Roles of TRIM32 in Corneal Epithelial Cells after Infection with Herpes Simplex Virus

Cellular Physiology and Biochemistry

Volumn 43, Issue 2, 2017, Pages 801-811

  Cui, Hao ^a,b   Liu, Ying ^a,c   Huang, Yifei ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b Harbin 242 Hospital   (China)

^c JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Corneal epithelial cells; Herpes Simplex Virus; In vitro; In vivo; Trim32

Indexed keywords

BETA INTERFERON; CELL PROTEIN; INTERFERON REGULATORY FACTOR 3; TRIM32 PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE; POLYUBIQUITIN; TRANSCRIPTION FACTOR; TRIM32 PROTEIN, HUMAN; TRIM32 PROTEIN, MOUSE; TRIPARTITE MOTIF PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORNEAL EPITHELIAL CELL; CYTOKINE PRODUCTION; DOWN REGULATION; EPITHELIUM CELL; FEMALE; HERPES SIMPLEX; HERPETIC STROMAL KERATITIS; HUMAN; HUMAN ALPHAHERPESVIRUS 1; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KERATITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UBIQUITINATION; UPREGULATION; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; CELL LINE; CORNEA; GENETICS; HERPES SIMPLEX KERATITIS; METABOLISM; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

ANIMALS; CELL LINE; CORNEA; DOWN-REGULATION; FEMALE; HERPESVIRUS 1, HUMAN; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; KERATITIS, HERPETIC; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; POLYUBIQUITIN; TRANSCRIPTION FACTORS; TRIPARTITE MOTIF PROTEINS; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

EID: 85032493349     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000481563     Document Type: Article

References (41)

