Coxsackievirus B3 induces crosstalk between autophagy and apoptosis to benefit its release after replicating in autophagosomes through a mechanism involving caspase cleavage of autophagy-related proteins

Infection, Genetics and Evolution

Volumn 26, Issue , 2014, Pages 95-102

  Xin, Le ^a   Xiao, Zonghui ^a   Ma, Xiaolin ^a   He, Feng ^a   Yao, Hailan ^a   Liu, Zhewei ^a  

^a CAPITAL INSTITUTE OF PEDIATRICS   (China)

Author keywords

Apoptosis; Atg5; Autophagy; Beclin 1; Caspase; Coxsackievirus B3

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; CASPASE;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DIVISION; CELL VIABILITY; CONTROLLED STUDY; COXSACKIE VIRUS B3; COXSACKIE VIRUS INFECTION; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFECTION RATE; LIFE CYCLE STAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SEQUENCE ANALYSIS; TRANSLATION INITIATION; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS TITRATION; CELL LINE; ENTEROVIRUS B; GENETICS; METABOLISM; PHAGOSOME; PHYSIOLOGY; VIROLOGY; VIRUS RELEASE;

APOPTOSIS; AUTOPHAGY; CASPASES; CELL LINE; COXSACKIEVIRUS INFECTIONS; ENTEROVIRUS B, HUMAN; HUMANS; PHAGOSOMES; TRANSCRIPTION, GENETIC; VIRUS RELEASE; VIRUS REPLICATION;

EID: 84901783314     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2014.05.005     Document Type: Article

References (32)

