Expression of checkpoint molecules on myeloid-derived suppressor cells

Immunology Letters

Volumn 192, Issue , 2017, Pages 1-6

  Ballbach, Marlene ^a   Dannert, Angelika ^a   Singh, Anurag ^a   Siegmund, Darina M ^a   Handgretinger, Rupert ^a   Piali, Luca ^b   Rieber, Nikolaus ^a,c   Hartl, Dominik ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Checkpoints; MDSC; Myeloid derived suppressor cells; PD 1; PD L1; T cell suppression

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN ANTIBODY; BLOCKING ANTIBODY;

ARTICLE; CELL CONTACT; CELL FUNCTION; CELL INTERACTION; COCULTURE; CONTROLLED STUDY; GRANULOCYTE; HUMAN; HUMAN CELL; INNATE IMMUNITY; MYELOID-DERIVED SUPPRESSOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; CELL COMMUNICATION; CELL CULTURE; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOTHERAPY; METABOLISM; MOLECULARLY TARGETED THERAPY; PROCEDURES;

ANTIBODIES, BLOCKING; B7-H1 ANTIGEN; CELL COMMUNICATION; CELLS, CULTURED; COCULTURE TECHNIQUES; HUMANS; IMMUNE TOLERANCE; IMMUNITY, INNATE; IMMUNOTHERAPY; MOLECULAR TARGETED THERAPY; MYELOID-DERIVED SUPPRESSOR CELLS; T-LYMPHOCYTES;

EID: 85030856536     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2017.10.001     Document Type: Article

References (41)

