Role of inhaled nitric oxide in the management of severe acute respiratory distress syndrome

Frontiers in Pediatrics

Volumn 4, Issue AUG, 2016, Pages

  Hunt, Juliette Lucinda ^a   Bronicki, Ronald A ^b   Anas, Nick ^a  

^a CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

Clinical trials; Inhaled nitric oxide; Mechanisms of action; Pediatric acute respiratory distress syndrome; Pulmonary hypertension

Indexed keywords

EID: 85029747807     PISSN: None     EISSN: 22962360     Source Type: Journal    
DOI: 10.3389/fped.2016.00074     Document Type: Review

References (49)

1. Adhikari NK, Burns KE, Friedrich JO, Granton JT, Cook DJ, Meade MO. Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ (2007) 334(7597):779. doi: 10.1136/bmj.39139.716794.55
2. Adhikari NK, Dellinger RP, Lundin S, Payen D, Vallet B, Gerlach H, et al. Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis. Crit Care Med (2014) 42(2):404-12. doi:10.1097/CCM.0b013e3182a27909
3. Afshari A, Brok J, Møller AM, Wetterslev J. Inhaled nitric oxide for acute respiratory distress syndrome and acute lung injury in adults and children: a systematic review with meta-analysis and trial sequential analysis. Anesth Analg (2011) 112(6):1411-21. doi:10.1213/ANE.0b013e31820bd185
4. Ballard RA, Truog WE, Cnaan A, Martin RJ, Ballard PL, Merrill JD, et al. Inhaled nitric oxide in preterm infants undergoing mechanical ventilation. N Engl J Med (2006) 355:343-53. doi:10.1056/NEJMoa061088
5. Clark RH, Kueser TJ, Walker MW, Southgate WM, Huckaby JL, Perez JA, et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group. N Engl J Med (2000) 342(7):469-74. doi:10.1056/NEJM200002173420704
6. Schreiber MD, Gin-Mestan K, Marks JD, Huo D, Lee G, Srisuparp P. Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N Engl J Med (2003) 349:2099-107. doi:10.1056/NEJMoa031154
7. Piantadosi CA, Schwartz DA. The acute respiratory distress syndrome. Ann Intern Med (2004) 141(6):460-70. doi:10.7326/0003-4819-141-6-200409210-00012
8. Network ARDS. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med (2000) 342:1301-8. doi:10.1056/NEJM200005043421801
9. Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA (1999) 282(1):54-61. doi:10.1001/jama.282.1.54
10. Tremblay LN, Slutsky AS. Ventilator-induced lung injury: from barotraumas to biotrauma. Proc Assoc Am Physicians (1998) 110:482-8
11. Gattinoni L, Tognoni G, Pesenti A, Taccone P, Mascheroni D, Labarta V, et al. Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med (2001) 345(8):568-73. doi:10.1056/NEJMoa010043
12. Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA. Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med (1995) 152(6 Pt 1):1818-24. doi:10.1164/ajrccm.152.6.8520742
13. Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis (1985) 132(3):485-9
14. Slutsky AS, Tremblay LN. Multiple system organ failure. Am J Respir Crit Care Med (1998) 157(6):1721-5. doi:10.1164/ajrccm.157.6.9709092
15. Zimmerman JJ, Akhtar SR, Caldwell E, Rubenfeld GD. Incidence and outcomes of pediatric acute lung injury. Pediatrics (2009) 124(1):87-95. doi:10.1542/peds.2007-2462
16. Rubenfeld GD, Caldwell E, Peabody E, et al. Prevalence and outcomes of acute lung injury. N Engl J Med (2005) 353:1685-93. doi:10.1056/NEJMoa050333
17. Ichinose F, Roberts JD Jr, Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation (2004) 109:3106-11. doi:10.1161/01.CIR.0000134595.80170.62
18. Smith LS, Zimmerman JJ, Martin TR. Mechanisms of acute respiratory distress syndrome in children and adults: a review and suggestions for future research. Pediatr Crit Care Med (2013) 14(6):631-43. doi:10.1097/PCC.0b013e318291753f
19. Greene KE, Wright JR, Steinberg KP, Ruzinski JT, Caldwell E, Wong WB, et al. Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Am J Respir Crit Care Med (1999) 160(6):1843-50. doi:10.1164/ajrccm.160.6.9901117
20. LeVine AM, Lotze A, Stanley S, Stroud C, O'Donnell R, Whitsett J, et al. Surfactant content in children with inflammatory lung disease. Crit Care Med (1996) 24(6):1062-7. doi:10.1097/00003246-199606000-00029
21. Duffett M, Choong K, Ng V, Randolph A, Cook DJ. Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis. Crit Care (2007) 11(3):R66. doi:10.1186/cc5944
22. Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med (1993) 328:399-405. doi:10.1056/NEJM199302113280605
23. Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med (1997) 336:597-604. doi:10.1056/NEJM199702273360901
24. Roberts JD Jr, Fineman JR, Morin FC, Shaul PW, Rimar S, Schreiber MD, et al. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. N Engl J Med (1997) 336:605-10. doi:10.1056/NEJM199702273360902
