposito, B.6    Merval, R.7    Proudfoot, A.8    Tedgui, A.9    Mallat, Z.10
  • 60
    • 84899621125 scopus 로고    scopus 로고
    • Interleukin-3/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency
    • Wang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I, Westerterp M, Tall AR. Interleukin-3/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency. Arterioscler Thromb Vasc Biol. 2014;34: 976-984.
    • (2014) Arterioscler Thromb Vasc Biol. , vol.34 , pp. 976-984
    • Wang, M.1    Subramanian, M.2    Abramowicz, S.3    Murphy, A.J.4    Gonen, A.5    Witztum, J.6    Welch, C.7    Tabas, I.8    Westerterp, M.9    Tall, A.R.10
  • 61
    • 84918784751 scopus 로고    scopus 로고
    • Cholesterol efflux pathways regulate myelopoiesis: a potential link to altered macrophage function in atherosclerosis
    • Murphy AJ, Dragoljevic D, Tall AR. Cholesterol efflux pathways regulate myelopoiesis: a potential link to altered macrophage function in atherosclerosis. Front Immunol. 2014;5:490.
    • (2014) Front Immunol. , vol.5 , pp. 490
    • Murphy, A.J.1    Dragoljevic, D.2    Tall, A.R.3
  • 63
    • 84875276500 scopus 로고    scopus 로고
    • Hypercholesterolemia links hematopoiesis with atherosclerosis
    • Soehnlein O, Swirski FK. Hypercholesterolemia links hematopoiesis with atherosclerosis. Trends Endocrinol Metab. 2013;24:129-136.
    • (2013) Trends Endocrinol Metab. , vol.24 , pp. 129-136
    • Soehnlein, O.1    Swirski, F.K.2
  • 65
    • 84873814446 scopus 로고    scopus 로고
    • Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs
    • Subramanian M, Thorp E, Hansson GK, Tabas I. Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs. J Clin Invest. 2013;123:179-188.
    • (2013) J Clin Invest. , vol.123 , pp. 179-188
    • Subramanian, M.1    Thorp, E.2    Hansson, G.K.3    Tabas, I.4
  • 66
    • 84900841713 scopus 로고    scopus 로고
    • Adaptive (T and B cells) immunity and control by dendritic cells in atherosclerosis
    • Ait-Oufella H, Sage AP, Mallat Z, Tedgui A. Adaptive (T and B cells) immunity and control by dendritic cells in atherosclerosis. Circ Res. 2014;114:1640- 1660.
    • (2014) Circ Res. , vol.114 , pp. 1640- 1660
    • Ait-Oufella, H.1    Sage, A.P.2    Mallat, Z.3    Tedgui, A.4
  • 67
    • 84899440659 scopus 로고    scopus 로고
    • Differential transmembrane domain GXXXG motif pairing impacts major histocompatibility complex (MHC) class II structure
    • Dixon AM, Drake L, Hughes KT, Sargent E, Hunt D, Harton JA, Drake JR. Differential transmembrane domain GXXXG motif pairing impacts major histocompatibility complex (MHC) class II structure. J Biol Chem. 2014;289:11695-11703.
    • (2014) J Biol Chem. , vol.289 , pp. 11695-11703
    • Dixon, A.M.1    Drake, L.2    Hughes, K.T.3    Sargent, E.4    Hunt, D.5    Harton, J.A.6    Drake, J.R.7
  • 68
    • 84923212055 scopus 로고    scopus 로고
    • MHC class II association with lipid rafts on the antigen presenting cell surface
    • Anderson HA, Roche PA. MHC class II association with lipid rafts on the antigen presenting cell surface. Biochim Biophys Acta. 2015;1853:775- 780.
    • (2015) Biochim Biophys Acta. , vol.1853 , pp. 775- 780
    • Anderson, H.A.1    Roche, P.A.2
  • 69
    • 72449193255 scopus 로고    scopus 로고
    • Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments
    • Jelinek D, Patrick SM, Kitt KN, Chan T, Francis GA, Garver WS. Physiological and coordinate downregulation of the NPC1 and NPC2 genes are associated with the sequestration of LDL-derived cholesterol within endocytic compartments. J Cell Biochem. 2009;108:1102-1116.
    • (2009) J Cell Biochem. , vol.108 , pp. 1102-1116
    • Jelinek, D.1    Patrick, S.M.2    Kitt, K.N.3    Chan, T.4    Francis, G.A.5    Garver, W.S.6
  • 70
    • 84949793837 scopus 로고    scopus 로고
    • Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism
    • Dubland JA, Francis GA. Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism. Front Cell Dev Biol. 2015;3:3.
