The role of IL-27 and its receptor in the pathogenesis of HIV/AIDS and anti-viral immune response

Current HIV Research

Volumn 15, Issue 4, 2017, Pages 279-284

  Zheng, Yu Huang ^a   Xiao, Shui Ling ^a   He, Bo ^a   He, Yan ^a   Zhou, Hua Ying ^a   Chen, Zi ^a   Zheng, Li Wen ^a   He, Mei ^a   Wang, Hong Yan ^a   Lin, Yi He ^a   Cao, Jing ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Gp130 CD4; HAART; HIV AIDS; IFN ; IL 27; IL 4

Indexed keywords

EFAVIRENZ PLUS LAMIVUDINE PLUS TENOFOVIR DISOPROXIL; EFAVIRENZ PLUS LAMIVUDINE PLUS ZIDOVUDINE; GAMMA INTERFERON; GLYCOPROTEIN GP 130; INTERLEUKIN 27; INTERLEUKIN 27 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN RECEPTOR; LAMIVUDINE PLUS NEVIRAPINE PLUS TENOFOVIR DISOPROXIL; LAMIVUDINE PLUS NEVIRAPINE PLUS ZIDOVUDINE; UNCLASSIFIED DRUG; CD3 ANTIGEN; GP130 ENVELOPE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS; IL27 PROTEIN, HUMAN; IL27RA PROTEIN, HUMAN; IL4 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; VIRUS ENVELOPE PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; BLOOD LEVEL; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LYMPHOCYTE COUNT; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; VIRAL LOAD TESTING; BLOOD; CHEMISTRY; IMMUNOLOGY;

ADULT; CD3 COMPLEX; CD4-POSITIVE T-LYMPHOCYTES; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HIV INFECTIONS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-4; INTERLEUKINS; MALE; RECEPTORS, INTERLEUKIN;

EID: 85029623016     PISSN: 1570162X     EISSN: 18734251     Source Type: Journal    
DOI: 10.2174/1570162X15666170517130339     Document Type: Article

References (26)

1. Armstrong-James D, Meintjes G, Brown GD. A neglected epidemic: fungal infections in HIV/AIDS. Trends Microbiol 2014; 22: 120-27.
2. Rios A. HIV-Related Hematological Malignancies: A Concise Review. Clin Lymphoma Myeloma Leuk 2014; 14S: S96-S103.
3. Donald KA, Hoare J, Eley B, Wilmshurst JM. Neurologic complications of pediatric human immunodeficiency virus: implications for clinical practice and management challenges in the African setting. Semin Pediatr Neurol 2014; 21: 3-11.
4. Wilson EM, Sereti I. Immune restoration after antiretroviral therapy: The pitfalls of hasty or incomplete repairs. Immunol Rev 2013; 254: 343-54.
5. Swaminathan S, Dai L, Lane HC, Imamichi T. Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection. Cytokine Growth Factor Rev 2013; 24: 571-7.
6. Batten M, Ghilardi N. The biology and therapeutic potential of interleukin 27. J Mol Med (Berl) 2007; 85: 661-72.
7. Levy Y. Cytokine therapies in HIV infection. Med Sci (Paris) 2006; 22: 751-4.
8. Imamichi T, Yang J, Huang DW, et al. IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages. AIDS 2008; 22: 39-45.
9. Hibbert L, Pflanz S, De Waal Malefyt R, Kastelein RA. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J Interferon Cytokine Res 2003; 23: 513-22.
10. Pflanz S, Timans JC, Cheung J, et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002; 16: 779-90.
11. Swaminathan S, Hu X, Zheng X, et al. Interleukin-27 treated human macrophages induce the expression of novel microRNAs which may mediate anti-viral properties. Biochem Biophys Res Commun 2013; 434: 228-34.
12. Pflanz S, Hibbert L, Mattson J, et al. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol 2004; 172: 2225-31.
13. Fakruddin JM, Lempicki RA, Gorelick RJ, et al. Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27. Blood 2007; 109: 1841-9.
14. Imamichi T, Yang J, Huang D W, et al. IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages. AIDS 2008; 22: 39-45.
15. Greenwell-Wild T, Vazquez N, Jin W, Rangel Z, Munson PJ, Wahl SM. Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon. Blood 2009; 114: 1864-74.
16. Chen Q, Swaminathan S, Yang D, et al. Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway. PLoS One 2013; 8: e59194.
17. Peng G, Lei K J, Jin W, Greenwell-Wild T, Wahl SM. Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity. J Exp Med 2006; 203: 41-6.
18. Mangeat B, Turelli P, Caron G, et al. Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature 2003; 424: 99-103.
19. Chen K, Huang J, Zhang C, et al. Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells. J Virol 2006; 80: 7645-57.
20. Guzzo C, Jung M, Graveline A, Banfield BW, Gee K. IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN. Sci Rep 2012; 2: 974.
21. Van Damme N, Goff D, Katsura C, et al. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe 2008; 3: 245-52.
22. Dai L, Lidie KB, Chen Q, et al. IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation. J Exp Med 2013; 210: 517-34.
23. Swaminathan S, Hu Z, Rupert AW, et al. Plasma interleukin-27 (IL-27) levels are not modulated in patients with chronic HIV-1 infection. PLoS One 2014; 9: e98989.
24. He L, Zhao J, Wang MH, et al. Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapynaive HIV-mono-infected and HIV/HCV-co-infected Chinese. PLoS One 2014; 9: e96792.
25. Guzzo C, Hopman W M, Che M N, Wobeser W, Gee K. IL-27-induced gene expression is downregulated in HIV-infected subjects. PLoS One 2012; 7: e45706.
26. Becker Y. Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing theTh1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy-a review. Virus Genes 2006; 33: 235-52.