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Volumn 29, Issue 6, 2012, Pages 757-768

Pharmacogenomics and personalized medicine: Wicked problems, ragged edges and ethical precipices

Author keywords

[No Author keywords available]

Indexed keywords

CANCER DRUG; ETHICAL ISSUES; ETHICAL QUESTION; ETHICAL THEORIES; GENETIC TESTING; LIFE EXPECTANCIES; PERSONALIZED MEDICINES; PHARMACOGENOMICS; PREMATURE DEATH; TARGETED CANCER THERAPY; WICKED PROBLEMS;

EID: 84865442326     PISSN: 18716784     EISSN: 18764347     Source Type: Journal    
DOI: 10.1016/j.nbt.2012.03.002     Document Type: Article
Times cited : (25)

References (53)
  • 1
    • 79953216429 scopus 로고    scopus 로고
    • Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan
    • Chen P., et al. Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N. Engl. J. Med. 2011, 364:1126-1133.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 1126-1133
    • Chen, P.1
  • 2
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathy-a genomewide study
    • Link E., et al. SLCO1B1 variants and statin-induced myopathy-a genomewide study. N. Engl. J. Med. 2008, 359:789-799.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 789-799
    • Link, E.1
  • 3
    • 84873071890 scopus 로고    scopus 로고
    • Ideas for how to take wicked problems seriously
    • Ethics (e-published ahead of print, 11/20/11 )
    • Whyte KP, Thompson PB. (2011) Ideas for how to take wicked problems seriously. J. Agric. Environ. Ethics (e-published ahead of print, 11/20/11 ). http://www.springerlink.com.proxy2.cl.msu.edu/content/k3582206v1688261/fulltext.pdf.
    • (2011) J. Agric. Environ.
    • Whyte, K.P.1    Thompson, P.B.2
  • 5
    • 68249134187 scopus 로고    scopus 로고
    • How much is life worth: cetuximab, non-small cell lung cancer, and the $440 billion question
    • Fojo T., Grady C. How much is life worth: cetuximab, non-small cell lung cancer, and the $440 billion question. J. Natl. Cancer Inst. 2009, 101:1044-1048.
    • (2009) J. Natl. Cancer Inst. , vol.101 , pp. 1044-1048
    • Fojo, T.1    Grady, C.2
  • 6
    • 9944238860 scopus 로고
    • Dilemmas in a general theory of planning
    • Rittel H.W., Webber M.M. Dilemmas in a general theory of planning. Policy Sci. 1973, 4:155-169.
    • (1973) Policy Sci. , vol.4 , pp. 155-169
    • Rittel, H.W.1    Webber, M.M.2
  • 7
    • 65549153613 scopus 로고    scopus 로고
    • Efficacy does not necessarily translate to cost effectiveness: a case study in the challenges associated with 21st-century cancer drug pricing
    • Hillner B.E., Smith T.J. Efficacy does not necessarily translate to cost effectiveness: a case study in the challenges associated with 21st-century cancer drug pricing. J. Clin. Onc. 2009, 27:2111-2113.
    • (2009) J. Clin. Onc. , vol.27 , pp. 2111-2113
    • Hillner, B.E.1    Smith, T.J.2
  • 9
    • 77649126524 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2010 update: a report from the American Heart Association
    • Lloyd-Jones D., et al. Heart disease and stroke statistics - 2010 update: a report from the American Heart Association. Circulation 2010, 121:e46-e215.
    • (2010) Circulation , vol.121
    • Lloyd-Jones, D.1
  • 10
    • 77953689844 scopus 로고    scopus 로고
    • Health spending projections through 2019: the recession's impact continues
    • Truffer C.J., et al. Health spending projections through 2019: the recession's impact continues. Hlth. Aff. 2010, 29:522-529.
    • (2010) Hlth. Aff. , vol.29 , pp. 522-529
    • Truffer, C.J.1
  • 11
    • 33749339052 scopus 로고    scopus 로고
    • The rise in spending among medicare beneficiaries: the role of chronic disease prevalence and changes in treatment intensity
    • Thorpe K.E., Howard D.H. The rise in spending among medicare beneficiaries: the role of chronic disease prevalence and changes in treatment intensity. Hlth. Aff. 2006, 25:w378-w388.
    • (2006) Hlth. Aff. , vol.25
    • Thorpe, K.E.1    Howard, D.H.2
  • 12
    • 80051580618 scopus 로고    scopus 로고
    • Cancer Statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R., et al. Cancer Statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J. Clin. 2011, 61:212-236.
