메뉴 건너뛰기




Volumn 47, Issue 1, 2017, Pages 183-198.e6

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

(42)  Takata, Kazuyuki a,b   Kozaki, Tatsuya a   Lee, Christopher Zhe Wei a   Thion, Morgane Sonia c   Otsuka, Masayuki a   Lim, Shawn a   Utami, Kagistia Hana d   Fidan, Kerem e   Park, Dong Shin a   Malleret, Benoit a,f   Chakarov, Svetoslav a   See, Peter a   Low, Donovan a   Low, Gillian a   Garcia Miralles, Marta d   Zeng, Ruizhu d   Zhang, Jinqiu d   Goh, Chi Ching a   Gul, Ahmet g   Hubert, Sandra a   more..


Author keywords

co culture; familial Mediterranean fever; hematopoiesis; induced pluripotent stem cells; IPSC; macrophages; microglia; neurons; primitive; pulmonary alveolar proteinosis; resident

Indexed keywords

BIOLOGICAL MARKER; CD11B ANTIGEN; CD276 ANTIGEN; CD38 ANTIGEN; CD45 ANTIGEN; CD48 ANTIGEN; CD81 ANTIGEN; CD9 ANTIGEN; CD93 ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; CXCL1 CHEMOKINE; CYCLIN DEPENDENT KINASE 9; CYCLIN DEPENDENT KINASE INHIBITOR 1B; F4 80 PROTEIN; FIBRINOGEN RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 6; ISG15 PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NFKBIA PROTEIN; PEPTIDES AND PROTEINS; RANTES; SIGLEC F; STEM CELL FACTOR; SURFACTANT PROTEIN B; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 3; UNCLASSIFIED DRUG; USP18 PROTEIN;

EID: 85030447045     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.06.017     Document Type: Article
Times cited : (242)

