Bioreactor-based production of glycoproteins in plant cell suspension cultures

Methods in Molecular Biology

Volumn 1674, Issue , 2018, Pages 129-146

  Holland, Tanja ^a   Buyel, Johannes Felix ^a,b  

^a FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Cultivation conditions; Plant cell culture; Process monitoring; Protein glycosylation; Stirred tank reactor

Indexed keywords

GLYCOPROTEIN; GLYCOSYLATED PROTEIN; POLYSACCHARIDE; RECOMBINANT PROTEIN;

BATCH FERMENTATION; CELL DIVISION; CELL ELONGATION; GENE EXPRESSION SYSTEM; HEALTH CARE SYSTEM; NONHUMAN; PLANT CELL; PLANT CELL CULTURE; PLASMA HALF LIFE; PROCESS MONITORING; PROTEIN GLYCOSYLATION; STIRRED REACTOR; SUSPENSION CELL CULTURE; BIOREACTOR; CELL CULTURE TECHNIQUE; FERMENTATION; GLYCOSYLATION; HALF LIFE TIME; METABOLISM; PHYSIOLOGY;

BIOREACTORS; CELL CULTURE TECHNIQUES; FERMENTATION; GLYCOPROTEINS; GLYCOSYLATION; HALF-LIFE; PLANT CELLS; POLYSACCHARIDES; RECOMBINANT PROTEINS;

EID: 85029696941     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-7312-5_11     Document Type: Chapter

References (45)

