Multihospital occurrence of pan-resistant Klebsiella pneumoniae sequence type 147 with an ISEcp1-directed blaOXA-181 insertion in the mgrB gene in the United Arab Emirates

Antimicrobial Agents and Chemotherapy

Volumn 61, Issue 7, 2017, Pages

  Sonnevend, Ágnes ^a   Ghazawi, Akela ^a   Hashmey, Rayhan ^b   Haidermota, Aliasgher ^c   Girgis, Safinaz ^c   Alfaresi, Mubarak ^d   Omar, Mohammed ^e   Paterson, David L ^f,g,h   Zowawi, Hosam M ^f,g,i,j   Pál, Tibor ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b TAWAM HOSPITAL   (United Arab Emirates)

^c MAFRAQ HOSPITAL   (United Arab Emirates)

^d Khalifa Hospital   (United Arab Emirates)

^e Umm Al Quwain Hospital   (United Arab Emirates)

^f UNIVERSITY OF QUEENSLAND   (Australia)

^g UNIVERSITY OF QUEENSLAND   (Australia)

^h WESLEY HOSPITAL   (Australia)

ⁱ KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^j King Abdulaziz Medical City   (Saudi Arabia)

more..

Author keywords

Carbapenems; Colistin; Klebsiella pneumoniae; Pan resistance

Indexed keywords

CARBAPENEMASE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEM DERIVATIVE; COLISTIN;

AGED; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL GENE; BLA NDM 5 GENE; BLA OXA 181 GENE; CLINICAL ARTICLE; GENE DELETION; GENE INSERTION SEQUENCE; GENE MUTATION; GENETIC RESISTANCE; GENETIC SIMILARITY; GENOTYPE; HUMAN; KLEBSIELLA PNEUMONIAE; MALE; MGRB GENE; NONHUMAN; PLASMID; PRIORITY JOURNAL; UNITED ARAB EMIRATES; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; SOUTH KOREA;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; COLISTIN; GENOTYPE; HUMANS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; PLASMIDS; REPUBLIC OF KOREA; UNITED ARAB EMIRATES;

EID: 85021887585     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00418-17     Document Type: Article

References (35)

