Cytokines in systemic lupus erythematosus: Far beyond Th1/Th2 dualism lupus: Cytokine profiles

Immunology and Cell Biology

Volumn 95, Issue 9, 2017, Pages 824-831

  Guimarães, Poliana Macedo ^a   Scavuzzi, Bruna Miglioranza ^a   Stadtlober, Nicole Perugini ^a   Franchi Santos, Lorena Flor Da Rosa ^a   Lozovoy, Marcell Alysson Batisti ^a   Iriyoda, Tatiana Mayumi Veiga ^a   Costa, Neide Tomimura ^a   Reiche, Edna Maria Vissoci ^a   Maes, Michael ^b   Dichi, Isaias ^a   Simão, Andréa Name Colado ^a  

^a University Hospital of Londrina   (Brazil)

^b DEAKIN UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; VITAMIN D; CYTOKINE;

ADULT; ARTICLE; BODY MASS; CASE CONTROL STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; SENSITIVITY AND SPECIFICITY; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; TH1 CELL; TH1 TH2 BALANCE; TH17 CELL; TH2 CELL; VITAMIN BLOOD LEVEL; B LYMPHOCYTE; CELL DIFFERENTIATION; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PROGNOSIS; REGULATORY T LYMPHOCYTE;

ADULT; B-LYMPHOCYTES; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; PROGNOSIS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH1-TH2 BALANCE; TH17 CELLS; TH2 CELLS; VITAMIN D;

EID: 85032174028     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2017.53     Document Type: Article

References (51)

