Male accessory gland inflammation, infertility, and sexual dysfunctions: a practical approach to diagnosis and therapy

Andrology

Volumn 5, Issue 6, 2017, Pages 1064-1072

  Calogero, A E ^a   Duca, Y ^a   Condorelli, R A ^a   La Vignera, S ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

infertility; male accessory gland inflammation; sexual dysfunctions

Indexed keywords

ANTIBIOTIC AGENT;

ANTIBIOTIC THERAPY; HUMAN; MALE ACCESSORY GLAND INFECTION; MALE INFERTILITY; MALE SEXUAL DYSFUNCTION; PRIORITY JOURNAL; REVIEW; RISK FACTOR; UROGENITAL TRACT INFECTION; COMPLICATION; INFLAMMATION; MALE; SEXUAL DYSFUNCTION; UROGENITAL TRACT DISEASE;

HUMANS; INFERTILITY, MALE; INFLAMMATION; MALE; MALE UROGENITAL DISEASES; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 85030719637     PISSN: 20472919     EISSN: 20472927     Source Type: Journal    
DOI: 10.1111/andr.12427     Document Type: Review

References (80)

1. Aitken RJ, Clarkson JS, Hargreave TB, Irvine DS & Wu FC. (1989) Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. J Androl 10, 214–220.
2. Aitken RJ, Gordon E, Harkiss D, Twigg JP, Milne P, Jennings Z & Irvine DS. (1998) Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa. Biol Reprod 59, 1037–1046.
3. Alshaker H, Sacco K, Alfraidi A, Muhammad A, Winkler M & Pchejetski D. (2015) Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma. Oncotarget 6, 35556–35563.
4. Anothaisintawee T, Attia J, Nickel JC, Thammakraisorn S, Numthavaj P, McEvoy M & Thakkinstian A. (2011) Management of chronic prostatitis/chronic pelvic pain syndrome: a systematic review and network meta-analysis. JAMA 5, 78–86.
5. Aydemir B, Onaran I, Kiziler AR, Alici B & Akyolcu MC. (2008) The influence of oxidative damage on viscosity of seminal fluid in infertile men. J Androl 29, 41–46.
6. Barroso G, Morshedi M & Oehninger S. (2000) Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa. Hum Reprod 15, 1338–1344.
7. Berghuis JP, Heiman JR, Rothman I & Berger RE. (1996) Psychological and physical factors involved in chronic idiopathic prostatitis. J Psychosom Res 41, 313–325.
8. Bernoulli J, Yatkin E, Konkol Y, Talvitie EM, Santti R & Streng T. (2008) Prostatic inflammation and obstructive voiding in the adult Noble rat: impact of the testosterone to estradiol ratio in serum. Prostate 68, 1296–1306.
9. Calogero AE, Condorelli RA, Russo GI & La Vignera S. (2017) Conservative nonhormonal options for the treatment of male infertility: antibiotics, anti-Inflammatory drugs, and antioxidants. Biomed Res Int 2017, 4650182.
10. Clemens JQ, Meenan RT, O'Keeffe Rosetti MC, Kimes T & Calhoun EA. (2007) Prevalence of and risk factors for prostatitis: population based assessment using physician assigned diagnoses. J Urol 178, 1333–1337.
11. Cocuzza M, Sikka SC, Athayde KS & Agarwal A. (2007) Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis. Int Braz J Urol 33, 603–621.
12. Comhaire F, Verschraegen G & Vermeulen L. (1980) Diagnosis of accessory gland infection and its possible role in male infertility. Int J Androl 3, 32–45.
13. Condorelli RA, Calogero AE, Vicari E, Duca Y, Favilla V, Morgia G, Cimino S, Di Mauro M & La Vignera S. (2013) Prevalence of male accessory gland inflammations/infections in patients with Type 2 diabetes mellitus. J Endocrinol Invest 36, 770–774.
14. Condorelli RA, Vicari E, Calogero AE & La Vignera S. (2014a) Male accessory gland inflammation prevalence in type 2 diabetic patients with symptoms possibly reflecting autonomic neuropathy. Asian J Androl 16, 761–766.
15. Condorelli RA, Calogero AE, Vicari E, Favilla V, Cimino S, Russo GI, Morgia G & La Vignera S. (2014b) Male accessory gland infection: relevance of serum total testosterone levels. Int J Endocrinol 2014, 915752.
16. Condorelli RA, Calogero AE, Mongioi’ L, Vicari E, Russo GI, Lanzafame F & La Vignera S. (2016a) Varicocele and concomitant dilation of the periprostatic venous plexus: effects on semen viscosity sperm parameters. J Endocrinol Invest 39, 543–547.