1. Paczosa MK, Mecsas J. 2016. Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biol Rev 80:629 – 661. https://doi.org/10.1128/MMBR.00078-15.
2. Hennequin C, Robin F. 2016. Correlation between antimicrobial resistance and virulence in Klebsiella pneumoniae. Eur J Clin Microbiol Infect Dis 35:333–341. https://doi.org/10.1007/s10096-015-2559-7.
3. Pitout JD, Nordmann P, Poirel L. 2015. Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance. Antimicrob Agents Chemother 59:5873–5884. https://doi.org/10.1128/AAC.01019-15.
4. Messaoudi A, Haenni M, Mansour W, Saras E, Bel Haj Khalifa A, Chaouch C, Naija W, Boujaafar N, Bouallegue O, Madec JY. 2017. ST147 NDM-1-producing Klebsiella pneumoniae spread in two Tunisian hospitals. J Antimicrob Chemother 72:315–316. https://doi.org/10.1093/jac/dkw401.
5. NDM-5-bearing IncFII-type plasmids of Klebsiella pneumoniae sequence type 147 transmitted by cross-border transfer of a patient. Antimicrob Agents Chemother 60:1932–1934. https://doi.org/10.1128/AAC.02722-15.
6. Sonnevend A, Ghazawi AA, Hashmey R, Jamal W, Rotimi VO, Shibl AM, Al-Jardani A, Al-Abri SS, Tariq WU, Weber S, Pal T. 2015. Characterization of carbapenem-resistant Enterobacteriaceae with high rate of autoch-thonous transmission in the Arabian Peninsula. PLoS One 10:e0131372. https://doi.org/10.1371/journal.pone.0131372.
7. Doi Y, Paterson DL. 2015. Carbapenemase-producing Enterobacteriaceae. Semin Respir Crit Care Med 36:74–84. https://doi.org/10.1055/s-0035-1544208.
8. Cannatelli A, D’Andrea MM, Giani T, Di Pilato V, Arena F, Ambretti S, Gaibani P, Rossolini GM. 2013. In vivo emergence of colistin resistance in Klebsiella pneumoniae producing KPC-type carbapenemases mediated by insertional inactivation of the PhoQ/PhoP mgrB regulator. Antimicrob Agents Chemother 57:5521–5526. https://doi.org/10.1128/AAC.01480-13.
9. Baron S, Hadjadj L, Rolain JM, Olaitan AO. 2016. Molecular mechanisms of polymyxin resistance: knowns and unknowns. Int J Antimicrob Agents 48:583–591. https://doi.org/10.1016/j.ijantimicag.2016.06.023.
10. Schwarz S, Johnson AP. 2016. Transferable resistance to colistin: a new but old threat. J Antimicrob Chemother 71:2066–2070. https://doi.org/10.1093/jac/dkw274.
11. Bathoorn E, Tsioutis C, da Silva Voorham JM, Scoulica EV, Ioannidou E, Zhou K, Rossen JW, Gikas A, Friedrich AW, Grundmann H. 2016. Emergence of pan-resistance in KPC-2 carbapenemase-producing Klebsiella pneumoniae in Crete, Greece: a close call. J Antimicrob Chemother 71:1207–1212. https://doi.org/10.1093/jac/dkv467.
12. Zowawi HM, Forde BM, Alfaresi M, Alzarouni A, Farahat Y, Chong TM, Yin WF, Chan KG, Li J, Schembri MA, Beatson SA, Paterson DL. 2015. Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae. Sci Rep 5:15082. https://doi.org/10.1038/srep15082.
13. Cho SY, Huh HJ, Baek JY, Chung NY, Ryu JG, Ki CS, Chung DR, Lee NY, Song JH. 2015. Klebsiella pneumoniae co-producing NDM-5 and OXA-181 carbapenemases, South Korea. Emerg Infect Dis 21:1088 –1089. https://doi.org/10.3201/eid2106.150048.
14. Falagas ME, Bliziotis IA, Kasiakou SK, Samonis G, Athanassopoulou P, Michalopoulos A. 2005. Outcome of infections due to pandrug-resistant (PDR) Gram-negative bacteria. BMC Infect Dis 5:24. https://doi.org/10.1186/1471-2334-5-24.
15. Weterings V, Zhou K, Rossen JW, van Stenis D, Thewessen E, Kluytmans J, Veenemans J. 2015. An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread. Eur J Clin Microbiol Infect Dis 34:1647–1655. https://doi.org/10.1007/s10096-015-2401-2.
16. Meletis G, Chatzidimitriou D, Malisiovas N. 2015. Double- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade. Eur J Clin Microbiol Infect Dis 34:1487–1493. https://doi.org/10.1007/s10096-015-2379-9.
17. Dortet L, Poirel L, Al Yaqoubi F, Nordmann P. 2012. NDM-1, OXA-48 and OXA-181 carbapenemase-producing Enterobacteriaceae in Sultanate of Oman. Clin Microbiol Infect 18:E144-8. https://doi.org/10.1111/j.1469-0691.2012.03796.x.
