-
1
-
-
85018500416
-
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
-
Chalmers ZR, Connelly CF, Fabrizio D, et al: Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Genome Med 9:34, 2017
-
(2017)
Genome Med
, vol.9
, pp. 34
-
-
Chalmers, Z.R.1
Connelly, C.F.2
Fabrizio, D.3
-
2
-
-
85020279899
-
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
-
epub ahead of print on May 8
-
Zehir A, Benayed R, Shah RH, et al: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med 10.1038/nm.4333 [epub ahead of print on May 8, 2017]
-
(2017)
Nat Med
-
-
Zehir, A.1
Benayed, R.2
Shah, R.H.3
-
3
-
-
84990048297
-
Limits to personalized cancer medicine
-
Tannock IF, Hickman JA: Limits to personalized cancer medicine. N Engl J Med 375:1289-1294, 2016
-
(2016)
N Engl J Med
, vol.375
, pp. 1289-1294
-
-
Tannock, I.F.1
Hickman, J.A.2
-
4
-
-
84865442326
-
Pharmacogenomics and personalized medicine: Wicked problems, ragged edges and ethical precipices
-
Fleck LM: Pharmacogenomics and personalized medicine: Wicked problems, ragged edges and ethical precipices. N Biotechnol 29:757-768, 2012
-
(2012)
N Biotechnol
, vol.29
, pp. 757-768
-
-
Fleck, L.M.1
-
5
-
-
84977103148
-
Shooting for the moon or flying too near the sun? Crossing the value Rubicon in precision cancer care
-
Lawler M, French D, Henderson R, et al: Shooting for the moon or flying too near the sun? Crossing the value Rubicon in precision cancer care. Public Health Genomics 19:132-136, 2016
-
(2016)
Public Health Genomics
, vol.19
, pp. 132-136
-
-
Lawler, M.1
French, D.2
Henderson, R.3
-
6
-
-
84986596477
-
Perspective: The precision-oncology illusion
-
Prasad V: Perspective: The precision-oncology illusion. Nature 537:S63, 2016
-
(2016)
Nature
, vol.537
, pp. S63
-
-
Prasad, V.1
-
7
-
-
85018364165
-
Waste, leaks, and failures in the biomarker pipeline
-
Ioannidis JPA, Bossuyt PMM: Waste, leaks, and failures in the biomarker pipeline. Clin Chem 63: 963-972, 2017
-
(2017)
Clin Chem
, vol.63
, pp. 963-972
-
-
Ioannidis, J.P.A.1
Bossuyt, P.M.M.2
-
8
-
-
84971635812
-
Problems, challenges and promises: Perspectives on precision medicine
-
Duffy DJ: Problems, challenges and promises: Perspectives on precision medicine. Brief Bioinform 17:494-504, 2016
-
(2016)
Brief Bioinform
, vol.17
, pp. 494-504
-
-
Duffy, D.J.1
-
9
-
-
85008457496
-
Limits to precision cancer medicine
-
Clark JW, Chabner BA: Limits to precision cancer medicine. N Engl J Med 376:96, 2017
-
(2017)
N Engl J Med
, vol.376
, pp. 96
-
-
Clark, J.W.1
Chabner, B.A.2
-
10
-
-
85013453521
-
Giving up on precision oncology? Not so fast!