    • (2015) Front Cell Dev Biol. , vol.3 , pp. 3
    • Dubland, J.A.1    Francis, G.A.2
  • 71
    • 84858279956 scopus 로고    scopus 로고
    • Early steps in reverse cholesterol transport: cholesteryl ester hydrolase and other hydrolases
    • Ghosh S. Early steps in reverse cholesterol transport: cholesteryl ester hydrolase and other hydrolases. Curr Opin Endocrinol Diabetes Obes. 2012;19:136-141.
    • (2012) Curr Opin Endocrinol Diabetes Obes. , vol.19 , pp. 136-141
    • Ghosh, S.1
  • 72
    • 79953239845 scopus 로고    scopus 로고
    • Macrophage cholesterol homeostasis and metabolic diseases: critical role of cholesteryl ester mobilization
    • Ghosh S. Macrophage cholesterol homeostasis and metabolic diseases: critical role of cholesteryl ester mobilization. Expert Rev Cardiovasc Ther. 2011;9:329-340.
    • (2011) Expert Rev Cardiovasc Ther. , vol.9 , pp. 329-340
    • Ghosh, S.1
  • 73
    • 84886797808 scopus 로고    scopus 로고
    • Macrophages in atherosclerosis: a dynamic balance
    • Moore KJ, Sheedy FJ, Fisher EA. Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol. 2013;13:709-721.
    • (2013) Nat Rev Immunol. , vol.13 , pp. 709-721
    • Moore, K.J.1    Sheedy, F.J.2    Fisher, E.A.3
  • 74
    • 84919346988 scopus 로고    scopus 로고
    • The human ABCG1 transporter mobilizes plasma membrane and late endosomal non-sphingomyelin-associated-cholesterol for efflux and esterification
    • Neufeld EB, O'Brien K, Walts AD, Stonik JA, Malide D, Combs CA, Remaley AT. The human ABCG1 transporter mobilizes plasma membrane and late endosomal non-sphingomyelin-associated-cholesterol for efflux and esterification. Biology (Basel). 2014;3:866-891.
    • (2014) Biology (Basel). , vol.3 , pp. 866-891
    • Neufeld, E.B.1    O'Brien, K.2    Walts, A.D.3    Stonik, J.A.4    Malide, D.5    Combs, C.A.6    Remaley, A.T.7
  • 75
    • 84938335974 scopus 로고    scopus 로고
    • LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling
    • Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife. 2015;4: e08009.
    • (2015) Elife. , vol.4
    • Ito, A.1    Hong, C.2    Rong, X.3    Zhu, X.4    Tarling, E.J.5    Hedde, P.N.6    Gratton, E.7    Parks, J.8    Tontonoz, P.9
  • 77
    • 84870051440 scopus 로고    scopus 로고
    • ABCA1 protein enhances Toll-like receptor 4 (TLR4)-stimulated interleukin-10 (IL-10) secretion through protein kinase a (PKA) activation
    • Ma L, Dong F, Zaid M, Kumar A, Zha X. ABCA1 protein enhances Toll-like receptor 4 (TLR4)-stimulated interleukin-10 (IL-10) secretion through protein kinase a (PKA) activation. J Biol Chem. 2012;287:40502-40512.
    • (2012) J Biol Chem. , vol.287 , pp. 40502-40512
    • Ma, L.1    Dong, F.2    Zaid, M.3    Kumar, A.4    Zha, X.5
  • 78
    • 84857636796 scopus 로고    scopus 로고
    • Regulation of ABCA1 functions by signaling pathways
    • Liu Y, Tang C. Regulation of ABCA1 functions by signaling pathways. Biochim Biophys Acta. 2012;1821:522-529.
    • (2012) Biochim Biophys Acta. , vol.1821 , pp. 522-529
    • Liu, Y.1    Tang, C.2
  • 79
    • 84867907667 scopus 로고    scopus 로고
    • Apolipoprotein A-I inhibits CD40 proinflammatory signaling via ATPbinding cassette transporter A1-mediated modulation of lipid raft in macrophages
    • Yin K, Chen WJ, Zhou ZG, Zhao GJ, Lv YC, Ouyang XP, Yu XH, Fu Y, Jiang ZS, Tang CK. Apolipoprotein A-I inhibits CD40 proinflammatory signaling via ATPbinding cassette transporter A1-mediated modulation of lipid raft in macrophages. J Atheroscler Thromb. 2012;19:823-836.
    • (2012) J Atheroscler Thromb. , vol.19 , pp. 823-836
    • Yin, K.1    Chen, W.J.2    Zhou, Z.G.3    Zhao, G.J.4    Lv, Y.C.5    Ouyang, X.P.6    Yu, X.H.7    Fu, Y.8    Jiang, Z.S.9    Tang, C.K.10
  • 80
    • 84912034512 scopus 로고    scopus 로고
    • AKT inhibition promotes ABCA1- mediated cholesterol efflux to ApoA-I through suppressing mTORC1
    • Dong F, Mo Z, Eid W, Courtney KC, Zha X. AKT inhibition promotes ABCA1- mediated cholesterol efflux to ApoA-I through suppressing mTORC1. PLoS One. 2014;9:e113789.