    • (2011) CA Cancer J. Clin. , vol.61 , pp. 212-236
    • Siegel, R.1
  • 13
    • 79953295767 scopus 로고    scopus 로고
    • European cancer mortality predictions for the year 2011
    • Malvezzi M., et al. European cancer mortality predictions for the year 2011. Ann. Onc. 2011, 22:947-956.
    • (2011) Ann. Onc. , vol.22 , pp. 947-956
    • Malvezzi, M.1
  • 14
    • 78650382003 scopus 로고    scopus 로고
    • Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?
    • Fojo T., Parkinson D.R. Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?. Clin. Cancer Res. 2010, 16:5972-5980.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5972-5980
    • Fojo, T.1    Parkinson, D.R.2
  • 15
    • 32944472716 scopus 로고    scopus 로고
    • Do oncologists believe new cancer drugs offer good value?
    • Nadler E., et al. Do oncologists believe new cancer drugs offer good value?. Oncologist 2006, 11:90-95.
    • (2006) Oncologist , vol.11 , pp. 90-95
    • Nadler, E.1
  • 16
    • 79955857876 scopus 로고    scopus 로고
    • Despite steep costs, payments for new cancer drugs make economic sense
    • Lichtenberg F.R. Despite steep costs, payments for new cancer drugs make economic sense. Nat. Med. 2011, 17:244.
    • (2011) Nat. Med. , vol.17 , pp. 244
    • Lichtenberg, F.R.1
  • 17
    • 70450031293 scopus 로고    scopus 로고
    • The effect of new cancer drug approvals on life expectancy of American cancer patients, 1978-2004
    • Lichtenberg F.R. The effect of new cancer drug approvals on life expectancy of American cancer patients, 1978-2004. Econ. Innov. New Technol. 2009, 18:407-428.
    • (2009) Econ. Innov. New Technol. , vol.18 , pp. 407-428
    • Lichtenberg, F.R.1
  • 18
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomized phase III trial
    • Pirker R., et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomized phase III trial. Lancet 2009, 373:1525-1531.
    • (2009) Lancet , vol.373 , pp. 1525-1531
    • Pirker, R.1
  • 19
    • 77949891126 scopus 로고    scopus 로고
    • Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099
    • Lynch T.J., et al. Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099. J. Clin. Oncol. 2010, 28:911-917.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 911-917
    • Lynch, T.J.1
  • 20
    • 80855153022 scopus 로고    scopus 로고
    • The climbing costs of cancer care
    • MacReady N. The climbing costs of cancer care. J. Natl. Cancer. Inst. 2011, 103:1433-1435.
    • (2011) J. Natl. Cancer. Inst. , vol.103 , pp. 1433-1435
    • MacReady, N.1
  • 21
    • 80755181119 scopus 로고    scopus 로고
    • Maintenance therapy comes of age for non-small-cell lung cancer, but at what cost?
    • Shepard F.A. Maintenance therapy comes of age for non-small-cell lung cancer, but at what cost?. J. Clin. Oncol. 2011, 29:4068-4070.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4068-4070
    • Shepard, F.A.1
  • 22
    • 77949529722 scopus 로고    scopus 로고
    • Cancer's next frontier: addressing high and increasing costs
    • Elkin E.B., Bach P.B. Cancer's next frontier: addressing high and increasing costs. JAMA 2010, 303:1086-1087.
    • (2010) JAMA , vol.303 , pp. 1086-1087
    • Elkin, E.B.1    Bach, P.B.2
  • 23
    • 78149313454 scopus 로고    scopus 로고
    • What is the value of oncology medicines?
    • Cohen J., Looney W. What is the value of oncology medicines?. Nat. Biotechnol. 2010, 28:1160-1163.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1160-1163
    • Cohen, J.1    Looney, W.2
  • 24
    • 68949112230 scopus 로고    scopus 로고
    • American Society of Clinical Oncology guidance statement: the cost of cancer care
    • Meropol N.J., et al. American Society of Clinical Oncology guidance statement: the cost of cancer care. J. Clin. Oncol. 2009, 27:3868-3874.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3868-3874
    • Meropol, N.J.1
  • 25
    • 78751647585 scopus 로고    scopus 로고
    • How affordable are targeted therapies in non-small cell lung cancer?
    • Coate L.E., Leighl N.B. How affordable are targeted therapies in non-small cell lung cancer?. Curr. Treat. Opt. Oncol. 2011, 12:1-11.
    • (2011) Curr. Treat. Opt. Oncol. , vol.12 , pp. 1-11