18. Zowawi HM, Sartor AL, Balkhy HH, Walsh TR, Al Johani SM, AlJindan RY, Alfaresi M, Ibrahim E, Al-Jardani A, Al-Abri S, Al Salman J, Dashti AA, Kutbi AH, Schlebusch S, Sidjabat HE, Paterson DL. 2014. Molecular characterization of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the countries of the Gulf Cooperation Council: dominance of OXA-48 and NDM producers. Antimicrob Agents Chemother 58:3085–3090. https://doi.org/10.1128/AAC.02050-13.
19. Jayol A, Nordmann P, Desroches M, Decousser JW, Poirel L. 2016. Acquisition of broad-spectrum cephalosporin resistance leading to colistin resistance in Klebsiella pneumoniae. Antimicrob Agents Chemother 60: 3199–3201. https://doi.org/10.1128/AAC.00237-16.
20. Abuzaid A, Hamouda A, Amyes SG. 2012. Klebsiella pneumoniae susceptibility to biocides and its association with cepA, qacΔE and qacE efflux pump genes and antibiotic resistance. J Hosp Infect 81:87–91. https://doi.org/10.1016/j.jhin.2012.03.003.
21. Wand ME, Bock LJ, Bonney LC, Sutton JM. 2017. Mechanisms of increased resistance to chlorhexidine and cross-resistance to colistin following exposure of Klebsiella pneumoniae clinical isolates to chlorhexidine. Antimicrob Agents Chemother 61:e01162-16. https://doi.org/10.1128/AAC.01162-16.
22. CLSI. 2014. Performance standard for antimicrobial susceptibility testing; M100-S24. Clinical and Laboratory Standards Institute, Wayne, PA.
23. EUCAST. 2016. Breakpoint tables for interpretation of MICs and zone diameters. http://www.eucast.org. Accessed 15 January 2016.
24. Brisse S, Fevre C, Passet V, Issenhuth-Jeanjean S, Tournebize R, Diancourt L, Grimont P. 2009. Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. PLoS One 4:e4982. https://doi.org/10.1371/journal.pone.0004982.
25. Johnson JR, Stell AL. 2000. Extended virulence genotypes of Escherichia coli strains from patients with urosepsis in relation to phylogeny and host compromise. J Infect Dis 181:261–272. https://doi.org/10.1086/315217.
26. Turton JF, Perry C, Elgohari S, Hampton CV. 2010. PCR characterization and typing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and virulence gene targets. J Med Microbiol 59:541–547. https://doi.org/10.1099/jmm.0.015198-0.
27. Sonnevend A, Ghazawi A, Alqahtani M, Shibl A, Jamal W, Hashmey R, Pal T. 2016. Plasmid-mediated colistin resistance in Escherichia coli from the Arabian Peninsula. Int J Infect Dis 50:85–90. https://doi.org/10.1016/j.ijid.2016.07.007.
28. Ghazawi A, Sonnevend A, Bonnin RA, Poirel L, Nordmann P, Hashmey R, Rizvi TA, M BH, Pal T. 2012. NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates. Clin Microbiol Infect 18:E34–6. https://doi.org/10.1111/j.1469-0691.2011.03726.x.
29. Gautom RK. 1997. Rapid pulsed-field gel electrophoresis protocol for typing of Escherichia coli O157:H7 and other gram-negative organisms in 1 day. J Clin Microbiol 35:2977–2980.
30. Diancourt L, Passet V, Verhoef J, Grimont PAD, Brisse S. 2005. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol 43:4178–4182. https://doi.org/10.1128/JCM.43.8.4178-4182.2005.
31. Kado CI, Liu ST. 1981. Rapid procedure for detection and isolation of large and small plasmids. J Bacteriol 145:1365–1373.
32. Sonnevend A, Al Baloushi A, Ghazawi A, Hashmey R, Girgis S, Hamadeh MB, Al Haj M, Pal T. 2013. Emergence and spread of NDM-1 producer Enterobacteriaceae with contribution of IncX3 plasmids in the United Arab Emirates. J Med Microbiol 62:1044–1050. https://doi.org/10.1099/jmm.0.059014-0.
33. Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, Aarestrup FM, Larsen MV. 2012. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother 67:2640–2644. https://doi.org/10.1093/jac/dks261.
34. Carattoli A, Zankari E, Garcia-Fernandez A, Voldby Larsen M, Lund O, Villa L, Moller Aarestrup F, Hasman H. 2014. In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing. Antimicrob Agents Chemother 58:3895–3903. https://doi.org/10.1128/AAC.02412-14.
35. Gambill BD, Summers AO. 1985. Versatile mercury-resistant cloning and expression vectors. Gene 39:293–297. https://doi.org/10.1016/0378-1119(85)90326-9.