메뉴 건너뛰기




Volumn 196, Issue 6, 2017, Pages 671-672

SPX-101 is a promising and novel nebulized ENaC inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE DERIVATIVE; EPITHELIAL SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL BLOCKING AGENT; GS 9411; SHORT PALATE, LUNG, AND NASAL EPITHELIAL CLONE 1; SPX 101; UNCLASSIFIED DRUG; BACTERIAL PROTEIN;

EID: 85029706843     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201705-0928ED     Document Type: Editorial
Times cited : (2)

References (16)
  • 1
    • 0036194724 scopus 로고    scopus 로고
    • Mucus clearance as a primary innate defense mechanism for mammalian airways
    • Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 2002;109:571–577.
    • (2002) J Clin Invest , vol.109 , pp. 571-577
    • Knowles, M.R.1    Boucher, R.C.2
  • 2
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW, Boucher RC. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 1998;95:1005–1015.
    • (1998) Cell , vol.95 , pp. 1005-1015
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3    Randell, S.H.4    Gatzy, J.T.5    Davis, C.W.6    Boucher, R.C.7
  • 3
    • 0022973473 scopus 로고
    • Na1 transport in cystic fibrosis respiratory epithelia: Abnormal basal rate and response to adenylate cyclase activation
    • Boucher RC, Stutts MJ, Knowles MR, Cantley L, Gatzy JT. Na1 transport in cystic fibrosis respiratory epithelia: abnormal basal rate and response to adenylate cyclase activation. J Clin Invest 1986;78:1245–1252.
    • (1986) J Clin Invest , vol.78 , pp. 1245-1252
    • Boucher, R.C.1    Stutts, M.J.2    Knowles, M.R.3    Cantley, L.4    Gatzy, J.T.5
  • 5
    • 33748778207 scopus 로고    scopus 로고
    • Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: A mechanism for sodium hyperabsorption in cystic fibrosis
    • Myerburg MM, Butterworth MB, McKenna EE, Peters KW, Frizzell RA, Kleyman TR, Pilewski JM. Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis. J Biol Chem 2006;281:27942–27949.
    • (2006) J Biol Chem , vol.281 , pp. 27942-27949
    • Myerburg, M.M.1    Butterworth, M.B.2    McKenna, E.E.3    Peters, K.W.4    Frizzell, R.A.5    Kleyman, T.R.6    Pilewski, J.M.7
  • 6
    • 33646138489 scopus 로고    scopus 로고
    • Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia
    • Tarran R, Trout L, Donaldson SH, Boucher RC. Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia. J Gen Physiol 2006;127:591–604.
    • (2006) J Gen Physiol , vol.127 , pp. 591-604
    • Tarran, R.1    Trout, L.2    Donaldson, S.H.3    Boucher, R.C.4
  • 7
    • 77957767326 scopus 로고    scopus 로고
    • The cystic fibrosis transmembrane conductance regulator impedes proteolytic stimulation of the epithelial Na1 channel
    • Gentzsch M, Dang H, Dang Y, Garcia-Caballero A, Suchindran H, Boucher RC, Stutts MJ. The cystic fibrosis transmembrane conductance regulator impedes proteolytic stimulation of the epithelial Na1 channel. J Biol Chem 2010;285:32227–32232.
    • (2010) J Biol Chem , vol.285 , pp. 32227-32232
    • Gentzsch, M.1    Dang, H.2    Dang, Y.3    Garcia-Caballero, A.4    Suchindran, H.5    Boucher, R.C.6    Stutts, M.J.7
  • 10
    • 77952891046 scopus 로고    scopus 로고
    • SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes
    • Rollins BM, Garcia-Caballero A, Stutts MJ, Tarran R. SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes. Channels (Austin) 2010;4: 255–259.
    • (2010) Channels (austin) , vol.4 , pp. 255-259
    • Rollins, B.M.1    Garcia-Caballero, A.2    Stutts, M.J.3    Tarran, R.4
  • 13
    • 2442718786 scopus 로고    scopus 로고
    • Increased airway epithelial Na1 absorption produces cystic fibrosis-like lung disease in mice
    • Mall M, Grubb BR, Harkema JR, O’Neal WK, Boucher RC. Increased airway epithelial Na1 absorption produces cystic fibrosis-like lung disease in mice. Nat Med 2004;10:487–493.
    • (2004) Nat Med , vol.10 , pp. 487-493
    • Mall, M.1    Grubb, B.R.2    Harkema, J.R.3    O’Neal, W.K.4    Boucher, R.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.