-
Warner JL: Giving up on precision oncology? Not so fast! Clin Transl Sci 10:128-129, 2017
-
(2017)
Clin Transl Sci
, vol.10
, pp. 128-129
-
-
Warner, J.L.1
-
13
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A, Grob J-J, Demidov LV, et al: Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial. Lancet 380:358-365, 2012
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.-J.2
Demidov, L.V.3
-
14
-
-
84879071011
-
Cri-zotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim D-W, Nakagawa K, et al: Cri-zotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 368:2385-2394, 2013
-
(2013)
N Engl J Med
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.-W.2
Nakagawa, K.3
-
15
-
-
0036727124
-
Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
-
Rubin BP, Schuetze SM, Eary JF, et al: Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 20: 3586-3591, 2002
-
(2002)
J Clin Oncol
, vol.20
, pp. 3586-3591
-
-
Rubin, B.P.1
Schuetze, S.M.2
Eary, J.F.3
-
16
-
-
84964378373
-
Efficacy and biological activity of imatinib in metastatic dermatofibrosarcoma protuberans (DFSP)
-
Stacchiotti S, Pantaleo MA, Negri T, et al: Efficacy and biological activity of imatinib in metastatic dermatofibrosarcoma protuberans (DFSP). Clin Cancer Res 22:837-846, 2016
-
(2016)
Clin Cancer Res
, vol.22
, pp. 837-846
-
-
Stacchiotti, S.1
Pantaleo, M.A.2
Negri, T.3
-
17
-
-
84928739294
-
AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer
-
Jänne PA, Yang JC-H, Kim D-W, et al: AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med 372:1689-1699, 2015
-
(2015)
N Engl J Med
, vol.372
, pp. 1689-1699
-
-
Jänne, P.A.1
Yang, J.C.-H.2
Kim, D.-W.3
-
19
-
-
85037358390
-
Comparison of 2 commercially available next-generation sequencing platforms in oncology
-
Kuderer NM, Burton KA, Blau S, et al: Comparison of 2 commercially available next-generation sequencing platforms in oncology. JAMA Oncol 3: 996-998, 2017
-
(2017)
JAMA Oncol
, vol.3
, pp. 996-998
-
-
Kuderer, N.M.1
Burton, K.A.2
Blau, S.3
-
20
-
-
84992447372
-
Conflicting interpretation of genetic variants and cancer risk by commercial laboratories as assessed by the prospective registry of multiplex testing
-
Balmaña J, Digiovanni L, Gaddam P, et al: Conflicting interpretation of genetic variants and cancer risk by commercial laboratories as assessed by the Prospective Registry of Multiplex Testing. J Clin Oncol 34:4071-4078, 2016
-
(2016)
J Clin Oncol
, vol.34
, pp. 4071-4078
-
-
Balmaña, J.1
Digiovanni, L.2
Gaddam, P.3
-
21
-
-
85020684018
-
Clinical variant classification: A comparison of public databases and a commercial testing laboratory
-
Gradishar W, Johnson K, Brown K, et al: Clinical variant classification: A comparison of public databases and a commercial testing laboratory. Oncologist 22:797-803, 2017
-
(2017)
Oncologist
, vol.22
, pp. 797-803
-
-
Gradishar, W.1
Johnson, K.2
Brown, K.3
-
22
-
-
84981225429
-
Automated identification of molecular effects of drugs (AIMED)
-
Fathiamini S, Johnson AM, Zeng J, et al: Automated identification of molecular effects of drugs (AIMED). J Am Med Inform Assoc 23:758-765, 2016
-
(2016)
J Am Med Inform Assoc
, vol.23
, pp. 758-765
-
-
Fathiamini, S.1
Johnson, A.M.2
Zeng, J.3
-
23
-
-
0025833975
-
Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
-
Ziemin-van der Poel S, McCabe NR, Gill HJ, et al: Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA 88: 10735-10739, 1991
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 10735-10739
-
-
Ziemin-Van der Poel, S.1
McCabe, N.R.2
Gill, H.J.3
-
25
-
-
84992463448
-
Integrating cancer genomic data into electronic health records
-
Warner JL, Jain SK, Levy MA: Integrating cancer genomic data into electronic health records. Genome Med 8:113, 2016
-
(2016)
Genome Med
, vol.8
, pp. 113
-
-
Warner, J.L.1
Jain, S.K.2
Levy, M.A.3
-
26
-
-
85029680923
-
-
Sync4Genes Foundation for the National Institutes of Health https: //fnihorg/
-