    • Coate, L.E.1    Leighl, N.B.2
  • 26
    • 77749292143 scopus 로고    scopus 로고
    • Economics and the new generation of targeted therapies for non-small cell lung cancer
    • Ramsey S.D. Economics and the new generation of targeted therapies for non-small cell lung cancer. J. Natl. Cancer Inst. 2010, 102:287-288.
    • (2010) J. Natl. Cancer Inst. , vol.102 , pp. 287-288
    • Ramsey, S.D.1
  • 27
    • 77950977929 scopus 로고    scopus 로고
    • The value of new chemotherapeutic agents for metastatic colorectal cancer
    • Howard D.H., et al. The value of new chemotherapeutic agents for metastatic colorectal cancer. Arch. Intern. Med. 2010, 170:537-542.
    • (2010) Arch. Intern. Med. , vol.170 , pp. 537-542
    • Howard, D.H.1
  • 28
    • 79955012384 scopus 로고    scopus 로고
    • The war on cancer: progress at what price?
    • Konski A. The war on cancer: progress at what price?. J. Clin. Oncol. 2011, 29:1503-1504.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1503-1504
    • Konski, A.1
  • 29
    • 33846976143 scopus 로고    scopus 로고
    • Cancer care, money, and the value of life: whose justice? Which rationality?
    • Sulmasy D.P. Cancer care, money, and the value of life: whose justice? Which rationality?. J. Clin. Oncol. 2007, 25:217-222.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 217-222
    • Sulmasy, D.P.1
  • 30
    • 78349275747 scopus 로고    scopus 로고
    • An official American Thoracic Society systematic review: insurance status and disparities in lung cancer practices and outcomes
    • Slatore C.G., et al. An official American Thoracic Society systematic review: insurance status and disparities in lung cancer practices and outcomes. Am. J. Respir. Crit. Car. Med. 2010, 182:1195-1205.
    • (2010) Am. J. Respir. Crit. Car. Med. , vol.182 , pp. 1195-1205
    • Slatore, C.G.1
  • 31
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker B.J., et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. New Engl. J. Med. 2001, 344:1031-1037.
    • (2001) New Engl. J. Med. , vol.344 , pp. 1031-1037
    • Druker, B.J.1
  • 32
    • 77953697842 scopus 로고    scopus 로고
    • Even better kinase inhibitors for chronic myeloid leukemia
    • Sawyers C.L. Even better kinase inhibitors for chronic myeloid leukemia. New Engl. J. Med. 2010, 362:2314-2315.
    • (2010) New Engl. J. Med. , vol.362 , pp. 2314-2315
    • Sawyers, C.L.1
  • 33
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian H., et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 2010, 362:2260-2270.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 2260-2270
    • Kantarjian, H.1
  • 34
    • 33845238711 scopus 로고    scopus 로고
    • How much will Herceptin really cost?
    • Barrett A., et al. How much will Herceptin really cost?. BMJ 2006, 333:1118-1120.
    • (2006) BMJ , vol.333 , pp. 1118-1120
    • Barrett, A.1
  • 35
    • 53749093040 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG2100
    • Schneider B.P., et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG2100. J. Clin. Oncol. 2008, 26:4672-4678.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 4672-4678
    • Schneider, B.P.1
  • 37
    • 84865418468 scopus 로고    scopus 로고
    • The Avastin denial: a chillingly blunt assertion of regulatory power against a drug for breast cancer
    • (Nov. 19), on-line opinion, Anonymous
    • Anonymous The Avastin denial: a chillingly blunt assertion of regulatory power against a drug for breast cancer. Wall Street J. 2011, (Nov. 19), on-line opinion.
    • (2011) Wall Street J.
  • 38
    • 84855458480 scopus 로고    scopus 로고
    • Why doesn't no mean no?
    • (Nov. 21), opinion. (Last accessed 1.12.12).
    • Nocera J. Why doesn't no mean no?. New York Times 2011, (Nov. 21), opinion. http://www.nytimes.com/2011/11/22/opinion/why-doesnt-no-mean-no.html? (Last accessed 1.12.12).
    • (2011) New York Times
    • Nocera, J.1
  • 39
    • 77950456465 scopus 로고    scopus 로고
    • Molecular predictors of efficacy to anti-EFGR agents in colorectal cancer patients
    • Ruzzo A., et al. Molecular predictors of efficacy to anti-EFGR agents in colorectal cancer patients. Curr. Cancer Drug Targets 2010, 10:68-79.