1. Gabrilovich, D.I., Nagaraj, S., Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9 (2009), 162–174.
2. Kwak, Y., Kim, H.E., Park, S.G., Insights into myeloid-Derived suppressor cells in inflammatory diseases. Arch. Immunol. Ther. Exp. (Warsz) 63 (2015), 269–285.
3. Jiang, J., Guo, W., Liang, X., Phenotypes, accumulation, and functions of myeloid-derived suppressor cells and associated treatment strategies in cancer patients. Hum. Immunol. 75 (2014), 1128–1137.
4. Damuzzo, V., Pinton, L., Desantis, G., Solito, S., Marigo, I., Bronte, V., et al. Complexity and challenges in defining myeloid-derived suppressor cells. Cytometry B Clin. Cytom. 88 (2014), 77–91.
5. Brandau, S., Trellakis, S., Bruderek, K., Schmaltz, D., Steller, G., Elian, M., et al. Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties. J. Leukoc. Biol. 89 (2011), 311–317.
6. Kusmartsev, S., Nefedova, Y., Yoder, D., Gabrilovich, D.I., Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. J. Immunolo. (Baltimore, Md 1950) 172 (2004), 989–999.
7. Mazzoni, A., Bronte, V., Visintin, A., Spitzer, J.H., Apolloni, E., Serafini, P., et al. Myeloid suppressor lines inhibit t cell responses by an NO-dependent mechanism. J. Immunol. 168 (2002), 689–695.
8. Blesson, S., Thiery, J., Gaudin, C., Stancou, R., Kolb, J.P., Moreau, J.L., et al. Analysis of the mechanisms of human cytotoxic T lymphocyte response inhibition by NO. Int. Immunol. 14 (2002), 1169–1178.
9. Jitschin, R., Braun, M., Buttner, M., Dettmer-Wilde, K., Bricks, J., Berger, J., et al. CLL-cells induce IDOhi CD14 + HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs. Blood 124 (2014), 750–760.
10. Holmgaard, R.B., Zamarin, D., Li, Y., Gasmi, B., Munn, D.H., Allison, J.P., et al. Tumor-expressed IDO recruits and activates MDSCs in a treg-dependent manner. Cell Rep. 13 (2015), 412–424.
11. Srivastava, M.K., Sinha, P., Clements, V.K., Rodriguez, P., Ostrand-Rosenberg, S., Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res. 70 (2010), 68–77.
12. Hanson, E.M., Clements, V.K., Sinha, P., Ilkovitch, D., Ostrand-Rosenberg, S., Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cells. J. Immunol. (Baltimore, Md: 1950) 183 (2009), 937–944.
13. Youn, J.-I., Nagaraj, S., Collazo, M., Gabrilovich, D.I., Subsets of myeloid-derived suppressor cells in tumor-Bearing mice. J. Immunol. 181 (2008), 5791–5802.
14. Thaventhiran, T., T cell co-inhibitory receptors-functions and signalling mechanisms. J. Clin. Cell. Immunol., 01, 2013.
15. Sheppard, K.A., Fitz, L.J., Lee, J.M., Benander, C., George, J.A., Wooters, J., et al. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett. 574 (2004), 37–41.
16. Fife, B.T., Pauken, K.E., Eagar, T.N., Obu, T., Wu, J., Tang, Q., et al. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat. Immunol. 10 (2009), 1185–1192.
17. Baecher-Allan, C., Brown, J.A., Freeman, G.J., Hafler, D.A., CD4 + CD25high regulatory cells in human peripheral blood. J. Immunol. 167 (2001), 1245–1253.
18. Patsoukis, N., Brown, J., Petkova, V., Liu, F., Li, L., Boussiotis, V.A., Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Sci. Signal., 5, 2012, ra46.
19. Gato-Canas, M., Zuazo, M., Arasanz, H., Ibanez-Vea, M., Lorenzo, L., Fernandez-Hinojal, G., et al. PDL1 signals through conserved sequence motifs to overcome interferon-mediated cytotoxicity. Cell Rep. 20 (2017), 1818–1829.
20. Liechtenstein, T., Perez-Janices, N., Gato, M., Caliendo, F., Kochan, G., Blanco-Luquin, I., et al. A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice. Oncotarget 5 (2014), 7843–7857.
21. Liechtenstein, T., Perez-Janices, N., Blanco-Luquin, I., Goyvaerts, C., Schwarze, J., Dufait, I., et al. Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy. Oncoimmunology, 3, 2014, e945378.
22. Butte, M.J., Keir, M.E., Phamduy, T.B., Sharpe, A.H., Freeman, G.J., Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 27 (2007), 111–122.
23. vanderMerwe, P.A., Bodian, D.L., Daenke, S., Linsley, P., Davis, S.J., CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 185 (1997), 393–403.
24. Schneider, H., Smith, X., Liu, H., Bismuth, G., Rudd, C.E., CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization. Eur. J. Immunol. 38 (2008), 40–47.
25. Ioannou, M., Alissafi, T., Lazaridis, I., Deraos, G., Matsoukas, J., Gravanis, A., et al. Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease. J. Immunol. (Baltimore, Md: 1950) 188 (2012), 1136–1146.
26. Rieber, N., Brand, A., Hector, A., Graepler-Mainka, U., Ost, M., Schafer, I., et al. Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease. J. Immunol. (Baltimore, Md: 1950) 190 (2013), 1276–1284.
27. Chikamatsu, K., Sakakura, K., Toyoda, M., Takahashi, K., Yamamoto, T., Masuyama, K., Immunosuppressive activity of CD14+ HLA-DR- cells in squamous cell carcinoma of the head and neck. Cancer Sci. 103 (2012), 976–983.
28. Huang, A., Zhang, B., Yan, W., Wang, B., Wei, H., Zhang, F., et al. Myeloid-derived suppressor cells regulate immune response in patients with chronic hepatitis B virus infection through PD-1-induced IL-10. J. Immunol. (Baltimore, Md: 1950) 193 (2014), 5461–5469.
29. Azzaoui, I., Uhel, F., Rossille, D., Pangault, C., Dulong, J., Le Priol, J., et al. T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid derived suppressor cells expressing IL-10, PD-L1 and S100A12. Blood 25 (2016), 1081–1092.
30. Pinton, L., Solito, S., Damuzzo, V., Francescato, S., Pozzuoli, A., Berizzi, A., et al. Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression. Oncotarget 7 (2016), 1168–1184.
31. Yang, R., Cai, Z., Zhang, Y., Yutzy, W.H., Roby, K.F., Roden RBS. CD80 in immune suppression by mouse ovarian carcinoma–associated Gr-1 + CD11b+ myeloid cells. Cancer Res. 66 (2006), 6807–6815.
32. Tumino, N., Turchi, F., Meschi, S., Lalle, E., Bordoni, V., Casetti, R., et al. In HIV-positive patients, myeloid-derived suppressor cells induce T-cell anergy by suppressing CD3zeta expression through ELF-1 inhibition. AIDS (London, England) 29 (2015), 2397–2407.
33. Bowers, N.L., Helton, E.S., Huijbregts, R.P., Goepfert, P.A., Heath, S.L., Hel, Z., Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway. PLoS Pathog., 10, 2014, e1003993.
34. Duraiswamy, J., Freeman, G.J., Coukos, G., Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-Cell function to prevent immune decline in ovarian cancer. Cancer Res. 73 (2013), 6900–6912.
35. Liu, Y., Yu, Y., Yang, S., Zeng, B., Zhang, Z., Jiao, G., et al. Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells. Cancer Immunol. Immunother.: CII 58 (2009), 687–697.
36. Noman, M.Z., Desantis, G., Janji, B., Hasmim, M., Karray, S., Dessen, P., et al. PD-L1 is a novel direct target of HIF-1 alpha., and its blockade under hypoxia enhanced MDSC-mediated T cell activation. Journal of Experimental. J. Exp. Med. 211 (2014), 781–790.
37. Mellor, A.L., Baban, B., Chandler, P., Marshall, B., Jhaver, K., Hansen, A., et al. Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J. Immunol. (Baltimore, Md: 1950) 171 (2003), 1652–1655.
38. Munn, D.H., Sharma, M.D., Mellor, A.L., Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J. Immunol.(Baltimore, Md: 1950) 172 (2004), 4100–4110.
39. Pan, P.Y., Ma, G., Weber, K.J., Ozao-Choy, J., Wang, G., Yin, B., et al. Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer. Cancer Res. 70 (2010), 99–108.
40. Leung, J., Suh, W.-K., Host B7-H4 regulates antitumor t cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J. Immunol. 190 (2013), 6651–6661.
41. Green, K.A., Wang, L., Noelle, R.J., Green, W.R., Selective involvement of the checkpoint regulator VISTA in suppression of B-Cell, but not T-Cell, responsiveness by monocytic myeloid-derived suppressor cells from mice infected with an immunodeficiency-causing retrovirus. J. Virol. 89 (2015), 9693–9698.