1. Nasto B (2007) Biotech at the beauty counter. Nat Biotechnol 25(6):617–619
2. Vojcic L, Pitzler C, Korfer G, Jakob F, Ronny M, Maurer KH, Schwaneberg U (2015) Advances in protease engineering for laundry detergents. New Biotechnol 32(6):629–634. doi:10.1016/j.nbt.2014.12.010
3. Li Q, Yi L, Marek P, Iverson BL (2013) Commercial proteases: present and future. FEBS Lett 587(8):1155–1163. doi:10.1016/j. febslet.2012.12.019
4. Schuster AC, Burghardt M, Alfarhan A, Bueno A, Hedrich R, Leide J, Thomas J, Riederer M (2016) Effectiveness of cuticular transpiration barriers in a desert plant at controlling water loss at high temperatures. AoB Plants 8. doi:10.1093/aobpla/plw027
5. Spiegel H, Stöger E, Twyman RM, Buyel JF (2016) Current status and perspectives of the molecular farming landscape. In: Kermode AR (ed) Molecular pharming: applications, challenges and emerging areas. Wiley-VCH, Weinheim
6. Buyel JF How plants can contribute to the supply of anti-cancer compounds. In: Malik S (ed) Biotechnoloy and production of anti-cancer compounds. Springer, Berlin
7. Caspi RR (2008) Immunotherapy of autoimmunity and cancer: the penalty for success. Nat Rev Immunol 8(12):970–976. doi:10.1038/nri2438
8. Shaaltiel Y, Gingis-Velitski S, Tzaban S, Fiks N, Tekoah Y, Aviezer D (2015) Plant-based oral delivery of beta-glucocerebrosidase as an enzyme replacement therapy for Gaucher’s disease. Plant Biotechnol J 13(8):1033–1040. doi:10.1111/pbi.12366
9. Chen LQ, Drake MR, Resch MG, Greene ER, Himmel ME, Chaffey PK, Beckham GT, Tan ZP (2014) Specificity of O-glycosylation in enhancing the stability and cellulose binding affinity of Family 1 carbohydrate-binding modules. Proc Natl Acad Sci U S A 111(21):7612–7617. doi:10.1073/pnas.1402518111
10. Hayes JM, Cosgrave EF, Struwe WB, Wormald M, Davey GP, Jefferis R, Rudd PM (2014) Glycosylation and Fc receptors. Curr Top Microbiol Immunol 382:165–199. doi:10.1007/978-3-319-07911-0_8
11. Sareneva T, Pirhonen J, Cantell K, Julkunen I (1995) N-glycosylation of human interferon-gamma: glycans at Asn-25 are critical for protease resistance. Biochem J 308(Pt 1):9–14
12. Sinclair AM, Elliott S (2005) Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins. J Pharm Sci 94(8):1626–1635. doi:10.1002/jps.20319
13. Strasser R (2016) Plant protein glycosylation. Glycobiology. doi:10.1093/glycob/cww023
14. Fischer R, Buyel JF, Holland T, Sack M, Schillberg S, Twyman RM Glyco-engineering of plant-based expression systems. In: Reichl U (ed) Glycobiotechnology, vol 10. Advances in biochemical engineering/biotechnology. Springer, Berlin
15. Tuse D (2011) Safety of plant-made pharmaceuticals product development and regulatory considerations based on case studies of two autologous human cancer vaccines. Hum Vaccines 7(3):322–330. doi:10.4161/Hv.7.3. 14213
16. Gomord V, Fitchette AC, Menu-Bouaouiche L, Saint-Jore-Dupas C, Plasson C, Michaud D, Faye L (2010) Plant-specific glycosylation patterns in the context of therapeutic protein production. Plant Biotechnol J 8(5):564–587. doi:10.1111/j.1467-7652.2009.00497.x
17. Mor TS (2015) Molecular pharming’s foot in the FDA’s door: protalix’s trailblazing story. Biotechnol Lett 37(11):2147–2150. doi:10. 1007/s10529-015-1908-z
18. Bethencourt V (2009) Virus stalls Genzyme plant. Nat Biotechnol 27(8):681–681. doi:10. 1038/nbt0809-681a
19. Mavituna F, Park JM (1987) Size distribution of plant cell aggregates in batch culture. Chem Eng J 35(1):B9–B14. doi:10.1016/0300-9467(87)80045-X
20. Nagata T, Hasezawa S, Depicker A (2013) Tobacco BY-2 Cells. Springer, Berlin
21. Holland T, Blessing D, Hellwig S, Sack M (2013) The in-line measurement of plant cell biomass using radio frequency impedance spectroscopy as a component of process analytical technology. Biotechnol J 8(10):1231–1240. doi:10.1002/biot.201300125
22. Holland T (2013) Development of plant suspension cultures with regard to industrial production of biopharmaceuticals, Dissertation/ Ph.D. thesis. Aachen, RWTH Aachen University. http://publications.rwth-aachen.de/record/229173/files/4829.pdf
23. Santos RB, Abranches R, Fischer R, Sack M, Holland T (2016) Putting the spotlight back on plant suspension cultures. Front Plant Sci 7:297. doi:10.3389/fpls.2016.00297
24. Holland T, Sack M, Rademacher T, Schmale K, Altmann F, Stadlmann J, Fischer R, Hellwig S (2010) Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2-suspension culture. Biotechnol Bioeng 107 (2):278–289. doi:10.1002/bit.22800
25. Trexler MM, McDonald KA, Jackman AP (2005) A cyclical semicontinuous process for production of human alpha 1-antitrypsin using metabolically induced plant cell suspension cultures. Biotechnol Prog 21(2):321–328. doi:10.1021/bp0498692
26. Hooker BS, Lee JM, An G (1990) Cultivation of plant cells in a stirred vessel: effect of impeller design. Biotechnol Bioeng 35(3):296–304. doi:10.1002/bit.260350311
27. Doran PM (1999) Design of mixing systems for plant cell suspensions in stirred reactors. Biotechnol Prog 15(3):319–335. doi:10. 1021/bp990042v
28. Eibl R, Werner S, Eibl D (2009) Bag bioreactor based on wave-induced motion: characteristics and applications. Adv Biochem Eng Biotechnol 115:55–87. doi:10.1007/10_2008_15
29. Terrier B, Courtois D, Henault N, Cuvier A, Bastin M, Aknin A, Dubreuil J, Petiard V (2007) Two new disposable bioreactors for plant cell culture: the wave and undertow bioreactor and the slug bubble bioreactor. Biotechnol Bioeng 96(5):914–923. doi:10. 1002/bit.21187
30. Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, Boldin-Adamsky SA, Silman I, Sussman JL, Futerman AH, Aviezer D (2007) Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher’s disease using a plant cell system. Plant Biotechnol J 5(5):579–590. doi:10.1111/j.1467-7652. 2007.00263.x
31. Wen SW, Jun He B, Liang H, Sun S (1996) A perfusion air-lift bioreactor for high density plant cell cultivation and secreted protein production. J Biotechnol 50(2):225–233. doi:10. 1016/0168-1656(96)01568-4
32. McDonald KA, Hong LM, Trombly DM, Xie Q, Jackman AP (2005) Production of human alpha-1-antitrypsin from transgenic rice cell culture in a membrane bioreactor. Biotechnol Prog 21(3):728–734. doi:10.1021/bp0496676
33. Tanaka H, Nishijima F, Suwa M, Iwamoto T (1983) Rotating drum fermentor for plant cell suspension cultures. Biotechnol Bioeng 25 (10):2359–2370. doi:10.1002/bit.260251007
34. Xu J, Ge X, Dolan MC (2011) Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures. Biotechnol Adv 29(3):278–299. doi:10.1016/j.bio techadv.2011.01.002
35. Huang TK, McDonald KA (2012) Bioreactor systems for in vitro production of foreign proteins using plant cell cultures. Biotechnol Adv 30(2):398–409. doi:10.1016/j.biotechadv. 2011.07.016
36. WW S, Arias R (2003) Continuous plant cell perfusion culture: bioreactor characterization and secreted enzyme production. J Biosci Bioeng 95(1):13–20. doi:10.1016/S1389-1723(03)80142-1
37. De Dobbeleer C, Cloutier M, Fouilland M, Legros R, Jolicoeur M (2006) A high-rate perfusion bioreactor for plant cells. Biotechnol Bioeng 95(6):1126–1137. doi:10.1002/bit. 21077
38. Chmiel H (2011) Bioprozesstechnik, vol 3. Springer, Spektrum. doi:10.1007/978-3-8274-2477-8
39. van Gulik WM, ten Hoopen HJ, Heijnen JJ (2001) The application of continuous culture for plant cell suspensions. Enzym Microb Technol 28(9–10):796–805
40. Miller RA, Shyluk JP, Gamborg OL, Kirkpatrick JW (1968) Phytostat for continuous culture and automatic sampling of plant-cell suspensions. Science 159(3814):540–542
41. Winkler M (1990) Chemical engineering problems in biotechnology, vol 1. Springer, Amsterdam
42. Huang TK, Plesha MA, McDonald KA (2010) Semicontinuous bioreactor production of a recombinant human therapeutic protein using a chemically inducible viral amplicon expression system in transgenic plant cell suspension cultures. Biotechnol Bioeng 106(3):408–421. doi:10.1002/bit.22713
43. Hogue RS, Lee JM, An G (1990) Production of a foreign protein product with genetically modified plant cells. Enzym Microb Technol 12(7):533–538
44. Georgiev MI, Weber J, Maciuk A (2009) Bio-processing of plant cell cultures for mass production of targeted compounds. Appl Microbiol Biotechnol 83(5):809–823. doi:10. 1007/s00253-009-2049-x
45. Schmale K, Rademacher T, Fischer R, Hellwig S (2006) Towards industrial usefulness - cryo-cell-banking of transgenic BY-2 cell cultures. J Biotechnol 124(1):302–311. doi:10.1016/j. jbiotec.2006.01.012