17. Condorelli RA, Vicari E, Mongioi LM, Russo GI, Morgia G, La Vignera S & Calogero AE. (2016b) Human papilloma virus infection in patients with male accessory gland infection: usefulness of the ultrasound evaluation. Int J Endocrinol 2016, 9174609.
18. Condorelli RA, Calogero AE & La Vignera S. (2016c) Hyperestrogenism and low serum testosterone-17β-estradiol ratio are associated with non-bacterial male accessory gland inflammation. Int J Immunopathol Pharmacol 29, 488–493.
19. Condorelli RA, Russo GI, Calogero AE, Morgia G & La Vignera S (2017) Chronic prostatitis and its detrimental impact on sperm parameters: a systematic review and meta-analysis. J Endocrinol Invest 9. https://doi.org/10.1007/s40618-017-0684-0.
20. Drossman DA, Camilleri M, Mayer EA & Whitehead WE. (2002) AGA technical review on irritable bowel syndrome. Gastroenterology 123, 2108–2131.
21. Everaert K, Mahmoud A, Depuydt C, Maeyaert M & Comhaire F. (2003) Chronic prostatitis and male accessory gland infection–is there an impact on male infertility (diagnosis and therapy)? Andrologia 35, 325–330.
22. Foresta C, Noventa M, De Toni L, Gizzo S & Garolla A. (2015) HPV-DNA sperm infection and infertility: from a systematic literature review to a possible clinical management proposal. Andrology 3, 163–173.
23. Fraczek M & Kurpisz M. (2007) Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa. J Androl 28, 325–333.
24. Giamarellou H, Tympanidis K, Bitos NA, Leonidas E & Daikos GK. (1984) Infertility and chronic prostatitis. Andrologia 16, 417–422.
25. Hoesl CE & Altwein JE. (2005) The probiotic approach: an alternative treatment option in urology. Eur Urol 47, 288–296.
26. Jia YL, Liu X, Yan JY, Chong LM, Li L, Ma AC, Zhou L & Sun ZY. (2015) The alteration of inflammatory markers and apoptosis on chronic prostatitis induced by estrogen and androgen. Int Urol Nephrol 47, 39–46.
27. Jungwirth A, Diemer T, Dohle GR, Giwercman A, Kopa Z, Krausz C & Tournaye H. (2015) Male accessory gland infections and infertility. In: Guidelines on Male Infertility, pp 25–27. European Association of Urology, Arnhem, The Netherlands.
28. Kaplan SA, Santarosa RP, D'Alisera PM, Fay BJ, Ikeguchi EF, Hendricks J, Klein L & Te AE. (1997) Pseudodyssynergia (contraction of the external sphincter during voiding) misdiagnosed as chronic nonbacterial prostatitis and the role of biofeedback as a therapeutic option. J Urol 157, 2234–2237.
29. Keltikangas-Järvinen L, Järvinen H & Lehtonen T. (1981) Psychic disturbances in patients with chronic prostatis. Ann Clin Res 13, 45–49.
30. Krieger JN, Nyberg L Jr & Nickel JC. (1999) NIH consensus definition and classification of prostatitis. JAMA 21, 236–237.
31. La Vignera S. (2012a) Male accessory gland infections: anatomical extension of inflammation and severity of symptoms evaluated by an original questionnaire. Andrologia 44(Suppl 1), 739–746.
32. La Vignera S. (2012b) Seminal vesicles of infertile patients with male accessory gland infection: ultrasound evaluation after prolonged treatment with tadalafil, a selective phosphodiesterase-5 inhibitor. Andrologia 45, 386–391.
33. La Vignera S, Calogero AE, Arancio A, Castiglione R, De Grande G & Vicari E. (2008) Transrectal ultrasonography in infertile patients with persistently elevated bacteriospermia. Asian J Androl 10, 731–740.
34. La Vignera S, Vicari E, Condorelli R, D'Agata R & Calogero AE. (2011a) Hypertrophic-congestive and fibro-sclerotic ultrasound variants of male accessory gland infection have different sperm output. J Endocrinol Invest 34, e330–e335.
35. La Vignera S, Vicari E, Condorelli RA, D'Agata R & Calogero AE. (2011b) Male accessory gland infection and sperm parameters (review). Int J Androl 34, e330–e347.
36. La Vignera S, Condorelli RA, Di Mauro M, D'Agata R, Vicari E & Calogero AE. (2011c) Seminal vesicles and diabetic neuropathy: ultrasound evaluation. J Androl 32, 478–483.
37. La Vignera S, Condorelli R, Vicari E, D'Agata R & Calogero AE. (2012a) High frequency of sexual dysfunction in patients with male accessory gland infections. Andrologia 44(Suppl 1), 438–446.
