Adjunctive azithromycin prophylaxis for cesarean delivery

New England Journal of Medicine

Volumn 375, Issue 13, 2016, Pages 1231-1241

  Tita, Alan T N ^a   Szychowski, Jeff M ^a,b   Boggess, Kim ^c,d   Saade, George ^f   Longo, Sherri ^h   Clark, Erin ^b,i   Esplin, Sean ^b,i   Cleary, Kirsten ^j   Wapner, Ron ^j   Letson, Kellett ^e   Owens, Michelle ^k   Abramovici, Adi ^g   Ambalavanan, Namasivayam ^a   Cutter, Gary ^b   Andrews, William ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b Department of Biostatistics ^*  (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e Mission Hospital   (United States)

^f UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^g UNIVERSITY OF TEXAS   (United States)

^h OCHSNER CLINIC FOUNDATION   (United States)

ⁱ UNIVERSITY OF UTAH   (United States)

^j Columbia University ^*  (United States)

^k UNIVERSITY OF MISSISSIPPI   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; PLACEBO; ANTIINFECTIVE AGENT;

ABDOMINAL ABSCESS; ADULT; ANTIBIOTIC PROPHYLAXIS; CESAREAN SECTION; CONFERENCE PAPER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENDOMETRITIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MENINGITIS; MULTICENTER STUDY; NECROTIZING FASCIITIS; NEWBORN DEATH; PELVIS ABSCESS; PNEUMONIA; POSTOPERATIVE INFECTION; PREGNANCY OUTCOME; PRIORITY JOURNAL; PYELONEPHRITIS; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SEPSIS; SURGICAL INFECTION; THROMBOPHLEBITIS; UNSPECIFIED SIDE EFFECT; CLINICAL TRIAL; NEWBORN; PREGNANCY; PUERPERAL INFECTION; SURGICAL WOUND INFECTION; SURVIVAL ANALYSIS; YOUNG ADULT;

ADULT; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; AZITHROMYCIN; CESAREAN SECTION; ENDOMETRITIS; FEMALE; HUMANS; INFANT, NEWBORN; PREGNANCY; PUERPERAL INFECTION; SEPSIS; SURGICAL WOUND INFECTION; SURVIVAL ANALYSIS; YOUNG ADULT;

EID: 84990041891     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1602044     Document Type: Conference Paper

References (30)

