Statin therapy and mortality from sepsis: A meta-analysis of randomized trials

American Journal of Medicine

Volumn 128, Issue 4, 2015, Pages 410-417.e1

  Deshpande, Abhishek ^a,b   Pasupuleti, Vinay ^b   Rothberg, Michael B ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Meta analysis; Mortality; Sepsis; Statins

Indexed keywords

ATORVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; ROSUVASTATIN;

ARTICLE; CLINICAL EVALUATION; DATA BASE; DISEASE SEVERITY; DRUG EFFICACY; HOSPITAL PATIENT; HUMAN; META ANALYSIS; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; SCORING SYSTEM; SEPSIS; SYSTEMATIC REVIEW; TREATMENT FAILURE; TRENDS;

HOSPITAL MORTALITY; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEPSIS; TREATMENT FAILURE;

EID: 84929517848     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2014.10.057     Document Type: Article

References (31)

1. A. Lever, and I. Mackenzie Sepsis: definition, epidemiology, and diagnosis BMJ 335 2007 879 883
2. E. Abraham, and M. Singer Mechanisms of sepsis-induced organ dysfunction Crit Care Med 35 2007 2408 2416
3. G. Kumar, N. Kumar, and A. Taneja Nationwide trends of severe sepsis in the 21st century (2000-2007) Chest 140 2011 1223 1231
4. M.K. Jain, and P.M. Ridker Anti-inflammatory effects of statins: clinical evidence and basic mechanisms Nat Rev Drug Discov 4 2005 977 987
5. J.K. Liao, and U. Laufs Pleiotropic effects of statins Ann Rev Pharmacol Toxicol 45 2005 89 118
6. B. Kwak, F. Mulhaupt, S. Myit, and F. Mach Statins as a newly recognized type of immunomodulator Nat Med 6 2000 1399 1402
7. A.P. Liappis, V.L. Kan, C.G. Rochester, and G.L. Simon The effect of statins on mortality in patients with bacteremia Clin Infect Dis 33 2001 1352 1357
8. M.W. Donnino, M.N. Cocchi, and M. Howell Statin therapy is associated with decreased mortality in patients with infection Acad Emerg Med 16 2009 230 234
9. W. Nseir, J. Mograbi, and O. Abu-Elheja The impact of prior long-term versus short-term statin use on the mortality of bacteraemic patients Infection 40 2012 41 48
10. P.P. Dobesh, D.G. Klepser, and T.R. McGuire Reduction in mortality associated with statin therapy in patients with severe sepsis Pharmacotherapy 29 2009 621 630
11. M.E. Falagas, G.C. Makris, D.K. Matthaiou, and P.I. Rafailidis Statins for infection and sepsis: a systematic review of the clinical evidence J Antimicrob Chemother 61 2008 774 785
12. S. Janda, A. Young, and J.M. Fitzgerald The effect of statins on mortality from severe infections and sepsis: a systematic review and meta-analysis J Crit Care 25 2010 656 e7-22
13. I.M. Tleyjeh, T. Kashour, and F.A. Hakim Statins for the prevention and treatment of infections: a systematic review and meta-analysis Arch Intern Med 169 2009 1658 1667
14. V. Novack, M. Eisinger, and A. Frenkel The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial Intensive Care Med 35 2009 1255 1260
15. J.M. Patel, C. Snaith, and D.R. Thickett Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial) Crit Care 16 2012 R231
16. P.S. Kruger, M.L. Harward, and M.A. Jones Continuation of statin therapy in patients with presumed infection: a randomized controlled trial Am J Respir Crit Care Med 183 2011 774 781
17. S. Dublin, M.L. Jackson, and J.C. Nelson Statin use and risk of community acquired pneumonia in older people: population based case-control study BMJ 338 2009 b2137
18. L. Pasin, G. Landoni, and M.L. Castro The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials PLoS One 8 2013 e82775
19. Y.D. Wan, T.W. Sun, and Q.C. Kan Effect of statin therapy on mortality from infection and sepsis: a meta-analysis of randomized and observational studies Crit Care 18 2014 R71
20. D. Moher, A. Liberati, and J. Tetzlaff Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement PLoS Med 6 2009 e1000097
21. A.R. Jadad, R.A. Moore, and D. Carroll Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17 1996 1 12
22. J.P. Higgins, D.G. Altman, and P.C. Gotzsche The Cochrane Collaboration's tool for assessing risk of bias in randomised trials BMJ 343 2011 d5928
23. M. Egger, G. Davey Smith, M. Schneider, and C. Minder Bias in meta-analysis detected by a simple, graphical test BMJ 315 1997 629 634
24. R. DerSimonian, and N. Laird Meta-analysis in clinical trials Control Clin Trials 7 1986 177 188
25. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis Crit Care Med 20 1992 864 874
26. P. Kruger, M. Bailey, and R. Bellomo A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis Am J Respir Crit Care Med 187 2013 743 750
27. L. Papazian, A. Roch, and P.E. Charles Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: a randomized clinical trial JAMA 310 2013 1692 1700
28. National Heart, Lung, and Blood Institute, ARDS Clinical Trials Network, J.D. Truwit, G.R. Bernard, and J. Steingrub Rosuvastatin for sepsis-associated acute respiratory distress syndrome N Engl J Med 370 2014 2191 2200
29. H.A. El Gendy, and N.M. Elsharnouby Safety and vasopressor effect of rosuvastatin in septic patients Egypt J Anaesth 30 2014 311 317
30. J.O. Friedrich, N.K. Adhikari, and J. Beyene Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data BMC Med Res Methodol 7 2007 5
31. S.R. Majumdar, F.A. McAlister, and D.T. Eurich Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study BMJ 333 2006 999