The effects of atorvastatin on inflammatory responses and mortality in septic shock: A single-center, randomized controlled trial

Indian Journal of Critical Care Medicine

Volumn 21, Issue 10, 2017, Pages 646-654

  Singh, Ratender ^a   Agarwal, Vikas ^a   Baronia, Arvind ^a   Kumar, Sudeep ^a   Poddar, Banani ^a   Azim, Afzal ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Inflammatory biomarkers; mortality; septic shock; statins

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; ATORVASTATIN; BILIRUBIN; C REACTIVE PROTEIN; CREATINE KINASE; CREATININE; HIGH DENSITY LIPOPROTEIN; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; PLACEBO; PROCALCITONIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; DRUG WITHDRAWAL; FEMALE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PLEIOTROPY; RANDOMIZED CONTROLLED TRIAL; SEPTIC SHOCK; SIDE EFFECT; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

EID: 85032455279     PISSN: 09725229     EISSN: 1998359X     Source Type: Journal    
DOI: 10.4103/ijccm.IJCCM_474_16     Document Type: Article

References (19)

1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016;315:801-10.
2. Blanco-Colio LM, Tuñón J, Martín-Ventura JL, Egido J. Anti-Inflammatory and immunomodulatory effects of statins. Kidney Int 2003;63:12-23.
3. Terblanche M, Almog Y, Rosenson RS, Smith TS, Hackam DG. Statins: Panacea for sepsis Lancet Infect Dis 2006;6:242-8.
4. Mekontso-dessap A, Brun-buisson C. Statins: The next step in adjuvant therapy for sepsis Intensive Care Med 2006;32:11-4.
5. Wan YD, Sun TW, Kan QC, Guan FX, Zhang SG. Effect of statin therapy on mortality from infection and sepsis: A meta-analysis of randomized and observational studies. Crit Care 2014;18:R71.
6. Deshpande A, Pasupuleti V, Rothberg MB. Statin therapy and mortality from sepsis: A meta-analysis of randomized trials. Am J Med 2015;128:410-70.
7. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41:580-637.
8. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;20:864-74.
9. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Intensive Care Med 2003;29:530-8.
10. Novack V, Eisinger M, Frenkel A, Terblanche M, Adhikari NK, Douvdevani A, et al. The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: A randomized double-blind placebo controlled clinical trial. Intensive Care Med 2009;35:1255-60.
11. Kruger PS, Harward ML, Jones MA, Joyce CJ, Kostner KM, Roberts MS, et al. Continuation of statin therapy in patients with presumed infection: A randomized controlled trial. Am J Respir Crit Care Med 2011;183:774-81.
12. Patel JM, Snaith C, Thickett DR, Linhartova L, Melody T, Hawkey P, et al. Randomized double-blind placebo-Controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS trial). Crit Care 2012;16:R231.
13. Kruger P, Bailey M, Bellomo R, Cooper DJ, Harward M, Higgins A, et al. A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis. Am J Respir Crit Care Med 2013;187:743-50.
14. Papazian L, Roch A, Charles PE, Penot-ragon C, Perrin G, Roulier P, et al. Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: A randomized clinical trial. JAMA 2013;310:1692-700.
15. El Gendy HA, Elsharnouby NM. Safety and vasopressor effect of rosuvastatin in septic patients. Egypt J Anaesth 2014;30:311-7.
16. National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, et al. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med 2014;370:2191-200.
17. Zheng Z, Jayaram R, Jiang L, Emberson J, Zhao Y, Li Q, et al. Perioperative rosuvastatin in cardiac surgery. N Engl J Med 2016;374:1744-53.
18. Prinz V, Laufs U, Gertz K, Kronenberg G, Balkaya M, Leithner C, et al. Intravenous rosuvastatin for acute stroke treatment: An animal study. Stroke 2008;39:433-8.
19. Laufs U, Adam O. Acute effects of statins. J Am Coll Cardiol 2012;59:71-3.