    • (2010) Curr. Cancer Drug Targets , vol.10 , pp. 68-79
    • Ruzzo, A.1
  • 40
    • 77956625930 scopus 로고    scopus 로고
    • th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2009
    • th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2009. Ann. Oncol. 2010, 21(Suppl. 6):vi1-vi10.
    • (2010) Ann. Oncol. , vol.21 , Issue.SUPPL. 6
    • VanCutsem, E.1
  • 41
    • 80052210041 scopus 로고    scopus 로고
    • KRAS and colorectal cancer: ethical and pragmatic issues in effecting real-time change in oncology clinical trials and practice
    • Blanke C.D., et al. KRAS and colorectal cancer: ethical and pragmatic issues in effecting real-time change in oncology clinical trials and practice. Oncologist 2011, 16:1061-1068.
    • (2011) Oncologist , vol.16 , pp. 1061-1068
    • Blanke, C.D.1
  • 42
    • 74749085829 scopus 로고    scopus 로고
    • Current progress in targeted therapy for colorectal cancer
    • Ortega J., et al. Current progress in targeted therapy for colorectal cancer. Cancer Control 2010, 17:7-15.
    • (2010) Cancer Control , vol.17 , pp. 7-15
    • Ortega, J.1
  • 43
    • 78650171978 scopus 로고    scopus 로고
    • Letting go: what should medicine do when it can't save your life?
    • Gawande A. Letting go: what should medicine do when it can't save your life?. New Yorker 2010, 36-51.
    • (2010) New Yorker , pp. 36-51
    • Gawande, A.1
  • 44
    • 80054714783 scopus 로고    scopus 로고
    • The intensity and variation of surgical care at the end of life: a retrospective cohort study
    • Kwok A.C., et al. The intensity and variation of surgical care at the end of life: a retrospective cohort study. Lancet 2011, 378:1408-1413.
    • (2011) Lancet , vol.378 , pp. 1408-1413
    • Kwok, A.C.1
  • 45
    • 84873067647 scopus 로고    scopus 로고
    • Aging out of health care? Ever-increasing costs prompt some doctors to ask if a patient can be too old for a lifesaving but expensive procedure
    • (Nov. 30). (Accessed 03.12.11)
    • Pevtzow L. Aging out of health care? Ever-increasing costs prompt some doctors to ask if a patient can be too old for a lifesaving but expensive procedure. Chicago Tribune 2011, (Nov. 30). http://www.chicagotribune.com/health/ct-x-surgery-for-old-20111130,0,3225217,print.story (Accessed 03.12.11).
    • (2011) Chicago Tribune
    • Pevtzow, L.1
  • 46
    • 79955393280 scopus 로고    scopus 로고
    • Cardiac care for older adults: time for a new paradigm
    • Forman D.E., et al. Cardiac care for older adults: time for a new paradigm. J. Am. Coll. Cardiol. 2011, 57:1801-1810.
    • (2011) J. Am. Coll. Cardiol. , vol.57 , pp. 1801-1810
    • Forman, D.E.1
  • 47
    • 79955858694 scopus 로고    scopus 로고
    • Just caring: health care rationing, terminal illness, and the medically least well off
    • Fleck L.M. Just caring: health care rationing, terminal illness, and the medically least well off. J. Law Med. Ethics 2011, 39:156-171.
    • (2011) J. Law Med. Ethics , vol.39 , pp. 156-171
    • Fleck, L.M.1
  • 48
    • 77954455413 scopus 로고    scopus 로고
    • Health rationing in Europe: can cancer get a fair hearing?
    • Wagstaff A. Health rationing in Europe: can cancer get a fair hearing?. Cancer World 2009, 24-31.
    • (2009) Cancer World , pp. 24-31
    • Wagstaff, A.1
  • 50
    • 77955877759 scopus 로고    scopus 로고
    • Early palliative care for patients with metastatic non-small-cell lung cancer
    • Temel J.S., et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N. Engl. J. Med. 2010, 363:733-742.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 733-742
    • Temel, J.S.1
  • 51
    • 54349110135 scopus 로고
    • Columbia University Press, New York
    • Rawls J. Political Liberalism 1993, Columbia University Press, New York.
    • (1993) Political Liberalism
    • Rawls, J.1
  • 52
    • 80053238941 scopus 로고    scopus 로고
    • Delivering affordable cancer care in high-income countries
    • Lancet Oncology Commission
    • Lancet Oncology Commission Delivering affordable cancer care in high-income countries. Lancet Oncol. 2011, 12:933-980.
    • (2011) Lancet Oncol. , vol.12 , pp. 933-980


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