Erratum: Effect of post–cesarean delivery oral cephalexin and metronidazole on surgical site infection among obese women: A randomized clinical trial (JAMA (2017) 318:11 (1026-1034) DOI: 10.1001/jama.2017.10567);Effect of post–cesarean delivery oral cephalexin and metronidazole on surgical site infection among obese women: A randomized clinical trial

JAMA - Journal of the American Medical Association

Volumn 318, Issue 11, 2017, Pages 1026-1034

  Valent, Amy M ^a   Dearmond, Chris ^b   Houston, Judy M ^c   Reddy, Srinidhi ^d   Masters, Heather R ^b   Gold, Alison ^e   Boldt, Michael ^b   Defranco, Emily ^b   Evans, Arthur T ^b   Warshak, Carri R ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d University of Texas Health Science Center   (United States)

^e Miami Ob Gyn LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFALEXIN; CEPHALOSPORIN; METRONIDAZOLE; PLACEBO; ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC PROPHYLAXIS; ARTICLE; CELLULITIS; CESAREAN SECTION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENDOMETRITIS; FEMALE; FEVER; HUMAN; INFECTION PREVENTION; INFECTION RATE; MAJOR CLINICAL STUDY; MORBIDITY; OBESITY; POSTOPERATIVE CARE; PREOPERATIVE CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURGICAL INFECTION; WOUND DEHISCENCE; ADVERSE EFFECTS; COMBINATION DRUG THERAPY; COMPLICATION; ORAL DRUG ADMINISTRATION; SURGICAL WOUND INFECTION;

ADMINISTRATION, ORAL; ADULT; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; CEPHALEXIN; CESAREAN SECTION; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; METRONIDAZOLE; OBESITY; POSTOPERATIVE CARE; SURGICAL WOUND INFECTION;

EID: 85029622393     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2017.16058     Document Type: Erratum

References (40)

