Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

Cell Reports

Volumn 21, Issue 2, 2017, Pages 517-532

  Watanabe, Momoko ^a,b   Buth, Jessie E ^a,b   Vishlaghi, Neda ^a,b   de la Torre Ubieta, Luis ^a,b,c   Taxidis, Jiannis ^a   Khakh, Baljit S ^a   Coppola, Giovanni ^a,b,c   Pearson, Caroline A ^a,b   Yamauchi, Ken ^a,b   Gong, Danyang ^a,b   Dai, Xinghong ^a,b   Damoiseaux, Robert ^a,b   Aliyari, Roghiyh ^b   Liebscher, Simone ^d   Schenke Layland, Katja ^a,d,e   Caneda, Christine ^b,c   Huang, Eric J ^f   Zhang, Ye ^b,c   Cheng, Genhong ^b   Geschwind, Daniel H ^a,b,c   Golshani, Peyman ^a,b,c   Sun, Ren ^a,b   Novitch, Bennett G ^a,b   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e FRAUNHOFER INSTITUTE FOR INTERFACIAL ENGINEERING AND BIOTECHNOLOGY IGB   (Germany)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cerebral cortex; differentiation; embryonic stem cell; human brain; neural development; neural stem cell; neurogenesis; organoid; Zika virus

Indexed keywords

STAT3 PROTEIN; ANTIRETROVIRUS AGENT; PROTEIN KINASE MER; PROTEIN TYROSINE KINASE; STAT3 PROTEIN, HUMAN; TYRO3 PROTEIN, HUMAN;

ARTICLE; BASAL GANGLION; BRAIN DEVELOPMENT; BRAIN DISEASE; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL STRUCTURE; CYTOPLASM; DISEASE ASSOCIATION; FETUS BRAIN; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROCEPHALY; NERVE CELL; NERVE POTENTIAL; NEUROEPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; ZIKA FEVER; ZIKA VIRUS; BRAIN CORTEX; CELL LINE; CYTOLOGY; DRUG EFFECT; EMBRYONIC STEM CELL; METABOLISM; ORGANOID; PRECLINICAL STUDY; PRIMARY CELL CULTURE; PROCEDURES; VIROLOGY;

ANTI-RETROVIRAL AGENTS; C-MER TYROSINE KINASE; CELL LINE; CEREBRAL CORTEX; DRUG EVALUATION, PRECLINICAL; EMBRYONIC STEM CELLS; HUMANS; NEURONS; ORGANOIDS; PRIMARY CELL CULTURE; RECEPTOR PROTEIN-TYROSINE KINASES; STAT3 TRANSCRIPTION FACTOR; ZIKA VIRUS;

EID: 85030862076     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.09.047     Document Type: Article

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