Obstetric surgical site infections: 2 grams compared with 3 grams of cefazolin in morbidly obese women

Obstetrics and Gynecology

Volumn 126, Issue 4, 2015, Pages 708-715

  Ahmadzia, Homa K ^a   Patel, Emily M ^a   Joshi, Dipa ^a   Liao, Caiyun ^a   Witter, Frank ^a   Heine, R Phillips ^a   Coleman, Jenell S ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFAZOLIN; ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC PROPHYLAXIS; BODY WEIGHT; CESAREAN SECTION; COHORT ANALYSIS; COMPARATIVE EFFECTIVENESS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; ENDOMETRITIS; FEMALE; HUMAN; INFECTION PREVENTION; INFECTION RISK; LENGTH OF STAY; MAJOR CLINICAL STUDY; MORBID OBESITY; OPERATIVE BLOOD LOSS; OUTCOME ASSESSMENT; PREGNANT WOMAN; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK REDUCTION; SURGICAL INFECTION; ADVERSE EFFECTS; CLINICAL TRIAL; COMPARATIVE STUDY; COMPLICATION; MULTICENTER STUDY; PREGNANCY; PREGNANCY COMPLICATION; SURGICAL WOUND INFECTION; YOUNG ADULT;

ADULT; ANTI-BACTERIAL AGENTS; CEFAZOLIN; CESAREAN SECTION; FEMALE; HUMANS; OBESITY, MORBID; PREGNANCY; PREGNANCY COMPLICATIONS; RETROSPECTIVE STUDIES; SURGICAL WOUND INFECTION; YOUNG ADULT;

EID: 84942785646     PISSN: 00297844     EISSN: 1873233X     Source Type: Journal    
DOI: 10.1097/AOG.0000000000001064     Document Type: Conference Paper

References (17)

1. Kirkland KB, Briggs JP, Trivette SL, Wilkinson WE, Sexton DJ. The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs. Infect Control Hosp Epidemiol 1999;20:725-30.
2. Schneid-Kofman N, Sheiner E, Levy A, Holcberg G. Risk factors for wound infection following cesarean deliveries. Int J Gynaecol Obstet 2005;90:10-5.
3. Tran TS, Jamulitrat S, Chongsuvivatwong V, Geater A. Risk factors for postcesarean surgical site infection. Obstet Gynecol 2000;95:367-71.
4. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol 1999;20:250-78.
5. Edmiston CE, Krepel C, Kelly H, Larson J, Andris D, Hennen C, et al. Perioperative antibiotic prophylaxis in the gastric bypass patient: do we achieve therapeutic levels? Surgery 2004;136:738-47.
6. Ho VP, Nicolau DP, Dakin GF, Pomp A, Rich BS, Towe CW, et al. Cefazolin dosing for surgical prophylaxis in morbidly obese patients. Surg Infect (Larchmt) 2012;13:33-7.
7. Douglas A, Udy AA, Wallis SC, Jarrett P, Stuart J, Lassig-Smith M, et al. Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm open repair surgery. Antimicrob Agents Chemo-ther 2011;55:5238-42.
8. Stitely M, Sweet M, Slain D, Alons L, Holls W, Hochberg C, et al. Plasma and tissue cefazolin concentrations in obese patients undergoing cesarean delivery and receiving differing preopera-tive doses of drug. Surg Infect (Larchmt) 2013;14:455-9.
9. Centers for Disease Control and Prevention. Surgical site infection event. 2014. Available at: http://www.cdc.gov/nhsn/PDFs/pscManual/9pscSSIcurrent.pdf. Retrieved June 22, 2015.
10. Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm 2013;70:195-283.
11. Use of prophylactic antibiotics in labor and delivery. Practice Bulletin No. 120. American College of Obstetricians and Gynecologists. Obstet Gynecol 2011;117:1472-83.
12. Maggio LND, DaCosta M, Rouse DJ, Hughes BJ, Hughes BL. Cefazolin prophylaxis in obese women undergoing cesarean delivery. Obstet Gynecol 2015;125:1205-10.
13. Craig WA. Pharmacokinetic/pharmacodynamic parameters: Rationale for antibacterial dosing of mice and men. Clin Infect Dis 1998;26:1-10.
14. Conner SN, Verticchio JC, Tuuli MG, Odibo AO, Macones GA, Cahill AG. Maternal obesity and risk of postce-sarean wound complications. Am J Perinatol 2014;31:299-304.
15. Mackeen AD, Berghella V, Larsen ML. Techniques and materials for skin closure in caesarean section. The Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD003577. DOI: 10.1002/14651858.CD003577.pub3.
16. Figueroa D, Jauk VC, Szychowski JM, Garner R, Biggio JR, Andrews WW, et al. Surgical staples compared with subcutic-ular suture for skin closure after cesarean delivery: a randomized controlled trial. Obstet Gynecol 2013;121:33-8.
17. Mackeen AD, Khalifeh A, Fleisher J, Vogell A, Han C, Sendecki J, et al. Suture compared with staple skin closure after cesarean delivery: a randomized controlled trial. Obstet Gyne-col 2014;123:1169-75.