-
1
-
-
0036795111
-
Analysis of induced sputum in adults with asthma: Identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
-
Green RH, Brightling CE, Woltmann G, et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002; 57: 875-879.
-
(2002)
Thorax
, vol.57
, pp. 875-879
-
-
Green, R.H.1
Brightling, C.E.2
Woltmann, G.3
-
2
-
-
84874196355
-
Distribution of sputum cellular phenotype in a large asthma cohort: Predicting factors for eosinophilic vs neutrophilic inflammation
-
Schleich FN, Manise M, Sele J, et al. Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation. BMC Pulm Med 2013; 13: 11.
-
(2013)
BMC Pulm Med
, vol.13
, pp. 11
-
-
Schleich, F.N.1
Manise, M.2
Sele, J.3
-
3
-
-
84885037157
-
New treatments for severe treatment-resistant asthma: Targeting the right patient
-
Chung KF. New treatments for severe treatment-resistant asthma: targeting the right patient. Lancet Respir Med 2013; 1: 639-652.
-
(2013)
Lancet Respir Med
, vol.1
, pp. 639-652
-
-
Chung, K.F.1
-
4
-
-
84893513577
-
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
-
Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014; 43: 343-373.
-
(2014)
Eur Respir J
, vol.43
, pp. 343-373
-
-
Chung, K.F.1
Wenzel, S.E.2
Brozek, J.L.3
-
5
-
-
85007464360
-
U-BIOPRED clinical adult asthma clusters linked to a subset of sputum-omics
-
Lefaudeux D, De Meulder B, Loza MJ, et al. U-BIOPRED clinical adult asthma clusters linked to a subset of sputum-omics. J Allergy Clin Immunol 2017; 139: 1797-1807.
-
(2017)
J Allergy Clin Immunol
, vol.139
, pp. 1797-1807
-
-
Lefaudeux, D.1
De Meulder, B.2
Loza, M.J.3
-
6
-
-
76149146032
-
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
-
Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010; 181: 315-323.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 315-323
-
-
Moore, W.C.1
Meyers, D.A.2
Wenzel, S.E.3
-
8
-
-
84899647833
-
Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data
-
Wu W, Bleecker E, Moore W, et al. Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J Allergy Clin Immunol 2014; 133: 1280-1288.
-
(2014)
J Allergy Clin Immunol
, vol.133
, pp. 1280-1288
-
-
Wu, W.1
Bleecker, E.2
Moore, W.3
-
9
-
-
84903834828
-
Importance of concomitant local and systemic eosinophilia in uncontrolled asthma
-
Schleich FN, Chevremont A, Paulus V, et al. Importance of concomitant local and systemic eosinophilia in uncontrolled asthma. Eur Respir J 2014; 44: 97-108.
-
(2014)
Eur Respir J
, vol.44
, pp. 97-108
-
-
Schleich, F.N.1
Chevremont, A.2
Paulus, V.3
-
10
-
-
84892509279
-
How variability in clinical phenotypes should guide research into disease mechanisms in asthma
-
Chung KF, Adcock IM. How variability in clinical phenotypes should guide research into disease mechanisms in asthma. Ann Am Thorac Soc 2013; 10: Suppl, S109-S117.
-
(2013)
Ann am Thorac Soc
, vol.10
, pp. S109-S117
-
-
Chung, K.F.1
Adcock, I.M.2
-
11
-
-
69249150516
-
T-helper type 2-driven inflammation defines major subphenotypes of asthma
-
Woodruff PG, Modrek B, Choy DF, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009; 180: 388-395.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 388-395
-
-
Woodruff, P.G.1
Modrek, B.2
Choy, D.F.3
-
12
-
-
85013420544
-
T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED
-
Kuo CS, Pavlidis S, Loza M, et al. T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED. Eur Respir J 2017; 49: 1602135.
-
Eur Respir J
, vol.49
, pp. 2017
-
-
Kuo, C.S.1
Pavlidis, S.2
Loza, M.3
-
13
-
-
84897434287
-
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma
-
Simpson JL, Phipps S, Baines KJ, et al. Elevated expression of the NLRP3 inflammasome in neutrophilic asthma. Eur Respir J 2014; 43: 1067-1076.
-
(2014)
Eur Respir J
, vol.43
, pp. 1067-1076
-
-
Simpson, J.L.1
Phipps, S.2
Baines, K.J.3
-
15
-
-
84961054838
-
Blood eosinophil count and prospective annual asthma disease burden: A UK cohort study
-
Price DB, Rigazio A, Campbell JD, et al. Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study. Lancet Respir Med 2015; 3: 849-858.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 849-858
-
-
Price, D.B.1
Rigazio, A.2
Campbell, J.D.3
-
16
-
-
85016302190
-
Clinical profile of patients with adult-onset eosinophilic asthma
-
de Groot JC, Storm H, Amelink M, et al. Clinical profile of patients with adult-onset eosinophilic asthma. ERJ Open Res 2016; 2: 00100-2015.
