Plasma interleukin-27 (IL-27) levels are not modulated in patients with chronic HIV-1 infection

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Swaminathan, Sanjay ^a,b,c,d   Hu, Zonghui ^e   Rupert, Adam W ^a   Higgins, Jeanette M ^a   Dewar, Robin L ^a   Stevens, Randy ^a   Chen, Qian ^a   Rehm, Catherine A ^e   Metcalf, Julia A ^e   Baseler, Michael W ^a   Lane, H Clifford ^e   Imamichi, Tomozumi ^a  

^a FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^b Department of Clinical Immunology Western Sydney Local Health District ^*  (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF WESTERN SYDNEY   (Australia)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CD14 ANTIGEN; CD163 ANTIGEN; D DIMER; INTERLEUKIN 27; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BIOLOGICAL MARKER;

ADULT; ARTICLE; BLOOD ANALYSIS; CD4 LYMPHOCYTE COUNT; CHRONIC DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS LOAD; BLOOD; CASE CONTROL STUDY; CD4+ T LYMPHOCYTE; COMPARATIVE STUDY; DRUG EFFECTS; FLOW CYTOMETRY; FOLLOW UP; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PLASMA; PROGNOSIS; VIROLOGY;

ADULT; ANTI-HIV AGENTS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; COHORT STUDIES; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-27; MALE; MIDDLE AGED; PLASMA; PROGNOSIS; VIRAL LOAD;

EID: 84902440618     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098989     Document Type: Article

References (23)

1. Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, et al. (2002) IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16: 779-790. (Pubitemid 34786477)
2. Batten M, Ghilardi N (2007) The biology and therapeutic potential of interleukin 27. J Mol Med (Berl) 85: 661-672. (Pubitemid 47063520)
3. Vignali DA, Kuchroo VK (2012) IL-12 family cytokines: immunological playmakers. Nat Immunol 13: 722-728.
4. Wojno ED, Hunter CA (2012) New directions in the basic and translational biology of interleukin-27. Trends Immunol 33: 91-97.
5. Fakruddin JM, Lempicki RA, Gorelick RJ, Yang J, Adelsberger JW, et al. (2007) Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27. Blood 109: 1841-1849. (Pubitemid 46348178)
6. Imamichi T, Yang J, Huang DW, Brann TW, Fullmer BA, et al. (2008) IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages. AIDS 22: 39-45. (Pubitemid 350294876)
7. Dai L, Lidie KB, Chen Q, Adelsberger JW, Zheng X, et al. (2013) IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation. J Exp Med 11: 517-534.
8. Greenwell-Wild T, Vazquez N, Jin W, Rangel Z, Munson PJ, et al. (2009) Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon. Blood 114: 1864-1874.
9. Chen Q, Swaminathan S, Yang D, Dai L, Sui H, et al. (2013) Interleukin-27 is a potent inhibitor of cis HIV-1 replication in Monocyte-derived Dendritic Cells via a Type I Interferon-independent pathway. PLoS One 8: e59194.
10. Swaminathan S, Dai L, Lane HC, Imamichi T (2013) Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection. Cytokine Growth Factor Rev In Press.
11. Guzzo C, Hopman WM, Che Mat NF, Wobeser W, Gee K (2010) Impact of HIV infection, highly active antiretroviral therapy, and hepatitis C coinfection on serum interleukin-27. AIDS 24: 1371-1374.
12. He L, Zhao J., Gan Y., Chen L., He M. (2011) Upregulation of interleukin-27 expression is correlated with higher CD4+ T cell counts in treatment of naive human immunodeficiency virus-infected Chinese. Journal of AIDS and HIV Research 3: 6-10.
13. Hunt PW (2012) HIV and inflammation: mechanisms and consequences. Curr HIV/AIDS Rep 9: 139-147.
14. Shen H, Xia L, Xiao W, Lu J (2011) Increased levels of interleukin-27 in patients with rheumatoid arthritis. Arthritis Rheum 63: 860-861.
15. Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, et al. (2008) Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 5: e203.
16. Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, et al. (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 12: 1365-1371. (Pubitemid 44924494)
17. Sandler NG, Wand H, Roque A, Law M, Nason MC, et al. (2011) Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis 203: 780-790.
18. Burdo TH, Lentz MR, Autissier P, Krishnan A, Halpern E, et al. (2011) Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy. J Infect Dis 204: 154-163.
19. Frey EA, Miller DS, Jahr TG, Sundan A, Bazil V, et al. (1992) Soluble CD14 participates in the response of cells to lipopolysaccharide. J Exp Med 176: 1665-1671.
20. Su GL, Dorko K, Strom SC, Nussler AK, Wang SC (1999) CD14 expression and production by human hepatocytes. J Hepatol 31: 435-442. (Pubitemid 29408725)
21. Fabriek BO, Dijkstra CD, van den Berg TK (2005) The macrophage scavenger receptor CD163. Immunobiology 210: 153-160. (Pubitemid 41025156)
22. Dewar RL, Highbarger HC, Sarmiento MD, Todd JA, Vasudevachari MB,et al. (1994)Application of branched DNA signal amplification to monitor human immunodeficiency virus type 1 burden in human plasma. J Infect Dis 170: 1172-1179. (Pubitemid 24328620)
23. Braun P, Ehret R, Wiesmann F, Zabbai F, Knickmann M, et al.(2007) Comparison of four commercial quantitative HIV-1 assays for viral load monitoring in clinical daily routine. Clin Chem Lab Med 45: 93-99. (Pubitemid 46155568)