A comprehensive method to quantify adaptations by male and female micewith hot flashes induced by the neurokinin b receptor agonist senktide

Endocrinology

Volumn 158, Issue 10, 2017, Pages 3259-3268

  Krull, Ashley A ^a,b   Larsen, Sarah A ^a   Clifton, Donald K ^a   Neal Perry, Genevieve ^a   Steiner, Robert A ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; PROTEIN FOS; SENKTIDE; VANILLOID RECEPTOR 1; NEUROKININ 3 RECEPTOR; PEPTIDE FRAGMENT; PROTEIN C FOS; SUBSTANCE P;

ADAPTIVE BEHAVIOR; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORE TEMPERATURE; FEMALE; HOT FLUSH; MALE; MEDIAL PREOPTIC AREA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; SKIN TEMPERATURE; THERMOCLINE; THERMOREGULATION; ADAPTATION; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL BEHAVIOR; BODY TEMPERATURE; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; DISEASE MODEL; HEAT; PATHOPHYSIOLOGY; PHYSIOLOGY; PREOPTIC AREA;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; CAPSAICIN; DISEASE MODELS, ANIMAL; FEMALE; HOT FLASHES; HOT TEMPERATURE; MALE; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; PREOPTIC AREA; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, NEUROKININ-3; SKIN TEMPERATURE; SUBSTANCE P;

EID: 85030647210     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2017-00142     Document Type: Article

References (36)