References (56)
  • 1
    • 84945942332 scopus 로고    scopus 로고
    • Lost in translation: pluripotent stem cell-derived hematopoiesis
    • Ackermann, M., Liebhaber, S., Klusmann, J.H., Lachmann, N., Lost in translation: pluripotent stem cell-derived hematopoiesis. EMBO Mol. Med. 7 (2015), 1388–1402.
    • (2015) EMBO Mol. Med. , vol.7 , pp. 1388-1402
    • Ackermann, M.1    Liebhaber, S.2    Klusmann, J.H.3    Lachmann, N.4
  • 6
    • 84989347290 scopus 로고    scopus 로고
    • Cytofkit: A bioconductor package for an integrated mass cytometry data analysis pipeline
    • Chen, H., Lau, M.C., Wong, M.T., Newell, E.W., Poidinger, M., Chen, J., Cytofkit: A bioconductor package for an integrated mass cytometry data analysis pipeline. PLoS Comput. Biol., 12, 2016, e1005112.
    • (2016) PLoS Comput. Biol. , vol.12 , pp. e1005112
    • Chen, H.1    Lau, M.C.2    Wong, M.T.3    Newell, E.W.4    Poidinger, M.5    Chen, J.6
  • 7
    • 58149235681 scopus 로고    scopus 로고
    • Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast
    • Cheng, X., Huber, T.L., Chen, V.C., Gadue, P., Keller, G.M., Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development 135 (2008), 3447–3458.
    • (2008) Development , vol.135 , pp. 3447-3458
    • Cheng, X.1    Huber, T.L.2    Chen, V.C.3    Gadue, P.4    Keller, G.M.5
  • 8
    • 70349202175 scopus 로고    scopus 로고
    • Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+ progenitors
    • Choi, K.D., Vodyanik, M.A., Slukvin, I.I., Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+ progenitors. J. Clin. Invest. 119 (2009), 2818–2829.
    • (2009) J. Clin. Invest. , vol.119 , pp. 2818-2829
    • Choi, K.D.1    Vodyanik, M.A.2    Slukvin, I.I.3
  • 9
    • 0034577943 scopus 로고    scopus 로고
    • IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
    • Chomarat, P., Banchereau, J., Davoust, J., Palucka, A.K., IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat. Immunol. 1 (2000), 510–514.
    • (2000) Nat. Immunol. , vol.1 , pp. 510-514
    • Chomarat, P.1    Banchereau, J.2    Davoust, J.3    Palucka, A.K.4
  • 10
    • 84869869406 scopus 로고    scopus 로고
    • The development of macrophages from human CD34+ haematopoietic stem cells in serum-free cultures is optimized by IL-3 and SCF
    • Clanchy, F.I., Hamilton, J.A., The development of macrophages from human CD34+ haematopoietic stem cells in serum-free cultures is optimized by IL-3 and SCF. Cytokine 61 (2013), 33–37.
    • (2013) Cytokine , vol.61 , pp. 33-37
    • Clanchy, F.I.1    Hamilton, J.A.2
  • 11
    • 16944365196 scopus 로고    scopus 로고
    • A candidate gene for familial Mediterranean fever
    • Consortium, F.F., French FMF Consortium. A candidate gene for familial Mediterranean fever. Nat. Genet. 17 (1997), 25–31.
    • (1997) Nat. Genet. , vol.17 , pp. 25-31
    • Consortium, F.F.1
  • 12
    • 84863201499 scopus 로고    scopus 로고
    • A novel in vitro human microglia model: characterization of human monocyte-derived microglia
    • Etemad, S., Zamin, R.M., Ruitenberg, M.J., Filgueira, L., A novel in vitro human microglia model: characterization of human monocyte-derived microglia. J. Neurosci. Methods 209 (2012), 79–89.
    • (2012) J. Neurosci. Methods , vol.209 , pp. 79-89
    • Etemad, S.1    Zamin, R.M.2    Ruitenberg, M.J.3    Filgueira, L.4
  • 13
    • 84946824415 scopus 로고    scopus 로고
    • Generation of integration-free induced pluripotent stem cells from a patient with Familial Mediterranean Fever (FMF)
    • Fidan, K., Kavaklıoğlu, G., Ebrahimi, A., Özlü, C., Ay, N.Z., Ruacan, A., Gül, A., Önder, T.T., Generation of integration-free induced pluripotent stem cells from a patient with Familial Mediterranean Fever (FMF). Stem Cell Res. (Amst.) 15 (2015), 694–696.
    • (2015) Stem Cell Res. (Amst.) , vol.15 , pp. 694-696
    • Fidan, K.1    Kavaklıoğlu, G.2    Ebrahimi, A.3    Özlü, C.4    Ay, N.Z.5    Ruacan, A.6    Gül, A.7    Önder, T.T.8
  • 14
    • 84946811351 scopus 로고    scopus 로고
    • Transgene-free disease-specific iPSC generation from fibroblasts and peripheral blood mononuclear cells