Sync4Genes: http://www.sync4genes.org/27. Foundation for the National Institutes of Health: https: //fnih.org/
-
-
-
-
27
-
-
85029685398
-
-
National Institutes of Health
-
National Institutes of Health: President’s Cancer Panel Reports. https://deainfo.nci.nih.gov/advisory/pcp/annualReports/
-
President’s Cancer Panel Reports
-
-
-
28
-
-
84865171465
-
The SMART platform: Early experience enabling substitutable applications for electronic health records
-
Mandl KD, Mandel JC, Murphy SN, et al: The SMART platform: Early experience enabling substitutable applications for electronic health records. J Am Med Inform Assoc 19:597-603, 2012
-
(2012)
J Am Med Inform Assoc
, vol.19
, pp. 597-603
-
-
Mandl, K.D.1
Mandel, J.C.2
Murphy, S.N.3
-
29
-
-
84995784013
-
SMART on FHIR: A standards-based, interoperable apps platform for electronic health records
-
Mandel JC, Kreda DA, Mandl KD, et al: SMART on FHIR: A standards-based, interoperable apps platform for electronic health records. J Am Med Inform Assoc 23:899-908, 2016
-
(2016)
J Am Med Inform Assoc
, vol.23
, pp. 899-908
-
-
Mandel, J.C.1
Kreda, D.A.2
Mandl, K.D.3
-
30
-
-
84938417255
-
Driving innovation in health systems through an apps-based information economy
-
Mandl KD, Mandel JC, Kohane IS: Driving innovation in health systems through an apps-based information economy. Cell Syst 1:8-13, 2015
-
(2015)
Cell Syst
, vol.1
, pp. 8-13
-
-
Mandl, K.D.1
Mandel, J.C.2
Kohane, I.S.3
-
32
-
-
0028982932
-
A novel p16INK4A transcript
-
Mao L, Merlo A, Bedi G, et al: A novel p16INK4A transcript. Cancer Res 55:2995-2997, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 2995-2997
-
-
Mao, L.1
Merlo, A.2
Bedi, G.3
-
33
-
-
84880467544
-
Clinical analysis and interpretation of cancer genome data
-
Van Allen EM, Wagle N, Levy MA: Clinical analysis and interpretation of cancer genome data. J Clin Oncol 31:1825-1833, 2013
-
(2013)
J Clin Oncol
, vol.31
, pp. 1825-1833
-
-
Van Allen, E.M.1
Wagle, N.2
Levy, M.A.3
-
34
-
-
84957699623
-
A classification system for clinical relevance of somatic variants identified in molecular profiling of cancer
-
Sukhai MA, Craddock KJ, Thomas M, et al: A classification system for clinical relevance of somatic variants identified in molecular profiling of cancer. Genet Med 18:128-136, 2016
-
(2016)
Genet Med
, vol.18
, pp. 128-136
-
-
Sukhai, M.A.1
Craddock, K.J.2
Thomas, M.3
-
35
-
-
84997207493
-
Somatic cancer variant curation and harmonization through consensus minimum variant level data
-
Ritter DI, Roychowdhury S, Roy A, et al: Somatic cancer variant curation and harmonization through consensus minimum variant level data. Genome Med 8:117, 2016
-
(2016)
Genome Med
, vol.8
, pp. 117
-
-
Ritter, D.I.1
Roychowdhury, S.2
Roy, A.3
-
36
-
-
85006371175
-
Standards and guidelines for the interpretation and reporting of sequence variants in cancer: A joint consensus recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists
-
Li MM, Datto M, Duncavage EJ, et al: Standards and guidelines for the interpretation and reporting of sequence variants in cancer: A joint consensus recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists. J Mol Diagn 19:4-23, 2017
-
(2017)
J Mol Diagn
, vol.19
, pp. 4-23
-
-
Li, M.M.1
Datto, M.2
Duncavage, E.J.3
-
37
-
-
84982253941
-
Analysis of protein-coding genetic variation in 60,706 humans
-
Lek M, Karczewski KJ, Minikel EV, et al: Analysis of protein-coding genetic variation in 60,706 humans. Nature 536:285-291, 2016
-
(2016)
Nature
, vol.536
, pp. 285-291
-
-
Lek, M.1
Karczewski, K.J.2
Minikel, E.V.3
-
38
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, et al: Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364: 2507-2516, 2011
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
39
-
-
84955216501
-
BRAF mutation in colorectal cancer: An update
-
Barras D: BRAF mutation in colorectal cancer: An update. Biomark Cancer 7:9-12, 2015 (suppl 1)
-
(2015)
Biomark Cancer
, vol.7
