NOD2 (nucleotide-binding oligomerization domain 2) is a major pathogenic mediator of coxsackievirus B3-induced myocarditis

Circulation: Heart Failure

Volumn 10, Issue 9, 2017, Pages

  Tschöpe, Carsten ^a,b   Müller, Irene ^a,b   Xia, Yu ^a   Savvatis, Konstantinos ^a   Pappritz, Kathleen ^a,b   Pinkert, Sandra ^c   Lassner, Dirk ^d   Heimesaat, Markus M ^a   Spillmann, Frank ^a   Miteva, Kapka ^a   Bereswill, Stefan ^a   Schultheiss, Heinz Peter ^d   Fechner, Henry ^c   Pieske, Burkert ^a,b,e   Kühl, Uwe ^a   Van Linthout, Sophie ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^c TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^d Institut Kardiale Diagnostik und Therapie (IKDT)   (Germany)

^e DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Coxsackievirus B3; Interleukin 1; Myocarditis; Nucleotide binding oligomerization domain 2

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CASPASE 3; CASPASE 7; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD3 ANTIGEN; CD4 ANTIGEN; CD68 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; APOPTOSIS REGULATORY PROTEIN; CARD15 PROTEIN, MOUSE; IL1B PROTEIN, MOUSE; INTERLEUKIN 1BETA; NLRP3 PROTEIN, MOUSE; NOD2 PROTEIN, HUMAN; PYCARD PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDITIS; CLINICAL ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; COXSACKIEVIRUS B3; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE BIOPSY; HEART MUSCLE FIBROSIS; HEMODYNAMICS; HUMAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS LOAD; VIRUS MYOCARDITIS; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; CASE CONTROL STUDY; CELL LINE; COXSACKIEVIRUS INFECTIONS; DEFICIENCY; DISEASE MODEL; ENTEROVIRUS B; GENETIC PREDISPOSITION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MYOCARDITIS; PATHOLOGY; PHENOTYPE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; VIROLOGY;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASE-CONTROL STUDIES; CASPASE 1; CELL LINE; COXSACKIEVIRUS INFECTIONS; DISEASE MODELS, ANIMAL; ENTEROVIRUS B, HUMAN; GENETIC PREDISPOSITION TO DISEASE; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERLEUKIN-1BETA; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDITIS; MYOCARDIUM; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; NOD2 SIGNALING ADAPTOR PROTEIN; PHENOTYPE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION; UP-REGULATION;

EID: 85030430946     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.117.003870     Document Type: Article

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