    • Fidan, K., Ebrahimi, A., Çağlayan, Ö.H., Özçimen, B., Önder, T.T., Transgene-free disease-specific iPSC generation from fibroblasts and peripheral blood mononuclear cells. Methods Mol. Biol. 1353 (2016), 215–231.
    • (2016) Methods Mol. Biol. , vol.1353 , pp. 215-231
    • Fidan, K.1    Ebrahimi, A.2    Çağlayan, Ö.H.3    Özçimen, B.4    Önder, T.T.5
  • 15
    • 33750936779 scopus 로고    scopus 로고
    • Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells
    • Gadue, P., Huber, T.L., Paddison, P.J., Keller, G.M., Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc. Natl. Acad. Sci. USA 103 (2006), 16806–16811.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 16806-16811
    • Gadue, P.1    Huber, T.L.2    Paddison, P.J.3    Keller, G.M.4
  • 16
    • 84867740805 scopus 로고    scopus 로고
    • Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    • Gautier, E.L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K.G., Gordonov, S., et al., Immunological Genome Consortium. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol. 13 (2012), 1118–1128.
    • (2012) Nat. Immunol. , vol.13 , pp. 1118-1128
    • Gautier, E.L.1    Shay, T.2    Miller, J.3    Greter, M.4    Jakubzick, C.5    Ivanov, S.6    Helft, J.7    Chow, A.8    Elpek, K.G.9    Gordonov, S.10
  • 17
    • 84960354901 scopus 로고    scopus 로고
    • Tissue-Resident Macrophage Ontogeny and Homeostasis
    • Ginhoux, F., Guilliams, M., Tissue-Resident Macrophage Ontogeny and Homeostasis. Immunity 44 (2016), 439–449.
    • (2016) Immunity , vol.44 , pp. 439-449
    • Ginhoux, F.1    Guilliams, M.2
  • 19
    • 84951335282 scopus 로고    scopus 로고
    • New insights into the multidimensional concept of macrophage ontogeny, activation and function
    • Ginhoux, F., Schultze, J.L., Murray, P.J., Ochando, J., Biswas, S.K., New insights into the multidimensional concept of macrophage ontogeny, activation and function. Nat. Immunol. 17 (2016), 34–40.
    • (2016) Nat. Immunol. , vol.17 , pp. 34-40
    • Ginhoux, F.1    Schultze, J.L.2    Murray, P.J.3    Ochando, J.4    Biswas, S.K.5
  • 21
    • 77950969390 scopus 로고    scopus 로고
    • Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells
    • Grigoriadis, A.E., Kennedy, M., Bozec, A., Brunton, F., Stenbeck, G., Park, I.H., Wagner, E.F., Keller, G.M., Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells. Blood 115 (2010), 2769–2776.
    • (2010) Blood , vol.115 , pp. 2769-2776
    • Grigoriadis, A.E.1    Kennedy, M.2    Bozec, A.3    Brunton, F.4    Stenbeck, G.5    Park, I.H.6    Wagner, E.F.7    Keller, G.M.8
  • 23
    • 84864628471 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes
    • HD iPSC Consortium. Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11 (2012), 264–278.
    • (2012) Cell Stem Cell , vol.11 , pp. 264-278
  • 24
    • 80051785308 scopus 로고    scopus 로고
    • Differentiation of mouse bone marrow derived stem cells toward microglia-like cells
    • Hinze, A., Stolzing, A., Differentiation of mouse bone marrow derived stem cells toward microglia-like cells. BMC Cell Biol., 12, 2011, 35.
    • (2011) BMC Cell Biol. , vol.12 , pp. 35
    • Hinze, A.1    Stolzing, A.2
  • 25
    • 84946564588 scopus 로고    scopus 로고
    • Ontogeny of Tissue-Resident Macrophages
    • Hoeffel, G., Ginhoux, F., Ontogeny of Tissue-Resident Macrophages. Front. Immunol., 6, 2015, 486.
    • (2015) Front. Immunol. , vol.6 , pp. 486
    • Hoeffel, G.1    Ginhoux, F.2
  • 26
    • 84928189502 scopus 로고    scopus 로고
    • C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
    • Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F.F., See, P., Beaudin, A.E., Lum, J., Low, I., Forsberg, E.C., et al. C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity 42 (2015), 665–678.
    • (2015) Immunity , vol.42 , pp. 665-678
    • Hoeffel, G.1    Chen, J.2    Lavin, Y.3    Low, D.4    Almeida, F.F.5    See, P.6    Beaudin, A.E.7    Lum, J.8    Low, I.9    Forsberg, E.C.10
  • 27
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • Jung, S., Aliberti, J., Graemmel, P., Sunshine, M.J., Kreutzberg, G.W., Sher, A., Littman, D.R., Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20 (2000), 4106–4114.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4106-4114