, pp. 9-12
-
-
Barras, D.1
-
40
-
-
84959928812
-
TP53 mutational status is predictive of pazopanib response in advanced sarcomas
-
Koehler K, Liebner D, Chen JL: TP53 mutational status is predictive of pazopanib response in advanced sarcomas. Ann Oncol 27:539-543, 2016
-
(2016)
Ann Oncol
, vol.27
, pp. 539-543
-
-
Koehler, K.1
Liebner, D.2
Chen, J.L.3
-
41
-
-
85018644112
-
Results from the phase III randomized trial of onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIB or IV non-small-cell lung cancer: METLung
-
Spigel DR, Edelman MJ, O’Byrne K, et al: Results from the phase III randomized trial of onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIB or IV non-small-cell lung cancer: METLung. J Clin Oncol 35:412-420, 2017
-
(2017)
J Clin Oncol
, vol.35
, pp. 412-420
-
-
Spigel, D.R.1
Edelman, M.J.2
O’Byrne, K.3
-
42
-
-
0025127021
-
Knowledge bases in medicine: A review
-
Perry CA: Knowledge bases in medicine: A review. Bull Med Libr Assoc 78:271-282, 1990
-
(1990)
Bull Med Libr Assoc
, vol.78
, pp. 271-282
-
-
Perry, C.A.1
-
44
-
-
84976904305
-
ClinVar: Public archive of interpretations of clinically relevant variants
-
Landrum MJ, Lee JM, Benson M, et al: ClinVar: Public archive of interpretations of clinically relevant variants. Nucleic Acids Res 44:D862-D868, 2016 (suppl D1)
-
(2016)
Nucleic Acids Res
, vol.44
, pp. D862-D868
-
-
Landrum, M.J.1
Lee, J.M.2
Benson, M.3
-
45
-
-
84930526399
-
ClinGen–the clinical genome resource
-
Rehm HL, Berg JS, Brooks LD, et al: ClinGen–the clinical genome resource. N Engl J Med 372: 2235-2242, 2015
-
(2015)
N Engl J Med
, vol.372
, pp. 2235-2242
-
-
Rehm, H.L.1
Berg, J.S.2
Brooks, L.D.3
-
47
-
-
85011275698
-
CIViC is a community knowledgebase for expert crowd-sourcing the clinical interpretation of variants in cancer
-
Griffith M, Spies NC, Krysiak K, et al: CIViC is a community knowledgebase for expert crowd-sourcing the clinical interpretation of variants in cancer. Nat Genet 49:170-174, 2017
-
(2017)
Nat Genet
, vol.49
, pp. 170-174
-
-
Griffith, M.1
Spies, N.C.2
Krysiak, K.3
-
48
-
-
85019771721
-
The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations
-
Huang L, Fernandes H, Zia H, et al: The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations. J Am Med Inform Assoc 24:513-519, 2017
-
(2017)
J Am Med Inform Assoc
, vol.24
, pp. 513-519
-
-
Huang, L.1
Fernandes, H.2
Zia, H.3
-
49
-
-
85029692197
-
-
National Center for Biotechnology Information All resources
-
National Center for Biotechnology Information: All resources. https://www.ncbi.nlm.nih.gov/guide/all/
-
-
-
-
50
-
-
85029687520
-
Use of public human genetic variant databases to support clinical validity for next generation sequencing-based in vitro diagnostics
-
Federal Register
-
Federal Register: Use of public human genetic variant databases to support clinical validity for next generation sequencing-based in vitro diagnostics; Draft guidance for stakeholders and Food and Drug Administration Staff; Availability. https:// www.federalregister.gov/documents/2016/07/08/2016-16200/use-of-public-human-genetic-variant-databases-to-support-clinical-validity-for-next-generation
-
Draft Guidance for Stakeholders and Food and Drug Administration Staff; Availability
-
-
-
52
-
-
84923762812
-
A new initiative on precision medicine
-
Collins FS, Varmus H: A new initiative on precision medicine. N Engl J Med 372:793-795, 2015
-
(2015)
N Engl J Med
, vol.372
, pp. 793-795
-
-
Collins, F.S.1
Varmus, H.2
-
53
-
-
85017658082
-
Cancer moonshot data and technology team: Enabling a national learning healthcare system for cancer to unleash the power of Data
-
Hsu ER, Klemm JD, Kerlavage AR, et al: Cancer moonshot data and technology team: Enabling a national learning healthcare system for cancer to unleash the power of Data. Clin Pharmacol Ther 101:613-615, 2017
-
(2017)
Clin Pharmacol Ther
, vol.101
, pp. 613-615
-
-
Hsu, E.R.1
Klemm, J.D.2
Kerlavage, A.R.3
|