In-vivo biological activity and glycosylation analysis of a biosimilar recombinant human follicle-stimulating hormone product (Bemfola) compared with its reference medicinal product (GONAL-f)

PLoS ONE

Volumn 12, Issue 9, 2017, Pages

  Mastrangeli, Renato ^a   Satwekar, Abhijeet ^a   Cutillo, Francesca ^a   Ciampolillo, Cinzia ^b   Palinsky, Wolf ^c   Longobardi, Salvatore ^a  

^a Merck Serono SpA   (Italy)

^b Istituto di Ricerche Biomediche Antoine Marxer SpA   (Italy)

^c MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; BIOSIMILAR AGENT; RECOMBINANT FOLLITROPIN; FOLLITROPIN; FUCOSE; GLYCOPEPTIDE; N ACETYLNEURAMINIC ACID; POLYSACCHARIDE; PROTEIN SUBUNIT; RECOMBINANT PROTEIN;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; IN VIVO STUDY; PEPTIDE MAPPING; PROTEIN GLYCOSYLATION; SIALYLATION; SIGNAL TRANSDUCTION; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; GLYCOSYLATION; HUMAN; METABOLISM; PROTEIN SUBUNIT; STANDARD;

ASPARAGINE; BIOSIMILAR PHARMACEUTICALS; FOLLICLE STIMULATING HORMONE; FOLLICLE STIMULATING HORMONE, HUMAN; FUCOSE; GLYCOPEPTIDES; GLYCOSYLATION; HUMANS; N-ACETYLNEURAMINIC ACID; PEPTIDE MAPPING; POLYSACCHARIDES; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; REFERENCE STANDARDS;

EID: 85029825574     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0184139     Document Type: Article

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