Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

Journal of Molecular Biology

Volumn 429, Issue 23, 2017, Pages 3650-3665

  Al Hilaly, Youssra K ^a,b   Pollack, Saskia J ^a   Vadukul, Devkee M ^a   Citossi, Francesca ^a   Rickard, Janet E ^c   Simpson, Michael ^d   Storey, John M D ^d,e   Harrington, Charles R ^c,e   Wischik, Claude M ^c,e   Serpell, Louise C ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b MUSTANSIRIYAH UNIVERSITY   (Iraq)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e TAURX THERAPEUTICS LTD   (United Kingdom)

Author keywords

Alzheimer's disease; disulfide; neurofibrillary tangles; paired helical filaments; tau

Indexed keywords

ALANINE; AMINO ACID; CYSTEINE; DISULFIDE; PROTEIN VARIANT; TAU PROTEIN; AMYLOID BETA PROTEIN; CROSS LINKING REAGENT;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ARTICLE; CIRCULAR DICHROISM; CROSS LINKING; ELECTRON MICROSCOPY; HUMAN; IN VITRO STUDY; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROCESSING; PROTEIN STRUCTURE; X RAY DIFFRACTION; BRAIN; CHEMISTRY; METABOLISM; NEUROFIBRILLARY TANGLE; PATHOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BRAIN; CROSS-LINKING REAGENTS; DISULFIDES; HUMANS; NEUROFIBRILLARY TANGLES; TAU PROTEINS;

EID: 85030644788     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2017.09.007     Document Type: Article

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