1. Berg CJ, Chang J, Callaghan WM, Whitehead SJ. Pregnancy-related mortality in the United States, 1991-1997. Obstet Gynecol 2003;101:289-96.
2. Mugford M, Kingston J, Chalmers I. Reducing the incidence of infection after caesarean section: implications of prophylaxis with antibiotics for hospital resources. BMJ 1989;299:1003-6.
3. Perencevich EN, Sands KE, Cosgrove SE, Guadagnoli E, Meara E, Platt R. Health and economic impact of surgical site infections diagnosed after hospital discharge. Emerg Infect Dis 2003; 9: 196-203.
4. DeFrances CJ, Cullen KA, Kozak LJ. National Hospital Discharge Survey: 2005 annual summary with detailed diagnosis and procedure data. Vital Health Stat 13 2007;165:1-209.
5. Gibbs RS. Clinical risk factors for puerperal infection. Obstet Gynecol 1980; 55:5 Suppl:178S-184S.
6. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 120: use of prophylactic antibiotics in labor and delivery. Obstet Gynecol 2011;117:1472-83.
7. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for prevention of surgical site infection, 1999: Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. Am J Infect Control 1999;27:97-132.
8. ASHP therapeutic guidelines on antimicrobial prophylaxis in surgery: American Society of Health-System Pharmacists. Am J Health Syst Pharm 1999; 56: 1839-88.
9. Centers for Medicare and Medicaid Services. 2008 Physician Quality Reporting Initiative (PQRI) specifications document (https://www.cms.gov/Medicare/Quality-Initiatives-Patient-Assessment-Instruments/PQRS/downloads/2008PQRIMeasureSpecificat ions123107.pdf).
10. Shojania KG, Duncan BW, McDonald KM, Wachter RM, Markowitz AJ. Making health care safer: a critical analysis of patient safety practices. Evid Rep Technol Assess (Summ) 2001; 43: 1-668.
11. Smaill FM, Grivell RM. Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. Cochrane Database Syst Rev 2014; 10: CD007482.
12. Chelmow D, Ruehli MS, Huang E. Prophylactic use of antibiotics for nonla-boring patients undergoing cesarean delivery with intact membranes: a meta-analysis. Am J Obstet Gynecol 2001; 184: 656-61.
13. Thigpen BD, Hood WA, Chauhan S, et al. Timing of prophylactic antibiotic ad-ministration in the uninfected laboring gravida: a randomized clinical trial. Am J Obstet Gynecol 2005;192:1864-8.
14. Costantine MM, Rahman M, Ghulmi-yah L, et al. Timing of perioperative antibiotics for cesarean delivery: a metaanaly-sis. Am J Obstet Gynecol 2008; 199(3): 301. e1-6.
15. Tita AT, Rouse DJ, Blackwell S, Saade GR, Spong CY, Andrews WW. Emerging concepts in antibiotic prophylaxis for ce-sarean delivery: a systematic review. Ob-stet Gynecol 2009;113:675-82.
16. Rosene K, Eschenbach DA, Tompkins LS, Kenny GE, Watkins H. Polymicrobial early postpartum endometritis with facultative and anaerobic bacteria, genital mycoplasmas, and Chlamydia trachoma-tis: treatment with piperacillin or cefoxi-tin. J Infect Dis 1986; 153: 1028-37.
17. Watts DH, Krohn MA, Hillier SL, Eschenbach DA. Bacterial vaginosis as a risk factor for post-cesarean endometri-tis. Obstet Gynecol 1990; 75: 52-8.
18. Roberts S, Maccato M, Faro S, Pinell P. The microbiology of post-cesarean wound morbidity. Obstet Gynecol 1993; 81:383-6.
19. Andrews WW, Shah SR, Goldenberg RL, Cliver SP, Hauth JC, Cassell GH. As-sociation of post-cesarean delivery endo-metritis with colonization of the chorio-amnion by Ureaplasma urealyticum. Obstet Gynecol 1995;85:509-14.
20. Keski-Nisula L, Kirkinen P, Katila ML, Ollikainen M, Suonio S, Saarikoski S. Amniotic fluid U. urealyticum colonization: significance for maternal peripartal infections at term. Am J Perinatol 1997; 14:151-6.
21. Yoon BH, Romero R, Park JS, et al. Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol 1998; 179: 1254-60.
22. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 101: ultrasonography in pregnancy. Obstet Gynecol 2009; 113: 451-61.
23. The National Healthcare Safety Network manual: patient safety component protocol. Atlanta: Centers for Diseases Control and Prevention, January 2008 (http://www.dhcs.ca.gov/provgovpart/initiatives/nqi/Documents/NHSNManPSPCurr.pdf).
24. Andrews WW, Hauth JC, Cliver SP, Savage K, Goldenberg RL. Randomized clinical trial of extended spectrum antibiotic prophylaxis with coverage for Urea-plasma urealyticum to reduce post-cesar-ean delivery endometritis. Obstet Gynecol 2003;101:1183-9.
25. Tita AT, Hauth JC, Grimes A, Owen J, Stamm AM, Andrews WW. Decreasing incidence of postcesarean endometritis with extended-spectrum antibiotic prophylaxis. Obstet Gynecol 2008; 111: 51-6.
26. Tita AT, Owen J, Stamm AM, Grimes A, Hauth JC, Andrews WW. Impact of ex-tended-spectrum antibiotic prophylaxis on incidence of postcesarean surgical wound infection. Am J Obstet Gynecol 2008; 199(3): 303.e1-3.
27. Pitt C, Sanchez-Ramos L, Kaunitz AM. Adjunctive intravaginal metronida-zole for the prevention of postcesarean endometritis: a randomized controlled trial. Obstet Gynecol 2001; 98: 745-50.
28. Meyer NL, Hosier KV, Scott K, Lip-scomb GH. Cefazolin versus cefazolin plus metronidazole for antibiotic prophylaxis at cesarean section. South Med J 2003;96:992-5.
29. Ray WA, Murray KT, Hall K, Arbogast PG, Stein CM. Azithromycin and the risk of cardiovascular death. N Engl J Med 2012;366:1881-90.
30. Svanström H, Pasternak B, Hviid A. Use of azithromycin and death from cardiovascular causes. N Engl J Med 2013; 368:1704-12.