38. La Vignera S, Calogero AE, Condorelli RA, Vicari LO, Catanuso M, D'Agata R & Vicari E. (2012b) Ultrasonographic evaluation of patients with male accessory gland infection. Andrologia 44(Suppl 1), 26–31.
39. La Vignera S, Condorelli R, D'Agata R, Vicari E & Calogero AE. (2012c) Semen alterations and flow-citometry evaluation in patients with male accessory gland infections. J Endocrinol Invest 35, 219–223.
40. La Vignera S, Condorelli RA, Calogero AE, Bellanca S, Salmeri M & Vicari E. (2012d) Persistence of ultrasound alterations after antibiotic treatment with levofloxacin in patients with male accessory gland infection. Asian J Androl 14, 879–883.
41. La Vignera S, Condorelli RA, Vicari E, Tumino D, Morgia G, Favilla V, Cimino S & Calogero AE. (2013) Markers of semen inflammation: supplementary semen analysis? J Reprod Immunol 100, 2–10.
42. La Vignera S, Condorelli RA, Vicari E, Salmeri M, Morgia G, Favilla V, Cimino S & Calogero AE. (2014) Microbiological investigation in male infertility: a practical overview. J Med Microbiol 63, 1–14.
43. La Vignera S, Vicari E, Condorelli RA, Franchina C, Scalia G, Morgia G, Perino A, Schillaci R & Calogero AE. (2015) Prevalence of human papilloma virus infection in patients with male accessory gland infection. Reprod Biomed Online 30, 385–391.
44. La Vignera S, Condorelli RA, Vicari E, Favilla V, Morgia G & Calogero AE. (2016) Acquired premature ejaculation and male accessory gland infection: relevance of ultrasound examination. Asian J Androl 18, 769–772.
45. Lanzafame FM, La Vignera S, Vicari E & Calogero AE. (2009) Oxidative stress and medical antioxidant treatment in male infertility. Reprod Biomed Online 19, 638–659.
46. Letkiewicz S, Międzybrodzki R, Kłak M, Jończyk E, Weber-Dąbrowska B & Górski A. (2010) The perspectives of the application of phage therapy in chronic bacterial prostatitis. FEMS Immunol Med Microbiol 60, 99–112.
47. Lewis SE & Simon L. (2010) Clinical implications of sperm DNA damage. Hum Fertil 13, 201–207.
48. Liang CZ, Zhang XJ, Hao ZY, Shi HQ & Wang KX. (2004) Prevalence of sexual dysfunction in Chinese men with chronic prostatitis. BJU Int 93, 568–707.
49. Litwin M, McNaughton-Collins M, Fowler FJ, Nickel JC, Calhoun EA, Pontari MA, Alexander RB, Farrar JT & O'Leary MP. (1999) The National Institutes of Health Chronic Prostatitis Symptom Index: development and validation of a new outcome measure. J Urol 162, 369–375.
50. Marconi M, Pilatz A, Wagenlehner F, Diemer T & Weidner W. (2009) Impact of infection on the secretory capacity of the male accessory glands. Int Braz J Urol 35, 299–308.
51. Mehik A, Hellström P, Sarpola A, Lukkarinen O & Järvelin MR. (2001) Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland. BJU Int 88, 35–38.
52. Meng J, Mostaghel EA, Vakar-Lopez F, Montgomery B, True L & Nelson PS. (2011) Testosterone regulates tight junction proteins and influences prostatic autoimmune responses. Horm Cancer 2, 145–156.
53. Moretti E, Baccetti B, Capitani S & Collodel G. (2005) Necrosis in human spermatozoa. II. Ultrastructural features and FISH study in semen from patients with recovered uro-genital infections. J Submicrosc Cytol Pathol 37, 93–98.
54. Naslund MJ, Strandberg JD & Coffey DS. (1988) The role of androgens and estrogens in the pathogenesis of experimental nonbacterial prostatitis. J Urol 140, 1049–1053.
55. Nickel JC. (1999) Prostatitis: evolving management strategies. Urol Clin North Am 26, 737–751.
56. Nickel JC. (2002) Prostatitis and related conditions. In: Campbell's Urology (eds PC Walsh, AB Retik, ED Vaughan & JA Wein), pp. 603–623. WB Saunders, Philadelphia.
57. Nickel JC, Downey J, Clark J, Ceri H & Olson M. (1995) Antibiotic pharmacokinetics in the inflamed prostate. J Urol 153, 527–529.
58. Nickel JC, Shoskes D, Wang Y, Alexander RB, Fowler JE Jr, Zeitlin S, O'Leary MP, Pontari MA, Schaeffer AJ, Landis JR, Nyberg L, Kusek JW & Propert KJ. (2006) How does the pre-massage and post-massage 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome? J Urol 176, 119–124.