1. Brisac C., Téoulé F., Autret A., Pelletier I., Colbère-Garapin F., Brenner C., Lemaire C., Blondel B. Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis. J. Virol. 2010, 84:12226-12235.
2. Besirli C.G., Chinskey N.D., Zheng Q.D., Zacks D.N. Autophagy activation in the injured photoreceptor inhibits fas-mediated apoptosis. Invest. Ophthalmol. Vis. Sci. 2011, 52:4193-4199.
3. Bozym R.A., Patel K., White C., Cheung K.H., Bergelson J.M., Morosky S.A., Coyne C.B. Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells. Mol. Biol. Cell 2011, 22:3010-3021.
4. Kemball Christopher C., Alirezaei Mehrdad, Flynn Claudia T., Wood Malcolm R., Harkins Stephanie, Kiosses William B., Lindsay Whitton J. Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo. J. Virol. 2010, 84:12110-12124.
5. Carthy C.M., Yanagawa B., Luo H., Granville D.J., Yang D., Cheung P., Cheung C., Esfandiarei M., Rudin C.M., Thompson C.B., Hunt D.W., McManus B.M. Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection. Virology 2003, 313:147-157.
6. Chau D.H., Yuan J., Zhang H., Cheung P., Lim T., Liu Z., Sall A., Yang D. Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1. Apoptosis 2007, 12:513-524.
7. Gnädig N.F., Beaucourt S., Campagnola G., Bordería A.V., Sanz-Ramos M., Gong P., Blanc H., Peersen O.B., Vignuzzi M. Coxsackievirus B3 mutator strains are attenuated in vivo. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E2294-E2303.
8. Hsu N.Y., Ilnytska O., Belov G., Santiana M., Chen Y.H., Takvorian P.M., Pau C., van der Schaar H., Kaushik-Basu N., Balla T., Cameron C.E., Ehrenfeld E., van Kuppeveld F.J., Altan-Bonnet N. Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell 2010, 141:799-811.
9. Jacobson M.D., Weil M., Raff M.C. Programmed cell death in animal development. Cell 1997, 88:347-354.
10. Kim K.S., Hufnagel G., Chapman N.M., Tracy S. The group B coxsackieviruses and myocarditis. Rev. Med. Virol. 2001, 11:355-368.
11. Knowlton K.U. CVB infection and mechanisms of viral cardiomyopathy. Curr. Top. Microbiol. Immunol. 2008, 323:315-335.
12. Klionsky D.J., Abdalla F.C., Abeliovich H., et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8:445-544.
13. Kyei G.B., Dinkins C., Davis A.S., Roberts E., Singh S.B., Dong C., Wu L., Kominami E., Ueno T., Yamamoto A., Federico M., Panganiban A., Vergne I., Deretic V. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J. Cell. Biol. 2009, 186:255-268.
14. Kihara A., Kabeya Y., Ohsumi Y., Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2001, 2:330-335.
15. Liu B., Fang M., Hu Y., Huang B., Li N., Chang C., Huang R., Xu X., Yang Z., Chen Z., Liu W. Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. Autophagy 2013, 23:416-430.
16. Luo S., Rubinsztein D.C. Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-X. Cell Death Differ. 2010, 17:268-277.
17. Liang Y., Li Y., Li Z., Liu Z., Zhang Z., Chang S., Wu J. Mechanism of folate deficiency-induced apoptosis in mouse embryonic stem cells: cell cycle arrest/apoptosis in G1/G0 mediated by microRNA-302a and tumor suppressor gene Lats2. Int. J. Biochem. Cell Biol. 2012, 44:1750-1760.
18. Li X., Li Z., Zhou W., Xing X., Huang L., Tian L., Chen J., Chen C., Ma X., Yang Z. Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells. Cell Death Dis. 2013, 4:e803-809.
19. You Min, Savaraj Niramol, Kuo Macus T., Wangpaichitr Medhi, Varona-Santos Javier, Wu Chunjing, Nguyen Dao M., Feun Lynn TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation. Mol. Cell. Biochem. 2013, 374:181-190.
20. Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat. Rev. Mol. Cell Biol. 2001, 2:211-216.
21. Reggiori F., Klionsky D.J. Autophagosomes: biogenesis from scratch?. Curr. Opin. Cell Biol. 2005, 17:415-422.
22. Rosenfeldt M.T., Ryan K.M. The multiple roles of autophagy in cancer. Carcinogenesis 2011, 32:955-963.
23. Saiki S., Sasazawa Y., Imamichi Y., Kawajiri S., Fujimaki T., Tanida I., Kobayashi H., Sato F., Sato S., Ishikawa K., Imoto M., Hattori N. Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy 2011, 7:176-187.
24. Schägger H. Tricine-SDS-PAGE. Nat. Protoc. 2006, 1:16-22.
25. Tam P.E. Coxsackievirus myocarditis: interplay between virus and host in the pathogenesis of heart disease. Viral Immunol. 2006, 19:133-146.
26. Tasdemir E., Galluzzi L., Maiuri M.C., Criollo A., Vitale I., Hangen E., Modjtahedi N., Kroemer G. Methods for assessing autophagy and autophagic cell death. Methods Mol. Biol. 2008, 445:29-76.
27. Wong J., Zhang J., Si X., Gao G., Mao I., McManus B.M., Luo H. Autophagosome supports coxsackievirus B3 replication in host cells. J. Virol. 2008, 82:9143-9153.
28. Wirawan E., Vande Walle L., Kersse K., Cornelis S., Claerhout S., Vanoverberghe I., Roelandt R., De Rycke R., Verspurten J., Declercq W., Agostinis P., Vanden Berghe T., Lippens S., Vandenabeele P. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis. 2010, 1:e18.
29. Xi X., Zhang X., Wang B., Wang T., Wang J., Huang H., Wang J., Jin Q., Zhao Z. The interplays between autophagy and apoptosis induced by enterovirus 71. PLoS One 2013, 8:e56966.
30. Yuan J.P., Zhao W., Wang H.T., Wu K.Y., Li T., Guo X.K., Tong S.Q. Coxsackievirus B3-induced apoptosis and caspase-3. Cell Res. 2003, 13:203-209.
31. You M., Savaraj N., Kuo M.T., Wangpaichitr M., Varona-Santos J., Wu C., Nguyen D.M., Feun L. TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation. Mol. Cell. Biochem. 2013, 374:181-190.
32. Zhang H.M., Yanagawa B., Cheung P., Luo H., Yuan J., Chau D., Wang A., Bohunek L., Wilson J.E., McManus B.M., Yang D. Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptotic cell death via a mitochondria-dependent pathway. Circ. Res. 2002, 90:1251-1258.