1. Lu R, Munroe ME, Guthridge JM, Bean KM, Fife DA, Chen H et al. Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies. J Autoimmun 2016; 74: 182-193.
2. Guo Y, Chai Q, Zhao Y, Li P, Qiao J, Huang J. Increased activation of toll-like receptors- 7 and -8 of peripheral blood mononuclear cells and upregulated serum cytokines in patients with pediatric systemic lupus erythematosus. Int J Clin Exp Med 2015; 8: 20472-20480.
3. Koenig KF, Groeschl I, Pesickova SS, Tesar V, Eisenberger U, Trendelenburg M. Serum cytokine profile in patients with active lupus nephritis. Cytokine 2012; 60: 410-416.
4. Postal M, Peliçari KO, Sinicato NA, Marini R, Costallat LTL, Appenzeller S. Th1/Th2 cytokine profile in childhood-onset systemic lupus erythematosus. Cytokine 2013; 61: 785-791.
5. Yap DYH, Lai KN, Yap DYH, Lai KN. Cytokines and their roles in the pathogenesis of systemic lupus erythematosus: from basics to recent advances. J Biomed Biotechnol 2010; 2010: 365083.
6. Talaat RM, Mohamed SF, Bassyouni IH, Raouf AA. Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: correlation with disease activity. Cytokine 2015; 72: 146-153.
7. Dolff S, Bijl M, Huitema MG, Limburg PC, Kallenberg CGM, Abdulahad WH. Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus. Clin Immunol 2011; 141: 197-204.
8. Miyake K, Akahoshi M, Nakashima H. Th subset balance in lupus nephritis. J Biomed Biotechnol 2011; 2011: 980286.
9. Theofilopoulos AN, Koundouris S, Kono DH, Lawson BR. The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity. Arthritis Res 2001; 3: 136-141.
10. Bettinotti MP, Hartung K, Deicher H, Messer G, Keller E, Weiss EH et al. Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus: TNFB-MHC haplotypes. Immunogenetics 1993; 37: 449-454.
11. Kim HY, Lee SH, Yang HI, Park SH, Cho CS, Kim TG et al. TNFB gene polymorphism in patients with systemic lupus erythematosus in Korean. Korean J Intern Med 1995; 10: 130-136.
12. Lozovoy M, Simao A, Hohmann M, Simao T, Barbosa D, Morimoto H et al. Inflammatory biomarkers and oxidative stress measurements in patients with systemic lupus erythematosus with or without metabolic syndrome. Lupus 2011; 20: 1356-1364.
13. Yap KS, Morand EF. Vitamin D and systemic lupus erythematosus: continued evolution. Int J Rheum Dis 2015; 18: 242-249.
14. Abou-Raya A, Abou-Raya S, Helmii M. The effect of vitamin D supplementation on inflammatory and hemostatic markers and disease activity in patients with systemic lupus erythematosus: a randomized placebo-controlled trial. J Rheumatol 2013; 40: 265-272.
15. Terrier B, Derian N, Schoindre Y, Chaara W, Geri G, Zahr N et al. Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. Arthritis Res Ther 2012; 14: R221.
16. Ritterhouse LL, Crowe SR, Niewold TB, Kamen DL, Macwana SR, Roberts VC et al. Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann Rheum Dis 2011; 70: 1569-1574.
17. Ben-Zvi I, Aranow C, Mackay M, Stanevsky A, Kamen DL, Marinescu LM et al. The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus. PLoS ONE 2010; 5: e9193.
18. Lemire JM, Adams JS, Sakai R, Jordan SC. 1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest 1984; 74: 657-661.
19. Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HFJ, O'Garra A. 1,25-Dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells. J Immunol 2001; 167: 4974-4980.
20. Chun H-Y, Chung J-W, Kim H-A, Yun J-M, Jeon J-Y, Ye Y-M et al. Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J Clin Immunol 2007; 27: 461-466.
21. Csiszαr A, Nagy G, Gergely P, Pozsonyi T, Piócsik E. Increased interferon-gamma (IFN- γ), IL-10 and decreased IL-4 mRNA expression in peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 2000; 122: 464-470.
22. Kim T, Kanayama Y, Negoro N, Okamura M, Takeda T, Inoue T. Serum levels of interferons in patients with systemic lupus erythematosus. Clin Exp Immunol 1987; 70: 562-569.
23. Lourenço EV, La Cava A. Cytokines in systemic lupus erythematosus. Curr Mol Med 2009; 9: 242-254.
24. Peng SL, Moslehi J, Craft J. Roles of interferon-gamma and interleukin-4 in murine lupus. J Clin Invest 1997; 99: 1936-1946.
25. Eriksson C, Rantapää-Dahlqvist S. Cytokines in relation to autoantibodies before onset of symptoms for systemic lupus erythematosus. Lupus 2014; 23: 691-696.
26. Godsell J, Rudloff I, Kandane-Rathnayake R, Hoi A, Nold MF, Morand EF et al. Clinical associations of IL-10 and IL-37 in systemic lupus erythematosus. Sci Rep 2016; 6: 1-10.
27. Tabarkiewicz J, Pogoda K, Karczmarczyk A, Pozarowski P, Giannopoulos K. The role of IL-17 and Th17 lymphocytes in autoimmune diseases. Arch Immunol Ther Exp (Warsz) 2015; 63: 435-449.
28. Arora V, Verma J, Marwah V, Kumar A, Anand D, Das N. Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects. Lupus 2012; 21: 596-603.
29. Ripley BJM, Goncalves B, Isenberg Da, Latchman DS, Rahman A. Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia. Ann Rheum Dis 2005; 64: 849-853.
30. Linker-Israeli M, Deans RJ, Wallace DJ, Prehn J, Ozeri-Chen T, Klinenberg JR. Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. Immunology 1991; 147: 117-123.
31. Metsärinne KP, Nordström DCE, Konttinen YT, Teppo AM, Fyhrquist FY. Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Rheumatol Int 1992; 12: 93-96.
32. Shah K, Lee W-W, Lee S-H, Kim SH, Kang SW, Craft J et al. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Res Ther 2010; 12: R53.
33. Sigdel KR, Duan L, Wang Y, Hu W, Wang N, Sun Q et al. Serum cytokines Th1, Th2, and Th17 expression profiling in active lupus nephritis-IV: from a Southern Chinese Han population. Mediators Inflamm 2016; 2016: 4927530.
34. Yang J, Yang X, Zou H, Li M. Oxidative stress and Treg and Th17 dysfunction in systemic lupus erythematosus. Oxid Med Cell Longev 2016; 2016: 1-9.
35. Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007; 56: 1010-1013.
36. Maes M, Berk M, Goehler L, Song C, Anderson G, Gałecki P et al. Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Med 2012; 10: 66.
37. Zhang J, Ai R, Chow F. The polymorphisms of HLA-DR and TNF B loci in northern Chinese Han nationality and susceptibility to systemic lupus erythematosus. Chin Med Sci J 1997; 12: 107-110.
38. Goldstein R, Sengar DP. Comparative studies of the major histocompatibility complex in French Canadian and non-French Canadian Caucasians with systemic lupus erythematosus. Arthritis Rheum 1993; 36: 1121-1127.
39. Muller K. Vitamin D3 metabolism in patients with rheumatic diseases: low serum levels of 25-hydroxyvitamin D3 in patients with systemic lupus erythematosus. Clin Rheumatol 1995; 14: 397-400.
40. Lertratanakul A, Wu P, Dyer A, Urowitz M, Gladman D, Fortin P et al. 25-hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus: data from a large international inception cohort. Arthritis Care Res (Hoboken) 2014; 66: 1167-1176.
41. Mandal M, Tripathy R, Panda AK, Pattanaik SS, Dakua S, Pradhan A et al. Vitamin D levels in Indian systemic lupus erythematosus patients: association with disease activity index and interferon alpha. Arthritis Res Ther 2014; 16: R49.
42. Souberbielle J-C, Body J-J, Lappe JM, Plebani M, Shoenfeld Y, Wang TJ et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmun Rev 2010; 9: 709-715.
43. Azrielant S, Shoenfeld Y. Eppur Si Muove: vitamin D is essential in preventing and modulating SLE. Lupus 2016; 25: 563-572.
44. Kokic V, Martinovic Kaliterna D, Radic M, Perkovic D, Cvek M, Capkun V. Relationship between vitamin D, IFN-?, and E2 levels in systemic lupus erythematosus. Lupus 2016; 25: 282-288.
45. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab 2009; 94: 26-34.
46. Gaitonde S, Samols D, Kushner I. C-reactive protein and systemic lupus erythematosus. Arthritis Rheum 2008; 59: 1814-1820.
47. Rexrode KM, Pradhan A, Manson JE, Buring JE, Ridker PM. Relationship of total and abdominal adiposity with CRP and IL-6 in women. Ann Epidemiol 2003; 13: 674-682.
48. Hochberg MC. Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1725-1725.
49. Bombardier C, Gladman D, Urowitz M, Caron D, Chang C. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 1992; 35: 630-640.
50. Majetschak M, Flohe S, Obertacke U, Schroder J, Staubach K, Nast-Kolb D et al. Relation of a TNF gene polymorphism to severe sepsis in trauma patients. AnnSurg 1999; 230: 207-214.
51. Majetschak M, Obertacke U, Schade FU, Bardenheuer M, Voggenreiter G, Bloemeke B et al. Tumor necrosis factor gene polymorphisms, leukocyte function, and sepsis susceptibility in blunt trauma patients. Clin Diagn Lab Immunol 2002; 9: 1205-1211.