59. Okamura N, Tajima Y, Ishikawa H, Yoshii S, Koiso K & Sugita Y. (1986) Lowered levels of bicarbonate in seminal plasma cause the poor sperm motility in human infertile patients. Fertil Steril 45, 265–272.
60. Potts RJ, Jefferies TM & Notarianni LJ. (1999) Antioxidant capacity of the epididymis. Hum Reprod 14, 2513–2516.
61. Quintar AA, Roth FD, De Paul AL, Aoki A & Maldonado CA. (2006) Toll-like receptor 4 in rat prostate: modulation by testosterone and acute bacterial infection in epithelial and stromal cells. Biol Reprod 75, 664–672.
62. Rodríguez MA, Afari N, Buchwald DS & National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Urological Chronic Pelvic Pain (2009) Evidence for overlap between urological and nonurological unexplained clinical conditions. J Urol 182, 2123–31.
63. Schlegel PN. (2012) Aromatase inhibitors for male infertility. Fertil Steril 98, 1359–1362.
64. Screponi E, Carosa E, Di Stasi SM, Pepe M, Carruba G & Jannini EA. (2001) Prevalence of chronic prostatitis in men with premature ejaculation. Urology 58, 198–202.
65. Twigg JP, Irvine DS & Aitken RJ. (1998) Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Hum Reprod 13, 1864–1871.
66. Ückert S, Waldkirch ES, Sonnenberg JE, Sandner P, Kuczyk MA & Hedlund P. (2011) Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles. J Sex Med 8, 3058–3065.
67. Ustinova EE, Fraser MO & Pezzone MA. (2010) Cross-talk and sensitization of bladder afferent nerves. Neurourol Urodyn 29, 77–81.
68. Vicari E. (1999) Seminal leukocyte concentration and related specific reactive oxygen species production in patients with male accessory gland infections. Hum Reprod 14, 2025–2030.
69. Vicari E. (2000) Effectiveness and limits of antimicrobial treatment on seminal leukocyte concentration and related reactive oxygen species production in patients with male accessory gland infection. Hum Reprod 15, 2536–2544.
70. Vicari E, Rubino C, De Palma A, Longo G, Lauretta M, Consoli S & Arancio A. (2001) Antioxidant therapeutic efficiency after the use of carnitine in infertile patients with bacterial or non bacterial prostato-vesiculo-epididymitis. Arch Ital Urol Androl 73, 15–25.
71. Vicari E, La Vignera S & Calogero AE. (2002) Antioxidant treatment with carnitines is effective in infertile patients with prostatovesiculoepididymitis and elevated seminal leukocyte concentrations after treatment with nonsteroidal anti-inflammatory compounds. Fertil Steril 78, 1203–1208.
72. Vicari E, Calogero AE, Condorelli RA, Vicari LO & La Vignera S. (2012) Male accessory gland infection frequency in infertile patients with chronic microbial prostatitis and irritable bowel syndrome. Int J Androl 35, 183–189.
73. Wagenlehner FM & Naber KG. (2006) Current challenges in the treatment of complicated urinary tract infections and prostatitis. Clin Microbiol Infect 12(Suppl 3), 67–80.
74. Weidner W, Krause W & Ludwig M. (1999) Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitis. Hum Reprod Update 5, 421–432.
75. Weidner W, Wagenlehner FM, Marconi M, Pilatz A, Pantke KH & Diemer T. (2008) Acute bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome: andrological implications. Andrologia 40, 105–112.
76. Weinstock LB, Geng B & Brandes SB. (2011) Chronic prostatitis and small intestinal bacterial overgrowth: effect of rifaximin. Can J Urol 18, 5826–5830.
77. Wilson MJ, Woodson M, Wiehr C, Reddy A & Sinha AA. (2004) Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostatitis in the lateral prostate lobe of the Wistar rat. Exp Mol Pathol 77, 7–17.
78. World Health Organization. (1993) Manual for the Standardized Investigation and Diagnosis of the Infertile Couple, p. 2. Cambridge University Press, Cambridge, UK.
79. Yang GQ, Li SW, Zheng H, Zhang WB, Hu WL & Zheng XM. (2009) Expression of estrogen receptor beta in benign prostatic hyperplasia complicated by chronic prostatitis. Zhonghua Nan KeXue 15, 314–317.
80. Yatkin E, Bernoulli J, Talvitie EM & Santti R. (2009) Inflammation and epithelial alterations in rat prostate: impact of the androgen to oestrogen ratio. Int J Androl 32, 399–410.