1. Centers for Disease Control and Prevention. Healthcare-associated infections. 2014. https://www.cdc.gov/hai/surveillance/. Accessed May 2, 2017.
2. Centers for Disease Control and Prevention. Obstetrical procedures. 2014. https://www.cdc.gov/nchs/fastats/obstetrical-procedures.htm. Accessed May 2, 2017.
3. Alanis MC, Villers MS, Law TL, Steadman EM, Robinson CJ. Complications of cesarean delivery in the massively obese parturient. Am J Obstet Gynecol. 2010;203(3):271.e1-271.e7.
4. Leth RA, Uldbjerg N, Nørgaard M, Møller JK, Thomsen RW. Obesity, diabetes, and the risk of infections diagnosed in hospital and post-discharge infections after cesarean section: a prospective cohort study. Acta Obstet Gynecol Scand. 2011;90 (5):501-509.
5. Tita AT, Szychowski JM, Boggess K, et al; C/SOAP Trial Consortium. Adjunctive azithromycin prophylaxis for cesarean delivery. N Engl J Med. 2016;375(13):1231-1241.
6. Wloch C, Wilson J, Lamagni T, Harrington P, Charlett A, Sheridan E. Risk factors for surgical site infection following caesarean section in England: results from a multicentre cohort study. BJOG. 2012;119(11):1324-1333.
7. Mackeen AD, Packard RE, Ota E, Berghella V, Baxter JK. Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery. Cochrane Database Syst Rev. 2014;(12):CD009516.
8. Witt A, Döner M, Petricevic L, et al. Antibiotic prophylaxis before surgery vs after cord clamping in elective cesarean delivery: a double-blind, prospective, randomized, placebo-controlled trial. Arch Surg. 2011;146(12):1404-1409.
9. ACOG practice bulletin 156: obesity in pregnancy. Obstet Gynecol. 2015;126(6):e112-e126.
10. Peppard WJ, Eberle DG, Kugler NW, Mabrey DM, Weigelt JA. Association between pre-operative cefazolin dose and surgical site infection in obese patients. Surg Infect (Larchmt). 2017;18(4):485-490.
11. Ahmadzia HK, Patel EM, Joshi D, et al. Obstetric surgical site infections: 2 grams compared with 3 grams of cefazolin in morbidly obese women. Obstet Gynecol. 2015;126(4):708-715.
12. Swank ML, Wing DA, Nicolau DP, McNulty JA. Increased 3-gram cefazolin dosing for cesarean delivery prophylaxis in obese women. Am J Obstet Gynecol. 2015;213(3):415.e1-415.e8.
13. Maggio L, Nicolau DP, DaCosta M, Rouse DJ, Hughes BL. Cefazolin prophylaxis in obese women undergoing cesarean delivery: a randomized controlled trial. Obstet Gynecol. 2015;125(5):1205-1210.
14. Andrews WW, Hauth JC, Cliver SP, Savage K, Goldenberg RL. Randomized clinical trial of extended spectrum antibiotic prophylaxis with coverage for Ureaplasma urealyticum to reduce post-cesarean delivery endometritis. Obstet Gynecol. 2003;101(6):1183-1189.
15. Meyer NL, Hosier KV, Scott K, Lipscomb GH. Cefazolin vs cefazolin plus metronidazole for antibiotic prophylaxis at cesarean section. South Med J. 2003;96(10):992-995.
16. Berghella V, Baxter JK, Chauhan SP. Evidence-based surgery for cesarean delivery. Am J Obstet Gynecol. 2005;193(5):1607-1617.
17. Dahlke JD, Mendez-Figueroa H, Rouse DJ, Berghella V, Baxter JK, Chauhan SP. Evidence-based surgery for cesarean delivery: an updated systematic review. Am J Obstet Gynecol. 2013;209(4):294-306.
18. Dallal GE. Wichmann-Hill random number generator. http://randomization.com/. Accessed October 28, 2016.
19. Centers for Disease Control and Prevention. Surveillance for surgical site infection (SSI) events; protocols. 2016. https://www.cdc.gov/nhsn/acute-care-hospital/ssi/. Accessed October 24, 2016.
20. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377-381.
21. Stamilio DM, Scifres CM. Extreme obesity and postcesarean maternal complications. Obstet Gynecol. 2014;124(2 Pt 1):227-232.
22. Kaimal AJ, Zlatnik MG, Cheng YW, et al. Effect of a change in policy regarding the timing of prophylactic antibiotics on the rate of postcesarean delivery surgical-site infections. Am J Obstet Gynecol. 2008;199(3):310.e1-310.e5.
23. Smaill FM, Gyte GM. Antibiotic prophylaxis vs no prophylaxis for preventing infection after cesarean section. Cochrane Database Syst Rev. 2010;(1):CD007482.
24. Nicolau DP, Patel KB, Quintiliani R, Nightingale CH. Cephalosporin-metronidazole combinations in the management of intra-abdominal infections. Diagn Microbiol Infect Dis. 1995;22(1-2):189-194.
25. Pierpont YN, Dinh TP, Salas RE, et al. Obesity and surgical wound healing: a current review. ISRN Obes. 2014;2014:638936.
26. Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014;6(265):265sr6.
27. Roberts S, Maccato M, Faro S, Pinell P. The microbiology of post-cesarean wound morbidity. Obstet Gynecol. 1993;81(3):383-386.
28. Austin MN, Beigi RH, Meyn LA, Hillier SL. Microbiologic response to treatment of bacterial vaginosis with topical clindamycin or metronidazole. J Clin Microbiol. 2005;43(9):4492-4497.
29. Bendesky A, Menéndez D, Ostrosky-Wegman P. Is metronidazole carcinogenic? Mutat Res. 2002; 511(2):133-144.
30. Janis JE, Harrison B. Wound healing, I: basic science. Plast Reconstr Surg. 2016;138(3)(suppl): 9S-17S.
31. Elliott JP, Flaherty JF. Comparison of lavage or intravenous antibiotics at cesarean section. Obstet Gynecol. 1986;67(1):29-32.
32. Westen EH, Kolk PR, van Velzen CL, et al. Single-dose compared with multiple day antibiotic prophylaxis for cesarean section in low-resource settings: a randomized controlled, noninferiority trial. Acta Obstet Gynecol Scand. 2015;94(1):43-49.
33. Lyimo FM, Massinde AN, Kidenya BR, Konje E, Mshana SE. Efficacy of single dose of gentamicin in combination with metronidazole vs multiple doses for prevention of post-caesarean infection: study protocol for a randomized controlled trial. Trials. 2012;13:89.
34. Tyrrell J, Richmond RC, Palmer TM, et al; Early Growth Genetics Consortium. Genetic evidence for causal relationships between maternal obesity-related traits and birth weight. JAMA. 2016; 315(11):1129-1140.
35. Villamor E, Tedroff K, Peterson M, et al. Association between maternal body mass index in early pregnancy and incidence of cerebral palsy. JAMA. 2017;317(9):925-936.
36. Goldstein RF, Abell SK, Ranasinha S, et al. Association of gestational weight gain with maternal and infant outcomes: a systematic review and meta-analysis. JAMA. 2017;317(21):2207-2225.
37. Kitsantas P, Pawloski LR. Maternal obesity, health status during pregnancy, and breastfeeding initiation and duration. J Matern Fetal Neonatal Med. 2010;23(2):135-141.
38. Passmore CM, McElnay JC, Rainey EA, D’Arcy PF. Metronidazole excretion in human milk and its effect on the suckling neonate. Br J Clin Pharmacol. 1988;26(1):45-51.
39. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60.
40. Benyamini L, Merlob P, Stahl B, et al. The safety of amoxicillin/clavulanic acid and cefuroxime during lactation. Ther Drug Monit. 2005;27(4):499-502.