GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8

Cell Host and Microbe

Volumn 22, Issue 4, 2017, Pages 507-518.e5

  Wandel, Michal P ^a   Pathe, Claudio ^a   Werner, Emma I ^a   Ellison, Cara J ^a   Boyle, Keith B ^a   von der Malsburg, Alexander ^a   Rohde, John ^b   Randow, Felix ^a,c  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b DALHOUSIE UNIVERSITY   (Canada)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

cell autonomous immunity; E3 ubiquitin ligase; effector proteins; GBP; host pathogen interaction; innate immunity; Ipa9.8; ubiquitin; ubiquitin coat

Indexed keywords

ACTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; GUANYLATE BINDING PROTEIN 1; GUANYLATE BINDING PROTEIN 2; GUANYLATE BINDING PROTEIN 4; INTERFERON; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; BACTERIAL PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOSOL; ENCAPSULATION; HUMAN; HUMAN CELL; INFECTION; MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SHIGELLA FLEXNERI; CELLULAR IMMUNITY; CHEMISTRY; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MICROBIOLOGY; PATHOGENICITY; THP-1 CELL LINE;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CYTOSOL; GTP-BINDING PROTEINS; HEK293 CELLS; HELA CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, INNATE; INTERFERONS; PROTEOLYSIS; SHIGELLA FLEXNERI; THP-1 CELLS; UBIQUITIN-PROTEIN LIGASES;

EID: 85032483951     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2017.09.007     Document Type: Article

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