    • Jung, S.1    Aliberti, J.2    Graemmel, P.3    Sunshine, M.J.4    Kreutzberg, G.W.5    Sher, A.6    Littman, D.R.7
  • 28
    • 84902266763 scopus 로고    scopus 로고
    • Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions
    • Kanke, K., Masaki, H., Saito, T., Komiyama, Y., Hojo, H., Nakauchi, H., Lichtler, A.C., Takato, T., Chung, U.I., Ohba, S., Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem Cell Reports 2 (2014), 751–760.
    • (2014) Stem Cell Reports , vol.2 , pp. 751-760
    • Kanke, K.1    Masaki, H.2    Saito, T.3    Komiyama, Y.4    Hojo, H.5    Nakauchi, H.6    Lichtler, A.C.7    Takato, T.8    Chung, U.I.9    Ohba, S.10
  • 29
    • 49349094179 scopus 로고    scopus 로고
    • Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3
    • Karlsson, K.R., Cowley, S., Martinez, F.O., Shaw, M., Minger, S.L., James, W., Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3. Exp. Hematol. 36 (2008), 1167–1175.
    • (2008) Exp. Hematol. , vol.36 , pp. 1167-1175
    • Karlsson, K.R.1    Cowley, S.2    Martinez, F.O.3    Shaw, M.4    Minger, S.L.5    James, W.6
  • 30
    • 33947587879 scopus 로고    scopus 로고
    • Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures
    • Kennedy, M., D'Souza, S.L., Lynch-Kattman, M., Schwantz, S., Keller, G., Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood 109 (2007), 2679–2687.
    • (2007) Blood , vol.109 , pp. 2679-2687
    • Kennedy, M.1    D'Souza, S.L.2    Lynch-Kattman, M.3    Schwantz, S.4    Keller, G.5
  • 31
    • 84871698997 scopus 로고    scopus 로고
    • T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures
    • Kennedy, M., Awong, G., Sturgeon, C.M., Ditadi, A., LaMotte-Mohs, R., Zúñiga-Pflücker, J.C., Keller, G., T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures. Cell Rep. 2 (2012), 1722–1735.
    • (2012) Cell Rep. , vol.2 , pp. 1722-1735
    • Kennedy, M.1    Awong, G.2    Sturgeon, C.M.3    Ditadi, A.4    LaMotte-Mohs, R.5    Zúñiga-Pflücker, J.C.6    Keller, G.7
  • 33
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., Amit, I., Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 159 (2014), 1312–1326.
    • (2014) Cell , vol.159 , pp. 1312-1326
    • Lavin, Y.1    Winter, D.2    Blecher-Gonen, R.3    David, E.4    Keren-Shaul, H.5    Merad, M.6    Jung, S.7    Amit, I.8
  • 34
    • 79957777958 scopus 로고    scopus 로고
    • Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
    • Li, W., Sun, W., Zhang, Y., Wei, W., Ambasudhan, R., Xia, P., Talantova, M., Lin, T., Kim, J., Wang, X., et al. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc. Natl. Acad. Sci. USA 108 (2011), 8299–8304.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 8299-8304
    • Li, W.1    Sun, W.2    Zhang, Y.3    Wei, W.4    Ambasudhan, R.5    Xia, P.6    Talantova, M.7    Lin, T.8    Kim, J.9    Wang, X.10
  • 38
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn, A., Kirchhoff, F., Helmchen, F., Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308 (2005), 1314–1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 39
    • 77950447292 scopus 로고    scopus 로고
    • In vitro differentiation of lineage-negative bone marrow cells into microglia-like cells
    • Noto, D., Takahashi, K., Miyake, S., Yamada, M., In vitro differentiation of lineage-negative bone marrow cells into microglia-like cells. Eur. J. Neurosci. 31 (2010), 1155–1163.
    • (2010) Eur. J. Neurosci. , vol.31 , pp. 1155-1163
    • Noto, D.1    Takahashi, K.2    Miyake, S.3    Yamada, M.4
  • 40
    • 44449152487 scopus 로고    scopus 로고
    • The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF
    • Pearson, S., Sroczynska, P., Lacaud, G., Kouskoff, V., The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF. Development 135 (2008), 1525–1535.
    • (2008) Development , vol.135 , pp. 1525-1535
    • Pearson, S.1    Sroczynska, P.2    Lacaud, G.3    Kouskoff, V.4
  • 42
    • 84926507971 scopus 로고    scopus 로고
    • limma powers differential expression analyses for RNA-sequencing and microarray studies