25. Davidson D, Barefield ES, Kattwinkel J, Dudell G, Damask M, Straube R, et al. Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO/PPHN Study Group. Pediatrics (1998) 101(3 Pt 1):325-34. doi:10.1542/peds.101.3.325
26. Approval Letter by US Food and Drug Administration on the FDA website. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/20845_INOmax_Approv.pdf
27. American Academy of Pediatrics Committee on Fetus and Newborn. Use of inhaled nitric oxide. Pediatrics (2000) 106(2 Pt 1):344-5. doi:10.1542/peds.106.2.344
28. Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J (2001) 357(Pt 3):593-615. doi:10.1042/0264-6021:3570593
29. Katz I. Inhaled Nitric Oxide: Therapeutic Uses And Potential Hazards. Glenview, IL: PCCSU (Vol. 25, Lesson 22) (2012)
30. Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM. Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction [published correction appears in Circulation. 1991;84: 2212]. Circulation (1991) 83:2038-47. doi:10.1161/01.CIR.83.6.2038
31. Roberts JD Jr, Chen TY, Kawai N, Wain J, Dupuy P, Shimouchi A, et al. Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb. Circ Res (1993) 72:246-54. doi:10.1161/01.RES.72.2.246
32. Joshi MS, Ferguson TB Jr, Han TH, Hyduke DR, Liao JC, Rassaf T, et al. Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions. Proc Natl Acad Sci U S A (2002) 99(16):10341-6. doi:10.1073/pnas.152149699
33. Radomski MW, Moncada S. Regulation of vascular homeostasis by nitric oxide. Thromb Haemost (1993) 70(1):36-41
34. Samama CM, Diaby M, Fellahi JL, Mdhafar A, Eyraud D, Arock M, et al. Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology (1995) 83(1):56-65. doi:10.1097/00000542-199507000-00007
35. Idell S, Maunder R, Fein AM, Switalska HI, Tuszynski GP, McLarty J, et al. Platelet-specific alpha-granule proteins and thrombospondin in bronchoalveolar lavage in the adult respiratory distress syndrome. Chest (1989) 96:1125-32. doi:10.1378/chest.96.5.1125
36. Mannick JB. Immunoregulatory and antimicrobial effects of nitrogen oxides. Proc Am Thorac Soc (2006) 3:161-5. doi:10.1513/pats.200505-048BG
37. Bogdan C. Nitric oxide and the immune response. Nat Immunol (2001) 2:907-16. doi:10.1038/ni1001-907
38. Kinsella JP, Parker TA, Galan H, Sheridan BC, Halbower AC, Abman SH. Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease. Pediatr Res (1997) 41:457-63. doi:10.1203/00006450-199704000-00002
39. Ruan S-Y, Huang T-M, Wu H-Y, Wu H-D, Yu C-J, Lai M-S. Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials. Crit Care (2015) 19(1):137. doi:10.1186/s13054-015-0880-2
40. Dobyns EL, Cornfield DN, Anas NG, Fortenberry JD, Tasker RC, Lynch A, et al. Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure. J Pediatr (1999) 134:406-12. doi:10.1016/S0022-3476(99)70196-4
41. Day RW, Allen EM, Witte MK. A randomized, controlled study of the 1-hour and 24-hour effects of inhaled nitric oxide therapy in children with acute hypoxemic respiratory failure. Chest (1997) 112(5):1324-31. doi:10.1378/chest.112.5.1324
42. Ibrahim TS, El-Mohamady HS. Inhaled nitric oxide and prone position: how far they can improve oxygenation in pediatric patients with acute respiratory distress syndrome? J Med Sci (2007) 7:390-5. doi:10.3923/jms.2007.390.395
43. Bronicki RA, Fortenberry J, Schreiber M, Checchia PA, Anas NG. Multicenter randomized controlled trial of inhaled nitric oxide for pediatric acute respiratory distress syndrome. J Pediatr (2015) 166(2):365-9.e1. doi:10.1016/j.jpeds.2014.10.011
44. Pediatric Acute Lung Injury Consensus Conference Group. Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med (2015) 16(5):428-39. doi:10.1097/PCC.0000000000000350
45. Santschi M, Jouvet P, Leclerc F, Gauvin F, Newth CJ, Carroll CL, et al. Acute lung injury in children: therapeutic practice and feasibility of international clinical trials. Pediatr Crit Care Med (2010) 11(6):681-9. doi:10.1097/PCC.0b013e3181d904c0
46. Varni JW, Seid M, Kurtin P. PedsQLTM 4.0: reliability and validity of the Pediatric Quality of Life InventoryTM Version 4.0 Generic Core Scales in healthy and patient populations. Med Care (2001) 39(8):800-12. doi:10.1097/00005650-200108000-00006
47. Graciano AL, Balko JA, Rahn DS, Ahmad N, Giroir BP. The Pediatric Multiple Organ Dysfunction Score (P-MODS): development and validation of an objective scale to measure the severity of multiple organ dysfunction in critically ill children. Crit Care Med (2005) 33(7):1484-91. doi:10.1097/01.CCM.0000170943.23633.47
48. Wong HR. Genome-wide expression profiling in pediatric septic shock. Pediatr Res (2013) 73(4 Pt 2):564-9. doi:10.1038/pr.2013.11
49. Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, et al. Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med (2015) 191(3):309-15. doi:10.1164/rccm.201410-1864OC