1. Xu F, Schillinger JA, Sternberg MR, Johnson RE, Lee FK, Nahmias AJ, Markowitz LE: Seroprevalence and coinfection with herpes simplex virus type 1 and type 2 in the United States, 1988-1994 J Infect Dis 2002;185:1019-1024.
2. Biswas PS, Rouse BT: Early events in HSV keratitis - setting the stage for a blinding disease. Microbes Infect 2005;7:799-810.
3. Bonini S, Rama P, Olzi D, Lambiase A: Neurotrophic keratitis. Eye (Lond) 2003;17:989-995.
4. Conrady CD, Zheng M, Fitzgerald KA., Liu C. Carr DJJ: Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16 Mucosal Immunol 2012;5:173-183.
5. Inoue, Y: Immunological aspects of herpetic stromal keratitis. Semin Ophthalmol 2008; 23:221-227.
6. Stetson DB, Medzhitov R: Type I interferons in host defense. Immunity 2006;25:373-381.
7. Wang BX, Fish EN: The yin and yang of viruses and interferons. Trends Immunol 2012;33:190-197.
8. Arpaia N, Barton GM: Toll-like receptors: key players in antiviral immunity. Curr Opin Virol 2011;1:447-454.
9. Luecke S, Paludan SR: Chapter Two-Innate Recognition of Alphaherpesvirus DNA. Adv Virus Res 2015;92: 63-100.
10. Barber GN: Cytoplasmic DNA innate immune pathways. Immunol Rev 2011;243:99-108.
11. Ishikawa H, Barber GN: STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008;455:674-678.
12. Ishikawa H, Ma Z, Barber GN: STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009;461:788-792.
13. Abe T, Harashima A, Xia T, Konno H, Konno K, Morales A, Ahn J, Gutman D, Barber GN: STING recognition of cytoplasmic DNA instigates cellular defense. Mol Cell 2013;50: 5-15.
14. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB: The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 2008;29:538-550.
15. Parker ZM, Murphy AA, Leib DA: Role of the DNA sensor STING in protection from lethal infection following corneal and intracerebral challenge with herpes simplex virus 1. J Virol 2015;89:11080-11091.
16. Royer DJ, Carr DJ: A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin. Mucosal Immunol 2016;9:1065-1075.
17. Lascano J, Uchil PD, Mothes W, Luban J: TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling. J Virol 2016;90:308-316.
18. Wang Y, He D, Yang L, Wen B, Dai J, Zhang Q, Kang J, He W, Ding Q, He D: TRIM26 functions as a novel tumor suppressor of hepatocellular carcinoma and its downregulation contributes to worse prognosis. Biochem Biophys Res Commun 2015;463:458-465.
19. Shibata M, Sato T, Nukiwa R, Ariga T, Hatakeyama S: TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation. Biochem Biophys Res Commun 2012;423:104-109.
20. Narayan K, Waggoner L, Pham ST, Hendricks GL, Waggoner SN, Conlon J, Wang JP, Fitzgerald KA, Kang J: TRIM13 is a negative regulator of MDA5-mediated type I interferon production. J Virol 2014;88:10748-10757.
21. Yan J, Li Q, Mao AP, Hu MM, Shu HB: TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination. J Mol Cell Biol 2014;6:154-163.
22. Yang C, Zhao X, Sun D, Yang L, Chong C, Pan Y, Chi X, Gao Y, Wang M, Shi X, Sun H, Lv J, Gao Y, Zhong J, Niu J, Sun B: Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A. Cell Mol Immunol 2016;13:94-102.
23. Fletcher AJ, Mallery DL, Watkinson RE, Dickson CF, James LC: Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. Proc Natl Acad Sci USA 2015;112:10014-10019.
24. Mulik S, Sharma S, Suryawanshi A, Veiga-Parga T, Reddy PB, Rajasagi NK, Rouse BT: Activation of endothelial roundabout receptor 4 reduces the severity of virus-induced keratitis. J Immunol 2011;186:7195-7204.
25. Shen FH, Wang SW, Yeh TM, Tung YY, Hsu SM, Chen SH: Absence of CXCL10 aggravates herpes stromal keratitis with reduced primary neutrophil influx in mice. J Virol 2013;87:8502-8510.
26. Royer DJ, Zheng M, Conrady CD, Carr DJ: Granulocytes in Ocular HSV-1 Infection: Opposing Roles of Mast Cells and Neutrophils Granulocytes in Ocular HSV-1 Infection. Invest Ophthalmol Vis Sci 2015;56:3763-3775.
27. Zhang J, Hu MM, Wang YY, Shu HB: TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J Biol Chem 2012; 287:28646-28655.
28. Liesegang TJ: Herpes simplex virus epidemiology and ocular importance. Cornea 2001;20:1-13.
29. Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T: Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo. Mol Cell 1998;1:507-518.
30. Schoser BG, Frosk P, Engel AG, Klutzny U, Lochmüller H, Wrogemann K: Commonality of TRIM32 mutation in causing sarcotubular myopathy and LGMD2H. Ann Neurol 2005;57:591-595.
31. Kudryashova E, Wu J, Havton LA, Spencer MJ: Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component. Hum Mol Genet 2009;18:1353-1367.
32. Chiang AP, Beck JS, Yen HJ, Tayeh MK, Scheetz TE, Swiderski RE, Nishimura DY, Braun TA, Kim KY, Huang J, Elbedour K, Carmi R, Slusarski DC, Casavant TL, Stone EM, Sheffield VC: Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). Proc Natl Acad Sci U S A 2006;103:6287-6292.
33. Albor A, El-Hizawi S, Horn EJ, Laederich M, Frosk P, Wrogemann K, Kulesz-Martin M: The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFκB. J Biol Chem 2006;281:25850-25866.
34. Saccone V, Palmieri M, Passamano L, Piluso G, Meroni G, Politano L, Nigro V: Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H. Hum Mutat 2008;29: 240-247.
35. Locke M, Tinsley CL, Benson MA, Blake DJ: TRIM32 is an E3 ubiquitin ligase for dysbindin. Hum Mol Genet 2009;18:2344-2358.
36. Siracusano G, Venuti A, Lombardo D, Mastino A, Esclatine A, Sciortino MT: Early activation of MyD88-mediated autophagy sustains HSV-1 replication in human monocytic THP-1 cells. Sci Rep 2016;6:31302.
37. Akira S, Uematsu S, Takeuchi O:Pathogen recognition and innate immunity. Cell 2006;124:783-801.
38. Medzhitov R: Recognition of microorganisms and activation of the immune response. Nature 2007;449:819-826.
39. Ran Y, Shu HB, Wang YY: MITA/STING: A central and multifaceted mediator in innate immune response. Cytokine Growth Factor Rev 2014;25:631-639.
40. Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, Kawai T, Akira S: The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 2010;33:765-776.
41. Rowe AM, Leger AS, Jeon S, Dhaliwal DK, Knickelbein JE, Hendricks RL: Herpes keratitis. Prog Retin Eye Res 2013;32:88-101.