    • Ritchie, M.E., Phipson, B., Wu, D., Hu, Y., Law, C.W., Shi, W., Smyth, G.K., limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res., 43, 2015, e47.
    • (2015) Nucleic Acids Res. , vol.43 , pp. e47
    • Ritchie, M.E.1    Phipson, B.2    Wu, D.3    Hu, Y.4    Law, C.W.5    Shi, W.6    Smyth, G.K.7
  • 44
    • 84943279510 scopus 로고    scopus 로고
    • Microglia function in central nervous system development and plasticity
    • Schafer, D.P., Stevens, B., Microglia function in central nervous system development and plasticity. Cold Spring Harb. Perspect. Biol., 7, 2015, a020545.
    • (2015) Cold Spring Harb. Perspect. Biol. , vol.7 , pp. a020545
    • Schafer, D.P.1    Stevens, B.2
  • 45
    • 84963520567 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease at 25 years
    • Selkoe, D.J., Hardy, J., The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol. Med. 8 (2016), 595–608.
    • (2016) EMBO Mol. Med. , vol.8 , pp. 595-608
    • Selkoe, D.J.1    Hardy, J.2
  • 46
    • 66149168690 scopus 로고    scopus 로고
    • Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells
    • Senju, S., Haruta, M., Matsunaga, Y., Fukushima, S., Ikeda, T., Takahashi, K., Okita, K., Yamanaka, S., Nishimura, Y., Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells. Stem Cells 27 (2009), 1021–1031.
    • (2009) Stem Cells , vol.27 , pp. 1021-1031
    • Senju, S.1    Haruta, M.2    Matsunaga, Y.3    Fukushima, S.4    Ikeda, T.5    Takahashi, K.6    Okita, K.7    Yamanaka, S.8    Nishimura, Y.9
  • 49
    • 84902133026 scopus 로고    scopus 로고
    • Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells
    • Sturgeon, C.M., Ditadi, A., Awong, G., Kennedy, M., Keller, G., Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells. Nat. Biotechnol. 32 (2014), 554–561.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 554-561
    • Sturgeon, C.M.1    Ditadi, A.2    Awong, G.3    Kennedy, M.4    Keller, G.5
  • 50
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., Yamanaka, S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006), 663–676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 51
    • 0030745449 scopus 로고    scopus 로고
    • Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever
    • The International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90 (1997), 797–807.
    • (1997) Cell , vol.90 , pp. 797-807
  • 53
    • 84942524460 scopus 로고    scopus 로고
    • Microglia: Dynamic mediators of synapse development and plasticity
    • Wu, Y., Dissing-Olesen, L., MacVicar, B.A., Stevens, B., Microglia: Dynamic mediators of synapse development and plasticity. Trends Immunol. 36 (2015), 605–613.
    • (2015) Trends Immunol. , vol.36 , pp. 605-613
    • Wu, Y.1    Dissing-Olesen, L.2    MacVicar, B.A.3    Stevens, B.4
  • 54
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn, T.A., Chawla, A., Pollard, J.W., Macrophage biology in development, homeostasis and disease. Nature 496 (2013), 445–455.
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 55
    • 0037313844 scopus 로고    scopus 로고
    • Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
    • Ying, Q.L., Stavridis, M., Griffiths, D., Li, M., Smith, A., Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat. Biotechnol. 21 (2003), 183–186.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 183-186
    • Ying, Q.L.1    Stavridis, M.2    Griffiths, D.3    Li, M.4    Smith, A.5
  • 56
    • 84866492339 scopus 로고    scopus 로고
    • Pure populations of murine macrophages from cultured embryonic stem cells. Application to studies of chemotaxis and apoptotic cell clearance
    • Zhuang, L., Pound, J.D., Willems, J.J., Taylor, A.H., Forrester, L.M., Gregory, C.D., Pure populations of murine macrophages from cultured embryonic stem cells. Application to studies of chemotaxis and apoptotic cell clearance. J. Immunol. Methods 385 (2012), 1–14.
    • (2012) J. Immunol. Methods , vol.385 , pp. 1-14
    • Zhuang, L.1    Pound, J.D.2    Willems, J.J.3    Taylor, A.H.4    Forrester, L.M.5    Gregory, C.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.