    • (2014) PLoS One. , vol.9
    • Dong, F.1    Mo, Z.2    Eid, W.3    Courtney, K.C.4    Zha, X.5
  • 82
    • 84919663377 scopus 로고    scopus 로고
    • Signal transduction by HDL: agonists, receptors, and signaling cascades
    • Nofer JR. Signal transduction by HDL: agonists, receptors, and signaling cascades. Handb Exp Pharmacol. 2015;224:229-256.
    • (2015) Handb Exp Pharmacol. , vol.224 , pp. 229-256
    • Nofer, J.R.1
  • 84
    • 33845971925 scopus 로고    scopus 로고
    • ATP-binding cassette transporter A1 expression disrupts raft membrane microdomains through its ATPase-related functions
    • Landry YD, Denis M, Nandi S, Bell S, Vaughan AM, Zha X. ATP-binding cassette transporter A1 expression disrupts raft membrane microdomains through its ATPase-related functions. J Biol Chem. 2006;281:36091- 36101.
    • (2006) J Biol Chem. , vol.281 , pp. 36091- 36101
    • Landry, Y.D.1    Denis, M.2    Nandi, S.3    Bell, S.4    Vaughan, A.M.5    Zha, X.6
  • 86
    • 84896751585 scopus 로고    scopus 로고
    • Lymphatic transport of high-density lipoproteins and chylomicrons
    • Randolph GJ, Miller NE. Lymphatic transport of high-density lipoproteins and chylomicrons. J Clin Invest. 2014;124:929-935.
    • (2014) J Clin Invest. , vol.124 , pp. 929-935
    • Randolph, G.J.1    Miller, N.E.2
  • 87
    • 84871865547 scopus 로고    scopus 로고
    • High density lipoprotein biogenesis, cholesterol efflux, and immune cell function
    • Sorci-Thomas MG, Thomas MJ. High density lipoprotein biogenesis, cholesterol efflux, and immune cell function. Arterioscler Thromb Vasc Biol. 2012;32:2561-2565.
    • (2012) Arterioscler Thromb Vasc Biol. , vol.32 , pp. 2561-2565
    • Sorci-Thomas, M.G.1    Thomas, M.J.2
  • 88
    • 84901404011 scopus 로고    scopus 로고
    • Mechanisms that regulate macrophage burden in atherosclerosis
    • Randolph GJ. Mechanisms that regulate macrophage burden in atherosclerosis. Circ Res. 2014;114:1757-1771.
    • (2014) Circ Res. , vol.114 , pp. 1757-1771
    • Randolph, G.J.1
  • 89
    • 79952736069 scopus 로고    scopus 로고
    • Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques
    • Feig JE, Parathath S, Rong JX, Mick SL, Vengrenyuk Y, Grauer L, Young SG, Fisher EA. Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation. 2011;123:989-998.
    • (2011) Circulation. , vol.123 , pp. 989-998
    • Feig, J.E.1    Parathath, S.2    Rong, J.X.3    Mick, S.L.4    Vengrenyuk, Y.5    Grauer, L.6    Young, S.G.7    Fisher, E.A.8
  • 93
    • 41349087302 scopus 로고    scopus 로고
    • Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts
    • Moretti S, Procopio A, Lazzarini R, Rippo MR, Testa R, Marra M, Tamagnone L, Catalano A. Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts. Blood. 2008;111:2290-2299.
    • (2008) Blood. , vol.111 , pp. 2290-2299
    • Moretti, S.1    Procopio, A.2    Lazzarini, R.3    Rippo, M.R.4    Testa, R.5    Marra, M.6    Tamagnone, L.7    Catalano, A.8
  • 95
    • 49049122021 scopus 로고    scopus 로고
    • Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H
    • Maisse C, Rossin A, Cahuzac N, Paradisi A, Klein C, Haillot ML, Herincs Z, Mehlen P, Hueber AO. Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H. Exp Cell Res. 2008;314:2544-2552.
    • (2008) Exp Cell Res. , vol.314 , pp. 2544-2552
    • Maisse, C.1    Rossin, A.2    Cahuzac, N.3    Paradisi, A.4    Klein, C.5    Haillot, M.L.6    Herincs, Z.7    Mehlen, P.8    Hueber, A.O.9
  • 99
    • 84872166189 scopus 로고    scopus 로고
    • Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure
    • Swirski FK, Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. 2013;339:161-166.
    • (2013) Science. , vol.339 , pp. 161-166
    • Swirski, F.K.1    Nahrendorf, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.