-
(2016)
ERJ Open Res
, vol.2
, pp. 00100-02015
-
-
De Groot, J.C.1
Storm, H.2
Amelink, M.3
-
17
-
-
85017095118
-
Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): A randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial
-
Chupp GL, Bradford ES, Albers FC, et al. Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial. Lancet Respir Med 2017; 5: 390-400.
-
(2017)
Lancet Respir Med
, vol.5
, pp. 390-400
-
-
Chupp, G.L.1
Bradford, E.S.2
Albers, F.C.3
-
18
-
-
84994908383
-
Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): A randomised, multicentre, placebo-controlled phase 3 trial
-
Bleecker ER, FitzGerald JM, Chanez P, et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet 2016; 388: 2115-2127.
-
(2016)
Lancet
, vol.388
, pp. 2115-2127
-
-
Bleecker, E.R.1
Fitzgerald, J.M.2
Chanez, P.3
-
19
-
-
85019110286
-
Severe eosinophilic asthma: A roadmap to consensus
-
Buhl R, Humbert M, Bjermer L, et al. Severe eosinophilic asthma: a roadmap to consensus. Eur Respir J 2017; 49: 1700634.
-
(2017)
Eur Respir J
, vol.49
-
-
Buhl, R.1
Humbert, M.2
Bjermer, L.3
-
20
-
-
84940540059
-
Biomarker qualification: Toward a multiple stakeholder framework for biomarker development, regulatory acceptance, and utilization
-
Amur S, LaVange L, Zineh I, et al. Biomarker qualification: toward a multiple stakeholder framework for biomarker development, regulatory acceptance, and utilization. Clin Pharmacol Ther 2015; 98: 34-46.
-
(2015)
Clin Pharmacol Ther
, vol.98
, pp. 34-46
-
-
Amur, S.1
Lavange, L.2
Zineh, I.3
-
21
-
-
84857429187
-
A systematic review and meta-analysis: Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils)
-
Petsky HL, Cates CJ, Lasserson TJ, et al. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils). Thorax 2012; 67: 199-208.
-
(2012)
Thorax
, vol.67
, pp. 199-208
-
-
Petsky, H.L.1
Cates, C.J.2
Lasserson, T.J.3
-
22
-
-
84939640508
-
Blood eosinophils as a marker of likely corticosteroid response in children with preschool wheeze: Time for an eosinophil guided clinical trial?
-
Gaillard EA, McNamara PS, Murray CS, et al. Blood eosinophils as a marker of likely corticosteroid response in children with preschool wheeze: time for an eosinophil guided clinical trial? Clin Exp Allergy 2015; 45: 1384-1395.
-
(2015)
Clin Exp Allergy
, vol.45
, pp. 1384-1395
-
-
Gaillard, E.A.1
McNamara, P.S.2
Murray, C.S.3
-
23
-
-
84865145614
-
Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
-
Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012; 380: 651-659.
-
(2012)
Lancet
, vol.380
, pp. 651-659
-
-
Pavord, I.D.1
Korn, S.2
Howarth, P.3
-
24
-
-
84907424177
-
Mepolizumab treatment in patients with severe eosinophilic asthma
-
Ortega HG, Liu MC, Pavord ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 2014; 371: 1198-1207.
-
(2014)
N Engl J Med
, vol.371
, pp. 1198-1207
-
-
Ortega, H.G.1
Liu, M.C.2
Pavord, I.D.3
-
25
-
-
84969941126
-
Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: A secondary analysis of the DREAM and MENSA studies
-
Ortega HG, Yancey SW, Mayer B, et al. Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies. Lancet Respir Med 2016; 4: 549-556.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 549-556
-
-
Ortega, H.G.1
Yancey, S.W.2
Mayer, B.3
-
26
-
-
84876883293
-
Exploring the effects of omalizumab in allergic asthma: An analysis of biomarkers in the EXTRA study
-
Hanania NA, Wenzel S, Rosen K, et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med 2013; 187: 804-811.
-
(2013)
Am J Respir Crit Care Med
, vol.187
, pp. 804-811
-
-
Hanania, N.A.1
Wenzel, S.2
Rosen, K.3
-
27
-
-
52049087356
-
Endotyping asthma: New insights into key pathogenic mechanisms in a complex, heterogeneous disease
-
Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 2008; 372: 1107-1119.
-
(2008)
Lancet
, vol.372
, pp. 1107-1119
-
-
Anderson, G.P.1
-
28
-
-
84920873293
-
Clinical phenotypes of asthma should link up with disease mechanisms
-
Chung KF, Adcock IM. Clinical phenotypes of asthma should link up with disease mechanisms. Curr Opin Allergy Clin Immunol 2015; 15: 56-62.
-
(2015)
Curr Opin Allergy Clin Immunol
, vol.15
, pp. 56-62
-
-
Chung, K.F.1
Adcock, I.M.2
-
29
-
-
85019098020
-
Perspectives of patients and healthcare professionals on mHealth for asthma self-management
-
Simpson AJ, Honkoop PJ, Kennington E, et al. Perspectives of patients and healthcare professionals on mHealth for asthma self-management. Eur Respir J 2017; 49; 1601966.
-
(2017)
Eur Respir J
, vol.49
-
-
Simpson, A.J.1
Honkoop, P.J.2
Kennington, E.3
|