1. Avis NE, Crawford SL, McKinlay SM. Psychosocial, behavioral, and health factors related to menopause symptomatology. Womens Health. 1997;3(2):103-120.
2. Feldman BM, Voda A, Gronseth E. The prevalence of hot flash and associated variables among perimenopausal women. Res Nurs Health. 1985;8(3):261-268.
3. Hunter MS, Gentry-Maharaj A, Ryan A, Burnell M, Lanceley A, Fraser L, Jacobs I, Menon U. Prevalence, frequency and problem rating of hot flushes persist in older postmenopausal women: impact of age, body mass index, hysterectomy, hormone therapy use, lifestyle and mood in a cross-sectional cohort study of 10, 418 British women aged 54-65. BJOG. 2012;119(1):40-50.
4. Ahmadi H, Daneshmand S. Androgen deprivation therapy: evidencebased management of side effects. BJU Int. 2013;111(4):543-548.
5. Spetz AC, Zetterlund EL, Varenhorst E, Hammar M. Incidence and management of hot flashes in prostate cancer. J Support Oncol. 2003;1(4):263-266, 269-270, 272-273, discussion 267-268, 271-272.
6. Rance NE, Dacks PA, Mittelman-Smith MA, Romanovsky AA, Krajewski-Hall SJ. Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes. Front Neuroendocrinol. 2013;34(3):211-227.
7. Irwig MS, Fraley GS, Smith JT, Acohido BV, Popa SM, Cunningham MJ, Gottsch ML, Clifton DK, Steiner RA. Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1mRNAin the male rat. Neuroendocrinology. 2004; 80(4):264-272.
8. Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, SteinerRA. Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci. 2009;29(38):11859-11866.
9. Pielecka-Fortuna J, Chu Z, Moenter SM. Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology. 2008;149(4):1979-1986.
10. Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, Lai J, Ciofi P, McMullen NT, Rance NE. Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology. 2012; 153(6):2800-2812.
11. Casper RF, Yen SS, Wilkes MM. Menopausal flushes: A neuroendocrine link with pulsatile luteninizing hormone secreation. Science. 1979;205(4408):823-825.
12. DeFazio J, Meldrum DR, Laufer L, Vale W, Rivier J, Lu JK, Judd HL. Induction of hot flashes in premenopausal women treated with a long-Acting GnRH agonist. J Clin Endocrinol Metab. 1983; 56(3):445-448.
13. Casper RF, Yen SS. Menopausal flushes: effect of pituitary gonadotropin desensitization by a potent luteinizing hormone-releasing factor agonist. J Clin Endocrinol Metab. 1981;53(5):1056-1058.
14. Meldrum DR, Erlik Y, Lu JK, Judd HL. Objectively recorded hot flushes in patients with pituitary insufficiency. J Clin Endocrinol Metab. 1981;52(4):684-687.
15. Dacks PA, Krajewski SJ, Rance NE. Activation of neurokinin 3 receptors in the median preoptic nucleus decreases core temperature in the rat. Endocrinology. 2011;152(12):4894-4905.
16. Krajewski SJ, Burke MC, Anderson MJ, McMullen NT, Rance NE. Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-Tracing and monosodium glutamate lesions in the rat. Neuroscience. 2010;166(2):680-697.
17. Yeo SH, Herbison AE. Projections of arcuate nucleus and rostral periventricular kisspeptin neurons in the adult female mouse brain. Endocrinology. 2011;152(6):2387-2399.
18. Gervais NJ, Viechweg SS, Mong JA, Lacreuse A. The middle-Aged ovariectomized marmoset (Callithrix jacchus) as a model of menopausal symptoms: Preliminary evidence. Neuroscience. 2016;337:1-8.
19. Kobayashi T, Tamura M, Hayashi M, Katsuura Y, Tanabe H, Ohta T, Komoriya K. Elevation of tail skin temperature in ovariectomized rats in relation to menopausal hot flushes. Am J Physiol Regul Integr Comp Physiol. 2000;278:R863-R869.
20. Albertson AJ, Skinner DC. A novel animal model to study hot flashes: no effect of gonadotropin-releasing hormone. Menopause. 2009;16(5):1030-1036.
21. Holinka CFM, Brincat M, Coelingh Bennink HJ. Preventive effect of oral estetrol in a menopausal hot flush model. Climacteric. 2008; 11(Suppl 1):15-21.
22. Shuto H, Yamauchi A, Ikeda M, Sohda Y, Koga A, Tominaga K, Egawa T, Kataoka Y. Forced exercise-induced flushing of tail skin in ovariectomized mice, as a new experimental model of menopausal hot flushes. J Pharmacol Sci. 2005;98(3):323-326.
23. Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, McMullen NT, Rance NE. Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature. Proc Natl Acad Sci USA. 2012; 109(48):19846-19851.
24. Sanchez-Alavez M, Alboni S, Conti B. Sex-And age-specific differences in core body temperature of C57Bl/6 mice. Age (Dordr). 2011;33(1):89-99.
25. Gordon CJ. Behavioral and autonomic thermoregulation in mice exposed to microwave radiation. J Appl Physiol. 1983;55(4): 1242-1248.
26. Gordon CJ. Relationship between autonomic and behavioral thermoregulation in the mouse. Physiol Behav. 1985;34(5): 687-690.
27. Gaskill BN, Gordon CJ, Pajor EA, Lucas JR, Davis JK, Garner JP. Heat or insulation: behavioral titration of mouse preference for warmth or access to a nest. PLoS One. 2012;7(3):e32799.
28. Freedman RR, Norton D, Woodward S, Corńelissen G. Core body temperature and circadian rhythm of hot flashes in menopausal women. J Clin Endocrinol Metab. 1995;80(8):2354-2358.
29. Freedman RR, Woodward S. Core body temperature during menopausal hot flushes. Fertil Steril. 1996;65(6):1141-1144.
30. Feketa VV, Zhang Y, Cao Z, Balasubramanian A, Flores CM, Player MR, Marrelli SP. Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. Crit Care Med. 2014;42(5):e355-e363.
31. Shimizu I, Iida T, Horiuchi N, Caterina MJ. 5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro. J Pharmacol Exp Ther. 2005; 314(3):1378-1385.
32. Jayasena CN, Comninos AN, Stefanopoulou E, Buckley A, Narayanaswamy S, Izzi-Engbeaya C, Abbara A, Ratnasabapathy R, Mogford J, Ng N, Sarang Z, Ghatei MA, Bloom SR, Hunter MS, Dhillo WS. Neurokinin B administration induces hot flushes in women. Sci Rep. 2015;5:8466.
33. Mittelman-Smith MA, Krajewski-Hall SJ, McMullen NT, Rance NE. Neurokinin 3 receptor-expressing neurons in the median preoptic nucleus modulate heat-dissipation effectors in the female rat. Endocrinology. 2015;156(7):2552-2562.
34. Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, Clifton DK, Mori Y, Tsukamura H, Maeda K, Steiner RA, Okamura H. Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci. 2010;30(8):3124-3132.
35. Oakley AE, Steiner RA, Chavkin C, Clifton DK, Ferrara LK, Reed SD. k Agonists as a novel therapy for menopausal hot flashes. Menopause. 2015;22(12):1328-1334.
36. George JT, Kakkar R, Marshall J, Scott ML, Finkelman RD, Ho TW, Veldhuis J, Skorupskaite K, Anderson RA, McIntosh S, Webber L. Neurokinin B receptor antagonism in women with polycystic ovary syndrome: A randomized, placebo-controlled trial. J Clin Endocrinol Metab. 2016;101(11):4313-4321.